Amino acid dipepetide frequency for Enterococcus ratti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.047AlaAla: 5.047 ± 0.103	0.52AlaCys: 0.52 ± 0.031	3.036AlaAsp: 3.036 ± 0.068	4.052AlaGlu: 4.052 ± 0.08	2.959AlaPhe: 2.959 ± 0.071	4.403AlaGly: 4.403 ± 0.104	1.14AlaHis: 1.14 ± 0.046	5.713AlaIle: 5.713 ± 0.111	5.282AlaLys: 5.282 ± 0.096	6.505AlaLeu: 6.505 ± 0.111	1.856AlaMet: 1.856 ± 0.061	3.013AlaAsn: 3.013 ± 0.071	1.847AlaPro: 1.847 ± 0.054	2.824AlaGln: 2.824 ± 0.063	2.474AlaArg: 2.474 ± 0.075	3.86AlaSer: 3.86 ± 0.068	3.762AlaThr: 3.762 ± 0.081	4.748AlaVal: 4.748 ± 0.097	0.524AlaTrp: 0.524 ± 0.028	2.451AlaTyr: 2.451 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.402CysAla: 0.402 ± 0.027	0.098CysCys: 0.098 ± 0.012	0.332CysAsp: 0.332 ± 0.024	0.378CysGlu: 0.378 ± 0.026	0.372CysPhe: 0.372 ± 0.025	0.591CysGly: 0.591 ± 0.032	0.175CysHis: 0.175 ± 0.018	0.456CysIle: 0.456 ± 0.024	0.316CysLys: 0.316 ± 0.021	0.785CysLeu: 0.785 ± 0.037	0.199CysMet: 0.199 ± 0.015	0.243CysAsn: 0.243 ± 0.018	0.295CysPro: 0.295 ± 0.024	0.323CysGln: 0.323 ± 0.023	0.246CysArg: 0.246 ± 0.02	0.488CysSer: 0.488 ± 0.03	0.365CysThr: 0.365 ± 0.025	0.436CysVal: 0.436 ± 0.03	0.079CysTrp: 0.079 ± 0.011	0.35CysTyr: 0.35 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.814AspAla: 2.814 ± 0.066	0.352AspCys: 0.352 ± 0.022	2.004AspAsp: 2.004 ± 0.06	3.801AspGlu: 3.801 ± 0.083	2.546AspPhe: 2.546 ± 0.063	2.842AspGly: 2.842 ± 0.082	1.062AspHis: 1.062 ± 0.045	3.546AspIle: 3.546 ± 0.084	3.202AspLys: 3.202 ± 0.078	4.6AspLeu: 4.6 ± 0.094	1.103AspMet: 1.103 ± 0.04	1.681AspAsn: 1.681 ± 0.057	1.797AspPro: 1.797 ± 0.053	2.201AspGln: 2.201 ± 0.065	2.039AspArg: 2.039 ± 0.054	2.72AspSer: 2.72 ± 0.066	2.441AspThr: 2.441 ± 0.057	3.184AspVal: 3.184 ± 0.074	0.509AspTrp: 0.509 ± 0.027	2.264AspTyr: 2.264 ± 0.062	0.002AspXaa: 0.002 ± 0.001
Glu	4.995GluAla: 4.995 ± 0.096	0.337GluCys: 0.337 ± 0.022	3.087GluAsp: 3.087 ± 0.075	6.86GluGlu: 6.86 ± 0.122	2.531GluPhe: 2.531 ± 0.07	3.554GluGly: 3.554 ± 0.076	1.122GluHis: 1.122 ± 0.041	5.99GluIle: 5.99 ± 0.096	7.988GluLys: 7.988 ± 0.127	7.277GluLeu: 7.277 ± 0.116	2.404GluMet: 2.404 ± 0.061	4.245GluAsn: 4.245 ± 0.077	1.657GluPro: 1.657 ± 0.055	3.398GluGln: 3.398 ± 0.083	3.147GluArg: 3.147 ± 0.077	3.197GluSer: 3.197 ± 0.063	4.076GluThr: 4.076 ± 0.093	4.697GluVal: 4.697 ± 0.094	0.69GluTrp: 0.69 ± 0.032	2.332GluTyr: 2.332 ± 0.061	0.002GluXaa: 0.002 ± 0.002
Phe	2.913PheAla: 2.913 ± 0.074	0.421PheCys: 0.421 ± 0.027	2.534PheAsp: 2.534 ± 0.06	2.948PheGlu: 2.948 ± 0.063	2.874PhePhe: 2.874 ± 0.076	3.075PheGly: 3.075 ± 0.083	0.986PheHis: 0.986 ± 0.039	3.807PheIle: 3.807 ± 0.083	2.66PheLys: 2.66 ± 0.072	5.028PheLeu: 5.028 ± 0.113	1.136PheMet: 1.136 ± 0.038	2.059PheAsn: 2.059 ± 0.046	1.61PhePro: 1.61 ± 0.05	1.678PheGln: 1.678 ± 0.051	1.509PheArg: 1.509 ± 0.042	3.798PheSer: 3.798 ± 0.09	2.564PheThr: 2.564 ± 0.064	3.09PheVal: 3.09 ± 0.07	0.452PheTrp: 0.452 ± 0.025	2.048PheTyr: 2.048 ± 0.066	0.0PheXaa: 0.0 ± 0.0
Gly	4.058GlyAla: 4.058 ± 0.102	0.476GlyCys: 0.476 ± 0.029	2.64GlyAsp: 2.64 ± 0.072	3.872GlyGlu: 3.872 ± 0.083	3.024GlyPhe: 3.024 ± 0.069	4.168GlyGly: 4.168 ± 0.106	1.098GlyHis: 1.098 ± 0.041	5.729GlyIle: 5.729 ± 0.119	5.075GlyLys: 5.075 ± 0.086	5.976GlyLeu: 5.976 ± 0.115	1.832GlyMet: 1.832 ± 0.065	2.848GlyAsn: 2.848 ± 0.068	1.287GlyPro: 1.287 ± 0.045	2.244GlyGln: 2.244 ± 0.061	2.377GlyArg: 2.377 ± 0.068	3.448GlySer: 3.448 ± 0.078	3.801GlyThr: 3.801 ± 0.083	4.335GlyVal: 4.335 ± 0.087	0.646GlyTrp: 0.646 ± 0.031	2.645GlyTyr: 2.645 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.208HisAla: 1.208 ± 0.041	0.156HisCys: 0.156 ± 0.014	0.764HisAsp: 0.764 ± 0.034	1.237HisGlu: 1.237 ± 0.046	1.16HisPhe: 1.16 ± 0.046	1.22HisGly: 1.22 ± 0.046	0.512HisHis: 0.512 ± 0.029	1.119HisIle: 1.119 ± 0.041	0.942HisLys: 0.942 ± 0.041	2.172HisLeu: 2.172 ± 0.064	0.426HisMet: 0.426 ± 0.025	0.627HisAsn: 0.627 ± 0.031	1.004HisPro: 1.004 ± 0.047	1.001HisGln: 1.001 ± 0.043	0.754HisArg: 0.754 ± 0.035	1.178HisSer: 1.178 ± 0.043	1.041HisThr: 1.041 ± 0.044	1.279HisVal: 1.279 ± 0.047	0.19HisTrp: 0.19 ± 0.016	0.956HisTyr: 0.956 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	5.519IleAla: 5.519 ± 0.108	0.693IleCys: 0.693 ± 0.031	4.551IleAsp: 4.551 ± 0.086	5.756IleGlu: 5.756 ± 0.087	3.638IlePhe: 3.638 ± 0.088	5.446IleGly: 5.446 ± 0.111	1.675IleHis: 1.675 ± 0.045	5.795IleIle: 5.795 ± 0.111	5.357IleLys: 5.357 ± 0.094	7.37IleLeu: 7.37 ± 0.121	1.756IleMet: 1.756 ± 0.058	3.773IleAsn: 3.773 ± 0.079	3.163IlePro: 3.163 ± 0.068	3.44IleGln: 3.44 ± 0.089	3.163IleArg: 3.163 ± 0.07	5.066IleSer: 5.066 ± 0.097	4.282IleThr: 4.282 ± 0.079	5.303IleVal: 5.303 ± 0.087	0.615IleTrp: 0.615 ± 0.034	2.96IleTyr: 2.96 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	4.816LysAla: 4.816 ± 0.099	0.31LysCys: 0.31 ± 0.021	3.619LysAsp: 3.619 ± 0.079	8.441LysGlu: 8.441 ± 0.129	2.22LysPhe: 2.22 ± 0.065	4.144LysGly: 4.144 ± 0.08	1.306LysHis: 1.306 ± 0.047	6.452LysIle: 6.452 ± 0.085	8.991LysLys: 8.991 ± 0.139	6.233LysLeu: 6.233 ± 0.102	2.679LysMet: 2.679 ± 0.068	4.999LysAsn: 4.999 ± 0.086	1.917LysPro: 1.917 ± 0.056	3.954LysGln: 3.954 ± 0.103	3.628LysArg: 3.628 ± 0.077	3.456LysSer: 3.456 ± 0.076	4.393LysThr: 4.393 ± 0.088	4.735LysVal: 4.735 ± 0.093	0.72LysTrp: 0.72 ± 0.04	2.545LysTyr: 2.545 ± 0.064	0.002LysXaa: 0.002 ± 0.002
Leu	7.464LeuAla: 7.464 ± 0.117	0.698LeuCys: 0.698 ± 0.034	4.665LeuAsp: 4.665 ± 0.094	6.443LeuGlu: 6.443 ± 0.11	5.309LeuPhe: 5.309 ± 0.129	6.115LeuGly: 6.115 ± 0.105	1.69LeuHis: 1.69 ± 0.047	7.476LeuIle: 7.476 ± 0.132	7.441LeuLys: 7.441 ± 0.117	10.645LeuLeu: 10.645 ± 0.162	2.545LeuMet: 2.545 ± 0.063	4.992LeuAsn: 4.992 ± 0.086	3.848LeuPro: 3.848 ± 0.078	3.614LeuGln: 3.614 ± 0.081	3.446LeuArg: 3.446 ± 0.077	7.044LeuSer: 7.044 ± 0.11	6.176LeuThr: 6.176 ± 0.095	6.268LeuVal: 6.268 ± 0.092	0.692LeuTrp: 0.692 ± 0.035	3.114LeuTyr: 3.114 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.827MetAla: 1.827 ± 0.06	0.154MetCys: 0.154 ± 0.014	1.322MetAsp: 1.322 ± 0.041	1.843MetGlu: 1.843 ± 0.051	1.015MetPhe: 1.015 ± 0.046	1.673MetGly: 1.673 ± 0.053	0.313MetHis: 0.313 ± 0.023	2.474MetIle: 2.474 ± 0.057	2.581MetLys: 2.581 ± 0.061	2.409MetLeu: 2.409 ± 0.071	0.855MetMet: 0.855 ± 0.04	1.672MetAsn: 1.672 ± 0.052	0.917MetPro: 0.917 ± 0.038	0.991MetGln: 0.991 ± 0.038	1.027MetArg: 1.027 ± 0.037	1.483MetSer: 1.483 ± 0.048	1.685MetThr: 1.685 ± 0.054	1.723MetVal: 1.723 ± 0.052	0.184MetTrp: 0.184 ± 0.018	0.788MetTyr: 0.788 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	2.793AsnAla: 2.793 ± 0.059	0.391AsnCys: 0.391 ± 0.027	2.268AsnAsp: 2.268 ± 0.054	3.939AsnGlu: 3.939 ± 0.081	2.142AsnPhe: 2.142 ± 0.063	3.344AsnGly: 3.344 ± 0.074	1.251AsnHis: 1.251 ± 0.041	3.395AsnIle: 3.395 ± 0.073	3.675AsnLys: 3.675 ± 0.086	4.36AsnLeu: 4.36 ± 0.079	1.166AsnMet: 1.166 ± 0.038	2.258AsnAsn: 2.258 ± 0.07	1.926AsnPro: 1.926 ± 0.061	2.821AsnGln: 2.821 ± 0.075	2.063AsnArg: 2.063 ± 0.058	2.561AsnSer: 2.561 ± 0.067	2.394AsnThr: 2.394 ± 0.073	3.01AsnVal: 3.01 ± 0.077	0.547AsnTrp: 0.547 ± 0.029	2.279AsnTyr: 2.279 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.06ProAla: 2.06 ± 0.064	0.183ProCys: 0.183 ± 0.015	1.631ProAsp: 1.631 ± 0.055	2.681ProGlu: 2.681 ± 0.069	1.791ProPhe: 1.791 ± 0.046	1.63ProGly: 1.63 ± 0.057	0.618ProHis: 0.618 ± 0.032	2.729ProIle: 2.729 ± 0.065	2.433ProLys: 2.433 ± 0.064	3.164ProLeu: 3.164 ± 0.063	0.784ProMet: 0.784 ± 0.032	1.746ProAsn: 1.746 ± 0.052	0.657ProPro: 0.657 ± 0.029	1.379ProGln: 1.379 ± 0.051	0.988ProArg: 0.988 ± 0.043	2.009ProSer: 2.009 ± 0.062	2.063ProThr: 2.063 ± 0.055	2.407ProVal: 2.407 ± 0.06	0.278ProTrp: 0.278 ± 0.021	1.377ProTyr: 1.377 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.391GlnAla: 3.391 ± 0.079	0.205GlnCys: 0.205 ± 0.019	1.468GlnAsp: 1.468 ± 0.044	3.634GlnGlu: 3.634 ± 0.106	1.74GlnPhe: 1.74 ± 0.052	2.252GlnGly: 2.252 ± 0.059	0.717GlnHis: 0.717 ± 0.03	3.119GlnIle: 3.119 ± 0.066	3.948GlnLys: 3.948 ± 0.102	5.221GlnLeu: 5.221 ± 0.092	1.261GlnMet: 1.261 ± 0.046	1.929GlnAsn: 1.929 ± 0.059	1.309GlnPro: 1.309 ± 0.052	2.367GlnGln: 2.367 ± 0.072	1.769GlnArg: 1.769 ± 0.057	2.11GlnSer: 2.11 ± 0.058	2.696GlnThr: 2.696 ± 0.06	2.864GlnVal: 2.864 ± 0.069	0.45GlnTrp: 0.45 ± 0.027	1.377GlnTyr: 1.377 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.099ArgAla: 2.099 ± 0.065	0.261ArgCys: 0.261 ± 0.018	1.476ArgAsp: 1.476 ± 0.06	2.777ArgGlu: 2.777 ± 0.074	1.989ArgPhe: 1.989 ± 0.054	2.062ArgGly: 2.062 ± 0.056	0.769ArgHis: 0.769 ± 0.033	3.108ArgIle: 3.108 ± 0.067	3.658ArgLys: 3.658 ± 0.081	4.152ArgLeu: 4.152 ± 0.091	1.198ArgMet: 1.198 ± 0.049	1.912ArgAsn: 1.912 ± 0.063	1.279ArgPro: 1.279 ± 0.051	1.879ArgGln: 1.879 ± 0.059	1.88ArgArg: 1.88 ± 0.059	2.099ArgSer: 2.099 ± 0.056	1.962ArgThr: 1.962 ± 0.055	2.412ArgVal: 2.412 ± 0.062	0.353ArgTrp: 0.353 ± 0.023	1.69ArgTyr: 1.69 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	3.335SerAla: 3.335 ± 0.076	0.403SerCys: 0.403 ± 0.029	2.814SerAsp: 2.814 ± 0.067	3.978SerGlu: 3.978 ± 0.087	3.4SerPhe: 3.4 ± 0.088	4.045SerGly: 4.045 ± 0.07	1.083SerHis: 1.083 ± 0.043	4.705SerIle: 4.705 ± 0.095	4.265SerLys: 4.265 ± 0.079	6.239SerLeu: 6.239 ± 0.109	1.503SerMet: 1.503 ± 0.047	2.705SerAsn: 2.705 ± 0.069	1.752SerPro: 1.752 ± 0.051	2.341SerGln: 2.341 ± 0.057	2.108SerArg: 2.108 ± 0.062	3.989SerSer: 3.989 ± 0.101	3.359SerThr: 3.359 ± 0.083	3.983SerVal: 3.983 ± 0.076	0.612SerTrp: 0.612 ± 0.03	2.392SerTyr: 2.392 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	3.797ThrAla: 3.797 ± 0.086	0.332ThrCys: 0.332 ± 0.02	2.823ThrAsp: 2.823 ± 0.071	3.403ThrGlu: 3.403 ± 0.08	2.712ThrPhe: 2.712 ± 0.069	3.886ThrGly: 3.886 ± 0.083	1.136ThrHis: 1.136 ± 0.039	5.189ThrIle: 5.189 ± 0.101	4.313ThrLys: 4.313 ± 0.088	5.446ThrLeu: 5.446 ± 0.096	1.364ThrMet: 1.364 ± 0.051	2.857ThrAsn: 2.857 ± 0.069	2.296ThrPro: 2.296 ± 0.062	2.197ThrGln: 2.197 ± 0.063	1.945ThrArg: 1.945 ± 0.062	3.43ThrSer: 3.43 ± 0.081	3.53ThrThr: 3.53 ± 0.095	4.093ThrVal: 4.093 ± 0.087	0.453ThrTrp: 0.453 ± 0.025	2.142ThrTyr: 2.142 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.81ValAla: 4.81 ± 0.101	0.5ValCys: 0.5 ± 0.028	3.344ValAsp: 3.344 ± 0.075	4.422ValGlu: 4.422 ± 0.087	3.005ValPhe: 3.005 ± 0.069	4.131ValGly: 4.131 ± 0.089	1.145ValHis: 1.145 ± 0.044	5.398ValIle: 5.398 ± 0.098	4.708ValLys: 4.708 ± 0.102	6.511ValLeu: 6.511 ± 0.119	1.802ValMet: 1.802 ± 0.055	2.98ValAsn: 2.98 ± 0.069	2.453ValPro: 2.453 ± 0.064	2.29ValGln: 2.29 ± 0.053	2.383ValArg: 2.383 ± 0.065	4.339ValSer: 4.339 ± 0.087	4.235ValThr: 4.235 ± 0.088	4.593ValVal: 4.593 ± 0.102	0.497ValTrp: 0.497 ± 0.024	2.415ValTyr: 2.415 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.464TrpAla: 0.464 ± 0.025	0.074TrpCys: 0.074 ± 0.011	0.396TrpAsp: 0.396 ± 0.025	0.6TrpGlu: 0.6 ± 0.029	0.474TrpPhe: 0.474 ± 0.029	0.597TrpGly: 0.597 ± 0.033	0.183TrpHis: 0.183 ± 0.018	0.651TrpIle: 0.651 ± 0.031	0.597TrpLys: 0.597 ± 0.031	1.201TrpLeu: 1.201 ± 0.048	0.242TrpMet: 0.242 ± 0.018	0.501TrpAsn: 0.501 ± 0.026	0.178TrpPro: 0.178 ± 0.015	0.533TrpGln: 0.533 ± 0.028	0.372TrpArg: 0.372 ± 0.026	0.536TrpSer: 0.536 ± 0.032	0.5TrpThr: 0.5 ± 0.03	0.494TrpVal: 0.494 ± 0.031	0.104TrpTrp: 0.104 ± 0.012	0.305TrpTyr: 0.305 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.207TyrAla: 2.207 ± 0.06	0.365TyrCys: 0.365 ± 0.023	1.936TyrAsp: 1.936 ± 0.057	2.522TyrGlu: 2.522 ± 0.064	2.29TyrPhe: 2.29 ± 0.065	2.403TyrGly: 2.403 ± 0.061	0.967TyrHis: 0.967 ± 0.043	2.466TyrIle: 2.466 ± 0.063	2.128TyrLys: 2.128 ± 0.066	4.39TyrLeu: 4.39 ± 0.094	0.825TyrMet: 0.825 ± 0.036	1.542TyrAsn: 1.542 ± 0.056	1.417TyrPro: 1.417 ± 0.046	2.35TyrGln: 2.35 ± 0.068	1.698TyrArg: 1.698 ± 0.057	2.197TyrSer: 2.197 ± 0.062	2.019TyrThr: 2.019 ± 0.06	2.306TyrVal: 2.306 ± 0.063	0.405TyrTrp: 0.405 ± 0.024	1.763TyrTyr: 1.763 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.002XaaLys: 0.002 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2411 proteins (662122 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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