Amino acid dipepetide frequency for Streptococcus iniae (Streptococcus shiloi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.218AlaAla: 5.218 ± 0.128
0.575AlaCys: 0.575 ± 0.028
3.963AlaAsp: 3.963 ± 0.091
4.45AlaGlu: 4.45 ± 0.111
3.654AlaPhe: 3.654 ± 0.082
4.739AlaGly: 4.739 ± 0.1
1.176AlaHis: 1.176 ± 0.044
6.489AlaIle: 6.489 ± 0.116
5.889AlaLys: 5.889 ± 0.116
7.853AlaLeu: 7.853 ± 0.127
1.958AlaMet: 1.958 ± 0.052
3.302AlaAsn: 3.302 ± 0.082
1.895AlaPro: 1.895 ± 0.063
3.146AlaGln: 3.146 ± 0.106
2.515AlaArg: 2.515 ± 0.059
5.021AlaSer: 5.021 ± 0.118
3.971AlaThr: 3.971 ± 0.093
4.902AlaVal: 4.902 ± 0.095
0.565AlaTrp: 0.565 ± 0.031
2.999AlaTyr: 2.999 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.341CysAla: 0.341 ± 0.026
0.063CysCys: 0.063 ± 0.013
0.383CysAsp: 0.383 ± 0.029
0.267CysGlu: 0.267 ± 0.019
0.374CysPhe: 0.374 ± 0.026
0.479CysGly: 0.479 ± 0.029
0.218CysHis: 0.218 ± 0.021
0.35CysIle: 0.35 ± 0.027
0.257CysLys: 0.257 ± 0.021
0.712CysLeu: 0.712 ± 0.037
0.146CysMet: 0.146 ± 0.016
0.242CysAsn: 0.242 ± 0.019
0.287CysPro: 0.287 ± 0.022
0.46CysGln: 0.46 ± 0.029
0.251CysArg: 0.251 ± 0.018
0.37CysSer: 0.37 ± 0.026
0.213CysThr: 0.213 ± 0.019
0.323CysVal: 0.323 ± 0.023
0.032CysTrp: 0.032 ± 0.007
0.243CysTyr: 0.243 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.774AspAla: 3.774 ± 0.087
0.385AspCys: 0.385 ± 0.023
3.11AspAsp: 3.11 ± 0.078
3.304AspGlu: 3.304 ± 0.086
3.236AspPhe: 3.236 ± 0.075
3.631AspGly: 3.631 ± 0.091
1.217AspHis: 1.217 ± 0.047
4.611AspIle: 4.611 ± 0.089
4.501AspLys: 4.501 ± 0.093
5.962AspLeu: 5.962 ± 0.109
1.487AspMet: 1.487 ± 0.05
2.556AspAsn: 2.556 ± 0.064
1.678AspPro: 1.678 ± 0.051
2.249AspGln: 2.249 ± 0.066
1.983AspArg: 1.983 ± 0.063
3.346AspSer: 3.346 ± 0.08
2.689AspThr: 2.689 ± 0.075
3.466AspVal: 3.466 ± 0.083
0.595AspTrp: 0.595 ± 0.028
3.131AspTyr: 3.131 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
5.512GluAla: 5.512 ± 0.12
0.284GluCys: 0.284 ± 0.021
3.679GluAsp: 3.679 ± 0.088
5.301GluGlu: 5.301 ± 0.109
2.32GluPhe: 2.32 ± 0.056
3.469GluGly: 3.469 ± 0.079
1.273GluHis: 1.273 ± 0.043
4.785GluIle: 4.785 ± 0.081
5.903GluLys: 5.903 ± 0.109
6.514GluLeu: 6.514 ± 0.121
1.952GluMet: 1.952 ± 0.054
3.691GluAsn: 3.691 ± 0.079
1.499GluPro: 1.499 ± 0.052
2.547GluGln: 2.547 ± 0.074
2.728GluArg: 2.728 ± 0.061
3.945GluSer: 3.945 ± 0.303
3.737GluThr: 3.737 ± 0.084
4.401GluVal: 4.401 ± 0.096
