Amino acid dipepetide frequency for Flavobacterium fontis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.589AlaAla: 5.589 ± 0.124
0.674AlaCys: 0.674 ± 0.031
3.416AlaAsp: 3.416 ± 0.065
4.09AlaGlu: 4.09 ± 0.08
3.702AlaPhe: 3.702 ± 0.078
4.573AlaGly: 4.573 ± 0.124
1.396AlaHis: 1.396 ± 0.045
5.191AlaIle: 5.191 ± 0.078
4.331AlaLys: 4.331 ± 0.087
8.026AlaLeu: 8.026 ± 0.12
1.676AlaMet: 1.676 ± 0.048
3.645AlaAsn: 3.645 ± 0.083
2.709AlaPro: 2.709 ± 0.081
3.899AlaGln: 3.899 ± 0.076
2.445AlaArg: 2.445 ± 0.059
4.335AlaSer: 4.335 ± 0.091
5.154AlaThr: 5.154 ± 0.134
5.026AlaVal: 5.026 ± 0.084
0.754AlaTrp: 0.754 ± 0.028
2.651AlaTyr: 2.651 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.711CysAla: 0.711 ± 0.049
0.111CysCys: 0.111 ± 0.012
0.446CysAsp: 0.446 ± 0.024
0.48CysGlu: 0.48 ± 0.023
0.475CysPhe: 0.475 ± 0.024
0.735CysGly: 0.735 ± 0.039
0.192CysHis: 0.192 ± 0.018
0.649CysIle: 0.649 ± 0.028
0.451CysLys: 0.451 ± 0.023
0.781CysLeu: 0.781 ± 0.028
0.162CysMet: 0.162 ± 0.014
0.457CysAsn: 0.457 ± 0.024
0.406CysPro: 0.406 ± 0.027
0.331CysGln: 0.331 ± 0.026
0.258CysArg: 0.258 ± 0.019
0.694CysSer: 0.694 ± 0.032
0.573CysThr: 0.573 ± 0.031
0.555CysVal: 0.555 ± 0.029
0.09CysTrp: 0.09 ± 0.009
0.35CysTyr: 0.35 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.934AspAla: 3.934 ± 0.076
0.499AspCys: 0.499 ± 0.027
2.338AspAsp: 2.338 ± 0.067
3.109AspGlu: 3.109 ± 0.066
3.366AspPhe: 3.366 ± 0.066
3.291AspGly: 3.291 ± 0.083
0.873AspHis: 0.873 ± 0.029
3.375AspIle: 3.375 ± 0.069
3.233AspLys: 3.233 ± 0.074
4.66AspLeu: 4.66 ± 0.077
0.947AspMet: 0.947 ± 0.033
2.497AspAsn: 2.497 ± 0.056
1.759AspPro: 1.759 ± 0.044
1.564AspGln: 1.564 ± 0.046
2.038AspArg: 2.038 ± 0.05
2.537AspSer: 2.537 ± 0.056
2.855AspThr: 2.855 ± 0.061
3.278AspVal: 3.278 ± 0.069
0.708AspTrp: 0.708 ± 0.026
2.618AspTyr: 2.618 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.957GluAla: 4.957 ± 0.091
0.388GluCys: 0.388 ± 0.021
2.736GluAsp: 2.736 ± 0.065
4.099GluGlu: 4.099 ± 0.082
2.565GluPhe: 2.565 ± 0.06
3.561GluGly: 3.561 ± 0.066
1.142GluHis: 1.142 ± 0.036
4.644GluIle: 4.644 ± 0.082
5.091GluLys: 5.091 ± 0.1
5.427GluLeu: 5.427 ± 0.09
1.552GluMet: 1.552 ± 0.045
3.685GluAsn: 3.685 ± 0.074
1.668GluPro: 1.668 ± 0.053
2.501GluGln: 2.501 ± 0.055
2.643GluArg: 2.643 ± 0.066
3.046GluSer: 3.046 ± 0.052
3.554GluThr: 3.554 ± 0.06
4.28GluVal: 4.28 ± 0.069
0.636GluTrp: 0.636 ± 0.025
