Amino acid dipepetide frequency for Chitinophagaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.651AlaAla: 10.651 ± 0.163
0.857AlaCys: 0.857 ± 0.032
4.768AlaAsp: 4.768 ± 0.077
4.726AlaGlu: 4.726 ± 0.088
4.15AlaPhe: 4.15 ± 0.07
8.158AlaGly: 8.158 ± 0.147
1.805AlaHis: 1.805 ± 0.046
4.822AlaIle: 4.822 ± 0.087
3.368AlaLys: 3.368 ± 0.085
9.725AlaLeu: 9.725 ± 0.134
1.818AlaMet: 1.818 ± 0.048
3.638AlaAsn: 3.638 ± 0.097
4.223AlaPro: 4.223 ± 0.086
4.31AlaGln: 4.31 ± 0.062
5.091AlaArg: 5.091 ± 0.093
6.185AlaSer: 6.185 ± 0.159
6.189AlaThr: 6.189 ± 0.214
6.049AlaVal: 6.049 ± 0.098
1.157AlaTrp: 1.157 ± 0.039
2.868AlaTyr: 2.868 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.911CysAla: 0.911 ± 0.039
0.144CysCys: 0.144 ± 0.012
0.406CysAsp: 0.406 ± 0.021
0.344CysGlu: 0.344 ± 0.019
0.424CysPhe: 0.424 ± 0.018
0.831CysGly: 0.831 ± 0.038
0.196CysHis: 0.196 ± 0.012
0.559CysIle: 0.559 ± 0.023
0.311CysLys: 0.311 ± 0.018
0.809CysLeu: 0.809 ± 0.031
0.169CysMet: 0.169 ± 0.012
0.431CysAsn: 0.431 ± 0.024
0.463CysPro: 0.463 ± 0.027
0.239CysGln: 0.239 ± 0.015
0.507CysArg: 0.507 ± 0.022
0.743CysSer: 0.743 ± 0.033
0.687CysThr: 0.687 ± 0.031
0.549CysVal: 0.549 ± 0.024
0.112CysTrp: 0.112 ± 0.01
0.296CysTyr: 0.296 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.187AspAla: 5.187 ± 0.078
0.403AspCys: 0.403 ± 0.021
2.501AspAsp: 2.501 ± 0.068
2.966AspGlu: 2.966 ± 0.073
2.562AspPhe: 2.562 ± 0.049
4.145AspGly: 4.145 ± 0.081
0.902AspHis: 0.902 ± 0.032
2.836AspIle: 2.836 ± 0.055
2.347AspLys: 2.347 ± 0.062
4.629AspLeu: 4.629 ± 0.083
0.93AspMet: 0.93 ± 0.026
2.038AspAsn: 2.038 ± 0.046
2.392AspPro: 2.392 ± 0.055
1.366AspGln: 1.366 ± 0.037
2.814AspArg: 2.814 ± 0.068
3.196AspSer: 3.196 ± 0.074
2.649AspThr: 2.649 ± 0.056
3.535AspVal: 3.535 ± 0.063
0.727AspTrp: 0.727 ± 0.023
2.095AspTyr: 2.095 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.225GluAla: 5.225 ± 0.108
0.366GluCys: 0.366 ± 0.019
2.415GluAsp: 2.415 ± 0.062
3.739GluGlu: 3.739 ± 0.102
1.952GluPhe: 1.952 ± 0.052
4.069GluGly: 4.069 ± 0.073
1.178GluHis: 1.178 ± 0.036
2.77GluIle: 2.77 ± 0.077
3.268GluLys: 3.268 ± 0.091
5.798GluLeu: 5.798 ± 0.122
1.235GluMet: 1.235 ± 0.037
2.018GluAsn: 2.018 ± 0.055
1.923GluPro: 1.923 ± 0.055
2.464GluGln: 2.464 ± 0.059
3.482GluArg: 3.482 ± 0.085
2.677GluSer: 2.677 ± 0.053
2.651GluThr: 2.651 ± 0.054
3.673GluVal: 3.673 ± 0.084
0.789GluTrp: 0.789 ± 0.027