0.533GluTrp: 0.533 ± 0.029
1.686GluTyr: 1.686 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.256PheAla: 3.256 ± 0.08
0.352PheCys: 0.352 ± 0.022
3.048PheAsp: 3.048 ± 0.075
2.943PheGlu: 2.943 ± 0.059
2.336PhePhe: 2.336 ± 0.076
3.184PheGly: 3.184 ± 0.078
0.825PheHis: 0.825 ± 0.038
3.347PheIle: 3.347 ± 0.093
2.84PheLys: 2.84 ± 0.072
4.818PheLeu: 4.818 ± 0.125
1.182PheMet: 1.182 ± 0.047
2.045PheAsn: 2.045 ± 0.059
1.522PhePro: 1.522 ± 0.054
1.633PheGln: 1.633 ± 0.057
1.457PheArg: 1.457 ± 0.046
3.475PheSer: 3.475 ± 0.071
2.637PheThr: 2.637 ± 0.065
2.966PheVal: 2.966 ± 0.079
0.448PheTrp: 0.448 ± 0.031
1.837PheTyr: 1.837 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.309GlyAla: 4.309 ± 0.106
0.421GlyCys: 0.421 ± 0.026
3.244GlyAsp: 3.244 ± 0.078
3.151GlyGlu: 3.151 ± 0.078
3.281GlyPhe: 3.281 ± 0.078
3.911GlyGly: 3.911 ± 0.1
1.417GlyHis: 1.417 ± 0.046
5.374GlyIle: 5.374 ± 0.095
4.847GlyLys: 4.847 ± 0.085
6.596GlyLeu: 6.596 ± 0.107
1.728GlyMet: 1.728 ± 0.051
2.742GlyAsn: 2.742 ± 0.073
1.381GlyPro: 1.381 ± 0.054
3.036GlyGln: 3.036 ± 0.069
2.375GlyArg: 2.375 ± 0.07
3.797GlySer: 3.797 ± 0.075
3.486GlyThr: 3.486 ± 0.092
4.1GlyVal: 4.1 ± 0.077
0.548GlyTrp: 0.548 ± 0.032
2.565GlyTyr: 2.565 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.103HisAla: 1.103 ± 0.043
0.144HisCys: 0.144 ± 0.015
1.053HisAsp: 1.053 ± 0.046
1.044HisGlu: 1.044 ± 0.044
1.366HisPhe: 1.366 ± 0.048
1.148HisGly: 1.148 ± 0.045
0.642HisHis: 0.642 ± 0.031
1.462HisIle: 1.462 ± 0.054
1.185HisLys: 1.185 ± 0.043
2.488HisLeu: 2.488 ± 0.077
0.512HisMet: 0.512 ± 0.031
0.753HisAsn: 0.753 ± 0.034
0.882HisPro: 0.882 ± 0.044
1.061HisGln: 1.061 ± 0.045
0.771HisArg: 0.771 ± 0.041
1.103HisSer: 1.103 ± 0.044
0.847HisThr: 0.847 ± 0.037
1.172HisVal: 1.172 ± 0.041
0.131HisTrp: 0.131 ± 0.014
1.155HisTyr: 1.155 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
6.25IleAla: 6.25 ± 0.113
0.611IleCys: 0.611 ± 0.031
4.653IleAsp: 4.653 ± 0.079
4.886IleGlu: 4.886 ± 0.09
3.275IlePhe: 3.275 ± 0.1
4.902IleGly: 4.902 ± 0.097
1.205IleHis: 1.205 ± 0.048
5.724IleIle: 5.724 ± 0.13
5.065IleLys: 5.065 ± 0.098
7.252IleLeu: 7.252 ± 0.139
1.806IleMet: 1.806 ± 0.061
3.543IleAsn: 3.543 ± 0.078
2.906IlePro: 2.906 ± 0.076
2.432IleGln: 2.432 ± 0.061
2.605IleArg: 2.605 ± 0.068
5.654IleSer: 5.654 ± 0.123
4.214IleThr: 4.214 ± 0.083
4.86IleVal: 4.86 ± 0.087
0.586IleTrp: 0.586 ± 0.037
2.589IleTyr: 2.589 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
5.95LysAla: 5.95 ± 0.135
0.293LysCys: 0.293 ± 0.024
4.486LysAsp: 4.486 ± 0.096
6.639LysGlu: 6.639 ± 0.122
1.852LysPhe: 1.852 ± 0.06
4.286LysGly: 4.286 ± 0.082
1.514LysHis: 1.514 ± 0.051
4.865LysIle: 4.865 ± 0.084
5.795LysLys: 5.795 ± 0.116
6.095LysLeu: 6.095 ± 0.092
2.237LysMet: 2.237 ± 0.051
3.669LysAsn: 3.669 ± 0.088
2.169LysPro: 2.169 ± 0.069
3.119LysGln: 3.119 ± 0.078
3.104LysArg: 3.104 ± 0.076
4.339LysSer: 4.339 ± 0.079
4.56LysThr: 4.56 ± 0.094
4.847LysVal: 4.847 ± 0.098
0.673LysTrp: 0.673 ± 0.029
2.294LysTyr: 2.294 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
8.762LeuAla: 8.762 ± 0.132
0.583LeuCys: 0.583 ± 0.031
5.739LeuAsp: 5.739 ± 0.11
6.86LeuGlu: 6.86 ± 0.122
4.612LeuPhe: 4.612 ± 0.127
6.175LeuGly: 6.175 ± 0.12
1.608LeuHis: 1.608 ± 0.047
7.443LeuIle: 7.443 ± 0.136
7.183LeuLys: 7.183 ± 0.115
10.609LeuLeu: 10.609 ± 0.21
2.619LeuMet: 2.619 ± 0.065
4.386LeuAsn: 4.386 ± 0.089
3.824LeuPro: 3.824 ± 0.076
3.579LeuGln: 3.579 ± 0.072
3.362LeuArg: 3.362 ± 0.074
7.922LeuSer: 7.922 ± 0.172
6.152LeuThr: 6.152 ± 0.106
7.0LeuVal: 7.0 ± 0.102
0.715LeuTrp: 0.715 ± 0.036
3.134LeuTyr: 3.134 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.288MetAla: 2.288 ± 0.057
0.134MetCys: 0.134 ± 0.015
1.309MetAsp: 1.309 ± 0.05
1.436MetGlu: 1.436 ± 0.05
0.864MetPhe: 0.864 ± 0.031
1.653MetGly: 1.653 ± 0.058
0.367MetHis: 0.367 ± 0.021
2.061MetIle: 2.061 ± 0.068
1.941MetLys: 1.941 ± 0.046
2.366MetLeu: 2.366 ± 0.067
0.819MetMet: 0.819 ± 0.039
1.202MetAsn: 1.202 ± 0.042
0.886MetPro: 0.886 ± 0.036
0.931MetGln: 0.931 ± 0.042
0.942MetArg: 0.942 ± 0.036
1.842MetSer: 1.842 ± 0.07
2.312MetThr: 2.312 ± 0.06
1.813MetVal: 1.813 ± 0.064
0.153MetTrp: 0.153 ± 0.015
0.611MetTyr: 0.611 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.208AsnAla: 3.208 ± 0.075
0.328AsnCys: 0.328 ± 0.023
2.583AsnAsp: 2.583 ± 0.057
2.425AsnGlu: 2.425 ± 0.066
1.953AsnPhe: 1.953 ± 0.056
3.374AsnGly: 3.374 ± 0.084
1.367AsnHis: 1.367 ± 0.047
3.121AsnIle: 3.121 ± 0.068
3.107AsnLys: 3.107 ± 0.081
4.525AsnLeu: 4.525 ± 0.096
1.197AsnMet: 1.197 ± 0.042
2.185AsnAsn: 2.185 ± 0.059
2.258AsnPro: 2.258 ± 0.057
2.686AsnGln: 2.686 ± 0.074
1.985AsnArg: 1.985 ± 0.06
2.68AsnSer: 2.68 ± 0.073
2.321AsnThr: 2.321 ± 0.073
2.629AsnVal: 2.629 ± 0.068
0.568AsnTrp: 0.568 ± 0.03
1.973AsnTyr: 1.973 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.063ProAla: 2.063 ± 0.067
