Amino acid dipepetide frequency for Streptomyces acidiscabies

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.048AlaAla: 19.048 ± 0.121	1.058AlaCys: 1.058 ± 0.02	7.961AlaAsp: 7.961 ± 0.061	8.53AlaGlu: 8.53 ± 0.079	3.495AlaPhe: 3.495 ± 0.037	12.739AlaGly: 12.739 ± 0.089	2.894AlaHis: 2.894 ± 0.038	3.455AlaIle: 3.455 ± 0.042	2.914AlaLys: 2.914 ± 0.049	14.636AlaLeu: 14.636 ± 0.096	2.269AlaMet: 2.269 ± 0.03	2.055AlaAsn: 2.055 ± 0.031	6.613AlaPro: 6.613 ± 0.066	3.821AlaGln: 3.821 ± 0.049	9.891AlaArg: 9.891 ± 0.078	6.143AlaSer: 6.143 ± 0.058	6.899AlaThr: 6.899 ± 0.063	12.284AlaVal: 12.284 ± 0.096	1.868AlaTrp: 1.868 ± 0.03	2.949AlaTyr: 2.949 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.022	0.08CysCys: 0.08 ± 0.006	0.463CysAsp: 0.463 ± 0.013	0.398CysGlu: 0.398 ± 0.011	0.208CysPhe: 0.208 ± 0.01	0.95CysGly: 0.95 ± 0.019	0.175CysHis: 0.175 ± 0.008	0.152CysIle: 0.152 ± 0.008	0.111CysLys: 0.111 ± 0.007	0.756CysLeu: 0.756 ± 0.017	0.108CysMet: 0.108 ± 0.007	0.142CysAsn: 0.142 ± 0.009	0.453CysPro: 0.453 ± 0.016	0.149CysGln: 0.149 ± 0.009	0.544CysArg: 0.544 ± 0.016	0.411CysSer: 0.411 ± 0.013	0.527CysThr: 0.527 ± 0.017	0.702CysVal: 0.702 ± 0.017	0.125CysTrp: 0.125 ± 0.006	0.15CysTyr: 0.15 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.747AspAla: 7.747 ± 0.06	0.415AspCys: 0.415 ± 0.012	3.694AspAsp: 3.694 ± 0.047	3.703AspGlu: 3.703 ± 0.041	1.665AspPhe: 1.665 ± 0.026	6.287AspGly: 6.287 ± 0.058	1.491AspHis: 1.491 ± 0.025	1.83AspIle: 1.83 ± 0.03	1.212AspLys: 1.212 ± 0.027	6.445AspLeu: 6.445 ± 0.053	0.798AspMet: 0.798 ± 0.017	1.033AspAsn: 1.033 ± 0.021	4.462AspPro: 4.462 ± 0.046	1.542AspGln: 1.542 ± 0.028	4.629AspArg: 4.629 ± 0.055	2.605AspSer: 2.605 ± 0.031	3.339AspThr: 3.339 ± 0.037	4.947AspVal: 4.947 ± 0.044	1.061AspTrp: 1.061 ± 0.023	1.133AspTyr: 1.133 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.327GluAla: 7.327 ± 0.07	0.367GluCys: 0.367 ± 0.012	2.705GluAsp: 2.705 ± 0.034	3.57GluGlu: 3.57 ± 0.051	1.628GluPhe: 1.628 ± 0.025	4.455GluGly: 4.455 ± 0.046	1.476GluHis: 1.476 ± 0.023	2.267GluIle: 2.267 ± 0.031	1.519GluLys: 1.519 ± 0.03	6.89GluLeu: 6.89 ± 0.075	0.871GluMet: 0.871 ± 0.019	1.095GluAsn: 1.095 ± 0.021	3.098GluPro: 3.098 ± 0.042	2.058GluGln: 2.058 ± 0.031	5.28GluArg: 5.28 ± 0.054	2.611GluSer: 2.611 ± 0.03	2.946GluThr: 2.946 ± 0.035	4.669GluVal: 4.669 ± 0.053	0.837GluTrp: 0.837 ± 0.019	1.189GluTyr: 1.189 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.747PheAla: 3.747 ± 0.043	0.253PheCys: 0.253 ± 0.01	1.954PheAsp: 1.954 ± 0.029	1.438PheGlu: 1.438 ± 0.028	0.875PhePhe: 0.875 ± 0.019	3.107PheGly: 3.107 ± 0.042	0.609PheHis: 0.609 ± 0.015	0.683PheIle: 0.683 ± 0.016	0.527PheLys: 0.527 ± 0.015	2.718PheLeu: 2.718 ± 0.037	0.393PheMet: 0.393 ± 0.014	0.578PheAsn: 0.578 ± 0.015	1.42PhePro: 1.42 ± 0.026	0.714PheGln: 0.714 ± 0.017	1.891PheArg: 1.891 ± 0.027	1.492PheSer: 1.492 ± 0.024	2.219PheThr: 2.219 ± 0.031	2.307PheVal: 2.307 ± 0.031	0.424PheTrp: 0.424 ± 0.013	0.603PheTyr: 0.603 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.874GlyAla: 10.874 ± 0.08	0.819GlyCys: 0.819 ± 0.017	5.196GlyAsp: 5.196 ± 0.05	5.386GlyGlu: 5.386 ± 0.051	2.987GlyPhe: 2.987 ± 0.035	8.525GlyGly: 8.525 ± 0.077	2.297GlyHis: 2.297 ± 0.029	3.475GlyIle: 3.475 ± 0.044	2.498GlyLys: 2.498 ± 0.043	9.236GlyLeu: 9.236 ± 0.071	1.987GlyMet: 1.987 ± 0.031	1.851GlyAsn: 1.851 ± 0.03	4.672GlyPro: 4.672 ± 0.055	2.668GlyGln: 2.668 ± 0.041	7.401GlyArg: 7.401 ± 0.06	5.155GlySer: 5.155 ± 0.052	6.531GlyThr: 6.531 ± 0.062	8.313GlyVal: 8.313 ± 0.069	1.713GlyTrp: 1.713 ± 0.027	2.391GlyTyr: 2.391 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.693HisAla: 2.693 ± 0.037	0.208HisCys: 0.208 ± 0.009	1.338HisAsp: 1.338 ± 0.025	1.181HisGlu: 1.181 ± 0.023	0.661HisPhe: 0.661 ± 0.016	2.305HisGly: 2.305 ± 0.031	0.708HisHis: 0.708 ± 0.018	0.702HisIle: 0.702 ± 0.015	0.364HisLys: 0.364 ± 0.011	2.575HisLeu: 2.575 ± 0.032	0.31HisMet: 0.31 ± 0.011	0.389HisAsn: 0.389 ± 0.013	1.858HisPro: 1.858 ± 0.027	0.642HisGln: 0.642 ± 0.014	2.048HisArg: 2.048 ± 0.03	1.009HisSer: 1.009 ± 0.018	1.4HisThr: 1.4 ± 0.022	1.7HisVal: 1.7 ± 0.031	0.379HisTrp: 0.379 ± 0.012	0.498HisTyr: 0.498 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.664IleAla: 4.664 ± 0.046	0.281IleCys: 0.281 ± 0.009	2.225IleAsp: 2.225 ± 0.033	1.903IleGlu: 1.903 ± 0.032	0.663IlePhe: 0.663 ± 0.016	3.478IleGly: 3.478 ± 0.039	0.612IleHis: 0.612 ± 0.018	0.782IleIle: 0.782 ± 0.02	0.715IleLys: 0.715 ± 0.017	2.485IleLeu: 2.485 ± 0.035	0.436IleMet: 0.436 ± 0.014	0.657IleAsn: 0.657 ± 0.018	1.796IlePro: 1.796 ± 0.025	0.743IleGln: 0.743 ± 0.017	2.208IleArg: 2.208 ± 0.033	1.695IleSer: 1.695 ± 0.029	2.231IleThr: 2.231 ± 0.035	2.797IleVal: 2.797 ± 0.036	0.372IleTrp: 0.372 ± 0.014	0.539IleTyr: 0.539 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.1LysAla: 3.1 ± 0.043	0.127LysCys: 0.127 ± 0.007	1.369LysAsp: 1.369 ± 0.031	1.179LysGlu: 1.179 ± 0.022	0.501LysPhe: 0.501 ± 0.014	1.954LysGly: 1.954 ± 0.03	0.433LysHis: 0.433 ± 0.012	0.858LysIle: 0.858 ± 0.019	0.881LysLys: 0.881 ± 0.026	2.167LysLeu: 2.167 ± 0.031	0.392LysMet: 0.392 ± 0.014	0.57LysAsn: 0.57 ± 0.018	1.328LysPro: 1.328 ± 0.029	0.688LysGln: 0.688 ± 0.019	1.425LysArg: 1.425 ± 0.026	1.255LysSer: 1.255 ± 0.028	1.362LysThr: 1.362 ± 0.031	2.038LysVal: 2.038 ± 0.036	0.309LysTrp: 0.309 ± 0.013	0.481LysTyr: 0.481 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.169LeuAla: 15.169 ± 0.098	0.831LeuCys: 0.831 ± 0.017	6.991LeuAsp: 6.991 ± 0.06	4.693LeuGlu: 4.693 ± 0.052	2.649LeuPhe: 2.649 ± 0.037	9.294LeuGly: 9.294 ± 0.073	2.306LeuHis: 2.306 ± 0.037	3.247LeuIle: 3.247 ± 0.04	2.254LeuLys: 2.254 ± 0.036	11.298LeuLeu: 11.298 ± 0.093	1.619LeuMet: 1.619 ± 0.025	1.778LeuAsn: 1.778 ± 0.029	6.493LeuPro: 6.493 ± 0.056	2.149LeuGln: 2.149 ± 0.032	8.618LeuArg: 8.618 ± 0.077	5.483LeuSer: 5.483 ± 0.05	7.522LeuThr: 7.522 ± 0.054	8.776LeuVal: 8.776 ± 0.064	1.38LeuTrp: 1.38 ± 0.025	1.97LeuTyr: 1.97 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.112MetAla: 2.112 ± 0.034	0.116MetCys: 0.116 ± 0.007	0.883MetAsp: 0.883 ± 0.018	0.72MetGlu: 0.72 ± 0.015	0.452MetPhe: 0.452 ± 0.014	1.26MetGly: 1.26 ± 0.025	0.327MetHis: 0.327 ± 0.012	0.666MetIle: 0.666 ± 0.017	0.403MetLys: 0.403 ± 0.012	1.609MetLeu: 1.609 ± 0.025	0.284MetMet: 0.284 ± 0.012	0.455MetAsn: 0.455 ± 0.012	1.08MetPro: 1.08 ± 0.02	0.413MetGln: 0.413 ± 0.013	1.389MetArg: 1.389 ± 0.026	1.294MetSer: 1.294 ± 0.022	1.57MetThr: 1.57 ± 0.023	1.237MetVal: 1.237 ± 0.025	0.213MetTrp: 0.213 ± 0.009	0.334MetTyr: 0.334 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.283AsnAla: 2.283 ± 0.029	0.177AsnCys: 0.177 ± 0.009	0.982AsnAsp: 0.982 ± 0.021	0.789AsnGlu: 0.789 ± 0.016	0.521AsnPhe: 0.521 ± 0.014	1.938AsnGly: 1.938 ± 0.039	0.402AsnHis: 0.402 ± 0.012	0.642AsnIle: 0.642 ± 0.014	0.438AsnLys: 0.438 ± 0.017	1.757AsnLeu: 1.757 ± 0.029	0.31AsnMet: 0.31 ± 0.013	0.482AsnAsn: 0.482 ± 0.017	1.434AsnPro: 1.434 ± 0.023	0.553AsnGln: 0.553 ± 0.017	1.312AsnArg: 1.312 ± 0.024	1.061AsnSer: 1.061 ± 0.027	1.225AsnThr: 1.225 ± 0.022	1.45AsnVal: 1.45 ± 0.025	0.314AsnTrp: 0.314 ± 0.011	0.451AsnTyr: 0.451 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.918ProAla: 7.918 ± 0.077	0.306ProCys: 0.306 ± 0.013	4.409ProAsp: 4.409 ± 0.051	4.245ProGlu: 4.245 ± 0.04	1.541ProPhe: 1.541 ± 0.026	6.335ProGly: 6.335 ± 0.065	1.372ProHis: 1.372 ± 0.025	1.242ProIle: 1.242 ± 0.022	1.241ProLys: 1.241 ± 0.023	5.349ProLeu: 5.349 ± 0.052	0.948ProMet: 0.948 ± 0.023	0.955ProAsn: 0.955 ± 0.018	3.235ProPro: 3.235 ± 0.05	1.795ProGln: 1.795 ± 0.028	3.72ProArg: 3.72 ± 0.044	3.305ProSer: 3.305 ± 0.042	3.318ProThr: 3.318 ± 0.044	5.535ProVal: 5.535 ± 0.049	0.924ProTrp: 0.924 ± 0.022	1.538ProTyr: 1.538 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.59GlnAla: 3.59 ± 0.043	0.169GlnCys: 0.169 ± 0.009	1.396GlnAsp: 1.396 ± 0.023	1.422GlnGlu: 1.422 ± 0.023	0.702GlnPhe: 0.702 ± 0.017	2.373GlnGly: 2.373 ± 0.033	0.665GlnHis: 0.665 ± 0.016	1.084GlnIle: 1.084 ± 0.021	0.644GlnLys: 0.644 ± 0.02	3.16GlnLeu: 3.16 ± 0.037	0.474GlnMet: 0.474 ± 0.014	0.527GlnAsn: 0.527 ± 0.018	1.569GlnPro: 1.569 ± 0.028	1.188GlnGln: 1.188 ± 0.028	2.268GlnArg: 2.268 ± 0.03	1.268GlnSer: 1.268 ± 0.022	1.38GlnThr: 1.38 ± 0.029	2.43GlnVal: 2.43 ± 0.034	0.47GlnTrp: 0.47 ± 0.014	0.644GlnTyr: 0.644 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.524ArgAla: 9.524 ± 0.08	0.539ArgCys: 0.539 ± 0.014	4.209ArgAsp: 4.209 ± 0.046	4.902ArgGlu: 4.902 ± 0.055	2.386ArgPhe: 2.386 ± 0.033	5.705ArgGly: 5.705 ± 0.049	2.004ArgHis: 2.004 ± 0.03	3.176ArgIle: 3.176 ± 0.037	1.677ArgLys: 1.677 ± 0.03	8.654ArgLeu: 8.654 ± 0.069	1.67ArgMet: 1.67 ± 0.029	1.294ArgAsn: 1.294 ± 0.025	4.527ArgPro: 4.527 ± 0.046	2.246ArgGln: 2.246 ± 0.033	7.287ArgArg: 7.287 ± 0.074	3.745ArgSer: 3.745 ± 0.04	5.59ArgThr: 5.59 ± 0.056	6.081ArgVal: 6.081 ± 0.06	1.348ArgTrp: 1.348 ± 0.024	1.83ArgTyr: 1.83 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.75SerAla: 6.75 ± 0.057	0.423SerCys: 0.423 ± 0.013	2.712SerAsp: 2.712 ± 0.032	2.416SerGlu: 2.416 ± 0.036	1.558SerPhe: 1.558 ± 0.03	6.016SerGly: 6.016 ± 0.06	1.001SerHis: 1.001 ± 0.021	1.407SerIle: 1.407 ± 0.027	1.07SerLys: 1.07 ± 0.025	5.047SerLeu: 5.047 ± 0.044	1.059SerMet: 1.059 ± 0.019	0.937SerAsn: 0.937 ± 0.022	3.265SerPro: 3.265 ± 0.039	1.241SerGln: 1.241 ± 0.021	3.645SerArg: 3.645 ± 0.04	2.954SerSer: 2.954 ± 0.047	3.201SerThr: 3.201 ± 0.04	4.459SerVal: 4.459 ± 0.041	0.944SerTrp: 0.944 ± 0.021	1.383SerTyr: 1.383 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.789ThrAla: 8.789 ± 0.064	0.436ThrCys: 0.436 ± 0.015	3.81ThrAsp: 3.81 ± 0.038	3.322ThrGlu: 3.322 ± 0.038	1.726ThrPhe: 1.726 ± 0.029	6.853ThrGly: 6.853 ± 0.069	1.324ThrHis: 1.324 ± 0.021	1.735ThrIle: 1.735 ± 0.028	1.267ThrLys: 1.267 ± 0.027	6.191ThrLeu: 6.191 ± 0.064	0.915ThrMet: 0.915 ± 0.02	1.116ThrAsn: 1.116 ± 0.023	4.641ThrPro: 4.641 ± 0.051	1.415ThrGln: 1.415 ± 0.025	4.114ThrArg: 4.114 ± 0.046	3.396ThrSer: 3.396 ± 0.042	4.138ThrThr: 4.138 ± 0.055	6.257ThrVal: 6.257 ± 0.052	0.982ThrTrp: 0.982 ± 0.022	1.488ThrTyr: 1.488 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.572ValAla: 10.572 ± 0.079	0.747ValCys: 0.747 ± 0.019	5.092ValAsp: 5.092 ± 0.051	5.007ValGlu: 5.007 ± 0.055	2.538ValPhe: 2.538 ± 0.031	6.742ValGly: 6.742 ± 0.061	2.058ValHis: 2.058 ± 0.033	2.819ValIle: 2.819 ± 0.03	1.878ValLys: 1.878 ± 0.035	9.619ValLeu: 9.619 ± 0.082	1.447ValMet: 1.447 ± 0.028	1.718ValAsn: 1.718 ± 0.032	5.373ValPro: 5.373 ± 0.053	2.175ValGln: 2.175 ± 0.028	7.47ValArg: 7.47 ± 0.062	4.591ValSer: 4.591 ± 0.043	6.02ValThr: 6.02 ± 0.051	8.435ValVal: 8.435 ± 0.087	1.215ValTrp: 1.215 ± 0.025	1.719ValTyr: 1.719 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.658TrpAla: 1.658 ± 0.024	0.149TrpCys: 0.149 ± 0.007	0.893TrpAsp: 0.893 ± 0.019	0.752TrpGlu: 0.752 ± 0.019	0.534TrpPhe: 0.534 ± 0.015	1.145TrpGly: 1.145 ± 0.025	0.405TrpHis: 0.405 ± 0.014	0.552TrpIle: 0.552 ± 0.016	0.397TrpLys: 0.397 ± 0.014	1.765TrpLeu: 1.765 ± 0.028	0.278TrpMet: 0.278 ± 0.01	0.451TrpAsn: 0.451 ± 0.014	0.774TrpPro: 0.774 ± 0.017	0.61TrpGln: 0.61 ± 0.015	1.326TrpArg: 1.326 ± 0.023	0.989TrpSer: 0.989 ± 0.023	1.177TrpThr: 1.177 ± 0.024	1.004TrpVal: 1.004 ± 0.02	0.336TrpTrp: 0.336 ± 0.013	0.394TrpTyr: 0.394 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.888TyrAla: 2.888 ± 0.031	0.174TyrCys: 0.174 ± 0.007	1.755TyrAsp: 1.755 ± 0.027	1.303TyrGlu: 1.303 ± 0.023	0.666TyrPhe: 0.666 ± 0.017	2.513TyrGly: 2.513 ± 0.033	0.408TyrHis: 0.408 ± 0.012	0.507TyrIle: 0.507 ± 0.015	0.409TyrLys: 0.409 ± 0.014	2.165TyrLeu: 2.165 ± 0.029	0.245TyrMet: 0.245 ± 0.01	0.437TyrAsn: 0.437 ± 0.014	1.137TyrPro: 1.137 ± 0.024	0.615TyrGln: 0.615 ± 0.017	1.927TyrArg: 1.927 ± 0.029	1.026TyrSer: 1.026 ± 0.022	1.319TyrThr: 1.319 ± 0.026	1.812TyrVal: 1.812 ± 0.027	0.377TyrTrp: 0.377 ± 0.013	0.501TyrTyr: 0.501 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7941 proteins (2604894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---