Amino acid dipepetide frequency for Carboxylicivirga sp. M1479

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.544AlaAla: 4.544 ± 0.07	0.771AlaCys: 0.771 ± 0.027	3.854AlaAsp: 3.854 ± 0.051	4.142AlaGlu: 4.142 ± 0.063	3.307AlaPhe: 3.307 ± 0.051	4.597AlaGly: 4.597 ± 0.06	1.28AlaHis: 1.28 ± 0.034	5.255AlaIle: 5.255 ± 0.072	4.253AlaLys: 4.253 ± 0.056	6.22AlaLeu: 6.22 ± 0.072	1.732AlaMet: 1.732 ± 0.037	3.661AlaAsn: 3.661 ± 0.054	2.066AlaPro: 2.066 ± 0.04	2.607AlaGln: 2.607 ± 0.045	2.304AlaArg: 2.304 ± 0.044	4.593AlaSer: 4.593 ± 0.06	3.382AlaThr: 3.382 ± 0.056	4.056AlaVal: 4.056 ± 0.061	0.73AlaTrp: 0.73 ± 0.025	2.899AlaTyr: 2.899 ± 0.049	0.001AlaXaa: 0.001 ± 0.001
Cys	0.48CysAla: 0.48 ± 0.02	0.122CysCys: 0.122 ± 0.01	0.519CysAsp: 0.519 ± 0.02	0.511CysGlu: 0.511 ± 0.019	0.434CysPhe: 0.434 ± 0.016	0.664CysGly: 0.664 ± 0.025	0.267CysHis: 0.267 ± 0.016	0.628CysIle: 0.628 ± 0.022	0.524CysLys: 0.524 ± 0.02	0.779CysLeu: 0.779 ± 0.022	0.2CysMet: 0.2 ± 0.011	0.483CysAsn: 0.483 ± 0.018	0.327CysPro: 0.327 ± 0.017	0.362CysGln: 0.362 ± 0.015	0.318CysArg: 0.318 ± 0.013	0.654CysSer: 0.654 ± 0.023	0.449CysThr: 0.449 ± 0.018	0.549CysVal: 0.549 ± 0.02	0.102CysTrp: 0.102 ± 0.008	0.377CysTyr: 0.377 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.974AspAla: 3.974 ± 0.055	0.444AspCys: 0.444 ± 0.018	3.491AspAsp: 3.491 ± 0.052	4.506AspGlu: 4.506 ± 0.063	3.17AspPhe: 3.17 ± 0.048	4.307AspGly: 4.307 ± 0.071	0.961AspHis: 0.961 ± 0.028	4.345AspIle: 4.345 ± 0.07	4.225AspLys: 4.225 ± 0.054	5.139AspLeu: 5.139 ± 0.063	1.39AspMet: 1.39 ± 0.032	3.326AspAsn: 3.326 ± 0.061	1.702AspPro: 1.702 ± 0.036	1.802AspGln: 1.802 ± 0.037	1.956AspArg: 1.956 ± 0.035	3.055AspSer: 3.055 ± 0.048	2.559AspThr: 2.559 ± 0.046	4.104AspVal: 4.104 ± 0.06	0.816AspTrp: 0.816 ± 0.027	2.906AspTyr: 2.906 ± 0.041	0.001AspXaa: 0.001 ± 0.001
Glu	4.712GluAla: 4.712 ± 0.072	0.475GluCys: 0.475 ± 0.018	3.386GluAsp: 3.386 ± 0.05	4.883GluGlu: 4.883 ± 0.069	2.759GluPhe: 2.759 ± 0.046	3.913GluGly: 3.913 ± 0.063	1.347GluHis: 1.347 ± 0.03	4.666GluIle: 4.666 ± 0.049	4.947GluLys: 4.947 ± 0.079	7.153GluLeu: 7.153 ± 0.086	1.829GluMet: 1.829 ± 0.036	3.552GluAsn: 3.552 ± 0.058	1.696GluPro: 1.696 ± 0.037	2.921GluGln: 2.921 ± 0.042	2.664GluArg: 2.664 ± 0.051	3.707GluSer: 3.707 ± 0.047	3.134GluThr: 3.134 ± 0.049	4.755GluVal: 4.755 ± 0.061	0.811GluTrp: 0.811 ± 0.025	2.569GluTyr: 2.569 