0.146ProCys: 0.146 ± 0.015
1.922ProAsp: 1.922 ± 0.06
2.689ProGlu: 2.689 ± 0.065
1.686ProPhe: 1.686 ± 0.062
1.696ProGly: 1.696 ± 0.056
0.663ProHis: 0.663 ± 0.03
2.58ProIle: 2.58 ± 0.065
2.48ProLys: 2.48 ± 0.065
3.006ProLeu: 3.006 ± 0.065
0.754ProMet: 0.754 ± 0.036
1.812ProAsn: 1.812 ± 0.062
0.581ProPro: 0.581 ± 0.055
1.322ProGln: 1.322 ± 0.044
0.968ProArg: 0.968 ± 0.038
2.195ProSer: 2.195 ± 0.055
1.928ProThr: 1.928 ± 0.071
2.332ProVal: 2.332 ± 0.069
0.273ProTrp: 0.273 ± 0.018
1.34ProTyr: 1.34 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.697GlnAla: 3.697 ± 0.111
0.137GlnCys: 0.137 ± 0.015
2.073GlnAsp: 2.073 ± 0.05
3.711GlnGlu: 3.711 ± 0.075
1.849GlnPhe: 1.849 ± 0.048
2.296GlnGly: 2.296 ± 0.064
0.678GlnHis: 0.678 ± 0.035
2.641GlnIle: 2.641 ± 0.058
3.496GlnLys: 3.496 ± 0.084
4.764GlnLeu: 4.764 ± 0.11
1.166GlnMet: 1.166 ± 0.043
2.0GlnAsn: 2.0 ± 0.058
1.077GlnPro: 1.077 ± 0.045
1.427GlnGln: 1.427 ± 0.051
1.388GlnArg: 1.388 ± 0.049
2.556GlnSer: 2.556 ± 0.078
2.44GlnThr: 2.44 ± 0.064
3.045GlnVal: 3.045 ± 0.067
0.341GlnTrp: 0.341 ± 0.023
1.169GlnTyr: 1.169 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.305ArgAla: 2.305 ± 0.069
0.183ArgCys: 0.183 ± 0.017
2.114ArgAsp: 2.114 ± 0.066
2.464ArgGlu: 2.464 ± 0.06
1.818ArgPhe: 1.818 ± 0.057
2.078ArgGly: 2.078 ± 0.066
0.915ArgHis: 0.915 ± 0.036
2.658ArgIle: 2.658 ± 0.062
2.652ArgLys: 2.652 ± 0.069
4.048ArgLeu: 4.048 ± 0.093
0.963ArgMet: 0.963 ± 0.04
1.665ArgAsn: 1.665 ± 0.055
1.173ArgPro: 1.173 ± 0.048
2.109ArgGln: 2.109 ± 0.064
1.738ArgArg: 1.738 ± 0.06
1.871ArgSer: 1.871 ± 0.055
1.767ArgThr: 1.767 ± 0.053
2.447ArgVal: 2.447 ± 0.063
0.261ArgTrp: 0.261 ± 0.021
1.462ArgTyr: 1.462 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.081SerAla: 4.081 ± 0.1
0.332SerCys: 0.332 ± 0.021
3.89SerAsp: 3.89 ± 0.081
4.404SerGlu: 4.404 ± 0.309
3.25SerPhe: 3.25 ± 0.078
4.614SerGly: 4.614 ± 0.079
1.653SerHis: 1.653 ± 0.052
4.871SerIle: 4.871 ± 0.136
4.504SerLys: 4.504 ± 0.091
7.233SerLeu: 7.233 ± 0.15
1.472SerMet: 1.472 ± 0.068
2.898SerAsn: 2.898 ± 0.076
2.154SerPro: 2.154 ± 0.057
3.447SerGln: 3.447 ± 0.083
2.425SerArg: 2.425 ± 0.067
4.386SerSer: 4.386 ± 0.121
3.331SerThr: 3.331 ± 0.135
4.035SerVal: 4.035 ± 0.091
0.583SerTrp: 0.583 ± 0.027
2.816SerTyr: 2.816 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
4.07ThrAla: 4.07 ± 0.084
0.296ThrCys: 0.296 ± 0.025
3.133ThrAsp: 3.133 ± 0.081
3.274ThrGlu: 3.274 ± 0.075
2.811ThrPhe: 2.811 ± 0.062
3.774ThrGly: 3.774 ± 0.083
1.038ThrHis: 1.038 ± 0.042
4.663ThrIle: 4.663 ± 0.076
3.863ThrLys: 3.863 ± 0.091
5.738ThrLeu: 5.738 ± 0.092
1.197ThrMet: 1.197 ± 0.047
2.461ThrAsn: 2.461 ± 0.081
2.438ThrPro: 2.438 ± 0.097
1.953ThrGln: 1.953 ± 0.062
1.874ThrArg: 1.874 ± 0.062
4.001ThrSer: 4.001 ± 0.135
3.155ThrThr: 3.155 ± 0.095
4.365ThrVal: 4.365 ± 0.12
0.506ThrTrp: 0.506 ± 0.027
2.332ThrTyr: 2.332 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
5.179ValAla: 5.179 ± 0.098
0.401ValCys: 0.401 ± 0.026
3.774ValAsp: 3.774 ± 0.084
3.978ValGlu: 3.978 ± 0.089
3.063ValPhe: 3.063 ± 0.075
4.048ValGly: 4.048 ± 0.086
1.053ValHis: 1.053 ± 0.046
5.059ValIle: 5.059 ± 0.096
4.452ValLys: 4.452 ± 0.085
6.391ValLeu: 6.391 ± 0.106
1.725ValMet: 1.725 ± 0.05
3.096ValAsn: 3.096 ± 0.07
2.29ValPro: 2.29 ± 0.066
1.925ValGln: 1.925 ± 0.06
2.288ValArg: 2.288 ± 0.06
4.956ValSer: 4.956 ± 0.105
4.776ValThr: 4.776 ± 0.123
4.198ValVal: 4.198 ± 0.106
0.502ValTrp: 0.502 ± 0.028
2.348ValTyr: 2.348 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.497TrpAla: 0.497 ± 0.028
0.041TrpCys: 0.041 ± 0.008
0.46TrpAsp: 0.46 ± 0.029
0.532TrpGlu: 0.532 ± 0.028
0.434TrpPhe: 0.434 ± 0.029
0.544TrpGly: 0.544 ± 0.033
0.174TrpHis: 0.174 ± 0.016
0.571TrpIle: 0.571 ± 0.033
0.526TrpLys: 0.526 ± 0.024
0.983TrpLeu: 0.983 ± 0.043
0.227TrpMet: 0.227 ± 0.02
0.503TrpAsn: 0.503 ± 0.025
0.167TrpPro: 0.167 ± 0.017
0.466TrpGln: 0.466 ± 0.029
0.322TrpArg: 0.322 ± 0.021
0.574TrpSer: 0.574 ± 0.03
0.518TrpThr: 0.518 ± 0.029
0.509TrpVal: 0.509 ± 0.029
0.093TrpTrp: 0.093 ± 0.012
0.303TrpTyr: 0.303 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.419TyrAla: 2.419 ± 0.061
0.303TyrCys: 0.303 ± 0.022
2.296TyrAsp: 2.296 ± 0.059
2.001TyrGlu: 2.001 ± 0.058
2.115TyrPhe: 2.115 ± 0.069
2.306TyrGly: 2.306 ± 0.058
1.02TyrHis: 1.02 ± 0.041
2.344TyrIle: 2.344 ± 0.067
2.302TyrLys: 2.302 ± 0.064
4.313TyrLeu: 4.313 ± 0.092
0.783TyrMet: 0.783 ± 0.036
1.723TyrAsn: 1.723 ± 0.053
1.367TyrPro: 1.367 ± 0.042
2.423TyrGln: 2.423 ± 0.066
1.611TyrArg: 1.611 ± 0.047
2.345TyrSer: 2.345 ± 0.069
1.887TyrThr: 1.887 ± 0.059
2.091TyrVal: 2.091 ± 0.051
0.337TyrTrp: 0.337 ± 0.023
1.752TyrTyr: 1.752 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2124 proteins (665596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski