Amino acid dipepetide frequency for Enterococcus aquimarinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.571AlaAla: 5.571 ± 0.144	0.562AlaCys: 0.562 ± 0.029	3.507AlaAsp: 3.507 ± 0.062	4.649AlaGlu: 4.649 ± 0.102	3.498AlaPhe: 3.498 ± 0.074	4.903AlaGly: 4.903 ± 0.095	1.311AlaHis: 1.311 ± 0.04	6.249AlaIle: 6.249 ± 0.114	4.667AlaLys: 4.667 ± 0.086	7.763AlaLeu: 7.763 ± 0.114	2.149AlaMet: 2.149 ± 0.058	3.002AlaAsn: 3.002 ± 0.067	2.23AlaPro: 2.23 ± 0.055	3.344AlaGln: 3.344 ± 0.074	2.702AlaArg: 2.702 ± 0.063	4.188AlaSer: 4.188 ± 0.077	4.609AlaThr: 4.609 ± 0.094	4.954AlaVal: 4.954 ± 0.091	0.591AlaTrp: 0.591 ± 0.031	2.612AlaTyr: 2.612 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.41CysAla: 0.41 ± 0.029	0.076CysCys: 0.076 ± 0.01	0.335CysAsp: 0.335 ± 0.02	0.41CysGlu: 0.41 ± 0.027	0.295CysPhe: 0.295 ± 0.021	0.574CysGly: 0.574 ± 0.028	0.218CysHis: 0.218 ± 0.02	0.384CysIle: 0.384 ± 0.023	0.2CysLys: 0.2 ± 0.017	0.66CysLeu: 0.66 ± 0.032	0.16CysMet: 0.16 ± 0.016	0.204CysAsn: 0.204 ± 0.017	0.288CysPro: 0.288 ± 0.02	0.306CysGln: 0.306 ± 0.023	0.243CysArg: 0.243 ± 0.018	0.392CysSer: 0.392 ± 0.027	0.304CysThr: 0.304 ± 0.021	0.391CysVal: 0.391 ± 0.023	0.059CysTrp: 0.059 ± 0.009	0.313CysTyr: 0.313 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.509AspAla: 3.509 ± 0.08	0.371AspCys: 0.371 ± 0.022	2.418AspAsp: 2.418 ± 0.062	4.223AspGlu: 4.223 ± 0.068	2.882AspPhe: 2.882 ± 0.064	3.359AspGly: 3.359 ± 0.078	1.114AspHis: 1.114 ± 0.038	3.556AspIle: 3.556 ± 0.075	2.614AspLys: 2.614 ± 0.068	5.143AspLeu: 5.143 ± 0.088	1.203AspMet: 1.203 ± 0.046	1.822AspAsn: 1.822 ± 0.045	1.94AspPro: 1.94 ± 0.049	2.298AspGln: 2.298 ± 0.057	2.015AspArg: 2.015 ± 0.056	2.612AspSer: 2.612 ± 0.059	2.657AspThr: 2.657 ± 0.055	3.627AspVal: 3.627 ± 0.076	0.68AspTrp: 0.68 ± 0.028	2.554AspTyr: 2.554 ± 0.064	0.001AspXaa: 0.001 ± 0.001
Glu	6.314GluAla: 6.314 ± 0.112	0.375GluCys: 0.375 ± 0.022	3.413GluAsp: 3.413 ± 0.072	7.125GluGlu: 7.125 ± 0.113	2.541GluPhe: 2.541 ± 0.068	4.204GluGly: 4.204 ± 0.083	1.221GluHis: 1.221 ± 0.042	5.947GluIle: 5.947 ± 0.092	6.278GluLys: 6.278 ± 0.105	7.011GluLeu: 7.011 ± 0.126	2.534GluMet: 2.534 ± 0.058	4.01GluAsn: 4.01 ± 0.07	1.742GluPro: 1.742 ± 0.057	3.449GluGln: 3.449 ± 0.074	3.013GluArg: 3.013 ± 0.067	3.596GluSer: 3.596 ± 0.078	4.601GluThr: 4.601 ± 0.091	5.338GluVal: 5.338 ± 0.084	0.802GluTrp: 0.802 ± 0.036	2.265GluTyr: 2.265 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.112PheAla: 3.112 ± 0.065	0.331PheCys: 0.331 ± 0.021	2.803PheAsp: 2.803 ± 0.059	3.279PheGlu: 3.279 ± 0.068	2.567PhePhe: 2.567 ± 0.075	3.293PheGly: 3.293 ± 0.077	0.851PheHis: 0.851 ± 0.037	3.649PheIle: 3.649 ± 0.088	2.306PheLys: 2.306 ± 0.061	4.815PheLeu: 4.815 ± 0.1	1.148PheMet: 1.148 ± 0.044	2.042PheAsn: 2.042 ± 0.055	1.746PhePro: 1.746 ± 0.055	1.797PheGln: 1.797 ± 0.059	1.529PheArg: 1.529 ± 0.045	3.519PheSer: 3.519 ± 0.076	2.59PheThr: 2.59 ± 0.055	3.203PheVal: 3.203 ± 0.076	0.426PheTrp: 0.426 ± 0.027	1.943PheTyr: 1.943 ± 0.065	0.0PheXaa: 0.0 ± 0.0
Gly	4.406GlyAla: 4.406 ± 0.095	0.476GlyCys: 0.476 ± 0.026	3.048GlyAsp: 3.048 ± 0.075	4.684GlyGlu: 4.684 ± 0.083	3.323GlyPhe: 3.323 ± 0.072	4.518GlyGly: 4.518 ± 0.097	1.294GlyHis: 1.294 ± 0.044	5.89GlyIle: 5.89 ± 0.098	4.449GlyLys: 4.449 ± 0.077	6.481GlyLeu: 6.481 ± 0.114	1.997GlyMet: 1.997 ± 0.054	2.738GlyAsn: 2.738 ± 0.057	1.551GlyPro: 1.551 ± 0.055	2.432GlyGln: 2.432 ± 0.061	2.516GlyArg: 2.516 ± 0.072	3.745GlySer: 3.745 ± 0.073	3.874GlyThr: 3.874 ± 0.087	4.964GlyVal: 4.964 ± 0.088	0.647GlyTrp: 0.647 ± 0.032	2.755GlyTyr: 2.755 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.221HisAla: 1.221 ± 0.045	0.15HisCys: 0.15 ± 0.015	0.947HisAsp: 0.947 ± 0.034	1.334HisGlu: 1.334 ± 0.049	1.184HisPhe: 1.184 ± 0.043	1.312HisGly: 1.312 ± 0.043	0.651HisHis: 0.651 ± 0.034	1.133HisIle: 1.133 ± 0.039	0.77HisLys: 0.77 ± 0.034	2.258HisLeu: 2.258 ± 0.053	0.384HisMet: 0.384 ± 0.023	0.606HisAsn: 0.606 ± 0.03	1.063HisPro: 1.063 ± 0.035	1.173HisGln: 1.173 ± 0.046	0.863HisArg: 0.863 ± 0.033	1.159HisSer: 1.159 ± 0.04	0.977HisThr: 0.977 ± 0.039	1.29HisVal: 1.29 ± 0.044	0.211HisTrp: 0.211 ± 0.016	1.001HisTyr: 1.001 ± 0.044	0.0HisXaa: 0.0 ± 0.0
Ile	6.101IleAla: 6.101 ± 0.095	0.559IleCys: 0.559 ± 0.026	4.699IleAsp: 4.699 ± 0.098	5.81IleGlu: 5.81 ± 0.085	3.421IlePhe: 3.421 ± 0.08	5.574IleGly: 5.574 ± 0.104	1.575IleHis: 1.575 ± 0.049	5.544IleIle: 5.544 ± 0.097	4.11IleLys: 4.11 ± 0.077	7.354IleLeu: 7.354 ± 0.119	1.63IleMet: 1.63 ± 0.048	3.153IleAsn: 3.153 ± 0.073	3.349IlePro: 3.349 ± 0.067	3.541IleGln: 3.541 ± 0.075	3.044IleArg: 3.044 ± 0.069	4.478IleSer: 4.478 ± 0.084	4.387IleThr: 4.387 ± 0.068	5.294IleVal: 5.294 ± 0.095	0.603IleTrp: 0.603 ± 0.031	2.575IleTyr: 2.575 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.371LysAla: 4.371 ± 0.086	0.283LysCys: 0.283 ± 0.021	3.131LysAsp: 3.131 ± 0.062	6.77LysGlu: 6.77 ± 0.111	1.616LysPhe: 1.616 ± 0.047	3.723LysGly: 3.723 ± 0.071	1.057LysHis: 1.057 ± 0.036	4.836LysIle: 4.836 ± 0.092	5.346LysLys: 5.346 ± 0.117	4.509LysLeu: 4.509 ± 0.09	2.252LysMet: 2.252 ± 0.053	3.4LysAsn: 3.4 ± 0.077	1.726LysPro: 1.726 ± 0.048	2.999LysGln: 2.999 ± 0.069	2.737LysArg: 2.737 ± 0.066	2.882LysSer: 2.882 ± 0.069	3.602LysThr: 3.602 ± 0.073	4.052LysVal: 4.052 ± 0.079	0.615LysTrp: 0.615 ± 0.031	1.914LysTyr: 1.914 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	8.444LeuAla: 8.444 ± 0.133	0.577LeuCys: 0.577 ± 0.029	4.952LeuAsp: 4.952 ± 0.089	6.917LeuGlu: 6.917 ± 0.103	5.101LeuPhe: 5.101 ± 0.117	6.356LeuGly: 6.356 ± 0.108	1.729LeuHis: 1.729 ± 0.051	7.298LeuIle: 7.298 ± 0.113	5.924LeuLys: 5.924 ± 0.099	10.274LeuLeu: 10.274 ± 0.184	2.567LeuMet: 2.567 ± 0.053	4.337LeuAsn: 4.337 ± 0.084	4.281LeuPro: 4.281 ± 0.079	3.835LeuGln: 3.835 ± 0.087	3.774LeuArg: 3.774 ± 0.074	6.682LeuSer: 6.682 ± 0.11	6.51LeuThr: 6.51 ± 0.092	6.591LeuVal: 6.591 ± 0.1	0.788LeuTrp: 0.788 ± 0.035	3.134LeuTyr: 3.134 ± 0.066	0.001LeuXaa: 0.001 ± 0.001
Met	2.142MetAla: 2.142 ± 0.061	0.123MetCys: 0.123 ± 0.013	1.431MetAsp: 1.431 ± 0.042	1.758MetGlu: 1.758 ± 0.052	0.963MetPhe: 0.963 ± 0.036	1.798MetGly: 1.798 ± 0.049	0.454MetHis: 0.454 ± 0.025	2.452MetIle: 2.452 ± 0.05	2.198MetLys: 2.198 ± 0.053	2.345MetLeu: 2.345 ± 0.062	0.893MetMet: 0.893 ± 0.038	1.557MetAsn: 1.557 ± 0.038	0.905MetPro: 0.905 ± 0.038	0.999MetGln: 0.999 ± 0.033	1.003MetArg: 1.003 ± 0.039	1.579MetSer: 1.579 ± 0.047	1.954MetThr: 1.954 ± 0.051	1.703MetVal: 1.703 ± 0.051	0.19MetTrp: 0.19 ± 0.015	0.738MetTyr: 0.738 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.721AsnAla: 2.721 ± 0.072	0.265AsnCys: 0.265 ± 0.018	2.328AsnAsp: 2.328 ± 0.056	3.272AsnGlu: 3.272 ± 0.074	1.798AsnPhe: 1.798 ± 0.059	3.079AsnGly: 3.079 ± 0.072	1.213AsnHis: 1.213 ± 0.041	3.086AsnIle: 3.086 ± 0.064	2.437AsnLys: 2.437 ± 0.061	3.987AsnLeu: 3.987 ± 0.073	1.052AsnMet: 1.052 ± 0.035	1.833AsnAsn: 1.833 ± 0.058	2.178AsnPro: 2.178 ± 0.053	2.882AsnGln: 2.882 ± 0.065	1.968AsnArg: 1.968 ± 0.05	2.129AsnSer: 2.129 ± 0.049	2.15AsnThr: 2.15 ± 0.055	2.934AsnVal: 2.934 ± 0.071	0.498AsnTrp: 0.498 ± 0.026	1.849AsnTyr: 1.849 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.415ProAla: 2.415 ± 0.059	0.193ProCys: 0.193 ± 0.019	1.976ProAsp: 1.976 ± 0.064	3.053ProGlu: 3.053 ± 0.064	1.922ProPhe: 1.922 ± 0.051	2.053ProGly: 2.053 ± 0.057	0.687ProHis: 0.687 ± 0.033	2.824ProIle: 2.824 ± 0.073	2.113ProLys: 2.113 ± 0.058	3.54ProLeu: 3.54 ± 0.069	0.926ProMet: 0.926 ± 0.035	1.707ProAsn: 1.707 ± 0.051	0.742ProPro: 0.742 ± 0.035	1.452ProGln: 1.452 ± 0.042	1.093ProArg: 1.093 ± 0.038	2.171ProSer: 2.171 ± 0.055	2.425ProThr: 2.425 ± 0.06	2.599ProVal: 2.599 ± 0.058	0.348ProTrp: 0.348 ± 0.021	1.488ProTyr: 1.488 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.86GlnAla: 3.86 ± 0.078	0.167GlnCys: 0.167 ± 0.014	1.739GlnAsp: 1.739 ± 0.049	3.703GlnGlu: 3.703 ± 0.076	1.842GlnPhe: 1.842 ± 0.046	2.732GlnGly: 2.732 ± 0.063	0.767GlnHis: 0.767 ± 0.032	3.127GlnIle: 3.127 ± 0.066	3.322GlnLys: 3.322 ± 0.068	5.094GlnLeu: 5.094 ± 0.116	1.362GlnMet: 1.362 ± 0.051	1.697GlnAsn: 1.697 ± 0.056	1.419GlnPro: 1.419 ± 0.046	2.695GlnGln: 2.695 ± 0.106	1.947GlnArg: 1.947 ± 0.053	2.465GlnSer: 2.465 ± 0.062	2.821GlnThr: 2.821 ± 0.06	3.053GlnVal: 3.053 ± 0.066	0.522GlnTrp: 0.522 ± 0.029	1.352GlnTyr: 1.352 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.314ArgAla: 2.314 ± 0.057	0.222ArgCys: 0.222 ± 0.02	1.764ArgAsp: 1.764 ± 0.057	2.997ArgGlu: 2.997 ± 0.066	1.993ArgPhe: 1.993 ± 0.064	2.28ArgGly: 2.28 ± 0.065	0.835ArgHis: 0.835 ± 0.034	2.995ArgIle: 2.995 ± 0.081	2.706ArgLys: 2.706 ± 0.062	4.268ArgLeu: 4.268 ± 0.073	1.195ArgMet: 1.195 ± 0.04	1.692ArgAsn: 1.692 ± 0.056	1.363ArgPro: 1.363 ± 0.05	2.081ArgGln: 2.081 ± 0.062	1.878ArgArg: 1.878 ± 0.058	2.031ArgSer: 2.031 ± 0.06	1.982ArgThr: 1.982 ± 0.055	2.514ArgVal: 2.514 ± 0.059	0.382ArgTrp: 0.382 ± 0.022	1.777ArgTyr: 1.777 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.667SerAla: 3.667 ± 0.071	0.349SerCys: 0.349 ± 0.028	2.931SerAsp: 2.931 ± 0.065	4.056SerGlu: 4.056 ± 0.079	3.169SerPhe: 3.169 ± 0.066	4.198SerGly: 4.198 ± 0.083	1.21SerHis: 1.21 ± 0.038	4.347SerIle: 4.347 ± 0.082	3.159SerLys: 3.159 ± 0.076	6.267SerLeu: 6.267 ± 0.106	1.456SerMet: 1.456 ± 0.045	2.412SerAsn: 2.412 ± 0.065	2.002SerPro: 2.002 ± 0.045	2.623SerGln: 2.623 ± 0.054	2.288SerArg: 2.288 ± 0.06	3.432SerSer: 3.432 ± 0.084	3.1SerThr: 3.1 ± 0.064	3.86SerVal: 3.86 ± 0.079	0.611SerTrp: 0.611 ± 0.031	2.349SerTyr: 2.349 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.972ThrAla: 3.972 ± 0.079	0.319ThrCys: 0.319 ± 0.023	2.964ThrAsp: 2.964 ± 0.067	3.701ThrGlu: 3.701 ± 0.075	2.971ThrPhe: 2.971 ± 0.06	4.164ThrGly: 4.164 ± 0.084	1.172ThrHis: 1.172 ± 0.045	5.2ThrIle: 5.2 ± 0.076	3.427ThrLys: 3.427 ± 0.076	6.027ThrLeu: 6.027 ± 0.092	1.438ThrMet: 1.438 ± 0.044	2.643ThrAsn: 2.643 ± 0.056	2.715ThrPro: 2.715 ± 0.069	2.347ThrGln: 2.347 ± 0.059	2.074ThrArg: 2.074 ± 0.051	3.374ThrSer: 3.374 ± 0.075	3.825ThrThr: 3.825 ± 0.089	4.151ThrVal: 4.151 ± 0.088	0.524ThrTrp: 0.524 ± 0.027	2.292ThrTyr: 2.292 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.553ValAla: 5.553 ± 0.091	0.477ValCys: 0.477 ± 0.024	3.674ValAsp: 3.674 ± 0.073	4.749ValGlu: 4.749 ± 0.085	3.269ValPhe: 3.269 ± 0.078	4.484ValGly: 4.484 ± 0.097	1.156ValHis: 1.156 ± 0.043	5.477ValIle: 5.477 ± 0.089	3.867ValLys: 3.867 ± 0.076	6.752ValLeu: 6.752 ± 0.104	1.878ValMet: 1.878 ± 0.056	2.882ValAsn: 2.882 ± 0.064	2.634ValPro: 2.634 ± 0.068	2.346ValGln: 2.346 ± 0.044	2.375ValArg: 2.375 ± 0.06	4.366ValSer: 4.366 ± 0.085	4.568ValThr: 4.568 ± 0.075	4.929ValVal: 4.929 ± 0.106	0.575ValTrp: 0.575 ± 0.03	2.197ValTyr: 2.197 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.549TrpAla: 0.549 ± 0.026	0.086TrpCys: 0.086 ± 0.011	0.515TrpAsp: 0.515 ± 0.029	0.679TrpGlu: 0.679 ± 0.029	0.508TrpPhe: 0.508 ± 0.029	0.622TrpGly: 0.622 ± 0.031	0.218TrpHis: 0.218 ± 0.017	0.683TrpIle: 0.683 ± 0.033	0.491TrpLys: 0.491 ± 0.025	1.179TrpLeu: 1.179 ± 0.043	0.269TrpMet: 0.269 ± 0.021	0.508TrpAsn: 0.508 ± 0.026	0.239TrpPro: 0.239 ± 0.019	0.614TrpGln: 0.614 ± 0.027	0.433TrpArg: 0.433 ± 0.026	0.513TrpSer: 0.513 ± 0.024	0.5TrpThr: 0.5 ± 0.024	0.498TrpVal: 0.498 ± 0.028	0.108TrpTrp: 0.108 ± 0.013	0.355TrpTyr: 0.355 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.408TyrAla: 2.408 ± 0.06	0.261TyrCys: 0.261 ± 0.019	2.025TyrAsp: 2.025 ± 0.053	2.605TyrGlu: 2.605 ± 0.066	2.087TyrPhe: 2.087 ± 0.062	2.561TyrGly: 2.561 ± 0.066	0.951TyrHis: 0.951 ± 0.038	2.127TyrIle: 2.127 ± 0.06	1.437TyrLys: 1.437 ± 0.051	4.348TyrLeu: 4.348 ± 0.085	0.693TyrMet: 0.693 ± 0.031	1.415TyrAsn: 1.415 ± 0.042	1.612TyrPro: 1.612 ± 0.048	2.473TyrGln: 2.473 ± 0.07	1.776TyrArg: 1.776 ± 0.05	2.171TyrSer: 2.171 ± 0.058	1.866TyrThr: 1.866 ± 0.052	2.266TyrVal: 2.266 ± 0.052	0.384TyrTrp: 0.384 ± 0.023	1.659TyrTyr: 1.659 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2342 proteins (724622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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