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.919PheAla: 2.919 ± 0.041	0.431PheCys: 0.431 ± 0.015	3.174PheAsp: 3.174 ± 0.048	3.146PheGlu: 3.146 ± 0.051	2.303PhePhe: 2.303 ± 0.046	3.187PheGly: 3.187 ± 0.055	0.799PheHis: 0.799 ± 0.023	3.603PheIle: 3.603 ± 0.046	3.307PheLys: 3.307 ± 0.048	3.728PheLeu: 3.728 ± 0.064	1.228PheMet: 1.228 ± 0.03	3.069PheAsn: 3.069 ± 0.055	1.506PhePro: 1.506 ± 0.033	1.336PheGln: 1.336 ± 0.028	1.628PheArg: 1.628 ± 0.031	3.596PheSer: 3.596 ± 0.053	2.778PheThr: 2.778 ± 0.048	3.031PheVal: 3.031 ± 0.047	0.557PheTrp: 0.557 ± 0.02	1.98PheTyr: 1.98 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.43GlyAla: 4.43 ± 0.06	0.637GlyCys: 0.637 ± 0.031	3.754GlyAsp: 3.754 ± 0.066	3.975GlyGlu: 3.975 ± 0.052	3.476GlyPhe: 3.476 ± 0.052	4.821GlyGly: 4.821 ± 0.081	1.295GlyHis: 1.295 ± 0.027	5.217GlyIle: 5.217 ± 0.063	4.455GlyLys: 4.455 ± 0.063	6.054GlyLeu: 6.054 ± 0.069	1.798GlyMet: 1.798 ± 0.039	3.452GlyAsn: 3.452 ± 0.063	1.422GlyPro: 1.422 ± 0.035	2.47GlyGln: 2.47 ± 0.042	2.382GlyArg: 2.382 ± 0.042	4.236GlySer: 4.236 ± 0.067	3.788GlyThr: 3.788 ± 0.07	4.757GlyVal: 4.757 ± 0.06	0.851GlyTrp: 0.851 ± 0.026	3.05GlyTyr: 3.05 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.109HisAla: 1.109 ± 0.026	0.224HisCys: 0.224 ± 0.012	0.954HisAsp: 0.954 ± 0.023	1.14HisGlu: 1.14 ± 0.032	1.138HisPhe: 1.138 ± 0.029	1.241HisGly: 1.241 ± 0.031	0.579HisHis: 0.579 ± 0.024	1.505HisIle: 1.505 ± 0.033	1.194HisLys: 1.194 ± 0.032	2.06HisLeu: 2.06 ± 0.045	0.461HisMet: 0.461 ± 0.017	1.023HisAsn: 1.023 ± 0.027	0.976HisPro: 0.976 ± 0.026	0.941HisGln: 0.941 ± 0.027	0.746HisArg: 0.746 ± 0.021	1.241HisSer: 1.241 ± 0.031	1.05HisThr: 1.05 ± 0.027	1.094HisVal: 1.094 ± 0.024	0.251HisTrp: 0.251 ± 0.014	0.949HisTyr: 0.949 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.069IleAla: 5.069 ± 0.064	0.627IleCys: 0.627 ± 0.018	5.059IleAsp: 5.059 ± 0.06	5.323IleGlu: 5.323 ± 0.067	2.834IlePhe: 2.834 ± 0.046	4.959IleGly: 4.959 ± 0.064	1.376IleHis: 1.376 ± 0.036	5.381IleIle: 5.381 ± 0.082	5.36IleLys: 5.36 ± 0.069	5.917IleLeu: 5.917 ± 0.084	1.467IleMet: 1.467 ± 0.033	4.748IleAsn: 4.748 ± 0.06	2.886IlePro: 2.886 ± 0.042	2.463IleGln: 2.463 ± 0.041	2.792IleArg: 2.792 ± 0.041	5.409IleSer: 5.409 ± 0.068	4.175IleThr: 4.175 ± 0.076	4.618IleVal: 4.618 ± 0.054	0.731IleTrp: 0.731 ± 0.021	2.709IleTyr: 2.709 ± 0.044	0.001IleXaa: 0.001 ± 0.001
Lys	5.069LysAla: 5.069 ± 0.078	0.456LysCys: 0.456 ± 0.015	3.988LysAsp: 3.988 ± 0.061	5.569LysGlu: 5.569 ± 0.091	2.296LysPhe: 2.296 ± 0.042	4.743LysGly: 4.743 ± 0.057	1.622LysHis: 1.622 ± 0.033	4.495LysIle: 4.495 ± 0.059	5.398LysLys: 5.398 ± 0.081	6.002LysLeu: 6.002 ± 0.076	1.93LysMet: 1.93 ± 0.04	3.911LysAsn: 3.911 ± 0.053	2.289LysPro: 2.289 ± 0.039	3.038LysGln: 3.038 ± 0.05	2.985LysArg: 2.985 ± 0.051	4.029LysSer: 4.029 ± 0.057	3.71LysThr: 3.71 ± 0.048	4.886LysVal: 4.886 ± 0.068	0.775LysTrp: 0.775 ± 0.023	2.897LysTyr: 2.897 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	6.057LeuAla: 6.057 ± 0.065	0.763LeuCys: 0.763 ± 0.025	4.946LeuAsp: 4.946 ± 0.058	5.541LeuGlu: 5.541 ± 0.071	4.481LeuPhe: 4.481 ± 0.061	5.497LeuGly: 5.497 ± 0.066	1.615LeuHis: 1.615 ± 0.035	6.647LeuIle: 6.647 ± 0.079	7.158LeuLys: 7.158 ± 0.077	9.143LeuLeu: 9.143 ± 0.108	2.414LeuMet: 2.414 ± 0.042	5.636LeuAsn: 5.636 ± 0.073	3.641LeuPro: 3.641 ± 0.051	3.217LeuGln: 3.217 ± 0.05	3.307LeuArg: 3.307 ± 0.049	7.492LeuSer: 7.492 ± 0.078	4.826LeuThr: 4.826 ± 0.064	5.555LeuVal: 5.555 ± 0.067	0.937LeuTrp: 0.937 ± 0.026	3.339LeuTyr: 3.339 ± 0.048	0.001LeuXaa: 0.001 ± 0.001
Met	2.064MetAla: 2.064 ± 0.038	0.219MetCys: 0.219 ± 0.011	1.49MetAsp: 1.49 ± 0.035	1.508MetGlu: 1.508 ± 0.031	0.866MetPhe: 0.866 ± 0.025	1.757MetGly: 1.757 ± 0.035	0.515MetHis: 0.515 ± 0.018	1.576MetIle: 1.576 ± 0.038	2.048MetLys: 2.048 ± 0.039	2.243MetLeu: 2.243 ± 0.042	0.712MetMet: 0.712 ± 0.027	1.44MetAsn: 1.44 ± 0.029	1.132MetPro: 1.132 ± 0.027	0.995MetGln: 0.995 ± 0.026	1.057MetArg: 1.057 ± 0.026	1.588MetSer: 1.588 ± 0.032	1.225MetThr: 1.225 ± 0.025	1.674MetVal: 1.674 ± 0.039	0.234MetTrp: 0.234 ± 0.012	0.75MetTyr: 0.75 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.7AsnAla: 3.7 ± 0.05	0.493AsnCys: 0.493 ± 0.019	3.342AsnAsp: 3.342 ± 0.05	3.769AsnGlu: 3.769 ± 0.052	2.441AsnPhe: 2.441 ± 0.044	4.212AsnGly: 4.212 ± 0.072	1.13AsnHis: 1.13 ± 0.026	4.378AsnIle: 4.378 ± 0.064	4.217AsnLys: 4.217 ± 0.061	4.772AsnLeu: 4.772 ± 0.067	1.413AsnMet: 1.413 ± 0.034	3.779AsnAsn: 3.779 ± 0.062	2.39AsnPro: 2.39 ± 0.047	2.105AsnGln: 2.105 ± 0.044	2.247AsnArg: 2.247 ± 0.042	3.595AsnSer: 3.595 ± 0.054	3.333AsnThr: 3.333 ± 0.061	3.468AsnVal: 3.468 ± 0.057	0.784AsnTrp: 0.784 ± 0.021	2.803AsnTyr: 2.803 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.179ProAla: 2.179 ± 0.036	0.257ProCys: 0.257 ± 0.014	2.27ProAsp: 2.27 ± 0.036	2.648ProGlu: 2.648 ± 0.043	1.806ProPhe: 1.806 ± 0.035	2.116ProGly: 2.116 ± 0.042	0.741ProHis: 0.741 ± 0.024	2.479ProIle: 2.479 ± 0.043	1.991ProLys: 1.991 ± 0.039	3.035ProLeu: 3.035 ± 0.05	0.833ProMet: 0.833 ± 0.023	2.005ProAsn: 2.005 ± 0.04	0.825ProPro: 0.825 ± 0.025	1.329ProGln: 1.329 ± 0.031	1.002ProArg: 1.002 ± 0.029	2.197ProSer: 2.197 ± 0.039	1.811ProThr: 1.811 ± 0.039	2.564ProVal: 2.564 ± 0.046	0.382ProTrp: 0.382 ± 0.015	1.486ProTyr: 1.486 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.521GlnAla: 2.521 ± 0.043	0.238GlnCys: 0.238 ± 0.013	1.672GlnAsp: 1.672 ± 0.036	2.397GlnGlu: 2.397 ± 0.038	1.709GlnPhe: 1.709 ± 0.034	1.988GlnGly: 1.988 ± 0.039	0.836GlnHis: 0.836 ± 0.023	2.585GlnIle: 2.585 ± 0.044	2.668GlnLys: 2.668 ± 0.048	4.249GlnLeu: 4.249 ± 0.068	1.072GlnMet: 1.072 ± 0.029	2.021GlnAsn: 2.021 ± 0.037	1.175GlnPro: 1.175 ± 0.026	1.8GlnGln: 1.8 ± 0.048	1.449GlnArg: 1.449 ± 0.028	2.439GlnSer: 2.439 ± 0.045	2.051GlnThr: 2.051 ± 0.035	2.422GlnVal: 2.422 ± 0.039	0.481GlnTrp: 0.481 ± 0.018	1.589GlnTyr: 1.589 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.137ArgAla: 2.137 ± 0.038	0.288ArgCys: 0.288 ± 0.014	1.915ArgAsp: 1.915 ± 0.035	2.237ArgGlu: 2.237 ± 0.041	2.038ArgPhe: 2.038 ± 0.042	2.05ArgGly: 2.05 ± 0.035	0.799ArgHis: 0.799 ± 0.026	3.044ArgIle: 3.044 ± 0.043	2.664ArgLys: 2.664 ± 0.044	3.74ArgLeu: 3.74 ± 0.057	1.045ArgMet: 1.045 ± 0.024	2.11ArgAsn: 2.11 ± 0.03	1.201ArgPro: 1.201 ± 0.031	1.429ArgGln: 1.429 ± 0.027	1.456ArgArg: 1.456 ± 0.034	2.166ArgSer: 2.166 ± 0.04	1.893ArgThr: 1.893 ± 0.033	2.399ArgVal: 2.399 ± 0.039	0.521ArgTrp: 0.521 ± 0.02	1.842ArgTyr: 1.842 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	4.13SerAla: 4.13 ± 0.052	0.676SerCys: 0.676 ± 0.023	4.02SerAsp: 4.02 ± 0.059	4.057SerGlu: 4.057 ± 0.059	3.662SerPhe: 3.662 ± 0.057	4.681SerGly: 4.681 ± 0.08	1.281SerHis: 1.281 ± 0.029	5.521SerIle: 5.521 ± 0.068	4.302SerLys: 4.302 ± 0.062	6.1SerLeu: 6.1 ± 0.071	1.553SerMet: 1.553 ± 0.031	3.951SerAsn: 3.951 ± 0.06	2.12SerPro: 2.12 ± 0.035	2.351SerGln: 2.351 ± 0.039	2.223SerArg: 2.223 ± 0.04	4.791SerSer: 4.791 ± 0.076	3.56SerThr: 3.56 ± 0.052	4.199SerVal: 4.199 ± 0.058	0.78SerTrp: 0.78 ± 0.025	3.008SerTyr: 3.008 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.427ThrAla: 3.427 ± 0.052	0.427ThrCys: 0.427 ± 0.018	3.079ThrAsp: 3.079 ± 0.051	3.129ThrGlu: 3.129 ± 0.045	2.553ThrPhe: 2.553 ± 0.045	3.977ThrGly: 3.977 ± 0.059	1.017ThrHis: 1.017 ± 0.026	4.588ThrIle: 4.588 ± 0.073	3.317ThrLys: 3.317 ± 0.053	4.795ThrLeu: 4.795 ± 0.06	1.052ThrMet: 1.052 ± 0.03	3.016ThrAsn: 3.016 ± 0.055	2.304ThrPro: 2.304 ± 0.038	1.816ThrGln: 1.816 ± 0.037	1.717ThrArg: 1.717 ± 0.041	3.592ThrSer: 3.592 ± 0.052	2.972ThrThr: 2.972 ± 0.049	3.519ThrVal: 3.519 ± 0.066	0.626ThrTrp: 0.626 ± 0.018	2.123ThrTyr: 2.123 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.329ValAla: 4.329 ± 0.062	0.661ValCys: 0.661 ± 0.02	4.142ValAsp: 4.142 ± 0.056	4.253ValGlu: 4.253 ± 0.059	3.281ValPhe: 3.281 ± 0.051	3.99ValGly: 3.99 ± 0.056	1.174ValHis: 1.174 ± 0.031	4.699ValIle: 4.699 ± 0.053	4.457ValLys: 4.457 ± 0.058	6.054ValLeu: 6.054 ± 0.072	1.617ValMet: 1.617 ± 0.036	3.833ValAsn: 3.833 ± 0.052	2.343ValPro: 2.343 ± 0.04	1.954ValGln: 1.954 ± 0.037	2.372ValArg: 2.372 ± 0.039	4.757ValSer: 4.757 ± 0.067	3.283ValThr: 3.283 ± 0.059	4.688ValVal: 4.688 ± 0.074	0.689ValTrp: 0.689 ± 0.023	2.648ValTyr: 2.648 ± 0.043	0.001ValXaa: 0.001 ± 0.001
Trp	0.735TrpAla: 0.735 ± 0.024	0.138TrpCys: 0.138 ± 0.009	0.691TrpAsp: 0.691 ± 0.021	0.742TrpGlu: 0.742 ± 0.023	0.558TrpPhe: 0.558 ± 0.018	0.814TrpGly: 0.814 ± 0.022	0.295TrpHis: 0.295 ± 0.016	0.715TrpIle: 0.715 ± 0.022	0.742TrpLys: 0.742 ± 0.022	1.118TrpLeu: 1.118 ± 0.03	0.395TrpMet: 0.395 ± 0.017	0.653TrpAsn: 0.653 ± 0.023	0.302TrpPro: 0.302 ± 0.013	0.556TrpGln: 0.556 ± 0.019	0.519TrpArg: 0.519 ± 0.023	0.817TrpSer: 0.817 ± 0.027	0.651TrpThr: 0.651 ± 0.024	0.714TrpVal: 0.714 ± 0.022	0.184TrpTrp: 0.184 ± 0.011	0.482TrpTyr: 0.482 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.673TyrAla: 2.673 ± 0.039	0.403TyrCys: 0.403 ± 0.016	2.432TyrAsp: 2.432 ± 0.04	2.401TyrGlu: 2.401 ± 0.04	2.194TyrPhe: 2.194 ± 0.037	2.805TyrGly: 2.805 ± 0.047	0.945TyrHis: 0.945 ± 0.024	2.578TyrIle: 2.578 ± 0.046	2.858TyrLys: 2.858 ± 0.042	3.913TyrLeu: 3.913 ± 0.058	0.951TyrMet: 0.951 ± 0.029	2.701TyrAsn: 2.701 ± 0.048	1.653TyrPro: 1.653 ± 0.036	1.871TyrGln: 1.871 ± 0.035	1.851TyrArg: 1.851 ± 0.038	3.012TyrSer: 3.012 ± 0.054	2.415TyrThr: 2.415 ± 0.049	2.17TyrVal: 2.17 ± 0.042	0.58TyrTrp: 0.58 ± 0.019	2.009TyrTyr: 2.009 ± 0.041	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4095 proteins (1561341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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