Amino acid dipepetide frequency for Asticcacaulis taihuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.895AlaAla: 14.895 ± 0.158	1.121AlaCys: 1.121 ± 0.031	6.892AlaAsp: 6.892 ± 0.084	6.494AlaGlu: 6.494 ± 0.095	4.599AlaPhe: 4.599 ± 0.063	9.492AlaGly: 9.492 ± 0.117	2.402AlaHis: 2.402 ± 0.046	5.8AlaIle: 5.8 ± 0.075	4.646AlaLys: 4.646 ± 0.073	12.792AlaLeu: 12.792 ± 0.155	3.132AlaMet: 3.132 ± 0.052	3.258AlaAsn: 3.258 ± 0.058	5.632AlaPro: 5.632 ± 0.086	4.501AlaGln: 4.501 ± 0.072	7.212AlaArg: 7.212 ± 0.105	6.196AlaSer: 6.196 ± 0.085	5.838AlaThr: 5.838 ± 0.09	7.806AlaVal: 7.806 ± 0.088	1.466AlaTrp: 1.466 ± 0.04	2.999AlaTyr: 2.999 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.012CysAla: 1.012 ± 0.03	0.087CysCys: 0.087 ± 0.009	0.542CysAsp: 0.542 ± 0.023	0.423CysGlu: 0.423 ± 0.022	0.294CysPhe: 0.294 ± 0.015	0.839CysGly: 0.839 ± 0.029	0.205CysHis: 0.205 ± 0.014	0.373CysIle: 0.373 ± 0.017	0.211CysLys: 0.211 ± 0.014	0.907CysLeu: 0.907 ± 0.03	0.138CysMet: 0.138 ± 0.009	0.226CysAsn: 0.226 ± 0.014	0.415CysPro: 0.415 ± 0.02	0.213CysGln: 0.213 ± 0.013	0.431CysArg: 0.431 ± 0.021	0.409CysSer: 0.409 ± 0.019	0.42CysThr: 0.42 ± 0.02	0.647CysVal: 0.647 ± 0.024	0.111CysTrp: 0.111 ± 0.011	0.214CysTyr: 0.214 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.609AspAla: 6.609 ± 0.081	0.459AspCys: 0.459 ± 0.023	3.453AspAsp: 3.453 ± 0.068	3.176AspGlu: 3.176 ± 0.059	2.461AspPhe: 2.461 ± 0.048	5.084AspGly: 5.084 ± 0.075	1.428AspHis: 1.428 ± 0.037	3.701AspIle: 3.701 ± 0.055	2.297AspLys: 2.297 ± 0.042	6.125AspLeu: 6.125 ± 0.07	1.649AspMet: 1.649 ± 0.038	1.741AspAsn: 1.741 ± 0.045	3.288AspPro: 3.288 ± 0.054	2.17AspGln: 2.17 ± 0.048	3.691AspArg: 3.691 ± 0.06	2.737AspSer: 2.737 ± 0.058	3.157AspThr: 3.157 ± 0.058	3.896AspVal: 3.896 ± 0.055	1.063AspTrp: 1.063 ± 0.031	2.032AspTyr: 2.032 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.459GluAla: 7.459 ± 0.104	0.307GluCys: 0.307 ± 0.018	2.892GluAsp: 2.892 ± 0.055	2.53GluGlu: 2.53 ± 0.058	1.573GluPhe: 1.573 ± 0.036	4.143GluGly: 4.143 ± 0.058	1.076GluHis: 1.076 ± 0.033	3.144GluIle: 3.144 ± 0.06	2.58GluLys: 2.58 ± 0.053	4.497GluLeu: 4.497 ± 0.062	1.417GluMet: 1.417 ± 0.031	1.693GluAsn: 1.693 ± 0.042	2.317GluPro: 2.317 ± 0.044	1.822GluGln: 1.822 ± 0.044	3.63GluArg: 3.63 ± 0.064	2.392GluSer: 2.392 ± 0.041	3.616GluThr: 3.616 ± 0.056	3.603GluVal: 3.603 ± 0.056	0.691GluTrp: 0.691 ± 0.029	