Amino acid dipepetide frequency for Reticulomyxa filosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.685AlaAla: 2.685 ± 0.021	0.841AlaCys: 0.841 ± 0.009	2.15AlaAsp: 2.15 ± 0.016	2.533AlaGlu: 2.533 ± 0.017	2.182AlaPhe: 2.182 ± 0.015	1.631AlaGly: 1.631 ± 0.013	1.184AlaHis: 1.184 ± 0.01	3.343AlaIle: 3.343 ± 0.017	3.882AlaLys: 3.882 ± 0.017	4.609AlaLeu: 4.609 ± 0.021	1.345AlaMet: 1.345 ± 0.012	3.405AlaAsn: 3.405 ± 0.02	1.491AlaPro: 1.491 ± 0.014	2.164AlaGln: 2.164 ± 0.017	1.852AlaArg: 1.852 ± 0.013	3.761AlaSer: 3.761 ± 0.019	3.103AlaThr: 3.103 ± 0.021	2.677AlaVal: 2.677 ± 0.018	0.48AlaTrp: 0.48 ± 0.006	1.359AlaTyr: 1.359 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.009	0.684CysCys: 0.684 ± 0.009	1.063CysAsp: 1.063 ± 0.01	1.006CysGlu: 1.006 ± 0.009	1.247CysPhe: 1.247 ± 0.012	1.02CysGly: 1.02 ± 0.011	0.529CysHis: 0.529 ± 0.007	1.439CysIle: 1.439 ± 0.011	1.388CysLys: 1.388 ± 0.011	2.069CysLeu: 2.069 ± 0.014	0.417CysMet: 0.417 ± 0.006	1.154CysAsn: 1.154 ± 0.011	0.675CysPro: 0.675 ± 0.008	0.793CysGln: 0.793 ± 0.008	0.743CysArg: 0.743 ± 0.007	1.765CysSer: 1.765 ± 0.017	0.875CysThr: 0.875 ± 0.009	1.732CysVal: 1.732 ± 0.014	0.253CysTrp: 0.253 ± 0.004	0.855CysTyr: 0.855 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.589AspAla: 2.589 ± 0.015	0.969AspCys: 0.969 ± 0.009	4.484AspAsp: 4.484 ± 0.036	4.463AspGlu: 4.463 ± 0.024	2.138AspPhe: 2.138 ± 0.013	2.706AspGly: 2.706 ± 0.017	1.338AspHis: 1.338 ± 0.011	4.218AspIle: 4.218 ± 0.022	4.795AspLys: 4.795 ± 0.028	4.182AspLeu: 4.182 ± 0.018	1.3AspMet: 1.3 ± 0.011	4.704AspAsn: 4.704 ± 0.025	1.612AspPro: 1.612 ± 0.01	1.873AspGln: 1.873 ± 0.013	2.009AspArg: 2.009 ± 0.018	3.55AspSer: 3.55 ± 0.018	2.905AspThr: 2.905 ± 0.016	3.458AspVal: 3.458 ± 0.019	0.683AspTrp: 0.683 ± 0.007	1.653AspTyr: 1.653 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	2.763GluAla: 2.763 ± 0.017	1.029GluCys: 1.029 ± 0.009	3.684GluAsp: 3.684 ± 0.022	7.069GluGlu: 7.069 ± 0.054	2.317GluPhe: 2.317 ± 0.013	2.267GluGly: 2.267 ± 0.018	1.757GluHis: 1.757 ± 0.013	4.296GluIle: 4.296 ± 0.021	7.58GluLys: 7.58 ± 0.03	5.647GluLeu: 5.647 ± 0.025	2.0GluMet: 2.0 ± 0.013	4.274GluAsn: 4.274 ± 0.023	1.447GluPro: 1.447 ± 0.012	3.518GluGln: 3.518 ± 0.022	3.077GluArg: 3.077 ± 0.021	4.11GluSer: 4.11 ± 0.019	3.55GluThr: 3.55 ± 0.018	2.717GluVal: 2.717 ± 0.017	0.927GluTrp: 0.927 ± 0.009	2.215GluTyr: 2.215 