Amino acid dipepetide frequency for Sphingomonas lenta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.128AlaAla: 21.128 ± 0.215	1.05AlaCys: 1.05 ± 0.037	8.26AlaAsp: 8.26 ± 0.096	8.617AlaGlu: 8.617 ± 0.121	4.28AlaPhe: 4.28 ± 0.071	12.506AlaGly: 12.506 ± 0.136	2.378AlaHis: 2.378 ± 0.051	5.657AlaIle: 5.657 ± 0.078	3.445AlaLys: 3.445 ± 0.065	14.608AlaLeu: 14.608 ± 0.149	3.558AlaMet: 3.558 ± 0.064	2.984AlaAsn: 2.984 ± 0.057	7.009AlaPro: 7.009 ± 0.088	4.535AlaGln: 4.535 ± 0.081	11.646AlaArg: 11.646 ± 0.133	6.244AlaSer: 6.244 ± 0.084	6.866AlaThr: 6.866 ± 0.102	10.213AlaVal: 10.213 ± 0.103	1.716AlaTrp: 1.716 ± 0.047	2.66AlaTyr: 2.66 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.916CysAla: 0.916 ± 0.029	0.087CysCys: 0.087 ± 0.012	0.465CysAsp: 0.465 ± 0.021	0.342CysGlu: 0.342 ± 0.017	0.269CysPhe: 0.269 ± 0.015	0.772CysGly: 0.772 ± 0.03	0.145CysHis: 0.145 ± 0.013	0.239CysIle: 0.239 ± 0.015	0.094CysLys: 0.094 ± 0.009	0.594CysLeu: 0.594 ± 0.025	0.114CysMet: 0.114 ± 0.01	0.156CysAsn: 0.156 ± 0.012	0.427CysPro: 0.427 ± 0.021	0.153CysGln: 0.153 ± 0.012	0.592CysArg: 0.592 ± 0.023	0.371CysSer: 0.371 ± 0.018	0.328CysThr: 0.328 ± 0.018	0.518CysVal: 0.518 ± 0.022	0.12CysTrp: 0.12 ± 0.011	0.143CysTyr: 0.143 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.689AspAla: 8.689 ± 0.102	0.423AspCys: 0.423 ± 0.021	3.356AspAsp: 3.356 ± 0.073	3.816AspGlu: 3.816 ± 0.063	1.962AspPhe: 1.962 ± 0.046	6.071AspGly: 6.071 ± 0.095	1.169AspHis: 1.169 ± 0.036	2.051AspIle: 2.051 ± 0.048	1.303AspLys: 1.303 ± 0.045	5.986AspLeu: 5.986 ± 0.079	1.197AspMet: 1.197 ± 0.034	1.021AspAsn: 1.021 ± 0.031	4.056AspPro: 4.056 ± 0.064	1.868AspGln: 1.868 ± 0.047	5.819AspArg: 5.819 ± 0.081	1.743AspSer: 1.743 ± 0.042	2.624AspThr: 2.624 ± 0.058	4.51AspVal: 4.51 ± 0.065	1.105AspTrp: 1.105 ± 0.034	1.442AspTyr: 1.442 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.146GluAla: 8.146 ± 0.124	0.27GluCys: 0.27 ± 0.017	2.722GluAsp: 2.722 ± 0.048	3.034GluGlu: 3.034 ± 0.067	1.517GluPhe: 1.517 ± 0.041	4.795GluGly: 4.795 ± 0.068	1.239GluHis: 1.239 ± 0.035	2.417GluIle: 2.417 ± 0.055	1.435GluLys: 1.435 ± 0.049	5.969GluLeu: 5.969 ± 0.088	1.202GluMet: 1.202 ± 0.035	1.188GluAsn: 1.188 ± 0.032	3.339GluPro: 3.339 ± 0.062	2.065GluGln: 2.065 ± 0.039	6.742GluArg: 6.742 ± 0.1	1.889GluSer: 1.889 ± 0.047	2.829GluThr: 2.829 ± 0.052	4.224GluVal: 4.224 ± 0.069	0.824GluTrp: 0.824 ± 0.029	0.988GluTyr: 0.988 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.76PheAla: 4.76 ± 0.076	0.228PheCys: 0.228 ± 0.014	2.588PheAsp: 2.588 ± 0.053	2.016PheGlu: 2.016 ± 0.049	1.278PhePhe: 1.278 ± 0.045	3.606PheGly: 3.606 ± 0.071	0.663PheHis: 0.663 ± 0.027	1.115PheIle: 1.115 ± 0.033	0.647PheLys: 0.647 ± 0.027	3.097PheLeu: 3.097 ± 0.06	0.629PheMet: 0.629 ± 0.023	0.871PheAsn: 0.871 ± 0.037	1.462PhePro: 1.462 ± 0.034	0.971PheGln: 0.971 ± 0.033	2.515PheArg: 2.515 ± 0.048	1.714PheSer: 1.714 ± 0.043	2.003PheThr: 2.003 ± 0.048	2.751PheVal: 2.751 ± 0.046	0.465PheTrp: 0.465 ± 0.016	0.853PheTyr: 0.853 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.232GlyAla: 11.232 ± 0.142	0.815GlyCys: 0.815 ± 0.027	5.278GlyAsp: 5.278 ± 0.095	5.464GlyGlu: 5.464 ± 0.085	3.607GlyPhe: 3.607 ± 0.072	9.081GlyGly: 9.081 ± 0.143	1.779GlyHis: 1.779 ± 0.043	3.24GlyIle: 3.24 ± 0.069	2.483GlyLys: 2.483 ± 0.057	8.999GlyLeu: 8.999 ± 0.101	2.157GlyMet: 2.157 ± 0.047	1.985GlyAsn: 1.985 ± 0.059	4.206GlyPro: 4.206 ± 0.062	2.94GlyGln: 2.94 ± 0.056	8.352GlyArg: 8.352 ± 0.097	4.583GlySer: 4.583 ± 0.081	4.74GlyThr: 4.74 ± 0.081	7.57GlyVal: 7.57 ± 0.082	1.696GlyTrp: 1.696 ± 0.046	2.291GlyTyr: 2.291 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.57HisAla: 2.57 ± 0.062	0.167HisCys: 0.167 ± 0.013	1.141HisAsp: 1.141 ± 0.032	1.031HisGlu: 1.031 ± 0.032	0.652HisPhe: 0.652 ± 0.025	1.943HisGly: 1.943 ± 0.044	0.6HisHis: 0.6 ± 0.026	0.676HisIle: 0.676 ± 0.024	0.326HisLys: 0.326 ± 0.019	1.919HisLeu: 1.919 ± 0.043	0.39HisMet: 0.39 ± 0.017	0.369HisAsn: 0.369 ± 0.017	1.309HisPro: 1.309 ± 0.039	0.508HisGln: 0.508 ± 0.023	1.603HisArg: 1.603 ± 0.043	0.685HisSer: 0.685 ± 0.026	0.619HisThr: 0.619 ± 0.024	1.439HisVal: 1.439 ± 0.044	0.302HisTrp: 0.302 ± 0.016	0.483HisTyr: 0.483 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.267IleAla: 6.267 ± 0.078	0.286IleCys: 0.286 ± 0.018	3.157IleAsp: 3.157 ± 0.055	2.891IleGlu: 2.891 ± 0.052	1.113IlePhe: 1.113 ± 0.034	4.372IleGly: 4.372 ± 0.073	0.666IleHis: 0.666 ± 0.026	1.277IleIle: 1.277 ± 0.039	0.853IleLys: 0.853 ± 0.032	3.086IleLeu: 3.086 ± 0.054	0.637IleMet: 0.637 ± 0.025	0.952IleAsn: 0.952 ± 0.031	1.716IlePro: 1.716 ± 0.038	0.954IleGln: 0.954 ± 0.029	2.975IleArg: 2.975 ± 0.051	1.685IleSer: 1.685 ± 0.04	2.121IleThr: 2.121 ± 0.052	3.566IleVal: 3.566 ± 0.062	0.469IleTrp: 0.469 ± 0.018	0.818IleTyr: 0.818 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.876LysAla: 2.876 ± 0.069	0.112LysCys: 0.112 ± 0.01	1.086LysAsp: 1.086 ± 0.035	0.955LysGlu: 0.955 ± 0.029	0.599LysPhe: 0.599 ± 0.025	1.966LysGly: 1.966 ± 0.047	0.447LysHis: 0.447 ± 0.021	0.89LysIle: 0.89 ± 0.037	0.76LysLys: 0.76 ± 0.033	2.92LysLeu: 2.92 ± 0.061	0.541LysMet: 0.541 ± 0.025	0.528LysAsn: 0.528 ± 0.022	1.731LysPro: 1.731 ± 0.04	0.728LysGln: 0.728 ± 0.029	2.293LysArg: 2.293 ± 0.056	1.155LysSer: 1.155 ± 0.039	1.185LysThr: 1.185 ± 0.035	1.728LysVal: 1.728 ± 0.048	0.29LysTrp: 0.29 ± 0.016	0.446LysTyr: 0.446 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.025LeuAla: 15.025 ± 0.15	0.695LeuCys: 0.695 ± 0.028	6.624LeuAsp: 6.624 ± 0.097	4.949LeuGlu: 4.949 ± 0.071	3.735LeuPhe: 3.735 ± 0.065	9.028LeuGly: 9.028 ± 0.092	1.792LeuHis: 1.792 ± 0.042	4.007LeuIle: 4.007 ± 0.063	2.46LeuLys: 2.46 ± 0.057	10.062LeuLeu: 10.062 ± 0.145	1.938LeuMet: 1.938 ± 0.042	2.285LeuAsn: 2.285 ± 0.047	5.794LeuPro: 5.794 ± 0.084	2.568LeuGln: 2.568 ± 0.042	7.825LeuArg: 7.825 ± 0.103	5.578LeuSer: 5.578 ± 0.079	5.476LeuThr: 5.476 ± 0.065	7.801LeuVal: 7.801 ± 0.108	1.255LeuTrp: 1.255 ± 0.035	1.905LeuTyr: 1.905 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.884MetAla: 2.884 ± 0.054	0.107MetCys: 0.107 ± 0.01	0.942MetAsp: 0.942 ± 0.032	0.893MetGlu: 0.893 ± 0.03	0.61MetPhe: 0.61 ± 0.023	1.783MetGly: 1.783 ± 0.043	0.368MetHis: 0.368 ± 0.017	1.054MetIle: 1.054 ± 0.029	0.626MetLys: 0.626 ± 0.022	2.401MetLeu: 2.401 ± 0.045	0.513MetMet: 0.513 ± 0.023	0.618MetAsn: 0.618 ± 0.025	1.358MetPro: 1.358 ± 0.036	0.547MetGln: 0.547 ± 0.023	1.99MetArg: 1.99 ± 0.047	1.202MetSer: 1.202 ± 0.037	1.553MetThr: 1.553 ± 0.036	1.427MetVal: 1.427 ± 0.035	0.203MetTrp: 0.203 ± 0.014	0.262MetTyr: 0.262 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.918AsnAla: 2.918 ± 0.052	0.178AsnCys: 0.178 ± 0.013	1.265AsnAsp: 1.265 ± 0.04	1.059AsnGlu: 1.059 ± 0.03	0.784AsnPhe: 0.784 ± 0.035	2.313AsnGly: 2.313 ± 0.061	0.387AsnHis: 0.387 ± 0.019	1.052AsnIle: 1.052 ± 0.038	0.531AsnLys: 0.531 ± 0.026	2.266AsnLeu: 2.266 ± 0.05	0.418AsnMet: 0.418 ± 0.017	0.586AsnAsn: 0.586 ± 0.026	1.554AsnPro: 1.554 ± 0.041	0.681AsnGln: 0.681 ± 0.027	1.814AsnArg: 1.814 ± 0.044	0.996AsnSer: 0.996 ± 0.031	1.031AsnThr: 1.031 ± 0.034	1.696AsnVal: 1.696 ± 0.042	0.343AsnTrp: 0.343 ± 0.017	0.579AsnTyr: 0.579 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.832ProAla: 7.832 ± 0.112	0.29ProCys: 0.29 ± 0.016	4.307ProAsp: 4.307 ± 0.062	3.883ProGlu: 3.883 ± 0.062	1.899ProPhe: 1.899 ± 0.036	5.352ProGly: 5.352 ± 0.074	1.052ProHis: 1.052 ± 0.033	2.255ProIle: 2.255 ± 0.042	1.345ProLys: 1.345 ± 0.038	5.065ProLeu: 5.065 ± 0.07	1.094ProMet: 1.094 ± 0.033	1.319ProAsn: 1.319 ± 0.035	3.272ProPro: 3.272 ± 0.083	1.622ProGln: 1.622 ± 0.043	3.732ProArg: 3.732 ± 0.068	2.697ProSer: 2.697 ± 0.052	2.803ProThr: 2.803 ± 0.051	4.878ProVal: 4.878 ± 0.079	0.678ProTrp: 0.678 ± 0.027	1.117ProTyr: 1.117 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.473GlnAla: 4.473 ± 0.065	0.164GlnCys: 0.164 ± 0.012	1.283GlnAsp: 1.283 ± 0.033	1.308GlnGlu: 1.308 ± 0.036	1.014GlnPhe: 1.014 ± 0.037	2.573GlnGly: 2.573 ± 0.049	0.496GlnHis: 0.496 ± 0.02	1.3GlnIle: 1.3 ± 0.032	0.58GlnLys: 0.58 ± 0.029	3.077GlnLeu: 3.077 ± 0.057	0.642GlnMet: 0.642 ± 0.023	0.639GlnAsn: 0.639 ± 0.025	1.897GlnPro: 1.897 ± 0.045	1.026GlnGln: 1.026 ± 0.036	2.478GlnArg: 2.478 ± 0.048	1.416GlnSer: 1.416 ± 0.035	1.494GlnThr: 1.494 ± 0.042	2.58GlnVal: 2.58 ± 0.051	0.341GlnTrp: 0.341 ± 0.016	0.559GlnTyr: 0.559 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	11.312ArgAla: 11.312 ± 0.135	0.536ArgCys: 0.536 ± 0.023	5.07ArgAsp: 5.07 ± 0.081	4.938ArgGlu: 4.938 ± 0.075	3.596ArgPhe: 3.596 ± 0.061	6.297ArgGly: 6.297 ± 0.082	1.743ArgHis: 1.743 ± 0.042	3.821ArgIle: 3.821 ± 0.064	1.636ArgLys: 1.636 ± 0.043	9.398ArgLeu: 9.398 ± 0.117	2.06ArgMet: 2.06 ± 0.037	1.793ArgAsn: 1.793 ± 0.045	4.886ArgPro: 4.886 ± 0.079	2.472ArgGln: 2.472 ± 0.046	7.898ArgArg: 7.898 ± 0.119	3.937ArgSer: 3.937 ± 0.074	4.235ArgThr: 4.235 ± 0.06	6.689ArgVal: 6.689 ± 0.092	1.483ArgTrp: 1.483 ± 0.036	2.07ArgTyr: 2.07 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.865SerAla: 5.865 ± 0.077	0.307SerCys: 0.307 ± 0.018	2.715SerAsp: 2.715 ± 0.055	2.271SerGlu: 2.271 ± 0.047	1.894SerPhe: 1.894 ± 0.043	4.976SerGly: 4.976 ± 0.065	0.817SerHis: 0.817 ± 0.026	2.048SerIle: 2.048 ± 0.049	1.077SerLys: 1.077 ± 0.034	4.431SerLeu: 4.431 ± 0.069	1.018SerMet: 1.018 ± 0.031	1.127SerAsn: 1.127 ± 0.036	2.869SerPro: 2.869 ± 0.052	1.149SerGln: 1.149 ± 0.035	3.549SerArg: 3.549 ± 0.057	2.297SerSer: 2.297 ± 0.06	2.446SerThr: 2.446 ± 0.054	3.588SerVal: 3.588 ± 0.061	0.755SerTrp: 0.755 ± 0.027	1.19SerTyr: 1.19 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.46ThrAla: 6.46 ± 0.083	0.346ThrCys: 0.346 ± 0.018	2.877ThrAsp: 2.877 ± 0.059	2.39ThrGlu: 2.39 ± 0.044	1.744ThrPhe: 1.744 ± 0.042	5.533ThrGly: 5.533 ± 0.087	0.837ThrHis: 0.837 ± 0.031	2.339ThrIle: 2.339 ± 0.045	1.082ThrLys: 1.082 ± 0.033	5.779ThrLeu: 5.779 ± 0.08	1.008ThrMet: 1.008 ± 0.032	1.131ThrAsn: 1.131 ± 0.035	3.568ThrPro: 3.568 ± 0.07	1.347ThrGln: 1.347 ± 0.041	3.878ThrArg: 3.878 ± 0.065	2.442ThrSer: 2.442 ± 0.05	2.649ThrThr: 2.649 ± 0.059	4.371ThrVal: 4.371 ± 0.068	0.574ThrTrp: 0.574 ± 0.025	1.108ThrTyr: 1.108 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.68ValAla: 11.68 ± 0.111	0.482ValCys: 0.482 ± 0.022	4.851ValAsp: 4.851 ± 0.083	5.262ValGlu: 5.262 ± 0.074	2.356ValPhe: 2.356 ± 0.047	6.429ValGly: 6.429 ± 0.078	1.455ValHis: 1.455 ± 0.039	3.175ValIle: 3.175 ± 0.06	1.738ValLys: 1.738 ± 0.043	7.396ValLeu: 7.396 ± 0.083	1.539ValMet: 1.539 ± 0.035	1.964ValAsn: 1.964 ± 0.046	4.285ValPro: 4.285 ± 0.073	2.15ValGln: 2.15 ± 0.045	6.495ValArg: 6.495 ± 0.09	3.859ValSer: 3.859 ± 0.067	4.637ValThr: 4.637 ± 0.065	6.619ValVal: 6.619 ± 0.096	0.94ValTrp: 0.94 ± 0.035	1.389ValTyr: 1.389 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.55TrpAla: 1.55 ± 0.04	0.118TrpCys: 0.118 ± 0.011	0.703TrpAsp: 0.703 ± 0.024	0.597TrpGlu: 0.597 ± 0.024	0.574TrpPhe: 0.574 ± 0.021	0.984TrpGly: 0.984 ± 0.03	0.273TrpHis: 0.273 ± 0.016	0.63TrpIle: 0.63 ± 0.026	0.322TrpLys: 0.322 ± 0.017	1.626TrpLeu: 1.626 ± 0.043	0.347TrpMet: 0.347 ± 0.019	0.407TrpAsn: 0.407 ± 0.018	0.756TrpPro: 0.756 ± 0.026	0.378TrpGln: 0.378 ± 0.02	1.64TrpArg: 1.64 ± 0.041	0.878TrpSer: 0.878 ± 0.029	0.904TrpThr: 0.904 ± 0.033	0.943TrpVal: 0.943 ± 0.029	0.308TrpTrp: 0.308 ± 0.018	0.279TrpTyr: 0.279 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.776TyrAla: 2.776 ± 0.049	0.183TyrCys: 0.183 ± 0.014	1.524TyrAsp: 1.524 ± 0.043	1.117TyrGlu: 1.117 ± 0.035	0.749TyrPhe: 0.749 ± 0.029	2.118TyrGly: 2.118 ± 0.053	0.425TyrHis: 0.425 ± 0.022	0.614TyrIle: 0.614 ± 0.023	0.497TyrLys: 0.497 ± 0.02	2.123TyrLeu: 2.123 ± 0.049	0.34TyrMet: 0.34 ± 0.018	0.529TyrAsn: 0.529 ± 0.023	0.997TyrPro: 0.997 ± 0.034	0.676TyrGln: 0.676 ± 0.025	2.036TyrArg: 2.036 ± 0.043	1.017TyrSer: 1.017 ± 0.032	0.919TyrThr: 0.919 ± 0.032	1.589TyrVal: 1.589 ± 0.04	0.349TyrTrp: 0.349 ± 0.02	0.545TyrTyr: 0.545 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3520 proteins (1111885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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