1.062GluTyr: 1.062 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.256PheAla: 4.256 ± 0.066	0.366PheCys: 0.366 ± 0.021	2.869PheAsp: 2.869 ± 0.05	2.132PheGlu: 2.132 ± 0.047	1.406PhePhe: 1.406 ± 0.039	3.579PheGly: 3.579 ± 0.057	0.821PheHis: 0.821 ± 0.026	1.999PheIle: 1.999 ± 0.049	1.428PheLys: 1.428 ± 0.038	3.209PheLeu: 3.209 ± 0.067	0.93PheMet: 0.93 ± 0.027	1.391PheAsn: 1.391 ± 0.039	1.498PhePro: 1.498 ± 0.034	1.051PheGln: 1.051 ± 0.033	1.924PheArg: 1.924 ± 0.036	2.418PheSer: 2.418 ± 0.048	2.31PheThr: 2.31 ± 0.047	2.627PheVal: 2.627 ± 0.05	0.578PheTrp: 0.578 ± 0.025	1.117PheTyr: 1.117 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.349GlyAla: 8.349 ± 0.099	0.711GlyCys: 0.711 ± 0.025	4.626GlyAsp: 4.626 ± 0.071	4.403GlyGlu: 4.403 ± 0.058	3.799GlyPhe: 3.799 ± 0.059	6.87GlyGly: 6.87 ± 0.101	2.02GlyHis: 2.02 ± 0.044	4.274GlyIle: 4.274 ± 0.066	3.697GlyLys: 3.697 ± 0.057	9.227GlyLeu: 9.227 ± 0.115	2.099GlyMet: 2.099 ± 0.047	2.399GlyAsn: 2.399 ± 0.056	3.134GlyPro: 3.134 ± 0.056	3.258GlyGln: 3.258 ± 0.061	4.99GlyArg: 4.99 ± 0.072	4.119GlySer: 4.119 ± 0.077	4.227GlyThr: 4.227 ± 0.072	6.037GlyVal: 6.037 ± 0.068	1.399GlyTrp: 1.399 ± 0.038	2.663GlyTyr: 2.663 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.107HisAla: 2.107 ± 0.046	0.191HisCys: 0.191 ± 0.013	1.473HisAsp: 1.473 ± 0.038	1.157HisGlu: 1.157 ± 0.034	0.874HisPhe: 0.874 ± 0.027	1.794HisGly: 1.794 ± 0.04	0.562HisHis: 0.562 ± 0.026	1.245HisIle: 1.245 ± 0.034	0.754HisLys: 0.754 ± 0.023	2.158HisLeu: 2.158 ± 0.046	0.633HisMet: 0.633 ± 0.025	0.66HisAsn: 0.66 ± 0.023	1.287HisPro: 1.287 ± 0.031	0.626HisGln: 0.626 ± 0.022	1.18HisArg: 1.18 ± 0.037	1.063HisSer: 1.063 ± 0.029	0.972HisThr: 0.972 ± 0.031	1.423HisVal: 1.423 ± 0.034	0.336HisTrp: 0.336 ± 0.018	0.695HisTyr: 0.695 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.476IleAla: 6.476 ± 0.071	0.541IleCys: 0.541 ± 0.019	3.841IleAsp: 3.841 ± 0.06	3.419IleGlu: 3.419 ± 0.057	1.759IlePhe: 1.759 ± 0.049	4.807IleGly: 4.807 ± 0.067	1.028IleHis: 1.028 ± 0.031	2.561IleIle: 2.561 ± 0.057	1.938IleLys: 1.938 ± 0.044	4.683IleLeu: 4.683 ± 0.074	1.194IleMet: 1.194 ± 0.033	1.803IleAsn: 1.803 ± 0.042	2.265IlePro: 2.265 ± 0.039	1.371IleGln: 1.371 ± 0.034	3.223IleArg: 3.223 ± 0.052	3.472IleSer: 3.472 ± 0.061	3.12IleThr: 3.12 ± 0.05	3.693IleVal: 3.693 ± 0.06	0.691IleTrp: 0.691 ± 0.026	1.308IleTyr: 1.308 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	5.776LysAla: 5.776 ± 0.085	0.202LysCys: 0.202 ± 0.015	2.279LysAsp: 2.279 ± 0.047	1.595LysGlu: 1.595 ± 0.039	1.133LysPhe: 1.133 ± 0.034	3.499LysGly: 3.499 ± 0.055	0.711LysHis: 0.711 ± 0.025	2.085LysIle: 2.085 ± 0.051	1.78LysLys: 1.78 ± 0.055	3.841LysLeu: 3.841 ± 0.051	0.988LysMet: 0.988 ± 0.031	1.192LysAsn: 1.192 ± 0.034	2.796LysPro: 2.796 ± 0.057	1.203LysGln: 1.203 ± 0.029	2.512LysArg: 2.512 ± 0.048	2.533LysSer: 2.533 ± 0.05	2.971LysThr: 2.971 ± 0.057	2.857LysVal: 2.857 ± 0.053	0.547LysTrp: 0.547 ± 0.023	0.938LysTyr: 0.938 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.626LeuAla: 11.626 ± 0.117	0.934LeuCys: 0.934 ± 0.029	5.848LeuAsp: 5.848 ± 0.075	4.891LeuGlu: 4.891 ± 0.082	3.57LeuPhe: 3.57 ± 0.065	7.584LeuGly: 7.584 ± 0.091	1.85LeuHis: 1.85 ± 0.037	5.616LeuIle: 5.616 ± 0.077	5.272LeuLys: 5.272 ± 0.061	8.5LeuLeu: 8.5 ± 0.123	2.637LeuMet: 2.637 ± 0.054	3.523LeuAsn: 3.523 ± 0.064	5.263LeuPro: 5.263 ± 0.074	2.856LeuGln: 2.856 ± 0.05	5.637LeuArg: 5.637 ± 0.08	7.004LeuSer: 7.004 ± 0.122	6.415LeuThr: 6.415 ± 0.16	6.361LeuVal: 6.361 ± 0.089	1.363LeuTrp: 1.363 ± 0.038	2.595LeuTyr: 2.595 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.254MetAla: 3.254 ± 0.051	0.164MetCys: 0.164 ± 0.011	1.321MetAsp: 1.321 ± 0.035	1.064MetGlu: 1.064 ± 0.03	0.692MetPhe: 0.692 ± 0.024	1.952MetGly: 1.952 ± 0.035	0.413MetHis: 0.413 ± 0.019	1.339MetIle: 1.339 ± 0.037	1.279MetLys: 1.279 ± 0.036	2.061MetLeu: 2.061 ± 0.053	0.687MetMet: 0.687 ± 0.024	0.806MetAsn: 0.806 ± 0.024	1.485MetPro: 1.485 ± 0.041	0.877MetGln: 0.877 ± 0.027	1.555MetArg: 1.555 ± 0.03	1.951MetSer: 1.951 ± 0.041	2.051MetThr: 2.051 ± 0.044	1.563MetVal: 1.563 ± 0.04	0.248MetTrp: 0.248 ± 0.015	0.391MetTyr: 0.391 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.606AsnAla: 3.606 ± 0.062	0.262AsnCys: 0.262 ± 0.016	1.878AsnAsp: 1.878 ± 0.046	1.444AsnGlu: 1.444 ± 0.034	1.146AsnPhe: 1.146 ± 0.038	2.872AsnGly: 2.872 ± 0.056	0.63AsnHis: 0.63 ± 0.024	1.704AsnIle: 1.704 ± 0.045	0.946AsnLys: 0.946 ± 0.031	3.235AsnLeu: 3.235 ± 0.063	0.724AsnMet: 0.724 ± 0.026	0.927AsnAsn: 0.927 ± 0.034	2.026AsnPro: 2.026 ± 0.046	0.949AsnGln: 0.949 ± 0.032	1.855AsnArg: 1.855 ± 0.038	1.574AsnSer: 1.574 ± 0.049	1.627AsnThr: 1.627 ± 0.042	2.073AsnVal: 2.073 ± 0.045	0.549AsnTrp: 0.549 ± 0.022	0.907AsnTyr: 0.907 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	6.04ProAla: 6.04 ± 0.083	0.325ProCys: 0.325 ± 0.017	3.855ProAsp: 3.855 ± 0.06	3.658ProGlu: 3.658 ± 0.061	2.002ProPhe: 2.002 ± 0.042	3.807ProGly: 3.807 ± 0.056	1.104ProHis: 1.104 ± 0.032	2.231ProIle: 2.231 ± 0.042	2.193ProLys: 2.193 ± 0.041	4.73ProLeu: 4.73 ± 0.072	1.095ProMet: 1.095 ± 0.027	1.54ProAsn: 1.54 ± 0.039	2.378ProPro: 2.378 ± 0.065	1.872ProGln: 1.872 ± 0.043	2.28ProArg: 2.28 ± 0.052	2.648ProSer: 2.648 ± 0.051	2.32ProThr: 2.32 ± 0.043	4.407ProVal: 4.407 ± 0.067	0.7ProTrp: 0.7 ± 0.025	1.437ProTyr: 1.437 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.51GlnAla: 4.51 ± 0.074	0.211GlnCys: 0.211 ± 0.015	1.53GlnAsp: 1.53 ± 0.034	1.309GlnGlu: 1.309 ± 0.033	1.129GlnPhe: 1.129 ± 0.032	2.717GlnGly: 2.717 ± 0.053	0.61GlnHis: 0.61 ± 0.022	2.006GlnIle: 2.006 ± 0.071	1.619GlnLys: 1.619 ± 0.037	2.957GlnLeu: 2.957 ± 0.097	0.989GlnMet: 0.989 ± 0.035	1.076GlnAsn: 1.076 ± 0.034	1.757GlnPro: 1.757 ± 0.037	1.121GlnGln: 1.121 ± 0.032	1.989GlnArg: 1.989 ± 0.049	2.196GlnSer: 2.196 ± 0.045	2.42GlnThr: 2.42 ± 0.042	2.646GlnVal: 2.646 ± 0.058	0.548GlnTrp: 0.548 ± 0.023	0.85GlnTyr: 0.85 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.305ArgAla: 6.305 ± 0.084	0.383ArgCys: 0.383 ± 0.02	3.602ArgAsp: 3.602 ± 0.069	3.256ArgGlu: 3.256 ± 0.055	2.666ArgPhe: 2.666 ± 0.052	3.89ArgGly: 3.89 ± 0.063	1.439ArgHis: 1.439 ± 0.038	3.557ArgIle: 3.557 ± 0.047	2.49ArgLys: 2.49 ± 0.051	7.07ArgLeu: 7.07 ± 0.092	1.521ArgMet: 1.521 ± 0.035	1.758ArgAsn: 1.758 ± 0.047	3.101ArgPro: 3.101 ± 0.056	2.335ArgGln: 2.335 ± 0.045	3.958ArgArg: 3.958 ± 0.077	2.88ArgSer: 2.88 ± 0.051	3.025ArgThr: 3.025 ± 0.055	3.89ArgVal: 3.89 ± 0.06	0.841ArgTrp: 0.841 ± 0.023	1.745ArgTyr: 1.745 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.338SerAla: 6.338 ± 0.09	0.373SerCys: 0.373 ± 0.021	3.488SerAsp: 3.488 ± 0.06	3.05SerGlu: 3.05 ± 0.055	2.286SerPhe: 2.286 ± 0.048	5.523SerGly: 5.523 ± 0.086	1.379SerHis: 1.379 ± 0.035	2.66SerIle: 2.66 ± 0.045	2.007SerLys: 2.007 ± 0.041	6.186SerLeu: 6.186 ± 0.096	1.277SerMet: 1.277 ± 0.032	1.655SerAsn: 1.655 ± 0.042	2.922SerPro: 2.922 ± 0.056	2.162SerGln: 2.162 ± 0.049	3.328SerArg: 3.328 ± 0.057	3.195SerSer: 3.195 ± 0.076	2.892SerThr: 2.892 ± 0.09	4.032SerVal: 4.032 ± 0.062	0.791SerTrp: 0.791 ± 0.029	1.543SerTyr: 1.543 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.57ThrAla: 6.57 ± 0.104	0.465ThrCys: 0.465 ± 0.022	3.282ThrAsp: 3.282 ± 0.058	2.668ThrGlu: 2.668 ± 0.051	2.153ThrPhe: 2.153 ± 0.048	5.506ThrGly: 5.506 ± 0.091	1.222ThrHis: 1.222 ± 0.032	2.79ThrIle: 2.79 ± 0.047	1.839ThrLys: 1.839 ± 0.05	6.242ThrLeu: 6.242 ± 0.082	1.058ThrMet: 1.058 ± 0.028	1.552ThrAsn: 1.552 ± 0.042	3.864ThrPro: 3.864 ± 0.063	2.099ThrGln: 2.099 ± 0.142	3.097ThrArg: 3.097 ± 0.049	3.224ThrSer: 3.224 ± 0.076	3.463ThrThr: 3.463 ± 0.165	4.189ThrVal: 4.189 ± 0.061	0.743ThrTrp: 0.743 ± 0.022	1.688ThrTyr: 1.688 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	7.75ValAla: 7.75 ± 0.1	0.647ValCys: 0.647 ± 0.023	3.866ValAsp: 3.866 ± 0.062	3.76ValGlu: 3.76 ± 0.061	2.785ValPhe: 2.785 ± 0.05	4.821ValGly: 4.821 ± 0.069	1.343ValHis: 1.343 ± 0.034	4.168ValIle: 4.168 ± 0.054	2.924ValLys: 2.924 ± 0.052	6.669ValLeu: 6.669 ± 0.083	1.947ValMet: 1.947 ± 0.044	2.192ValAsn: 2.192 ± 0.053	3.263ValPro: 3.263 ± 0.057	2.035ValGln: 2.035 ± 0.042	4.311ValArg: 4.311 ± 0.063	4.677ValSer: 4.677 ± 0.064	4.662ValThr: 4.662 ± 0.074	5.23ValVal: 5.23 ± 0.08	0.951ValTrp: 0.951 ± 0.032	1.713ValTyr: 1.713 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.297TrpAla: 1.297 ± 0.036	0.124TrpCys: 0.124 ± 0.01	0.68TrpAsp: 0.68 ± 0.024	0.583TrpGlu: 0.583 ± 0.025	0.558TrpPhe: 0.558 ± 0.026	1.036TrpGly: 1.036 ± 0.036	0.352TrpHis: 0.352 ± 0.019	0.679TrpIle: 0.679 ± 0.025	0.558TrpLys: 0.558 ± 0.024	1.766TrpLeu: 1.766 ± 0.043	0.401TrpMet: 0.401 ± 0.02	0.537TrpAsn: 0.537 ± 0.023	0.738TrpPro: 0.738 ± 0.022	0.72TrpGln: 0.72 ± 0.025	1.135TrpArg: 1.135 ± 0.03	0.882TrpSer: 0.882 ± 0.028	0.789TrpThr: 0.789 ± 0.027	0.832TrpVal: 0.832 ± 0.025	0.287TrpTrp: 0.287 ± 0.015	0.399TrpTyr: 0.399 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.935TyrAla: 2.935 ± 0.054	0.245TyrCys: 0.245 ± 0.015	2.002TyrAsp: 2.002 ± 0.047	1.433TyrGlu: 1.433 ± 0.038	1.025TyrPhe: 1.025 ± 0.03	2.486TyrGly: 2.486 ± 0.056	0.594TyrHis: 0.594 ± 0.021	1.264TyrIle: 1.264 ± 0.038	0.981TyrLys: 0.981 ± 0.03	2.49TyrLeu: 2.49 ± 0.05	0.638TyrMet: 0.638 ± 0.028	1.007TyrAsn: 1.007 ± 0.035	1.194TyrPro: 1.194 ± 0.036	0.947TyrGln: 0.947 ± 0.029	1.774TyrArg: 1.774 ± 0.045	1.513TyrSer: 1.513 ± 0.042	1.42TyrThr: 1.42 ± 0.036	1.901TyrVal: 1.901 ± 0.045	0.448TyrTrp: 0.448 ± 0.02	0.887TyrTyr: 0.887 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3569 proteins (1177575 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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