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.368PheAla: 2.368 ± 0.015	1.262PheCys: 1.262 ± 0.011	2.875PheAsp: 2.875 ± 0.018	3.007PheGlu: 3.007 ± 0.015	5.014PhePhe: 5.014 ± 0.04	2.498PheGly: 2.498 ± 0.014	1.25PheHis: 1.25 ± 0.01	3.02PheIle: 3.02 ± 0.019	2.874PheLys: 2.874 ± 0.016	4.646PheLeu: 4.646 ± 0.024	0.951PheMet: 0.951 ± 0.009	2.5PheAsn: 2.5 ± 0.017	1.466PhePro: 1.466 ± 0.013	2.126PheGln: 2.126 ± 0.014	1.674PheArg: 1.674 ± 0.012	3.586PheSer: 3.586 ± 0.022	1.89PheThr: 1.89 ± 0.012	3.675PheVal: 3.675 ± 0.021	0.683PheTrp: 0.683 ± 0.006	1.72PheTyr: 1.72 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	1.885GlyAla: 1.885 ± 0.016	0.786GlyCys: 0.786 ± 0.008	2.424GlyAsp: 2.424 ± 0.015	2.352GlyGlu: 2.352 ± 0.016	1.712GlyPhe: 1.712 ± 0.014	3.094GlyGly: 3.094 ± 0.03	1.86GlyHis: 1.86 ± 0.017	2.766GlyIle: 2.766 ± 0.017	3.47GlyLys: 3.47 ± 0.021	3.332GlyLeu: 3.332 ± 0.018	1.038GlyMet: 1.038 ± 0.01	3.007GlyAsn: 3.007 ± 0.018	0.983GlyPro: 0.983 ± 0.009	1.753GlyGln: 1.753 ± 0.013	1.887GlyArg: 1.887 ± 0.016	3.44GlySer: 3.44 ± 0.022	2.292GlyThr: 2.292 ± 0.015	2.544GlyVal: 2.544 ± 0.018	0.569GlyTrp: 0.569 ± 0.006	1.575GlyTyr: 1.575 ± 0.012	0.0GlyXaa: 0.0 ± 0.0
His	1.247HisAla: 1.247 ± 0.012	0.72HisCys: 0.72 ± 0.009	1.399HisAsp: 1.399 ± 0.011	1.58HisGlu: 1.58 ± 0.013	1.473HisPhe: 1.473 ± 0.01	1.092HisGly: 1.092 ± 0.012	0.975HisHis: 0.975 ± 0.012	1.851HisIle: 1.851 ± 0.013	1.969HisLys: 1.969 ± 0.014	2.675HisLeu: 2.675 ± 0.015	0.576HisMet: 0.576 ± 0.007	1.645HisAsn: 1.645 ± 0.014	1.087HisPro: 1.087 ± 0.012	1.166HisGln: 1.166 ± 0.01	1.132HisArg: 1.132 ± 0.009	2.409HisSer: 2.409 ± 0.014	1.599HisThr: 1.599 ± 0.012	1.654HisVal: 1.654 ± 0.013	0.412HisTrp: 0.412 ± 0.007	1.033HisTyr: 1.033 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.465IleAla: 3.465 ± 0.018	1.93IleCys: 1.93 ± 0.015	3.699IleAsp: 3.699 ± 0.017	4.338IleGlu: 4.338 ± 0.022	3.392IlePhe: 3.392 ± 0.019	3.015IleGly: 3.015 ± 0.017	1.808IleHis: 1.808 ± 0.013	4.55IleIle: 4.55 ± 0.026	4.82IleLys: 4.82 ± 0.024	5.693IleLeu: 5.693 ± 0.025	1.275IleMet: 1.275 ± 0.011	3.742IleAsn: 3.742 ± 0.02	2.295IlePro: 2.295 ± 0.014	3.271IleGln: 3.271 ± 0.019	3.433IleArg: 3.433 ± 0.021	4.635IleSer: 4.635 ± 0.023	3.376IleThr: 3.376 ± 0.017	3.903IleVal: 3.903 ± 0.02	1.016IleTrp: 1.016 ± 0.014	2.341IleTyr: 2.341 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.521LysAla: 3.521 ± 0.016	1.393LysCys: 1.393 ± 0.011	4.735LysAsp: 4.735 ± 0.026	7.259LysGlu: 7.259 ± 0.033	2.871LysPhe: 2.871 ± 0.016	3.18LysGly: 3.18 ± 0.02	2.386LysHis: 2.386 ± 0.016	5.437LysIle: 5.437 ± 0.027	13.212LysLys: 13.212 ± 0.062	6.476LysLeu: 6.476 ± 0.027	2.103LysMet: 2.103 ± 0.014	5.603LysAsn: 5.603 ± 0.023	2.202LysPro: 2.202 ± 0.015	5.016LysGln: 5.016 ± 0.023	4.066LysArg: 4.066 ± 0.02	5.736LysSer: 5.736 ± 0.025	4.93LysThr: 4.93 ± 0.02	3.526LysVal: 3.526 ± 0.013	1.054LysTrp: 1.054 ± 0.01	3.088LysTyr: 3.088 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	3.956LeuAla: 3.956 ± 0.02	2.205LeuCys: 2.205 ± 0.014	4.163LeuAsp: 4.163 ± 0.02	5.424LeuGlu: 5.424 ± 0.026	5.544LeuPhe: 5.544 ± 0.021	3.251LeuGly: 3.251 ± 0.021	2.594LeuHis: 2.594 ± 0.018	5.175LeuIle: 5.175 ± 0.025	7.423LeuLys: 7.423 ± 0.029	9.434LeuLeu: 9.434 ± 0.036	1.912LeuMet: 1.912 ± 0.012	4.836LeuAsn: 4.836 ± 0.022	3.249LeuPro: 3.249 ± 0.02	5.199LeuGln: 5.199 ± 0.023	3.884LeuArg: 3.884 ± 0.021	7.227LeuSer: 7.227 ± 0.024	4.314LeuThr: 4.314 ± 0.019	4.4LeuVal: 4.4 ± 0.021	1.444LeuTrp: 1.444 ± 0.014	2.889LeuTyr: 2.889 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	1.173MetAla: 1.173 ± 0.01	0.483MetCys: 0.483 ± 0.006	1.367MetAsp: 1.367 ± 0.011	1.711MetGlu: 1.711 ± 0.013	1.06MetPhe: 1.06 ± 0.009	0.839MetGly: 0.839 ± 0.009	0.608MetHis: 0.608 ± 0.007	1.516MetIle: 1.516 ± 0.013	2.203MetLys: 2.203 ± 0.015	2.051MetLeu: 2.051 ± 0.013	0.595MetMet: 0.595 ± 0.007	1.451MetAsn: 1.451 ± 0.012	0.697MetPro: 0.697 ± 0.008	1.181MetGln: 1.181 ± 0.01	0.92MetArg: 0.92 ± 0.009	1.823MetSer: 1.823 ± 0.012	1.405MetThr: 1.405 ± 0.011	1.031MetVal: 1.031 ± 0.01	0.28MetTrp: 0.28 ± 0.004	0.906MetTyr: 0.906 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.624AsnAla: 3.624 ± 0.024	1.084AsnCys: 1.084 ± 0.009	4.9AsnAsp: 4.9 ± 0.028	5.365AsnGlu: 5.365 ± 0.025	2.199AsnPhe: 2.199 ± 0.015	3.595AsnGly: 3.595 ± 0.021	1.537AsnHis: 1.537 ± 0.013	4.204AsnIle: 4.204 ± 0.022	5.724AsnLys: 5.724 ± 0.024	4.242AsnLeu: 4.242 ± 0.019	1.241AsnMet: 1.241 ± 0.011	9.153AsnAsn: 9.153 ± 0.082	2.014AsnPro: 2.014 ± 0.016	2.508AsnGln: 2.508 ± 0.017	2.214AsnArg: 2.214 ± 0.014	4.704AsnSer: 4.704 ± 0.026	3.992AsnThr: 3.992 ± 0.024	3.798AsnVal: 3.798 ± 0.019	0.691AsnTrp: 0.691 ± 0.008	1.849AsnTyr: 1.849 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	1.309ProAla: 1.309 ± 0.012	0.443ProCys: 0.443 ± 0.006	1.634ProAsp: 1.634 ± 0.014	1.656ProGlu: 1.656 ± 0.012	1.898ProPhe: 1.898 ± 0.012	0.987ProGly: 0.987 ± 0.008	0.84ProHis: 0.84 ± 0.009	1.988ProIle: 1.988 ± 0.014	2.515ProLys: 2.515 ± 0.016	3.277ProLeu: 3.277 ± 0.018	0.721ProMet: 0.721 ± 0.009	2.108ProAsn: 2.108 ± 0.014	1.782ProPro: 1.782 ± 0.017	1.529ProGln: 1.529 ± 0.015	1.223ProArg: 1.223 ± 0.01	3.096ProSer: 3.096 ± 0.02	2.299ProThr: 2.299 ± 0.046	1.703ProVal: 1.703 ± 0.013	0.355ProTrp: 0.355 ± 0.005	0.957ProTyr: 0.957 ± 0.008	0.0ProXaa: 0.0 ± 0.0
Gln	2.018GlnAla: 2.018 ± 0.017	0.931GlnCys: 0.931 ± 0.008	1.916GlnAsp: 1.916 ± 0.012	2.822GlnGlu: 2.822 ± 0.02	2.261GlnPhe: 2.261 ± 0.017	1.502GlnGly: 1.502 ± 0.012	1.442GlnHis: 1.442 ± 0.012	3.349GlnIle: 3.349 ± 0.018	4.275GlnLys: 4.275 ± 0.022	5.037GlnLeu: 5.037 ± 0.025	1.526GlnMet: 1.526 ± 0.013	2.68GlnAsn: 2.68 ± 0.017	1.392GlnPro: 1.392 ± 0.017	3.968GlnGln: 3.968 ± 0.039	2.216GlnArg: 2.216 ± 0.014	3.933GlnSer: 3.933 ± 0.021	2.806GlnThr: 2.806 ± 0.017	2.383GlnVal: 2.383 ± 0.016	0.75GlnTrp: 0.75 ± 0.009	1.649GlnTyr: 1.649 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	1.923ArgAla: 1.923 ± 0.012	0.741ArgCys: 0.741 ± 0.008	2.225ArgAsp: 2.225 ± 0.017	2.71ArgGlu: 2.71 ± 0.018	1.928ArgPhe: 1.928 ± 0.013	1.781ArgGly: 1.781 ± 0.015	1.25ArgHis: 1.25 ± 0.011	2.801ArgIle: 2.801 ± 0.017	3.671ArgLys: 3.671 ± 0.016	3.966ArgLeu: 3.966 ± 0.018	1.007ArgMet: 1.007 ± 0.009	2.434ArgAsn: 2.434 ± 0.013	1.309ArgPro: 1.309 ± 0.014	2.233ArgGln: 2.233 ± 0.014	2.341ArgArg: 2.341 ± 0.015	3.027ArgSer: 3.027 ± 0.018	2.061ArgThr: 2.061 ± 0.014	2.301ArgVal: 2.301 ± 0.014	0.476ArgTrp: 0.476 ± 0.007	1.563ArgTyr: 1.563 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	3.573SerAla: 3.573 ± 0.019	1.497SerCys: 1.497 ± 0.015	4.117SerAsp: 4.117 ± 0.022	4.173SerGlu: 4.173 ± 0.019	3.67SerPhe: 3.67 ± 0.019	3.858SerGly: 3.858 ± 0.026	1.987SerHis: 1.987 ± 0.014	4.704SerIle: 4.704 ± 0.022	6.248SerLys: 6.248 ± 0.024	6.579SerLeu: 6.579 ± 0.025	1.57SerMet: 1.57 ± 0.011	5.847SerAsn: 5.847 ± 0.027	3.198SerPro: 3.198 ± 0.026	3.563SerGln: 3.563 ± 0.018	2.814SerArg: 2.814 ± 0.018	8.058SerSer: 8.058 ± 0.047	4.341SerThr: 4.341 ± 0.023	4.032SerVal: 4.032 ± 0.02	0.8SerTrp: 0.8 ± 0.008	2.261SerTyr: 2.261 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	2.847ThrAla: 2.847 ± 0.021	0.974ThrCys: 0.974 ± 0.009	2.602ThrAsp: 2.602 ± 0.015	3.003ThrGlu: 3.003 ± 