Amino acid dipepetide frequency for Chitinivibrio alkaliphilus ACht1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.461AlaAla: 6.461 ± 0.116	0.904AlaCys: 0.904 ± 0.041	3.954AlaAsp: 3.954 ± 0.082	5.508AlaGlu: 5.508 ± 0.099	3.121AlaPhe: 3.121 ± 0.069	5.839AlaGly: 5.839 ± 0.103	2.07AlaHis: 2.07 ± 0.046	4.218AlaIle: 4.218 ± 0.079	2.857AlaLys: 2.857 ± 0.073	8.191AlaLeu: 8.191 ± 0.115	1.854AlaMet: 1.854 ± 0.052	1.894AlaAsn: 1.894 ± 0.057	3.052AlaPro: 3.052 ± 0.057	3.179AlaGln: 3.179 ± 0.078	4.313AlaArg: 4.313 ± 0.087	4.186AlaSer: 4.186 ± 0.07	3.801AlaThr: 3.801 ± 0.076	5.892AlaVal: 5.892 ± 0.098	0.733AlaTrp: 0.733 ± 0.03	2.764AlaTyr: 2.764 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.901CysAla: 0.901 ± 0.036	0.216CysCys: 0.216 ± 0.015	0.586CysAsp: 0.586 ± 0.028	0.699CysGlu: 0.699 ± 0.035	0.429CysPhe: 0.429 ± 0.024	1.038CysGly: 1.038 ± 0.044	0.284CysHis: 0.284 ± 0.021	0.906CysIle: 0.906 ± 0.039	0.435CysLys: 0.435 ± 0.026	0.856CysLeu: 0.856 ± 0.037	0.285CysMet: 0.285 ± 0.019	0.385CysAsn: 0.385 ± 0.021	0.524CysPro: 0.524 ± 0.024	0.269CysGln: 0.269 ± 0.018	0.695CysArg: 0.695 ± 0.034	0.892CysSer: 0.892 ± 0.039	0.782CysThr: 0.782 ± 0.035	0.631CysVal: 0.631 ± 0.031	0.054CysTrp: 0.054 ± 0.008	0.258CysTyr: 0.258 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.3AspAla: 4.3 ± 0.086	0.47AspCys: 0.47 ± 0.031	3.441AspAsp: 3.441 ± 0.112	3.796AspGlu: 3.796 ± 0.083	2.823AspPhe: 2.823 ± 0.064	3.747AspGly: 3.747 ± 0.099	1.318AspHis: 1.318 ± 0.057	4.878AspIle: 4.878 ± 0.086	1.935AspLys: 1.935 ± 0.054	5.172AspLeu: 5.172 ± 0.08	1.632AspMet: 1.632 ± 0.047	1.704AspAsn: 1.704 ± 0.054	2.319AspPro: 2.319 ± 0.057	1.394AspGln: 1.394 ± 0.05	3.015AspArg: 3.015 ± 0.066	4.019AspSer: 4.019 ± 0.088	4.631AspThr: 4.631 ± 0.105	3.418AspVal: 3.418 ± 0.075	0.576AspTrp: 0.576 ± 0.028	1.88AspTyr: 1.88 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.018GluAla: 5.018 ± 0.094	0.577GluCys: 0.577 ± 0.029	4.032GluAsp: 4.032 ± 0.076	7.135GluGlu: 7.135 ± 0.132	2.558GluPhe: 2.558 ± 0.059	4.333GluGly: 4.333 ± 0.078	1.722GluHis: 1.722 ± 0.044	5.191GluIle: 5.191 ± 0.087	5.262GluLys: 5.262 ± 0.103	6.165GluLeu: 6.165 ± 0.098	1.85GluMet: 1.85 ± 0.049	3.125GluAsn: 3.125 ± 0.065	2.012GluPro: 2.012 ± 0.082	3.043GluGln: 3.043 ± 0.074	4.23GluArg: 4.23 ± 0.083	4.005GluSer: 4.005 ± 0.08	4.187GluThr: 4.187 ± 0.073	4.389GluVal: 4.389 ± 0.075	0.706GluTrp: 0.706 ± 0.032	3.048GluTyr: 3.048 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	3.021PheAla: 3.021 ± 0.063	0.622PheCys: 0.622 ± 0.032	2.563PheAsp: 2.563 ± 0.051	2.496PheGlu: 2.496 ± 0.059	2.896PhePhe: 2.896 ± 0.077	3.025PheGly: 3.025 ± 0.061	1.091PheHis: 1.091 ± 0.036	2.842PheIle: 2.842 ± 0.071	1.269PheLys: 1.269 ± 0.044	4.731PheLeu: 4.731 ± 0.115	0.95PheMet: 0.95 ± 0.035	1.392PheAsn: 1.392 ± 0.046	1.894PhePro: 1.894 ± 0.054	1.25PheGln: 1.25 ± 0.038	2.263PheArg: 2.263 ± 0.061	4.9PheSer: 4.9 ± 0.096	2.914PheThr: 2.914 ± 0.067	2.662PheVal: 2.662 ± 0.062	0.492PheTrp: 0.492 ± 0.027	1.623PheTyr: 1.623 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	5.512GlyAla: 5.512 ± 0.091	0.83GlyCys: 0.83 ± 0.034	4.261GlyAsp: 4.261 ± 0.094	4.965GlyGlu: 4.965 ± 0.08	3.189GlyPhe: 3.189 ± 0.074	5.411GlyGly: 5.411 ± 0.109	1.496GlyHis: 1.496 ± 0.051	5.29GlyIle: 5.29 ± 0.085	3.655GlyLys: 3.655 ± 0.089	5.374GlyLeu: 5.374 ± 0.088	1.883GlyMet: 1.883 ± 0.053	2.467GlyAsn: 2.467 ± 0.059	1.651GlyPro: 1.651 ± 0.044	1.969GlyGln: 1.969 ± 0.051	3.985GlyArg: 3.985 ± 0.082	4.164GlySer: 4.164 ± 0.077	4.439GlyThr: 4.439 ± 0.074	5.559GlyVal: 5.559 ± 0.09	0.763GlyTrp: 0.763 ± 0.032	2.736GlyTyr: 2.736 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.845HisAla: 1.845 ± 0.061	0.346HisCys: 0.346 ± 0.021	1.5HisAsp: 1.5 ± 0.048	1.724HisGlu: 1.724 ± 0.048	1.175HisPhe: 1.175 ± 0.04	2.201HisGly: 2.201 ± 0.065	0.795HisHis: 0.795 ± 0.033	1.981HisIle: 1.981 ± 0.051	0.866HisLys: 0.866 ± 0.037	2.402HisLeu: 2.402 ± 0.057	0.589HisMet: 0.589 ± 0.03	0.843HisAsn: 0.843 ± 0.034	1.303HisPro: 1.303 ± 0.039	0.629HisGln: 0.629 ± 0.027	1.822HisArg: 1.822 ± 0.054	1.688HisSer: 1.688 ± 0.053	1.991HisThr: 1.991 ± 0.055	1.413HisVal: 1.413 ± 0.045	0.248HisTrp: 0.248 ± 0.015	0.798HisTyr: 0.798 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.169IleAla: 5.169 ± 0.087	0.742IleCys: 0.742 ± 0.031	4.249IleAsp: 4.249 ± 0.073	4.345IleGlu: 4.345 ± 0.083	2.609IlePhe: 2.609 ± 0.065	3.985IleGly: 3.985 ± 0.071	1.977IleHis: 1.977 ± 0.051	4.145IleIle: 4.145 ± 0.092	2.2IleLys: 2.2 ± 0.063	6.699IleLeu: 6.699 ± 0.124	1.224IleMet: 1.224 ± 0.042	2.167IleAsn: 2.167 ± 0.063	3.757IlePro: 3.757 ± 0.07	2.487IleGln: 2.487 ± 0.06	4.035IleArg: 4.035 ± 0.07	5.827IleSer: 5.827 ± 0.095	4.697IleThr: 4.697 ± 0.078	3.945IleVal: 3.945 ± 0.087	0.48IleTrp: 0.48 ± 0.029	2.031IleTyr: 2.031 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	2.912LysAla: 2.912 ± 0.077	0.416LysCys: 0.416 ± 0.029	2.554LysAsp: 2.554 ± 0.072	4.199LysGlu: 4.199 ± 0.096	1.045LysPhe: 1.045 ± 0.038	2.736LysGly: 2.736 ± 0.07	1.038LysHis: 1.038 ± 0.042	3.392LysIle: 3.392 ± 0.08	4.146LysLys: 4.146 ± 0.117	3.263LysLeu: 3.263 ± 0.077	1.223LysMet: 1.223 ± 0.047	2.519LysAsn: 2.519 ± 0.06	1.358LysPro: 1.358 ± 0.041	1.795LysGln: 1.795 ± 0.049	2.802LysArg: 2.802 ± 0.074	2.528LysSer: 2.528 ± 0.061	2.975LysThr: 2.975 ± 0.075	2.349LysVal: 2.349 ± 0.071	0.358LysTrp: 0.358 ± 0.021	1.534LysTyr: 1.534 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.802LeuAla: 6.802 ± 0.11	1.382LeuCys: 1.382 ± 0.046	4.715LeuAsp: 4.715 ± 0.09	5.915LeuGlu: 5.915 ± 0.106	5.593LeuPhe: 5.593 ± 0.111	6.013LeuGly: 6.013 ± 0.091	2.767LeuHis: 2.767 ± 0.057	5.63LeuIle: 5.63 ± 0.116	3.828LeuLys: 3.828 ± 0.101	10.375LeuLeu: 10.375 ± 0.174	2.132LeuMet: 2.132 ± 0.053	2.866LeuAsn: 2.866 ± 0.065	4.506LeuPro: 4.506 ± 0.079	3.636LeuGln: 3.636 ± 0.073	6.285LeuArg: 6.285 ± 0.091	8.499LeuSer: 8.499 ± 0.126	5.457LeuThr: 5.457 ± 0.099	5.345LeuVal: 5.345 ± 0.087	1.036LeuTrp: 1.036 ± 0.04	3.357LeuTyr: 3.357 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.081MetAla: 2.081 ± 0.053	0.207MetCys: 0.207 ± 0.017	1.484MetAsp: 1.484 ± 0.042	1.899MetGlu: 1.899 ± 0.052	0.603MetPhe: 0.603 ± 0.029	2.003MetGly: 2.003 ± 0.052	0.474MetHis: 0.474 ± 0.022	1.458MetIle: 1.458 ± 0.053	1.64MetLys: 1.64 ± 0.043	1.817MetLeu: 1.817 ± 0.048	0.506MetMet: 0.506 ± 0.024	1.122MetAsn: 1.122 ± 0.04	0.988MetPro: 0.988 ± 0.038	0.75MetGln: 0.75 ± 0.033	1.325MetArg: 1.325 ± 0.04	1.515MetSer: 1.515 ± 0.046	1.184MetThr: 1.184 ± 0.041	1.734MetVal: 1.734 ± 0.045	0.159MetTrp: 0.159 ± 0.01	0.599MetTyr: 0.599 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.402AsnAla: 2.402 ± 0.062	0.378AsnCys: 0.378 ± 0.021	1.65AsnAsp: 1.65 ± 0.052	1.93AsnGlu: 1.93 ± 0.051	1.393AsnPhe: 1.393 ± 0.041	2.063AsnGly: 2.063 ± 0.06	0.863AsnHis: 0.863 ± 0.033	2.891AsnIle: 2.891 ± 0.071	1.561AsnLys: 1.561 ± 0.054	3.229AsnLeu: 3.229 ± 0.069	0.975AsnMet: 0.975 ± 0.038	1.427AsnAsn: 1.427 ± 0.048	1.793AsnPro: 1.793 ± 0.053	0.997AsnGln: 0.997 ± 0.035	2.442AsnArg: 2.442 ± 0.059	2.405AsnSer: 2.405 ± 0.059	2.434AsnThr: 2.434 ± 0.06	1.815AsnVal: 1.815 ± 0.048	0.347AsnTrp: 0.347 ± 0.023	1.246AsnTyr: 1.246 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.202ProAla: 3.202 ± 0.071	0.443ProCys: 0.443 ± 0.029	2.462ProAsp: 2.462 ± 0.061	3.476ProGlu: 3.476 ± 0.09	2.035ProPhe: 2.035 ± 0.054	2.914ProGly: 2.914 ± 0.065	1.477ProHis: 1.477 ± 0.047	2.0ProIle: 2.0 ± 0.051	1.342ProLys: 1.342 ± 0.048	4.439ProLeu: 4.439 ± 0.089	0.86ProMet: 0.86 ± 0.031	1.072ProAsn: 1.072 ± 0.038	1.828ProPro: 1.828 ± 0.051	1.755ProGln: 1.755 ± 0.049	2.436ProArg: 2.436 ± 0.059	2.594ProSer: 2.594 ± 0.059	1.935ProThr: 1.935 ± 0.057	3.196ProVal: 3.196 ± 0.07	0.522ProTrp: 0.522 ± 0.026	1.579ProTyr: 1.579 ± 0.055	0.0ProXaa: 0.0 ± 0.0
Gln	2.544GlnAla: 2.544 ± 0.059	0.296GlnCys: 0.296 ± 0.019	2.021GlnAsp: 2.021 ± 0.056	3.338GlnGlu: 3.338 ± 0.073	1.296GlnPhe: 1.296 ± 0.041	2.524GlnGly: 2.524 ± 0.058	0.748GlnHis: 0.748 ± 0.03	2.136GlnIle: 2.136 ± 0.061	2.545GlnLys: 2.545 ± 0.065	2.863GlnLeu: 2.863 ± 0.063	0.86GlnMet: 0.86 ± 0.028	1.617GlnAsn: 1.617 ± 0.052	0.914GlnPro: 0.914 ± 0.04	1.588GlnGln: 1.588 ± 0.054	2.466GlnArg: 2.466 ± 0.068	1.92GlnSer: 1.92 ± 0.056	1.667GlnThr: 1.667 ± 0.052	2.03GlnVal: 2.03 ± 0.057	0.439GlnTrp: 0.439 ± 0.025	1.349GlnTyr: 1.349 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.251ArgAla: 4.251 ± 0.089	0.554ArgCys: 0.554 ± 0.03	3.615ArgAsp: 3.615 ± 0.075	4.912ArgGlu: 4.912 ± 0.082	2.821ArgPhe: 2.821 ± 0.068	4.156ArgGly: 4.156 ± 0.083	1.496ArgHis: 1.496 ± 0.05	4.466ArgIle: 4.466 ± 0.079	2.979ArgLys: 2.979 ± 0.071	5.198ArgLeu: 5.198 ± 0.08	1.436ArgMet: 1.436 ± 0.041	2.238ArgAsn: 2.238 ± 0.059	1.942ArgPro: 1.942 ± 0.053	2.047ArgGln: 2.047 ± 0.052	3.978ArgArg: 3.978 ± 0.089	3.724ArgSer: 3.724 ± 0.072	3.076ArgThr: 3.076 ± 0.059	3.992ArgVal: 3.992 ± 0.077	0.661ArgTrp: 0.661 ± 0.032	2.243ArgTyr: 2.243 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	5.025SerAla: 5.025 ± 0.079	0.857SerCys: 0.857 ± 0.035	3.456SerAsp: 3.456 ± 0.083	3.943SerGlu: 3.943 ± 0.079	3.726SerPhe: 3.726 ± 0.076	4.999SerGly: 4.999 ± 0.091	1.99SerHis: 1.99 ± 0.051	4.474SerIle: 4.474 ± 0.069	2.307SerLys: 2.307 ± 0.062	8.368SerLeu: 8.368 ± 0.121	1.706SerMet: 1.706 ± 0.04	1.844SerAsn: 1.844 ± 0.049	3.595SerPro: 3.595 ± 0.062	2.501SerGln: 2.501 ± 0.055	4.105SerArg: 4.105 ± 0.073	4.983SerSer: 4.983 ± 0.09	3.708SerThr: 3.708 ± 0.077	4.895SerVal: 4.895 ± 0.08	0.795SerTrp: 0.795 ± 0.036	2.52SerTyr: 2.52 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	5.108ThrAla: 5.108 ± 0.093	0.536ThrCys: 0.536 ± 0.028	3.092ThrAsp: 3.092 ± 0.073	4.049ThrGlu: 4.049 ± 0.077	2.387ThrPhe: 2.387 ± 0.061	4.784ThrGly: 4.784 ± 0.069	1.677ThrHis: 1.677 ± 0.049	4.223ThrIle: 4.223 ± 0.077	2.093ThrLys: 2.093 ± 0.063	6.48ThrLeu: 6.48 ± 0.102	1.338ThrMet: 1.338 ± 0.042	1.681ThrAsn: 1.681 ± 0.044	3.694ThrPro: 3.694 ± 0.066	1.817ThrGln: 1.817 ± 0.041	2.835ThrArg: 2.835 ± 0.059	3.556ThrSer: 3.556 ± 0.061	3.788ThrThr: 3.788 ± 0.08	4.613ThrVal: 4.613 ± 0.083	0.502ThrTrp: 0.502 ± 0.028	2.265ThrTyr: 2.265 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.832ValAla: 4.832 ± 0.08	0.822ValCys: 0.822 ± 0.03	3.857ValAsp: 3.857 ± 0.068	4.837ValGlu: 4.837 ± 0.072	3.125ValPhe: 3.125 ± 0.066	4.26ValGly: 4.26 ± 0.074	1.71ValHis: 1.71 ± 0.047	3.766ValIle: 3.766 ± 0.072	2.382ValLys: 2.382 ± 0.066	6.358ValLeu: 6.358 ± 0.106	1.321ValMet: 1.321 ± 0.044	2.079ValAsn: 2.079 ± 0.059	2.577ValPro: 2.577 ± 0.063	2.617ValGln: 2.617 ± 0.06	3.894ValArg: 3.894 ± 0.074	5.144ValSer: 5.144 ± 0.08	3.667ValThr: 3.667 ± 0.081	5.059ValVal: 5.059 ± 0.096	0.631ValTrp: 0.631 ± 0.027	2.488ValTyr: 2.488 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.673TrpAla: 0.673 ± 0.029	0.123TrpCys: 0.123 ± 0.013	0.7TrpAsp: 0.7 ± 0.031	0.784TrpGlu: 0.784 ± 0.031	0.424TrpPhe: 0.424 ± 0.025	0.835TrpGly: 0.835 ± 0.037	0.256TrpHis: 0.256 ± 0.018	0.664TrpIle: 0.664 ± 0.026	0.573TrpLys: 0.573 ± 0.026	0.715TrpLeu: 0.715 ± 0.033	0.254TrpMet: 0.254 ± 0.017	0.553TrpAsn: 0.553 ± 0.027	0.296TrpPro: 0.296 ± 0.022	0.372TrpGln: 0.372 ± 0.023	0.563TrpArg: 0.563 ± 0.025	0.594TrpSer: 0.594 ± 0.028	0.42TrpThr: 0.42 ± 0.027	0.639TrpVal: 0.639 ± 0.033	0.137TrpTrp: 0.137 ± 0.013	0.447TrpTyr: 0.447 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.736TyrAla: 2.736 ± 0.059	0.405TyrCys: 0.405 ± 0.023	2.276TyrAsp: 2.276 ± 0.061	2.64TyrGlu: 2.64 ± 0.062	1.65TyrPhe: 1.65 ± 0.048	2.732TyrGly: 2.732 ± 0.067	0.909TyrHis: 0.909 ± 0.038	2.22TyrIle: 2.22 ± 0.058	1.263TyrLys: 1.263 ± 0.039	3.444TyrLeu: 3.444 ± 0.064	0.668TyrMet: 0.668 ± 0.029	1.249TyrAsn: 1.249 ± 0.042	1.562TyrPro: 1.562 ± 0.048	1.065TyrGln: 1.065 ± 0.035	2.296TyrArg: 2.296 ± 0.062	2.656TyrSer: 2.656 ± 0.06	2.766TyrThr: 2.766 ± 0.061	1.85TyrVal: 1.85 ± 0.044	0.38TyrTrp: 0.38 ± 0.025	1.491TyrTyr: 1.491 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2304 proteins (774486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---