1.686GluTyr: 1.686 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
4.094PheAla: 4.094 ± 0.06
0.471PheCys: 0.471 ± 0.02
2.636PheAsp: 2.636 ± 0.057
2.41PheGlu: 2.41 ± 0.056
2.396PhePhe: 2.396 ± 0.063
3.661PheGly: 3.661 ± 0.058
0.866PheHis: 0.866 ± 0.031
2.409PheIle: 2.409 ± 0.052
1.649PheLys: 1.649 ± 0.047
4.301PheLeu: 4.301 ± 0.092
0.806PheMet: 0.806 ± 0.031
2.331PheAsn: 2.331 ± 0.052
1.893PhePro: 1.893 ± 0.045
1.503PheGln: 1.503 ± 0.042
2.82PheArg: 2.82 ± 0.048
3.308PheSer: 3.308 ± 0.061
3.26PheThr: 3.26 ± 0.077
3.125PheVal: 3.125 ± 0.062
0.594PheTrp: 0.594 ± 0.024
1.671PheTyr: 1.671 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
7.222GlyAla: 7.222 ± 0.129
1.003GlyCys: 1.003 ± 0.053
3.535GlyAsp: 3.535 ± 0.056
3.352GlyGlu: 3.352 ± 0.068
3.672GlyPhe: 3.672 ± 0.066
6.777GlyGly: 6.777 ± 0.198
1.415GlyHis: 1.415 ± 0.042
4.782GlyIle: 4.782 ± 0.071
4.084GlyLys: 4.084 ± 0.082
6.758GlyLeu: 6.758 ± 0.095
1.865GlyMet: 1.865 ± 0.046
3.824GlyAsn: 3.824 ± 0.094
2.161GlyPro: 2.161 ± 0.051
2.553GlyGln: 2.553 ± 0.055
4.144GlyArg: 4.144 ± 0.081
5.655GlySer: 5.655 ± 0.149
5.885GlyThr: 5.885 ± 0.221
5.075GlyVal: 5.075 ± 0.077
1.13GlyTrp: 1.13 ± 0.037
2.908GlyTyr: 2.908 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.476HisAla: 1.476 ± 0.042
0.219HisCys: 0.219 ± 0.015
0.96HisAsp: 0.96 ± 0.029
0.994HisGlu: 0.994 ± 0.037
1.248HisPhe: 1.248 ± 0.038
1.282HisGly: 1.282 ± 0.041
0.531HisHis: 0.531 ± 0.024
1.169HisIle: 1.169 ± 0.037
0.808HisLys: 0.808 ± 0.029
1.968HisLeu: 1.968 ± 0.048
0.394HisMet: 0.394 ± 0.02
0.809HisAsn: 0.809 ± 0.031
1.244HisPro: 1.244 ± 0.037
0.679HisGln: 0.679 ± 0.027
1.218HisArg: 1.218 ± 0.039
1.202HisSer: 1.202 ± 0.033
1.119HisThr: 1.119 ± 0.03
1.15HisVal: 1.15 ± 0.038
0.308HisTrp: 0.308 ± 0.018
0.923HisTyr: 0.923 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.383IleAla: 5.383 ± 0.078
0.589IleCys: 0.589 ± 0.029
3.437IleAsp: 3.437 ± 0.071
3.156IleGlu: 3.156 ± 0.079
2.12IlePhe: 2.12 ± 0.053
4.337IleGly: 4.337 ± 0.083
1.072IleHis: 1.072 ± 0.032
2.954IleIle: 2.954 ± 0.076
2.225IleLys: 2.225 ± 0.059
4.48IleLeu: 4.48 ± 0.092
0.854IleMet: 0.854 ± 0.028
2.738IleAsn: 2.738 ± 0.057
2.594IlePro: 2.594 ± 0.049
1.713IleGln: 1.713 ± 0.039
3.5IleArg: 3.5 ± 0.066
3.541IleSer: 3.541 ± 0.078
3.591IleThr: 3.591 ± 0.089
3.833IleVal: 3.833 ± 0.071
0.532IleTrp: 0.532 ± 0.025
1.791IleTyr: 1.791 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.2LysAla: 4.2 ± 0.089
0.266LysCys: 0.266 ± 0.017
2.568LysAsp: 2.568 ± 0.056
3.226LysGlu: 3.226 ± 0.084
1.496LysPhe: 1.496 ± 0.046
3.717LysGly: 3.717 ± 0.073
0.854LysHis: 0.854 ± 0.036
2.466LysIle: 2.466 ± 0.064
3.147LysLys: 3.147 ± 0.081
4.149LysLeu: 4.149 ± 0.088
1.296LysMet: 1.296 ± 0.037
1.989LysAsn: 1.989 ± 0.059
2.13LysPro: 2.13 ± 0.051
1.842LysGln: 1.842 ± 0.047
2.578LysArg: 2.578 ± 0.059
2.377LysSer: 2.377 ± 0.065
2.663LysThr: 2.663 ± 0.06
3.189LysVal: 3.189 ± 0.068
0.597LysTrp: 0.597 ± 0.023
1.529LysTyr: 1.529 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
8.688LeuAla: 8.688 ± 0.13
0.992LeuCys: 0.992 ± 0.033
4.596LeuAsp: 4.596 ± 0.077
5.093LeuGlu: 5.093 ± 0.122
4.775LeuPhe: 4.775 ± 0.092
6.128LeuGly: 6.128 ± 0.09
2.264LeuHis: 2.264 ± 0.057
4.502LeuIle: 4.502 ± 0.083
4.518LeuLys: 4.518 ± 0.103
11.575LeuLeu: 11.575 ± 0.178
2.125LeuMet: 2.125 ± 0.048
3.998LeuAsn: 3.998 ± 0.064
4.902LeuPro: 4.902 ± 0.075
4.901LeuGln: 4.901 ± 0.087
6.415LeuArg: 6.415 ± 0.099
6.508LeuSer: 6.508 ± 0.088
5.269LeuThr: 5.269 ± 0.107
6.439LeuVal: 6.439 ± 0.083
1.082LeuTrp: 1.082 ± 0.037
3.023LeuTyr: 3.023 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.844MetAla: 1.844 ± 0.047
0.127MetCys: 0.127 ± 0.012
1.022MetAsp: 1.022 ± 0.032
1.306MetGlu: 1.306 ± 0.044
0.618MetPhe: 0.618 ± 0.03
1.489MetGly: 1.489 ± 0.038
0.472MetHis: 0.472 ± 0.022
1.134MetIle: 1.134 ± 0.037
1.548MetLys: 1.548 ± 0.035
2.049MetLeu: 2.049 ± 0.048
0.551MetMet: 0.551 ± 0.025
1.073MetAsn: 1.073 ± 0.035
1.115MetPro: 1.115 ± 0.034
1.027MetGln: 1.027 ± 0.036
1.293MetArg: 1.293 ± 0.038
1.187MetSer: 1.187 ± 0.034
1.092MetThr: 1.092 ± 0.033
1.265MetVal: 1.265 ± 0.04
0.179MetTrp: 0.179 ± 0.012
0.517MetTyr: 0.517 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
4.233AsnAla: 4.233 ± 0.108
0.38AsnCys: 0.38 ± 0.02
2.286AsnAsp: 2.286 ± 0.046
2.35AsnGlu: 2.35 ± 0.05
1.973AsnPhe: 1.973 ± 0.051
4.244AsnGly: 4.244 ± 0.132
0.729AsnHis: 0.729 ± 0.027
2.659AsnIle: 2.659 ± 0.055
1.903AsnLys: 1.903 ± 0.05
3.87AsnLeu: 3.87 ± 0.07
0.81AsnMet: 0.81 ± 0.028
2.453AsnAsn: 2.453 ± 0.085
2.615AsnPro: 2.615 ± 0.07
1.359AsnGln: 1.359 ± 0.043
2.405AsnArg: 2.405 ± 0.06
2.694AsnSer: 2.694 ± 0.085
2.904AsnThr: 2.904 ± 0.109
3.122AsnVal: 3.122 ± 0.07
0.707AsnTrp: 0.707 ± 0.026
1.793AsnTyr: 1.793 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
5.091ProAla: 5.091 ± 0.104
0.283ProCys: 0.283 ± 0.019
2.615ProAsp: 2.615 ± 0.05
2.755ProGlu: 2.755 ± 0.064
2.126ProPhe: 2.126 ± 0.048
3.65ProGly: 3.65 ± 0.061
0.824ProHis: 0.824 ± 0.033
2.078ProIle: 2.078 ± 0.051
1.853ProLys: 1.853 ± 0.044
3.885ProLeu: 3.885 ± 0.061
0.942ProMet: 0.942 ± 0.03
1.893ProAsn: 1.893 ± 0.05
1.495ProPro: 1.495 ± 0.049
1.759ProGln: 1.759 ± 0.039
1.905ProArg: 1.905 ± 0.044
2.786ProSer: 2.786 ± 0.071
2.456ProThr: 2.456 ± 0.085
3.848ProVal: 3.848 ± 0.072
0.486ProTrp: 0.486 ± 0.022
1.632ProTyr: 1.632 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.191GlnAla: 3.191 ± 0.06
0.258GlnCys: 0.258 ± 0.015
1.539GlnAsp: 1.539 ± 0.042
2.078GlnGlu: 2.078 ± 0.054
1.681GlnPhe: 1.681 ± 0.041
2.44GlnGly: 2.44 ± 0.05
0.866GlnHis: 0.866 ± 0.027
1.651GlnIle: 1.651 ± 0.038
2.062GlnLys: 2.062 ± 0.056
4.49GlnLeu: 4.49 ± 0.077
0.932GlnMet: 0.932 ± 0.034
1.581GlnAsn: 1.581 ± 0.044
2.01GlnPro: 2.01 ± 0.047
2.395GlnGln: 2.395 ± 0.065
2.57GlnArg: 2.57 ± 0.056
2.117GlnSer: 2.117 ± 0.042
2.213GlnThr: 2.213 ± 0.049
2.843GlnVal: 2.843 ± 0.057
0.652GlnTrp: 0.652 ± 0.03
1.485GlnTyr: 1.485 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
4.389ArgAla: 4.389 ± 0.078
0.438ArgCys: 0.438 ± 0.023
2.751ArgAsp: 2.751 ± 0.065
3.119ArgGlu: 3.119 ± 0.079
3.077ArgPhe: 3.077 ± 0.058
3.346ArgGly: 3.346 ± 0.063
1.168ArgHis: 1.168 ± 0.034
3.901ArgIle: 3.901 ± 0.07
3.192ArgLys: 3.192 ± 0.066
5.506ArgLeu: 5.506 ± 0.104
1.575ArgMet: 1.575 ± 0.046
2.997ArgAsn: 2.997 ± 0.066
2.296ArgPro: 2.296 ± 0.054
2.245ArgGln: 2.245 ± 0.057
3.52ArgArg: 3.52 ± 0.086
3.609ArgSer: 3.609 ± 0.063
3.139ArgThr: 3.139 ± 0.059
3.645ArgVal: 3.645 ± 0.069
0.828ArgTrp: 0.828 ± 0.033
2.379ArgTyr: 2.379 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
6.136SerAla: 6.136 ± 0.141
0.629SerCys: 0.629 ± 0.025
3.054SerAsp: 3.054 ± 0.06
2.925SerGlu: 2.925 ± 0.059
3.545SerPhe: 3.545 ± 0.077
6.208SerGly: 6.208 ± 0.168
0.9SerHis: 0.9 ± 0.031
3.836SerIle: 3.836 ± 0.064
2.485SerLys: 2.485 ± 0.06
6.087SerLeu: 6.087 ± 0.08
1.294SerMet: 1.294 ± 0.04
3.06SerAsn: 3.06 ± 0.09
2.461SerPro: 2.461 ± 0.067
1.726SerGln: 1.726 ± 0.049
2.904SerArg: 2.904 ± 0.056
4.145SerSer: 4.145 ± 0.121
3.901SerThr: 3.901 ± 0.13
4.747SerVal: 4.747 ± 0.103
0.962SerTrp: 0.962 ± 0.035
2.402SerTyr: 2.402 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
6.333ThrAla: 6.333 ± 0.206
0.464ThrCys: 0.464 ± 0.024
3.03ThrAsp: 3.03 ± 0.062
2.806ThrGlu: 2.806 ± 0.06
2.771ThrPhe: 2.771 ± 0.078
5.511ThrGly: 5.511 ± 0.162
1.078ThrHis: 1.078 ± 0.035
3.81ThrIle: 3.81 ± 0.099
2.021ThrLys: 2.021 ± 0.047
5.803ThrLeu: 5.803 ± 0.088
1.067ThrMet: 1.067 ± 0.03
2.614ThrAsn: 2.614 ± 0.119
3.293ThrPro: 3.293 ± 0.08
2.019ThrGln: 2.019 ± 0.039
2.756ThrArg: 2.756 ± 0.054
3.829ThrSer: 3.829 ± 0.171
4.071ThrThr: 4.071 ± 0.17
5.264ThrVal: 5.264 ± 0.181
0.843ThrTrp: 0.843 ± 0.035
2.395ThrTyr: 2.395 ± 0.093
0.0ThrXaa: 0.0 ± 0.0
Val
6.452ValAla: 6.452 ± 0.102
0.737ValCys: 0.737 ± 0.028
3.478ValAsp: 3.478 ± 0.069
3.587ValGlu: 3.587 ± 0.074
3.055ValPhe: 3.055 ± 0.062
4.309ValGly: 4.309 ± 0.068
1.511ValHis: 1.511 ± 0.04
3.599ValIle: 3.599 ± 0.068
3.08ValLys: 3.08 ± 0.067
7.196ValLeu: 7.196 ± 0.097
1.263ValMet: 1.263 ± 0.036
3.395ValAsn: 3.395 ± 0.125
3.247ValPro: 3.247 ± 0.059
2.959ValGln: 2.959 ± 0.05
4.113ValArg: 4.113 ± 0.07
4.45ValSer: 4.45 ± 0.089
4.779ValThr: 4.779 ± 0.149
4.813ValVal: 4.813 ± 0.075
0.803ValTrp: 0.803 ± 0.031
2.402ValTyr: 2.402 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.901TrpAla: 0.901 ± 0.036
0.128TrpCys: 0.128 ± 0.011
0.668TrpAsp: 0.668 ± 0.03
0.628TrpGlu: 0.628 ± 0.028
0.593TrpPhe: 0.593 ± 0.026
0.854TrpGly: 0.854 ± 0.027
0.311TrpHis: 0.311 ± 0.016
0.731TrpIle: 0.731 ± 0.029
0.825TrpLys: 0.825 ± 0.032
1.343TrpLeu: 1.343 ± 0.039
0.394TrpMet: 0.394 ± 0.019
0.768TrpAsn: 0.768 ± 0.033
0.403TrpPro: 0.403 ± 0.022
0.609TrpGln: 0.609 ± 0.024
0.75TrpArg: 0.75 ± 0.029
0.878TrpSer: 0.878 ± 0.037
0.872TrpThr: 0.872 ± 0.04
0.805TrpVal: 0.805 ± 0.032
0.26TrpTrp: 0.26 ± 0.013
0.514TrpTyr: 0.514 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.95TyrAla: 2.95 ± 0.06
0.377TyrCys: 0.377 ± 0.022
1.954TyrAsp: 1.954 ± 0.04
1.819TyrGlu: 1.819 ± 0.051
1.97TyrPhe: 1.97 ± 0.049
2.646TyrGly: 2.646 ± 0.056
0.758TyrHis: 0.758 ± 0.026
1.769TyrIle: 1.769 ± 0.044
1.581TyrLys: 1.581 ± 0.044
3.373TyrLeu: 3.373 ± 0.062
0.59TyrMet: 0.59 ± 0.024
1.843TyrAsn: 1.843 ± 0.05
1.501TyrPro: 1.501 ± 0.04
1.386TyrGln: 1.386 ± 0.035
2.334TyrArg: 2.334 ± 0.051
2.319TyrSer: 2.319 ± 0.057
2.388TyrThr: 2.388 ± 0.088
2.264TyrVal: 2.264 ± 0.058
0.486TyrTrp: 0.486 ± 0.02
1.612TyrTyr: 1.612 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3060 proteins (1114154 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski