Amino acid dipepetide frequency for Kribbella sp. VKM Ac-2575

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.299AlaAla: 19.299 ± 0.138
0.875AlaCys: 0.875 ± 0.021
8.062AlaAsp: 8.062 ± 0.061
7.959AlaGlu: 7.959 ± 0.086
3.559AlaPhe: 3.559 ± 0.044
12.67AlaGly: 12.67 ± 0.08
2.163AlaHis: 2.163 ± 0.032
4.945AlaIle: 4.945 ± 0.056
3.465AlaLys: 3.465 ± 0.049
12.861AlaLeu: 12.861 ± 0.096
2.465AlaMet: 2.465 ± 0.028
2.491AlaAsn: 2.491 ± 0.038
5.622AlaPro: 5.622 ± 0.063
3.611AlaGln: 3.611 ± 0.04
8.052AlaArg: 8.052 ± 0.073
6.021AlaSer: 6.021 ± 0.054
7.618AlaThr: 7.618 ± 0.066
11.572AlaVal: 11.572 ± 0.091
1.845AlaTrp: 1.845 ± 0.03
2.659AlaTyr: 2.659 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.781CysAla: 0.781 ± 0.019
0.092CysCys: 0.092 ± 0.007
0.427CysAsp: 0.427 ± 0.013
0.362CysGlu: 0.362 ± 0.013
0.215CysPhe: 0.215 ± 0.009
0.807CysGly: 0.807 ± 0.021
0.164CysHis: 0.164 ± 0.008
0.201CysIle: 0.201 ± 0.009
0.126CysLys: 0.126 ± 0.008
0.692CysLeu: 0.692 ± 0.018
0.104CysMet: 0.104 ± 0.007
0.17CysAsn: 0.17 ± 0.009
0.431CysPro: 0.431 ± 0.015
0.178CysGln: 0.178 ± 0.009
0.482CysArg: 0.482 ± 0.015
0.451CysSer: 0.451 ± 0.014
0.451CysThr: 0.451 ± 0.015
0.55CysVal: 0.55 ± 0.016
0.118CysTrp: 0.118 ± 0.007
0.148CysTyr: 0.148 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.03AspAla: 7.03 ± 0.058
0.377AspCys: 0.377 ± 0.014
3.768AspAsp: 3.768 ± 0.048
3.937AspGlu: 3.937 ± 0.043
1.635AspPhe: 1.635 ± 0.028
6.122AspGly: 6.122 ± 0.057
1.411AspHis: 1.411 ± 0.025
1.887AspIle: 1.887 ± 0.028
1.453AspLys: 1.453 ± 0.027
6.771AspLeu: 6.771 ± 0.058
0.689AspMet: 0.689 ± 0.018
1.226AspAsn: 1.226 ± 0.024
4.336AspPro: 4.336 ± 0.048
2.054AspGln: 2.054 ± 0.034
4.5AspArg: 4.5 ± 0.045
2.836AspSer: 2.836 ± 0.036
2.777AspThr: 2.777 ± 0.036
4.858AspVal: 4.858 ± 0.048
1.085AspTrp: 1.085 ± 0.021
1.234AspTyr: 1.234 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
6.427GluAla: 6.427 ± 0.066
0.28GluCys: 0.28 ± 0.012
2.474GluAsp: 2.474 ± 0.029
2.726GluGlu: 2.726 ± 0.045
1.543GluPhe: 1.543 ± 0.025
3.448GluGly: 3.448 ± 0.037
1.416GluHis: 1.416 ± 0.024
2.418GluIle: 2.418 ± 0.034
1.347GluLys: 1.347 ± 0.027
7.324GluLeu: 7.324 ± 0.068
0.818GluMet: 0.818 ± 0.02
1.067GluAsn: 1.067 ± 0.022
3.17GluPro: 3.17 ± 0.048
2.354GluGln: 2.354 ± 0.035
4.484GluArg: 4.484 ± 0.049
2.636GluSer: 2.636 ± 0.039
2.772GluThr: 2.772 ± 0.034
4.681GluVal: 4.681 ± 0.05
0.809GluTrp: 0.809 ± 0.022
1.137GluTyr: 1.137 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.805PheAla: 3.805 ± 0.042
0.262PheCys: 0.262 ± 0.01
2.16PheAsp: 2.16 ± 0.03
1.546PheGlu: 1.546 ± 0.027
0.935PhePhe: 0.935 ± 0.022
3.212PheGly: 3.212 ± 0.041
0.604PheHis: 0.604 ± 0.015
0.882PheIle: 0.882 ± 0.02
0.646PheLys: 0.646 ± 0.017
2.649PheLeu: 2.649 ± 0.037
0.387PheMet: 0.387 ± 0.012
0.681PheAsn: 0.681 ± 0.019
1.363PhePro: 1.363 ± 0.024
0.772PheGln: 0.772 ± 0.018
1.826PheArg: 1.826 ± 0.03
1.642PheSer: 1.642 ± 0.026
2.054PheThr: 2.054 ± 0.035
2.677PheVal: 2.677 ± 0.038
0.487PheTrp: 0.487 ± 0.014
0.7PheTyr: 0.7 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
9.505GlyAla: 9.505 ± 0.077
0.795GlyCys: 0.795 ± 0.019
4.986GlyAsp: 4.986 ± 0.052
4.481GlyGlu: 4.481 ± 0.054
3.061GlyPhe: 3.061 ± 0.038
7.786GlyGly: 7.786 ± 0.07
1.94GlyHis: 1.94 ± 0.033
3.935GlyIle: 3.935 ± 0.043
2.767GlyLys: 2.767 ± 0.043
9.483GlyLeu: 9.483 ± 0.072
1.803GlyMet: 1.803 ± 0.025
2.188GlyAsn: 2.188 ± 0.036
4.452GlyPro: 4.452 ± 0.053
2.981GlyGln: 2.981 ± 0.047
6.491GlyArg: 6.491 ± 0.055
5.627GlySer: 5.627 ± 0.061
5.79GlyThr: 5.79 ± 0.057
7.586GlyVal: 7.586 ± 0.055
1.878GlyTrp: 1.878 ± 0.028
2.397GlyTyr: 2.397 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.178HisAla: 2.178 ± 0.034
0.176HisCys: 0.176 ± 0.009
1.241HisAsp: 1.241 ± 0.024
1.09HisGlu: 1.09 ± 0.023
0.622HisPhe: 0.622 ± 0.016
1.965HisGly: 1.965 ± 0.031
0.621HisHis: 0.621 ± 0.017
0.594HisIle: 0.594 ± 0.017
0.37HisLys: 0.37 ± 0.012
2.367HisLeu: 2.367 ± 0.035
0.254HisMet: 0.254 ± 0.012
0.443HisAsn: 0.443 ± 0.013
1.553HisPro: 1.553 ± 0.03
0.733HisGln: 0.733 ± 0.018
1.758HisArg: 1.758 ± 0.029
0.995HisSer: 0.995 ± 0.023
1.079HisThr: 1.079 ± 0.023
1.569HisVal: 1.569 ± 0.026
0.397HisTrp: 0.397 ± 0.015
0.473HisTyr: 0.473 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
5.741IleAla: 5.741 ± 0.054
0.324IleCys: 0.324 ± 0.012
2.769IleAsp: 2.769 ± 0.039
2.383IleGlu: 2.383 ± 0.032
1.019IlePhe: 1.019 ± 0.025
4.248IleGly: 4.248 ± 0.053
0.692IleHis: 0.692 ± 0.016
1.144IleIle: 1.144 ± 0.026
0.901IleLys: 0.901 ± 0.021
3.019IleLeu: 3.019 ± 0.037
0.443IleMet: 0.443 ± 0.013
0.869IleAsn: 0.869 ± 0.018
2.073IlePro: 2.073 ± 0.035
0.985IleGln: 0.985 ± 0.02
2.594IleArg: 2.594 ± 0.032
2.258IleSer: 2.258 ± 0.03
2.745IleThr: 2.745 ± 0.041
3.387IleVal: 3.387 ± 0.039
0.527IleTrp: 0.527 ± 0.014
0.75IleTyr: 0.75 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
3.355LysAla: 3.355 ± 0.048
0.124LysCys: 0.124 ± 0.008
1.325LysAsp: 1.325 ± 0.027
1.066LysGlu: 1.066 ± 0.024
0.638LysPhe: 0.638 ± 0.018
1.744LysGly: 1.744 ± 0.033
0.535LysHis: 0.535 ± 0.014
1.053LysIle: 1.053 ± 0.026
0.868LysLys: 0.868 ± 0.029
2.722LysLeu: 2.722 ± 0.038
0.43LysMet: 0.43 ± 0.015
0.649LysAsn: 0.649 ± 0.019
1.755LysPro: 1.755 ± 0.035
0.89LysGln: 0.89 ± 0.021
1.443LysArg: 1.443 ± 0.026
1.383LysSer: 1.383 ± 0.029
1.627LysThr: 1.627 ± 0.038
2.381LysVal: 2.381 ± 0.039
0.338LysTrp: 0.338 ± 0.011
0.634LysTyr: 0.634 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
14.776LeuAla: 14.776 ± 0.101
0.688LeuCys: 0.688 ± 0.016
6.717LeuAsp: 6.717 ± 0.062
4.914LeuGlu: 4.914 ± 0.05
2.804LeuPhe: 2.804 ± 0.041
9.185LeuGly: 9.185 ± 0.063
2.06LeuHis: 2.06 ± 0.033
4.215LeuIle: 4.215 ± 0.04
2.227LeuLys: 2.227 ± 0.037
11.22LeuLeu: 11.22 ± 0.092
1.633LeuMet: 1.633 ± 0.031
2.07LeuAsn: 2.07 ± 0.028
6.165LeuPro: 6.165 ± 0.054
2.868LeuGln: 2.868 ± 0.036
7.806LeuArg: 7.806 ± 0.061
5.823LeuSer: 5.823 ± 0.055
7.203LeuThr: 7.203 ± 0.055
9.349LeuVal: 9.349 ± 0.071
1.362LeuTrp: 1.362 ± 0.026
1.961LeuTyr: 1.961 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
2.046MetAla: 2.046 ± 0.028
0.086MetCys: 0.086 ± 0.006
0.797MetAsp: 0.797 ± 0.019
0.677MetGlu: 0.677 ± 0.019
0.502MetPhe: 0.502 ± 0.016
1.126MetGly: 1.126 ± 0.023
0.334MetHis: 0.334 ± 0.01
0.755MetIle: 0.755 ± 0.019
0.501MetLys: 0.501 ± 0.013
1.778MetLeu: 1.778 ± 0.025
0.3MetMet: 0.3 ± 0.012
0.476MetAsn: 0.476 ± 0.013
1.065MetPro: 1.065 ± 0.023
0.452MetGln: 0.452 ± 0.012
1.221MetArg: 1.221 ± 0.023
1.378MetSer: 1.378 ± 0.025
1.645MetThr: 1.645 ± 0.023
1.39MetVal: 1.39 ± 0.022
0.182MetTrp: 0.182 ± 0.008
0.308MetTyr: 0.308 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.506AsnAla: 2.506 ± 0.038
0.195AsnCys: 0.195 ± 0.009
1.263AsnAsp: 1.263 ± 0.028
1.021AsnGlu: 1.021 ± 0.021
0.634AsnPhe: 0.634 ± 0.017
2.286AsnGly: 2.286 ± 0.04
0.492AsnHis: 0.492 ± 0.014
0.715AsnIle: 0.715 ± 0.017
0.545AsnLys: 0.545 ± 0.017
2.238AsnLeu: 2.238 ± 0.029
0.318AsnMet: 0.318 ± 0.011
0.616AsnAsn: 0.616 ± 0.021
1.648AsnPro: 1.648 ± 0.028
0.793AsnGln: 0.793 ± 0.016
1.46AsnArg: 1.46 ± 0.023
1.24AsnSer: 1.24 ± 0.026
1.31AsnThr: 1.31 ± 0.029
1.639AsnVal: 1.639 ± 0.028
0.429AsnTrp: 0.429 ± 0.014
0.58AsnTyr: 0.58 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.896ProAla: 7.896 ± 0.072
0.284ProCys: 0.284 ± 0.01
4.248ProAsp: 4.248 ± 0.047
3.61ProGlu: 3.61 ± 0.041
1.492ProPhe: 1.492 ± 0.024
5.701ProGly: 5.701 ± 0.052
1.087ProHis: 1.087 ± 0.031
1.958ProIle: 1.958 ± 0.028
1.376ProLys: 1.376 ± 0.026
4.919ProLeu: 4.919 ± 0.053
1.003ProMet: 1.003 ± 0.017
1.263ProAsn: 1.263 ± 0.029
3.163ProPro: 3.163 ± 0.058
1.696ProGln: 1.696 ± 0.032
3.164ProArg: 3.164 ± 0.041
3.302ProSer: 3.302 ± 0.045
3.766ProThr: 3.766 ± 0.056
5.021ProVal: 5.021 ± 0.05
0.959ProTrp: 0.959 ± 0.021
1.353ProTyr: 1.353 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.077GlnAla: 4.077 ± 0.048
0.149GlnCys: 0.149 ± 0.008
1.311GlnAsp: 1.311 ± 0.024
1.353GlnGlu: 1.353 ± 0.024
0.876GlnPhe: 0.876 ± 0.019
2.167GlnGly: 2.167 ± 0.033
0.703GlnHis: 0.703 ± 0.018
1.279GlnIle: 1.279 ± 0.022
0.722GlnLys: 0.722 ± 0.019
3.912GlnLeu: 3.912 ± 0.04
0.482GlnMet: 0.482 ± 0.016
0.71GlnAsn: 0.71 ± 0.016
2.024GlnPro: 2.024 ± 0.041
1.49GlnGln: 1.49 ± 0.033
2.485GlnArg: 2.485 ± 0.036
1.513GlnSer: 1.513 ± 0.024
1.733GlnThr: 1.733 ± 0.028
2.908GlnVal: 2.908 ± 0.035
0.535GlnTrp: 0.535 ± 0.017
0.882GlnTyr: 0.882 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.66ArgAla: 7.66 ± 0.068
0.47ArgCys: 0.47 ± 0.016
3.817ArgAsp: 3.817 ± 0.047
3.876ArgGlu: 3.876 ± 0.045
2.252ArgPhe: 2.252 ± 0.03
4.94ArgGly: 4.94 ± 0.053
1.576ArgHis: 1.576 ± 0.031
3.313ArgIle: 3.313 ± 0.04
1.765ArgLys: 1.765 ± 0.027
8.018ArgLeu: 8.018 ± 0.072
1.577ArgMet: 1.577 ± 0.024
1.499ArgAsn: 1.499 ± 0.026
4.119ArgPro: 4.119 ± 0.044
2.333ArgGln: 2.333 ± 0.038
6.632ArgArg: 6.632 ± 0.066
4.125ArgSer: 4.125 ± 0.046
4.614ArgThr: 4.614 ± 0.042
5.175ArgVal: 5.175 ± 0.049
1.351ArgTrp: 1.351 ± 0.024
1.753ArgTyr: 1.753 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.845SerAla: 6.845 ± 0.07
0.391SerCys: 0.391 ± 0.013
2.936SerAsp: 2.936 ± 0.039
2.569SerGlu: 2.569 ± 0.037
1.752SerPhe: 1.752 ± 0.028
5.838SerGly: 5.838 ± 0.06
1.059SerHis: 1.059 ± 0.021
2.118SerIle: 2.118 ± 0.029
1.347SerLys: 1.347 ± 0.028
5.226SerLeu: 5.226 ± 0.05
1.218SerMet: 1.218 ± 0.024
1.24SerAsn: 1.24 ± 0.026
3.153SerPro: 3.153 ± 0.034
1.589SerGln: 1.589 ± 0.026
3.72SerArg: 3.72 ± 0.035
3.492SerSer: 3.492 ± 0.046
3.918SerThr: 3.918 ± 0.049
4.532SerVal: 4.532 ± 0.047
1.103SerTrp: 1.103 ± 0.021
1.504SerTyr: 1.504 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.485ThrAla: 8.485 ± 0.068
0.436ThrCys: 0.436 ± 0.015
3.697ThrAsp: 3.697 ± 0.039
3.236ThrGlu: 3.236 ± 0.041
1.912ThrPhe: 1.912 ± 0.03
6.366ThrGly: 6.366 ± 0.058
1.126ThrHis: 1.126 ± 0.021
2.534ThrIle: 2.534 ± 0.035
1.625ThrLys: 1.625 ± 0.026
5.753ThrLeu: 5.753 ± 0.05
1.065ThrMet: 1.065 ± 0.018
1.363ThrAsn: 1.363 ± 0.028
4.18ThrPro: 4.18 ± 0.055
1.616ThrGln: 1.616 ± 0.026
3.581ThrArg: 3.581 ± 0.035
3.741ThrSer: 3.741 ± 0.048
4.559ThrThr: 4.559 ± 0.059
5.822ThrVal: 5.822 ± 0.061
1.02ThrTrp: 1.02 ± 0.022
1.506ThrTyr: 1.506 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
11.127ValAla: 11.127 ± 0.082
0.602ValCys: 0.602 ± 0.018
5.439ValAsp: 5.439 ± 0.048
4.716ValGlu: 4.716 ± 0.049
2.495ValPhe: 2.495 ± 0.033
6.954ValGly: 6.954 ± 0.063
1.688ValHis: 1.688 ± 0.027
3.649ValIle: 3.649 ± 0.044
1.988ValLys: 1.988 ± 0.034
9.711ValLeu: 9.711 ± 0.068
1.453ValMet: 1.453 ± 0.024
1.871ValAsn: 1.871 ± 0.031
4.923ValPro: 4.923 ± 0.037
2.429ValGln: 2.429 ± 0.032
6.084ValArg: 6.084 ± 0.054
4.666ValSer: 4.666 ± 0.043
5.608ValThr: 5.608 ± 0.058
8.858ValVal: 8.858 ± 0.088
1.115ValTrp: 1.115 ± 0.022
1.547ValTyr: 1.547 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
1.603TrpAla: 1.603 ± 0.024
0.142TrpCys: 0.142 ± 0.007
0.83TrpAsp: 0.83 ± 0.02
0.642TrpGlu: 0.642 ± 0.019
0.602TrpPhe: 0.602 ± 0.017
1.076TrpGly: 1.076 ± 0.024
0.393TrpHis: 0.393 ± 0.012
0.734TrpIle: 0.734 ± 0.017
0.439TrpLys: 0.439 ± 0.015
1.945TrpLeu: 1.945 ± 0.03
0.343TrpMet: 0.343 ± 0.01
0.51TrpAsn: 0.51 ± 0.017
0.89TrpPro: 0.89 ± 0.018
0.706TrpGln: 0.706 ± 0.017
1.264TrpArg: 1.264 ± 0.023
1.173TrpSer: 1.173 ± 0.025
1.148TrpThr: 1.148 ± 0.024
1.119TrpVal: 1.119 ± 0.023
0.393TrpTrp: 0.393 ± 0.015
0.395TrpTyr: 0.395 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.672TyrAla: 2.672 ± 0.036
0.204TyrCys: 0.204 ± 0.01
1.72TyrAsp: 1.72 ± 0.03
1.165TyrGlu: 1.165 ± 0.022
0.741TyrPhe: 0.741 ± 0.02
2.291TyrGly: 2.291 ± 0.036
0.415TyrHis: 0.415 ± 0.013
0.541TyrIle: 0.541 ± 0.014
0.483TyrLys: 0.483 ± 0.016
2.436TyrLeu: 2.436 ± 0.033
0.234TyrMet: 0.234 ± 0.01
0.526TyrAsn: 0.526 ± 0.016
1.175TyrPro: 1.175 ± 0.022
0.782TyrGln: 0.782 ± 0.021
1.821TyrArg: 1.821 ± 0.028
1.245TyrSer: 1.245 ± 0.028
1.206TyrThr: 1.206 ± 0.026
1.849TyrVal: 1.849 ± 0.028
0.416TyrTrp: 0.416 ± 0.014
0.584TyrTyr: 0.584 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7379 proteins (2437599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski