Amino acid dipepetide frequency for Tremella mesenterica (Jelly fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.173AlaAla: 6.173 ± 0.058	0.791AlaCys: 0.791 ± 0.015	3.252AlaAsp: 3.252 ± 0.032	4.421AlaGlu: 4.421 ± 0.042	2.46AlaPhe: 2.46 ± 0.029	4.715AlaGly: 4.715 ± 0.039	1.552AlaHis: 1.552 ± 0.02	3.479AlaIle: 3.479 ± 0.034	3.418AlaLys: 3.418 ± 0.037	6.952AlaLeu: 6.952 ± 0.052	1.686AlaMet: 1.686 ± 0.02	2.124AlaAsn: 2.124 ± 0.028	4.201AlaPro: 4.201 ± 0.047	2.918AlaGln: 2.918 ± 0.032	4.354AlaArg: 4.354 ± 0.035	6.248AlaSer: 6.248 ± 0.042	4.136AlaThr: 4.136 ± 0.037	4.345AlaVal: 4.345 ± 0.035	0.98AlaTrp: 0.98 ± 0.017	1.752AlaTyr: 1.752 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.635CysAla: 0.635 ± 0.014	0.184CysCys: 0.184 ± 0.009	0.518CysAsp: 0.518 ± 0.011	0.503CysGlu: 0.503 ± 0.011	0.387CysPhe: 0.387 ± 0.01	0.755CysGly: 0.755 ± 0.02	0.265CysHis: 0.265 ± 0.009	0.509CysIle: 0.509 ± 0.012	0.415CysLys: 0.415 ± 0.011	1.115CysLeu: 1.115 ± 0.019	0.219CysMet: 0.219 ± 0.007	0.292CysAsn: 0.292 ± 0.01	0.621CysPro: 0.621 ± 0.014	0.411CysGln: 0.411 ± 0.012	0.571CysArg: 0.571 ± 0.013	0.776CysSer: 0.776 ± 0.015	0.575CysThr: 0.575 ± 0.011	0.677CysVal: 0.677 ± 0.014	0.168CysTrp: 0.168 ± 0.006	0.266CysTyr: 0.266 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.425AspAla: 3.425 ± 0.031	0.504AspCys: 0.504 ± 0.011	4.21AspAsp: 4.21 ± 0.05	4.795AspGlu: 4.795 ± 0.049	1.834AspPhe: 1.834 ± 0.024	3.972AspGly: 3.972 ± 0.036	1.37AspHis: 1.37 ± 0.021	2.87AspIle: 2.87 ± 0.028	2.543AspLys: 2.543 ± 0.032	5.247AspLeu: 5.247 ± 0.043	1.319AspMet: 1.319 ± 0.018	1.682AspAsn: 1.682 ± 0.019	3.664AspPro: 3.664 ± 0.033	2.105AspGln: 2.105 ± 0.023	3.113AspArg: 3.113 ± 0.03	4.06AspSer: 4.06 ± 0.029	2.99AspThr: 2.99 ± 0.029	3.721AspVal: 3.721 ± 0.031	0.864AspTrp: 0.864 ± 0.014	1.323AspTyr: 1.323 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.554GluAla: 4.554 ± 0.039	0.535GluCys: 0.535 ± 0.013	4.517GluAsp: 4.517 ± 0.046	7.02GluGlu: 7.02 ± 0.065	1.593GluPhe: 1.593 ± 0.021	4.83GluGly: 4.83 ± 0.035	1.333GluHis: 1.333 ± 0.021	3.252GluIle: 3.252 ± 0.035	4.058GluLys: 4.058 ± 0.047	5.057GluLeu: 5.057 ± 0.043	1.885GluMet: 1.885 ± 0.024	2.228GluAsn: 2.228 ± 0.023	2.626GluPro: 2.626 ± 0.031	2.324GluGln: 2.324 ± 0.031	4.516GluArg: 4.516 ± 0.045	4.372GluSer: 4.372 ± 0.037	3.608GluThr: 3.608 ± 0.034	4.173GluVal: 4.173 ± 0.033	0.973GluTrp: 0.973 ± 0.016	1.542GluTyr: 1.542 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.301PheAla: 2.301 ± 0.028	0.424PheCys: 0.424 ± 0.01	2.053PheAsp: 2.053 ± 0.022	1.845PheGlu: 1.845 ± 0.023	1.277PhePhe: 1.277 ± 0.019	2.48PheGly: 2.48 ± 0.034	0.851PheHis: 0.851 ± 0.017	1.535PheIle: 1.535 ± 0.022	1.319PheLys: 1.319 ± 0.018	3.044PheLeu: 3.044 ± 0.03	0.603PheMet: 0.603 ± 0.013	1.142PheAsn: 1.142 ± 0.019	2.049PhePro: 2.049 ± 0.027	1.17PheGln: 1.17 ± 0.018	1.758PheArg: 1.758 ± 0.025	2.939PheSer: 2.939 ± 0.027	1.969PheThr: 1.969 ± 0.022	1.988PheVal: 1.988 ± 0.024	0.471PheTrp: 0.471 ± 0.01	0.823PheTyr: 0.823 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.008GlyAla: 4.008 ± 0.044	0.686GlyCys: 0.686 ± 0.016	3.577GlyAsp: 3.577 ± 0.036	4.612GlyGlu: 4.612 ± 0.038	2.29GlyPhe: 2.29 ± 0.028	6.025GlyGly: 6.025 ± 0.068	1.636GlyHis: 1.636 ± 0.023	3.345GlyIle: 3.345 ± 0.032	4.129GlyLys: 4.129 ± 0.038	5.989GlyLeu: 5.989 ± 0.043	2.003GlyMet: 2.003 ± 0.031	2.396GlyAsn: 2.396 ± 0.032	3.461GlyPro: 3.461 ± 0.036	2.867GlyGln: 2.867 ± 0.034	4.373GlyArg: 4.373 ± 0.038	5.773GlySer: 5.773 ± 0.046	3.859GlyThr: 3.859 ± 0.037	4.49GlyVal: 4.49 ± 0.037	1.29GlyTrp: 1.29 ± 0.021	1.843GlyTyr: 1.843 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.581HisAla: 1.581 ± 0.02	0.257HisCys: 0.257 ± 0.009	1.246HisAsp: 1.246 ± 0.021	1.273HisGlu: 1.273 ± 0.019	0.848HisPhe: 0.848 ± 0.015	1.533HisGly: 1.533 ± 0.023	0.943HisHis: 0.943 ± 0.017	1.227HisIle: 1.227 ± 0.016	0.879HisLys: 0.879 ± 0.015	2.715HisLeu: 2.715 ± 0.032	0.47HisMet: 0.47 ± 0.01	0.799HisAsn: 0.799 ± 0.015	2.245HisPro: 2.245 ± 0.031	1.007HisGln: 1.007 ± 0.017	1.507HisArg: 1.507 ± 0.021	2.391HisSer: 2.391 ± 0.032	1.543HisThr: 1.543 ± 0.021	1.492HisVal: 1.492 ± 0.018	0.295HisTrp: 0.295 ± 0.008	0.584HisTyr: 0.584 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.399IleAla: 3.399 ± 0.034	0.598IleCys: 0.598 ± 0.012	2.818IleAsp: 2.818 ± 0.032	2.725IleGlu: 2.725 ± 0.028	1.693IlePhe: 1.693 ± 0.026	3.098IleGly: 3.098 ± 0.034	1.318IleHis: 1.318 ± 0.018	2.562IleIle: 2.562 ± 0.03	2.265IleLys: 2.265 ± 0.025	4.515IleLeu: 4.515 ± 0.043	0.957IleMet: 0.957 ± 0.014	1.791IleAsn: 1.791 ± 0.022	3.989IlePro: 3.989 ± 0.037	1.887IleGln: 1.887 ± 0.024	2.989IleArg: 2.989 ± 0.03	4.709IleSer: 4.709 ± 0.04	2.969IleThr: 2.969 ± 0.026	2.851IleVal: 2.851 ± 0.028	0.672IleTrp: 0.672 ± 0.014	1.196IleTyr: 1.196 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.74LysAla: 3.74 ± 0.034	0.426LysCys: 0.426 ± 0.012	2.787LysAsp: 2.787 ± 0.035	3.94LysGlu: 3.94 ± 0.044	1.199LysPhe: 1.199 ± 0.018	3.451LysGly: 3.451 ± 0.031	1.038LysHis: 1.038 ± 0.015	2.236LysIle: 2.236 ± 0.026	3.352LysLys: 3.352 ± 0.048	3.825LysLeu: 3.825 ± 0.038	1.1LysMet: 1.1 ± 0.018	1.572LysAsn: 1.572 ± 0.021	2.724LysPro: 2.724 ± 0.032	1.675LysGln: 1.675 ± 0.023	3.748LysArg: 3.748 ± 0.031	3.858LysSer: 3.858 ± 0.041	2.917LysThr: 2.917 ± 0.03	3.075LysVal: 3.075 ± 0.035	0.68LysTrp: 0.68 ± 0.015	1.143LysTyr: 1.143 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	6.979LeuAla: 6.979 ± 0.051	1.019LeuCys: 1.019 ± 0.017	5.063LeuAsp: 5.063 ± 0.04	5.514LeuGlu: 5.514 ± 0.042	2.924LeuPhe: 2.924 ± 0.029	5.999LeuGly: 5.999 ± 0.055	2.316LeuHis: 2.316 ± 0.025	4.132LeuIle: 4.132 ± 0.039	4.068LeuLys: 4.068 ± 0.042	8.617LeuLeu: 8.617 ± 0.07	1.609LeuMet: 1.609 ± 0.021	3.188LeuAsn: 3.188 ± 0.031	7.09LeuPro: 7.09 ± 0.054	3.528LeuGln: 3.528 ± 0.034	5.802LeuArg: 5.802 ± 0.04	9.027LeuSer: 9.027 ± 0.053	5.334LeuThr: 5.334 ± 0.039	5.268LeuVal: 5.268 ± 0.047	1.05LeuTrp: 1.05 ± 0.016	2.004LeuTyr: 2.004 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.683MetAla: 1.683 ± 0.021	0.21MetCys: 0.21 ± 0.006	1.306MetAsp: 1.306 ± 0.015	1.509MetGlu: 1.509 ± 0.021	0.683MetPhe: 0.683 ± 0.012	1.669MetGly: 1.669 ± 0.025	0.318MetHis: 0.318 ± 0.01	1.086MetIle: 1.086 ± 0.018	1.043MetLys: 1.043 ± 0.018	1.754MetLeu: 1.754 ± 0.02	0.587MetMet: 0.587 ± 0.013	0.849MetAsn: 0.849 ± 0.016	1.196MetPro: 1.196 ± 0.017	0.688MetGln: 0.688 ± 0.014	1.344MetArg: 1.344 ± 0.021	2.437MetSer: 2.437 ± 0.023	1.602MetThr: 1.602 ± 0.021	1.3MetVal: 1.3 ± 0.02	0.267MetTrp: 0.267 ± 0.008	0.495MetTyr: 0.495 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.332AsnAla: 2.332 ± 0.03	0.312AsnCys: 0.312 ± 0.009	1.926AsnAsp: 1.926 ± 0.021	2.01AsnGlu: 2.01 ± 0.02	1.096AsnPhe: 1.096 ± 0.017	2.872AsnGly: 2.872 ± 0.034	0.949AsnHis: 0.949 ± 0.017	1.805AsnIle: 1.805 ± 0.023	1.534AsnLys: 1.534 ± 0.021	3.276AsnLeu: 3.276 ± 0.027	0.773AsnMet: 0.773 ± 0.016	1.323AsnAsn: 1.323 ± 0.026	2.686AsnPro: 2.686 ± 0.031	1.456AsnGln: 1.456 ± 0.024	1.843AsnArg: 1.843 ± 0.02	2.951AsnSer: 2.951 ± 0.038	2.247AsnThr: 2.247 ± 0.029	2.339AsnVal: 2.339 ± 0.025	0.436AsnTrp: 0.436 ± 0.01	0.783AsnTyr: 0.783 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.455ProAla: 4.455 ± 0.049	0.467ProCys: 0.467 ± 0.013	3.291ProAsp: 3.291 ± 0.034	3.562ProGlu: 3.562 ± 0.034	2.185ProPhe: 2.185 ± 0.025	3.866ProGly: 3.866 ± 0.043	1.784ProHis: 1.784 ± 0.025	3.495ProIle: 3.495 ± 0.035	2.711ProLys: 2.711 ± 0.028	6.081ProLeu: 6.081 ± 0.042	1.206ProMet: 1.206 ± 0.019	2.546ProAsn: 2.546 ± 0.028	7.581ProPro: 7.581 ± 0.1	2.677ProGln: 2.677 ± 0.04	3.823ProArg: 3.823 ± 0.041	9.155ProSer: 9.155 ± 0.084	5.54ProThr: 5.54 ± 0.049	3.822ProVal: 3.822 ± 0.033	0.68ProTrp: 0.68 ± 0.013	1.553ProTyr: 1.553 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.194GlnAla: 3.194 ± 0.034	0.353GlnCys: 0.353 ± 0.01	2.018GlnAsp: 2.018 ± 0.024	2.369GlnGlu: 2.369 ± 0.028	1.014GlnPhe: 1.014 ± 0.016	2.493GlnGly: 2.493 ± 0.029	1.004GlnHis: 1.004 ± 0.019	1.944GlnIle: 1.944 ± 0.023	1.656GlnLys: 1.656 ± 0.024	3.428GlnLeu: 3.428 ± 0.03	0.918GlnMet: 0.918 ± 0.019	1.52GlnAsn: 1.52 ± 0.024	2.782GlnPro: 2.782 ± 0.04	2.001GlnGln: 2.001 ± 0.055	2.477GlnArg: 2.477 ± 0.028	3.644GlnSer: 3.644 ± 0.036	2.675GlnThr: 2.675 ± 0.032	2.421GlnVal: 2.421 ± 0.026	0.505GlnTrp: 0.505 ± 0.012	0.98GlnTyr: 0.98 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.282ArgAla: 4.282 ± 0.039	0.556ArgCys: 0.556 ± 0.012	3.235ArgAsp: 3.235 ± 0.033	4.214ArgGlu: 4.214 ± 0.041	1.872ArgPhe: 1.872 ± 0.022	3.923ArgGly: 3.923 ± 0.037	1.595ArgHis: 1.595 ± 0.022	2.902ArgIle: 2.902 ± 0.029	3.563ArgLys: 3.563 ± 0.035	5.674ArgLeu: 5.674 ± 0.042	1.483ArgMet: 1.483 ± 0.023	2.055ArgAsn: 2.055 ± 0.023	4.215ArgPro: 4.215 ± 0.042	2.668ArgGln: 2.668 ± 0.027	5.468ArgArg: 5.468 ± 0.057	5.466ArgSer: 5.466 ± 0.054	3.508ArgThr: 3.508 ± 0.032	3.393ArgVal: 3.393 ± 0.029	0.903ArgTrp: 0.903 ± 0.016	1.543ArgTyr: 1.543 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.158SerAla: 6.158 ± 0.048	0.726SerCys: 0.726 ± 0.015	4.745SerAsp: 4.745 ± 0.043	4.67SerGlu: 4.67 ± 0.042	3.069SerPhe: 3.069 ± 0.028	6.025SerGly: 6.025 ± 0.05	2.592SerHis: 2.592 ± 0.035	4.517SerIle: 4.517 ± 0.034	3.962SerLys: 3.962 ± 0.036	8.61SerLeu: 8.61 ± 0.055	1.849SerMet: 1.849 ± 0.022	3.527SerAsn: 3.527 ± 0.037	7.837SerPro: 7.837 ± 0.084	3.855SerGln: 3.855 ± 0.041	5.543SerArg: 5.543 ± 0.044	12.773SerSer: 12.773 ± 0.134	7.452SerThr: 7.452 ± 0.057	4.966SerVal: 4.966 ± 0.036	1.007SerTrp: 1.007 ± 0.017	1.945SerTyr: 1.945 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	4.307ThrAla: 4.307 ± 0.04	0.641ThrCys: 0.641 ± 0.014	2.872ThrAsp: 2.872 ± 0.027	3.202ThrGlu: 3.202 ± 0.03	2.32ThrPhe: 2.32 ± 0.024	4.006ThrGly: 4.006 ± 0.037	1.542ThrHis: 1.542 ± 0.022	3.245ThrIle: 3.245 ± 0.029	2.591ThrLys: 2.591 ± 0.033	5.8ThrLeu: 5.8 ± 0.041	1.176ThrMet: 1.176 ± 0.018	2.275ThrAsn: 2.275 ± 0.025	5.596ThrPro: 5.596 ± 0.049	2.375ThrGln: 2.375 ± 0.03	3.422ThrArg: 3.422 ± 0.034	7.41ThrSer: 7.41 ± 0.065	4.604ThrThr: 4.604 ± 0.047	3.5ThrVal: 3.5 ± 0.03	0.766ThrTrp: 0.766 ± 0.015	1.595ThrTyr: 1.595 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.065ValAla: 4.065 ± 0.036	0.678ValCys: 0.678 ± 0.013	3.716ValAsp: 3.716 ± 0.033	4.433ValGlu: 4.433 ± 0.049	1.988ValPhe: 1.988 ± 0.024	4.3ValGly: 4.3 ± 0.04	1.411ValHis: 1.411 ± 0.019	3.048ValIle: 3.048 ± 0.029	3.268ValLys: 3.268 ± 0.032	5.351ValLeu: 5.351 ± 0.047	1.379ValMet: 1.379 ± 0.018	2.203ValAsn: 2.203 ± 0.025	3.781ValPro: 3.781 ± 0.032	2.309ValGln: 2.309 ± 0.026	3.576ValArg: 3.576 ± 0.032	4.87ValSer: 4.87 ± 0.038	3.35ValThr: 3.35 ± 0.029	4.172ValVal: 4.172 ± 0.037	0.835ValTrp: 0.835 ± 0.017	1.485ValTyr: 1.485 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.971TrpAla: 0.971 ± 0.017	0.179TrpCys: 0.179 ± 0.007	0.871TrpAsp: 0.871 ± 0.019	0.998TrpGlu: 0.998 ± 0.015	0.448TrpPhe: 0.448 ± 0.01	0.928TrpGly: 0.928 ± 0.018	0.283TrpHis: 0.283 ± 0.008	0.633TrpIle: 0.633 ± 0.012	0.75TrpLys: 0.75 ± 0.015	1.128TrpLeu: 1.128 ± 0.016	0.33TrpMet: 0.33 ± 0.011	0.542TrpAsn: 0.542 ± 0.012	0.553TrpPro: 0.553 ± 0.013	0.496TrpGln: 0.496 ± 0.01	0.93TrpArg: 0.93 ± 0.016	1.068TrpSer: 1.068 ± 0.016	0.864TrpThr: 0.864 ± 0.016	0.826TrpVal: 0.826 ± 0.015	0.292TrpTrp: 0.292 ± 0.009	0.366TrpTyr: 0.366 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.716TyrAla: 1.716 ± 0.021	0.314TyrCys: 0.314 ± 0.008	1.588TyrAsp: 1.588 ± 0.022	1.381TyrGlu: 1.381 ± 0.023	0.863TyrPhe: 0.863 ± 0.014	1.707TyrGly: 1.707 ± 0.025	0.734TyrHis: 0.734 ± 0.013	1.178TyrIle: 1.178 ± 0.02	0.963TyrLys: 0.963 ± 0.017	2.354TyrLeu: 2.354 ± 0.023	0.474TyrMet: 0.474 ± 0.01	0.893TyrAsn: 0.893 ± 0.017	1.583TyrPro: 1.583 ± 0.025	0.979TyrGln: 0.979 ± 0.019	1.365TyrArg: 1.365 ± 0.02	1.9TyrSer: 1.9 ± 0.024	1.502TyrThr: 1.502 ± 0.021	1.402TyrVal: 1.402 ± 0.018	0.321TyrTrp: 0.321 ± 0.008	0.688TyrTyr: 0.688 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8061 proteins (3984402 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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