0.018	2.611ThrPhe: 2.611 ± 0.015	2.144ThrGly: 2.144 ± 0.014	1.432ThrHis: 1.432 ± 0.011	4.189ThrIle: 4.189 ± 0.023	4.641ThrLys: 4.641 ± 0.022	4.979ThrLeu: 4.979 ± 0.019	1.261ThrMet: 1.261 ± 0.01	4.002ThrAsn: 4.002 ± 0.023	2.099ThrPro: 2.099 ± 0.015	2.521ThrGln: 2.521 ± 0.018	1.985ThrArg: 1.985 ± 0.014	4.376ThrSer: 4.376 ± 0.023	4.671ThrThr: 4.671 ± 0.036	2.854ThrVal: 2.854 ± 0.015	0.589ThrTrp: 0.589 ± 0.007	1.808ThrTyr: 1.808 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	2.829ValAla: 2.829 ± 0.017	1.474ValCys: 1.474 ± 0.013	2.967ValAsp: 2.967 ± 0.018	3.322ValGlu: 3.322 ± 0.017	2.899ValPhe: 2.899 ± 0.016	2.295ValGly: 2.295 ± 0.023	1.487ValHis: 1.487 ± 0.01	3.778ValIle: 3.778 ± 0.019	3.772ValLys: 3.772 ± 0.018	5.132ValLeu: 5.132 ± 0.023	1.351ValMet: 1.351 ± 0.012	3.107ValAsn: 3.107 ± 0.018	1.885ValPro: 1.885 ± 0.015	2.523ValGln: 2.523 ± 0.017	2.412ValArg: 2.412 ± 0.013	4.327ValSer: 4.327 ± 0.02	2.881ValThr: 2.881 ± 0.016	3.561ValVal: 3.561 ± 0.023	0.872ValTrp: 0.872 ± 0.01	2.015ValTyr: 2.015 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.402TrpAla: 0.402 ± 0.006	0.297TrpCys: 0.297 ± 0.005	1.39TrpAsp: 1.39 ± 0.019	0.63TrpGlu: 0.63 ± 0.007	0.537TrpPhe: 0.537 ± 0.008	0.461TrpGly: 0.461 ± 0.006	0.291TrpHis: 0.291 ± 0.005	1.037TrpIle: 1.037 ± 0.01	1.276TrpLys: 1.276 ± 0.011	1.07TrpLeu: 1.07 ± 0.011	0.352TrpMet: 0.352 ± 0.006	1.072TrpAsn: 1.072 ± 0.009	0.309TrpPro: 0.309 ± 0.005	0.47TrpGln: 0.47 ± 0.006	0.534TrpArg: 0.534 ± 0.007	0.929TrpSer: 0.929 ± 0.008	0.73TrpThr: 0.73 ± 0.009	0.574TrpVal: 0.574 ± 0.006	0.175TrpTrp: 0.175 ± 0.004	0.438TrpTyr: 0.438 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.519TyrAla: 1.519 ± 0.011	0.943TyrCys: 0.943 ± 0.009	1.837TyrAsp: 1.837 ± 0.012	1.822TyrGlu: 1.822 ± 0.012	2.13TyrPhe: 2.13 ± 0.014	1.553TyrGly: 1.553 ± 0.012	1.136TyrHis: 1.136 ± 0.012	2.337TyrIle: 2.337 ± 0.017	2.056TyrLys: 2.056 ± 0.013	3.427TyrLeu: 3.427 ± 0.019	0.757TyrMet: 0.757 ± 0.007	1.913TyrAsn: 1.913 ± 0.016	1.127TyrPro: 1.127 ± 0.011	1.481TyrGln: 1.481 ± 0.012	1.331TyrArg: 1.331 ± 0.01	2.397TyrSer: 2.397 ± 0.017	1.571TyrThr: 1.571 ± 0.011	2.368TyrVal: 2.368 ± 0.015	0.466TyrTrp: 0.466 ± 0.006	1.517TyrTyr: 1.517 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 39903 proteins (12687417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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