2.028GluTyr: 2.028 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.378PheAla: 3.378 ± 0.07
0.511PheCys: 0.511 ± 0.026
3.127PheAsp: 3.127 ± 0.06
3.376PheGlu: 3.376 ± 0.067
2.939PhePhe: 2.939 ± 0.085
3.595PheGly: 3.595 ± 0.076
1.005PheHis: 1.005 ± 0.035
3.375PheIle: 3.375 ± 0.066
3.043PheLys: 3.043 ± 0.072
4.77PheLeu: 4.77 ± 0.086
1.161PheMet: 1.161 ± 0.041
2.937PheAsn: 2.937 ± 0.068
1.938PhePro: 1.938 ± 0.05
1.943PheGln: 1.943 ± 0.05
1.907PheArg: 1.907 ± 0.051
3.665PheSer: 3.665 ± 0.077
3.78PheThr: 3.78 ± 0.09
3.292PheVal: 3.292 ± 0.063
0.671PheTrp: 0.671 ± 0.031
2.16PheTyr: 2.16 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.524GlyAla: 4.524 ± 0.093
0.763GlyCys: 0.763 ± 0.033
2.873GlyAsp: 2.873 ± 0.058
3.144GlyGlu: 3.144 ± 0.062
3.648GlyPhe: 3.648 ± 0.072
4.522GlyGly: 4.522 ± 0.103
1.146GlyHis: 1.146 ± 0.036
5.158GlyIle: 5.158 ± 0.093
4.687GlyLys: 4.687 ± 0.083
6.037GlyLeu: 6.037 ± 0.089
1.725GlyMet: 1.725 ± 0.047
3.554GlyAsn: 3.554 ± 0.088
1.5GlyPro: 1.5 ± 0.044
2.366GlyGln: 2.366 ± 0.053
2.131GlyArg: 2.131 ± 0.057
3.921GlySer: 3.921 ± 0.075
5.012GlyThr: 5.012 ± 0.149
4.557GlyVal: 4.557 ± 0.078
0.861GlyTrp: 0.861 ± 0.036
2.801GlyTyr: 2.801 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.161HisAla: 1.161 ± 0.043
0.236HisCys: 0.236 ± 0.019
0.918HisAsp: 0.918 ± 0.032
1.168HisGlu: 1.168 ± 0.04
1.332HisPhe: 1.332 ± 0.045
1.12HisGly: 1.12 ± 0.035
0.617HisHis: 0.617 ± 0.027
1.229HisIle: 1.229 ± 0.041
1.03HisLys: 1.03 ± 0.037
1.976HisLeu: 1.976 ± 0.052
0.318HisMet: 0.318 ± 0.02
0.936HisAsn: 0.936 ± 0.034
1.067HisPro: 1.067 ± 0.035
0.98HisGln: 0.98 ± 0.034
0.808HisArg: 0.808 ± 0.029
1.07HisSer: 1.07 ± 0.034
1.011HisThr: 1.011 ± 0.029
1.089HisVal: 1.089 ± 0.036
0.288HisTrp: 0.288 ± 0.018
1.001HisTyr: 1.001 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.749IleAla: 5.749 ± 0.089
0.655IleCys: 0.655 ± 0.039
4.035IleAsp: 4.035 ± 0.076
4.545IleGlu: 4.545 ± 0.082
3.0IlePhe: 3.0 ± 0.062
4.598IleGly: 4.598 ± 0.089
1.389IleHis: 1.389 ± 0.046
4.706IleIle: 4.706 ± 0.093
4.205IleLys: 4.205 ± 0.078
6.106IleLeu: 6.106 ± 0.096
1.209IleMet: 1.209 ± 0.038
3.746IleAsn: 3.746 ± 0.076
3.328IlePro: 3.328 ± 0.062
3.012IleGln: 3.012 ± 0.06
2.816IleArg: 2.816 ± 0.061
4.231IleSer: 4.231 ± 0.066
4.807IleThr: 4.807 ± 0.086
4.646IleVal: 4.646 ± 0.083
0.623IleTrp: 0.623 ± 0.024
2.399IleTyr: 2.399 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.981LysAla: 4.981 ± 0.101
0.353LysCys: 0.353 ± 0.017
3.237LysAsp: 3.237 ± 0.067
4.647LysGlu: 4.647 ± 0.086
2.462LysPhe: 2.462 ± 0.058
4.078LysGly: 4.078 ± 0.074
1.107LysHis: 1.107 ± 0.033
5.174LysIle: 5.174 ± 0.093
5.661LysLys: 5.661 ± 0.111
5.328LysLeu: 5.328 ± 0.09
1.861LysMet: 1.861 ± 0.054
4.104LysAsn: 4.104 ± 0.082
2.356LysPro: 2.356 ± 0.055
2.392LysGln: 2.392 ± 0.058
2.613LysArg: 2.613 ± 0.055
3.874LysSer: 3.874 ± 0.081
4.135LysThr: 4.135 ± 0.077
4.246LysVal: 4.246 ± 0.078
0.664LysTrp: 0.664 ± 0.025
2.447LysTyr: 2.447 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
6.538LeuAla: 6.538 ± 0.098
0.86LeuCys: 0.86 ± 0.028
4.654LeuAsp: 4.654 ± 0.08
5.886LeuGlu: 5.886 ± 0.106
5.249LeuPhe: 5.249 ± 0.1
6.12LeuGly: 6.12 ± 0.104
1.937LeuHis: 1.937 ± 0.048
6.099LeuIle: 6.099 ± 0.107
6.449LeuLys: 6.449 ± 0.105
9.327LeuLeu: 9.327 ± 0.176
2.155LeuMet: 2.155 ± 0.057
5.056LeuAsn: 5.056 ± 0.082
3.993LeuPro: 3.993 ± 0.076
4.231LeuGln: 4.231 ± 0.073
3.798LeuArg: 3.798 ± 0.068
5.996LeuSer: 5.996 ± 0.091
5.982LeuThr: 5.982 ± 0.093
5.913LeuVal: 5.913 ± 0.089
1.041LeuTrp: 1.041 ± 0.04
3.358LeuTyr: 3.358 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.803MetAla: 1.803 ± 0.047
0.119MetCys: 0.119 ± 0.011
1.141MetAsp: 1.141 ± 0.033
1.536MetGlu: 1.536 ± 0.04
0.792MetPhe: 0.792 ± 0.03
1.578MetGly: 1.578 ± 0.049
0.484MetHis: 0.484 ± 0.022
1.431MetIle: 1.431 ± 0.043
1.998MetLys: 1.998 ± 0.047
1.808MetLeu: 1.808 ± 0.046
0.613MetMet: 0.613 ± 0.03
1.246MetAsn: 1.246 ± 0.037
0.872MetPro: 0.872 ± 0.031
1.014MetGln: 1.014 ± 0.034
1.042MetArg: 1.042 ± 0.033
1.256MetSer: 1.256 ± 0.041
1.29MetThr: 1.29 ± 0.038
1.489MetVal: 1.489 ± 0.039
0.164MetTrp: 0.164 ± 0.015
0.726MetTyr: 0.726 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.35AsnAla: 4.35 ± 0.087
0.483AsnCys: 0.483 ± 0.027
2.899AsnAsp: 2.899 ± 0.067
3.105AsnGlu: 3.105 ± 0.071
2.807AsnPhe: 2.807 ± 0.067
4.214AsnGly: 4.214 ± 0.102
1.014AsnHis: 1.014 ± 0.036
3.392AsnIle: 3.392 ± 0.075
2.89AsnLys: 2.89 ± 0.08
4.77AsnLeu: 4.77 ± 0.095
1.086AsnMet: 1.086 ± 0.036
3.255AsnAsn: 3.255 ± 0.096
3.127AsnPro: 3.127 ± 0.074
2.369AsnGln: 2.369 ± 0.06
2.335AsnArg: 2.335 ± 0.055
3.173AsnSer: 3.173 ± 0.077
3.734AsnThr: 3.734 ± 0.111
3.535AsnVal: 3.535 ± 0.083
0.716AsnTrp: 0.716 ± 0.035
2.558AsnTyr: 2.558 ± 0.072
0.0AsnXaa: 0.0 ± 0.0
Pro
2.778ProAla: 2.778 ± 0.092
0.298ProCys: 0.298 ± 0.023
2.051ProAsp: 2.051 ± 0.047
2.982ProGlu: 2.982 ± 0.064
2.166ProPhe: 2.166 ± 0.047
2.283ProGly: 2.283 ± 0.059
0.728ProHis: 0.728 ± 0.026
2.781ProIle: 2.781 ± 0.054
2.538ProLys: 2.538 ± 0.059
3.462ProLeu: 3.462 ± 0.071
0.955ProMet: 0.955 ± 0.033
2.586ProAsn: 2.586 ± 0.064
1.085ProPro: 1.085 ± 0.045
1.694ProGln: 1.694 ± 0.05
1.04ProArg: 1.04 ± 0.037
2.28ProSer: 2.28 ± 0.058
2.76ProThr: 2.76 ± 0.095
2.844ProVal: 2.844 ± 0.072
0.387ProTrp: 0.387 ± 0.024
1.564ProTyr: 1.564 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.878GlnAla: 2.878 ± 0.059
0.36GlnCys: 0.36 ± 0.029
1.579GlnAsp: 1.579 ± 0.048
2.585GlnGlu: 2.585 ± 0.056
2.046GlnPhe: 2.046 ± 0.054
2.218GlnGly: 2.218 ± 0.05
0.912GlnHis: 0.912 ± 0.034
2.681GlnIle: 2.681 ± 0.061
3.396GlnLys: 3.396 ± 0.072
4.361GlnLeu: 4.361 ± 0.074
0.985GlnMet: 0.985 ± 0.036
2.472GlnAsn: 2.472 ± 0.077
1.734GlnPro: 1.734 ± 0.049
2.008GlnGln: 2.008 ± 0.05
1.9GlnArg: 1.9 ± 0.044
2.291GlnSer: 2.291 ± 0.049
2.553GlnThr: 2.553 ± 0.053
2.529GlnVal: 2.529 ± 0.057
0.625GlnTrp: 0.625 ± 0.028
1.557GlnTyr: 1.557 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.302ArgAla: 2.302 ± 0.052
0.254ArgCys: 0.254 ± 0.016
1.833ArgAsp: 1.833 ± 0.047
2.391ArgGlu: 2.391 ± 0.057
2.338ArgPhe: 2.338 ± 0.06
1.951ArgGly: 1.951 ± 0.045
0.754ArgHis: 0.754 ± 0.027
3.149ArgIle: 3.149 ± 0.06
2.811ArgLys: 2.811 ± 0.068
3.917ArgLeu: 3.917 ± 0.065
1.146ArgMet: 1.146 ± 0.031
2.208ArgAsn: 2.208 ± 0.058
1.339ArgPro: 1.339 ± 0.045
1.484ArgGln: 1.484 ± 0.043
1.508ArgArg: 1.508 ± 0.042
1.992ArgSer: 1.992 ± 0.048
2.065ArgThr: 2.065 ± 0.044
2.496ArgVal: 2.496 ± 0.056
0.533ArgTrp: 0.533 ± 0.025
1.828ArgTyr: 1.828 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.88SerAla: 3.88 ± 0.071
0.67SerCys: 0.67 ± 0.035
2.794SerAsp: 2.794 ± 0.058
3.152SerGlu: 3.152 ± 0.057
3.437SerPhe: 3.437 ± 0.063
4.618SerGly: 4.618 ± 0.09
1.086SerHis: 1.086 ± 0.033
4.338SerIle: 4.338 ± 0.068
3.665SerLys: 3.665 ± 0.074
5.681SerLeu: 5.681 ± 0.08
1.262SerMet: 1.262 ± 0.036
3.447SerAsn: 3.447 ± 0.086
2.326SerPro: 2.326 ± 0.066
2.245SerGln: 2.245 ± 0.051
2.126SerArg: 2.126 ± 0.05
3.69SerSer: 3.69 ± 0.081
3.67SerThr: 3.67 ± 0.089
3.949SerVal: 3.949 ± 0.072
0.679SerTrp: 0.679 ± 0.025
2.487SerTyr: 2.487 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
5.06ThrAla: 5.06 ± 0.144
0.491ThrCys: 0.491 ± 0.03
3.156ThrAsp: 3.156 ± 0.068
3.306ThrGlu: 3.306 ± 0.063
3.622ThrPhe: 3.622 ± 0.076
4.563ThrGly: 4.563 ± 0.123
1.223ThrHis: 1.223 ± 0.039
4.68ThrIle: 4.68 ± 0.075
3.177ThrLys: 3.177 ± 0.068
6.914ThrLeu: 6.914 ± 0.102
1.043ThrMet: 1.043 ± 0.039
3.287ThrAsn: 3.287 ± 0.103
3.586ThrPro: 3.586 ± 0.098
2.85ThrGln: 2.85 ± 0.057
1.961ThrArg: 1.961 ± 0.053
3.89ThrSer: 3.89 ± 0.098
4.92ThrThr: 4.92 ± 0.18
4.795ThrVal: 4.795 ± 0.128
0.738ThrTrp: 0.738 ± 0.044
2.69ThrTyr: 2.69 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.143ValAla: 5.143 ± 0.099
0.655ValCys: 0.655 ± 0.027
3.488ValAsp: 3.488 ± 0.061
3.734ValGlu: 3.734 ± 0.067
3.541ValPhe: 3.541 ± 0.077
4.073ValGly: 4.073 ± 0.066
1.18ValHis: 1.18 ± 0.039
4.573ValIle: 4.573 ± 0.082
4.011ValLys: 4.011 ± 0.073
6.492ValLeu: 6.492 ± 0.106
1.493ValMet: 1.493 ± 0.038
3.614ValAsn: 3.614 ± 0.075
2.549ValPro: 2.549 ± 0.065
2.432ValGln: 2.432 ± 0.052
2.555ValArg: 2.555 ± 0.063
4.227ValSer: 4.227 ± 0.074
4.568ValThr: 4.568 ± 0.102
5.004ValVal: 5.004 ± 0.088
0.693ValTrp: 0.693 ± 0.03
2.678ValTyr: 2.678 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.768TrpAla: 0.768 ± 0.028
0.119TrpCys: 0.119 ± 0.011
0.602TrpAsp: 0.602 ± 0.025
0.738TrpGlu: 0.738 ± 0.026
0.573TrpPhe: 0.573 ± 0.025
0.785TrpGly: 0.785 ± 0.038
0.238TrpHis: 0.238 ± 0.015
0.791TrpIle: 0.791 ± 0.031
0.732TrpLys: 0.732 ± 0.028
0.989TrpLeu: 0.989 ± 0.035
0.332TrpMet: 0.332 ± 0.019
0.83TrpAsn: 0.83 ± 0.032
0.273TrpPro: 0.273 ± 0.02
0.474TrpGln: 0.474 ± 0.021
0.462TrpArg: 0.462 ± 0.025
0.698TrpSer: 0.698 ± 0.037
0.738TrpThr: 0.738 ± 0.036
0.801TrpVal: 0.801 ± 0.031
0.143TrpTrp: 0.143 ± 0.013
0.472TrpTyr: 0.472 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.801TyrAla: 2.801 ± 0.061
0.41TyrCys: 0.41 ± 0.021
2.157TyrAsp: 2.157 ± 0.049
2.128TyrGlu: 2.128 ± 0.05
2.511TyrPhe: 2.511 ± 0.065
2.457TyrGly: 2.457 ± 0.056
0.931TyrHis: 0.931 ± 0.032
2.385TyrIle: 2.385 ± 0.05
2.319TyrLys: 2.319 ± 0.058
3.809TyrLeu: 3.809 ± 0.07
0.719TyrMet: 0.719 ± 0.028
2.253TyrAsn: 2.253 ± 0.07
1.645TyrPro: 1.645 ± 0.047
1.883TyrGln: 1.883 ± 0.055
1.914TyrArg: 1.914 ± 0.049
2.335TyrSer: 2.335 ± 0.054
2.792TyrThr: 2.792 ± 0.075
2.378TyrVal: 2.378 ± 0.055
0.543TyrTrp: 0.543 ± 0.026
1.87TyrTyr: 1.87 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2756 proteins (933078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski