Amino acid dipepetide frequency for Candidatus Methanoperedens nitroreducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.789AlaAla: 5.789 ± 0.118	0.864AlaCys: 0.864 ± 0.035	3.819AlaAsp: 3.819 ± 0.064	4.44AlaGlu: 4.44 ± 0.081	2.808AlaPhe: 2.808 ± 0.066	6.097AlaGly: 6.097 ± 0.101	1.272AlaHis: 1.272 ± 0.039	5.926AlaIle: 5.926 ± 0.09	3.951AlaLys: 3.951 ± 0.072	7.164AlaLeu: 7.164 ± 0.105	1.899AlaMet: 1.899 ± 0.047	2.435AlaAsn: 2.435 ± 0.061	2.37AlaPro: 2.37 ± 0.051	2.096AlaGln: 2.096 ± 0.061	3.965AlaArg: 3.965 ± 0.075	4.433AlaSer: 4.433 ± 0.079	3.342AlaThr: 3.342 ± 0.071	5.634AlaVal: 5.634 ± 0.093	0.671AlaTrp: 0.671 ± 0.027	2.253AlaTyr: 2.253 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.734CysAla: 0.734 ± 0.028	0.223CysCys: 0.223 ± 0.018	0.582CysAsp: 0.582 ± 0.026	0.699CysGlu: 0.699 ± 0.028	0.373CysPhe: 0.373 ± 0.02	1.189CysGly: 1.189 ± 0.042	0.581CysHis: 0.581 ± 0.072	0.812CysIle: 0.812 ± 0.029	0.618CysLys: 0.618 ± 0.025	0.742CysLeu: 0.742 ± 0.029	0.296CysMet: 0.296 ± 0.017	0.413CysAsn: 0.413 ± 0.022	0.728CysPro: 0.728 ± 0.035	0.259CysGln: 0.259 ± 0.016	0.583CysArg: 0.583 ± 0.028	0.72CysSer: 0.72 ± 0.035	0.633CysThr: 0.633 ± 0.028	0.649CysVal: 0.649 ± 0.027	0.084CysTrp: 0.084 ± 0.01	0.327CysTyr: 0.327 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.008AspAla: 4.008 ± 0.081	0.616AspCys: 0.616 ± 0.031	2.73AspAsp: 2.73 ± 0.069	4.231AspGlu: 4.231 ± 0.068	2.463AspPhe: 2.463 ± 0.052	3.645AspGly: 3.645 ± 0.087	0.852AspHis: 0.852 ± 0.032	6.029AspIle: 6.029 ± 0.084	3.458AspLys: 3.458 ± 0.074	4.83AspLeu: 4.83 ± 0.083	1.581AspMet: 1.581 ± 0.042	2.23AspAsn: 2.23 ± 0.054	2.327AspPro: 2.327 ± 0.06	1.001AspGln: 1.001 ± 0.036	3.027AspArg: 3.027 ± 0.061	3.244AspSer: 3.244 ± 0.078	3.064AspThr: 3.064 ± 0.076	3.802AspVal: 3.802 ± 0.067	0.6AspTrp: 0.6 ± 0.028	2.137AspTyr: 2.137 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.894GluAla: 4.894 ± 0.105	0.68GluCys: 0.68 ± 0.029	3.531GluAsp: 3.531 ± 0.061	5.514GluGlu: 5.514 ± 0.118	2.756GluPhe: 2.756 ± 0.059	4.191GluGly: 4.191 ± 0.072	1.436GluHis: 1.436 ± 0.039	6.551GluIle: 6.551 ± 0.098	5.831GluLys: 5.831 ± 0.109	7.174GluLeu: 7.174 ± 0.101	1.848GluMet: 1.848 ± 0.045	3.153GluAsn: 3.153 ± 0.064	2.306GluPro: 2.306 ± 0.048	1.978GluGln: 1.978 ± 0.055	4.327GluArg: 4.327 ± 0.079	3.738GluSer: 3.738 ± 0.074	3.261GluThr: 3.261 ± 0.072	4.59GluVal: 4.59 ± 0.08	0.687GluTrp: 0.687 ± 0.028	2.532GluTyr: 2.532 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	2.653PheAla: 2.653 ± 0.066	0.461PheCys: 0.461 ± 0.024	2.422PheAsp: 2.422 ± 0.05	2.729PheGlu: 2.729 ± 0.065	1.838PhePhe: 1.838 ± 0.062	3.035PheGly: 3.035 ± 0.069	0.655PheHis: 0.655 ± 0.026	3.526PheIle: 3.526 ± 0.074	2.316PheLys: 2.316 ± 0.055	3.764PheLeu: 3.764 ± 0.085	0.959PheMet: 0.959 ± 0.036	1.879PheAsn: 1.879 ± 0.051	1.431PhePro: 1.431 ± 0.038	0.934PheGln: 0.934 ± 0.038	1.905PheArg: 1.905 ± 0.048	2.942PheSer: 2.942 ± 0.062	2.276PheThr: 2.276 ± 0.048	2.606PheVal: 2.606 ± 0.061	0.463PheTrp: 0.463 ± 0.025	1.497PheTyr: 1.497 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.173GlyAla: 5.173 ± 0.096	0.935GlyCys: 0.935 ± 0.036	3.776GlyAsp: 3.776 ± 0.078	4.721GlyGlu: 4.721 ± 0.087	3.293GlyPhe: 3.293 ± 0.059	5.165GlyGly: 5.165 ± 0.108	1.275GlyHis: 1.275 ± 0.038	7.235GlyIle: 7.235 ± 0.119	4.849GlyLys: 4.849 ± 0.077	6.043GlyLeu: 6.043 ± 0.099	2.109GlyMet: 2.109 ± 0.051	2.831GlyAsn: 2.831 ± 0.083	1.679GlyPro: 1.679 ± 0.043	1.512GlyGln: 1.512 ± 0.042	3.551GlyArg: 3.551 ± 0.068	4.562GlySer: 4.562 ± 0.085	4.422GlyThr: 4.422 ± 0.087	4.754GlyVal: 4.754 ± 0.077	0.837GlyTrp: 0.837 ± 0.03	2.914GlyTyr: 2.914 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.342HisAla: 1.342 ± 0.039	0.249HisCys: 0.249 ± 0.018	1.038HisAsp: 1.038 ± 0.035	1.205HisGlu: 1.205 ± 0.038	0.739HisPhe: 0.739 ± 0.026	1.428HisGly: 1.428 ± 0.04	0.392HisHis: 0.392 ± 0.021	1.554HisIle: 1.554 ± 0.04	0.926HisLys: 0.926 ± 0.034	1.599HisLeu: 1.599 ± 0.041	0.455HisMet: 0.455 ± 0.025	0.82HisAsn: 0.82 ± 0.031	1.03HisPro: 1.03 ± 0.034	0.438HisGln: 0.438 ± 0.025	0.995HisArg: 0.995 ± 0.034	1.092HisSer: 1.092 ± 0.035	0.995HisThr: 0.995 ± 0.034	1.143HisVal: 1.143 ± 0.041	0.163HisTrp: 0.163 ± 0.015	0.642HisTyr: 0.642 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.514IleAla: 6.514 ± 0.096	0.888IleCys: 0.888 ± 0.031	5.094IleAsp: 5.094 ± 0.095	6.555IleGlu: 6.555 ± 0.095	3.423IlePhe: 3.423 ± 0.076	6.059IleGly: 6.059 ± 0.085	1.484IleHis: 1.484 ± 0.042	7.375IleIle: 7.375 ± 0.11	6.004IleLys: 6.004 ± 0.09	8.057IleLeu: 8.057 ± 0.119	1.959IleMet: 1.959 ± 0.041	3.822IleAsn: 3.822 ± 0.075	3.882IlePro: 3.882 ± 0.068	2.192IleGln: 2.192 ± 0.053	4.551IleArg: 4.551 ± 0.078	6.217IleSer: 6.217 ± 0.089	5.162IleThr: 5.162 ± 0.089	5.363IleVal: 5.363 ± 0.084	0.747IleTrp: 0.747 ± 0.031	2.834IleTyr: 2.834 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.122LysAla: 4.122 ± 0.072	0.67LysCys: 0.67 ± 0.029	3.77LysAsp: 3.77 ± 0.066	5.864LysGlu: 5.864 ± 0.105	2.041LysPhe: 2.041 ± 0.055	4.06LysGly: 4.06 ± 0.067	1.109LysHis: 1.109 ± 0.034	5.607LysIle: 5.607 ± 0.083	5.462LysLys: 5.462 ± 0.084	5.397LysLeu: 5.397 ± 0.08	1.763LysMet: 1.763 ± 0.048	3.499LysAsn: 3.499 ± 0.068	2.32LysPro: 2.32 ± 0.047	1.896LysGln: 1.896 ± 0.047	3.557LysArg: 3.557 ± 0.068	3.502LysSer: 3.502 ± 0.06	3.557LysThr: 3.557 ± 0.067	3.658LysVal: 3.658 ± 0.067	0.613LysTrp: 0.613 ± 0.028	2.29LysTyr: 2.29 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.638LeuAla: 6.638 ± 0.11	0.958LeuCys: 0.958 ± 0.033	5.208LeuAsp: 5.208 ± 0.074	6.169LeuGlu: 6.169 ± 0.094	3.753LeuPhe: 3.753 ± 0.087	6.193LeuGly: 6.193 ± 0.1	1.584LeuHis: 1.584 ± 0.042	7.882LeuIle: 7.882 ± 0.113	6.449LeuLys: 6.449 ± 0.102	8.808LeuLeu: 8.808 ± 0.13	2.327LeuMet: 2.327 ± 0.049	4.013LeuAsn: 4.013 ± 0.072	3.698LeuPro: 3.698 ± 0.061	2.148LeuGln: 2.148 ± 0.049	5.041LeuArg: 5.041 ± 0.085	6.661LeuSer: 6.661 ± 0.089	4.672LeuThr: 4.672 ± 0.071	5.804LeuVal: 5.804 ± 0.088	0.828LeuTrp: 0.828 ± 0.033	2.897LeuTyr: 2.897 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.901MetAla: 1.901 ± 0.051	0.228MetCys: 0.228 ± 0.014	1.503MetAsp: 1.503 ± 0.038	1.76MetGlu: 1.76 ± 0.044	0.883MetPhe: 0.883 ± 0.037	1.937MetGly: 1.937 ± 0.049	0.49MetHis: 0.49 ± 0.022	1.954MetIle: 1.954 ± 0.05	1.826MetLys: 1.826 ± 0.044	2.359MetLeu: 2.359 ± 0.059	0.71MetMet: 0.71 ± 0.04	1.218MetAsn: 1.218 ± 0.035	1.172MetPro: 1.172 ± 0.038	0.783MetGln: 0.783 ± 0.029	1.704MetArg: 1.704 ± 0.04	1.462MetSer: 1.462 ± 0.041	1.245MetThr: 1.245 ± 0.036	1.812MetVal: 1.812 ± 0.043	0.218MetTrp: 0.218 ± 0.016	0.701MetTyr: 0.701 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.945AsnAla: 2.945 ± 0.061	0.485AsnCys: 0.485 ± 0.028	1.969AsnAsp: 1.969 ± 0.056	2.74AsnGlu: 2.74 ± 0.056	1.702AsnPhe: 1.702 ± 0.047	2.705AsnGly: 2.705 ± 0.063	0.653AsnHis: 0.653 ± 0.027	4.44AsnIle: 4.44 ± 0.074	2.594AsnLys: 2.594 ± 0.061	3.88AsnLeu: 3.88 ± 0.067	1.049AsnMet: 1.049 ± 0.035	2.305AsnAsn: 2.305 ± 0.071	2.265AsnPro: 2.265 ± 0.057	1.113AsnGln: 1.113 ± 0.037	2.213AsnArg: 2.213 ± 0.05	2.615AsnSer: 2.615 ± 0.076	2.418AsnThr: 2.418 ± 0.068	2.691AsnVal: 2.691 ± 0.071	0.484AsnTrp: 0.484 ± 0.027	1.569AsnTyr: 1.569 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.934ProAla: 2.934 ± 0.065	0.425ProCys: 0.425 ± 0.021	2.876ProAsp: 2.876 ± 0.059	3.581ProGlu: 3.581 ± 0.061	1.629ProPhe: 1.629 ± 0.039	3.178ProGly: 3.178 ± 0.064	0.787ProHis: 0.787 ± 0.025	2.546ProIle: 2.546 ± 0.056	1.95ProLys: 1.95 ± 0.045	3.481ProLeu: 3.481 ± 0.066	0.844ProMet: 0.844 ± 0.034	1.191ProAsn: 1.191 ± 0.035	1.622ProPro: 1.622 ± 0.046	1.136ProGln: 1.136 ± 0.037	1.606ProArg: 1.606 ± 0.042	2.271ProSer: 2.271 ± 0.048	2.084ProThr: 2.084 ± 0.088	3.585ProVal: 3.585 ± 0.063	0.376ProTrp: 0.376 ± 0.02	1.466ProTyr: 1.466 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.883GlnAla: 1.883 ± 0.047	0.277GlnCys: 0.277 ± 0.017	1.349GlnAsp: 1.349 ± 0.041	1.874GlnGlu: 1.874 ± 0.051	0.909GlnPhe: 0.909 ± 0.033	1.513GlnGly: 1.513 ± 0.041	0.486GlnHis: 0.486 ± 0.022	2.205GlnIle: 2.205 ± 0.049	1.883GlnLys: 1.883 ± 0.046	2.208GlnLeu: 2.208 ± 0.047	0.753GlnMet: 0.753 ± 0.028	1.214GlnAsn: 1.214 ± 0.051	0.904GlnPro: 0.904 ± 0.03	0.852GlnGln: 0.852 ± 0.038	1.62GlnArg: 1.62 ± 0.045	1.446GlnSer: 1.446 ± 0.044	1.334GlnThr: 1.334 ± 0.041	1.722GlnVal: 1.722 ± 0.052	0.244GlnTrp: 0.244 ± 0.016	0.909GlnTyr: 0.909 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.802ArgAla: 3.802 ± 0.08	0.617ArgCys: 0.617 ± 0.032	3.071ArgAsp: 3.071 ± 0.064	4.174ArgGlu: 4.174 ± 0.075	2.219ArgPhe: 2.219 ± 0.049	3.499ArgGly: 3.499 ± 0.076	0.884ArgHis: 0.884 ± 0.029	4.887ArgIle: 4.887 ± 0.077	3.502ArgLys: 3.502 ± 0.071	4.924ArgLeu: 4.924 ± 0.079	1.668ArgMet: 1.668 ± 0.047	2.136ArgAsn: 2.136 ± 0.049	1.78ArgPro: 1.78 ± 0.049	1.374ArgGln: 1.374 ± 0.039	2.898ArgArg: 2.898 ± 0.065	3.099ArgSer: 3.099 ± 0.058	2.689ArgThr: 2.689 ± 0.056	3.462ArgVal: 3.462 ± 0.064	0.568ArgTrp: 0.568 ± 0.026	2.132ArgTyr: 2.132 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.311SerAla: 4.311 ± 0.081	0.723SerCys: 0.723 ± 0.04	3.603SerAsp: 3.603 ± 0.086	4.197SerGlu: 4.197 ± 0.079	2.579SerPhe: 2.579 ± 0.054	5.407SerGly: 5.407 ± 0.088	1.169SerHis: 1.169 ± 0.04	5.688SerIle: 5.688 ± 0.092	3.74SerLys: 3.74 ± 0.069	5.658SerLeu: 5.658 ± 0.092	1.555SerMet: 1.555 ± 0.04	2.632SerAsn: 2.632 ± 0.076	2.519SerPro: 2.519 ± 0.059	1.598SerGln: 1.598 ± 0.045	3.352SerArg: 3.352 ± 0.062	4.256SerSer: 4.256 ± 0.088	3.339SerThr: 3.339 ± 0.063	4.083SerVal: 4.083 ± 0.069	0.628SerTrp: 0.628 ± 0.03	2.084SerTyr: 2.084 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.059ThrAla: 4.059 ± 0.082	0.627ThrCys: 0.627 ± 0.031	3.064ThrAsp: 3.064 ± 0.069	3.34ThrGlu: 3.34 ± 0.06	2.055ThrPhe: 2.055 ± 0.052	5.001ThrGly: 5.001 ± 0.093	0.967ThrHis: 0.967 ± 0.031	4.369ThrIle: 4.369 ± 0.08	2.884ThrLys: 2.884 ± 0.053	4.831ThrLeu: 4.831 ± 0.076	1.124ThrMet: 1.124 ± 0.033	1.947ThrAsn: 1.947 ± 0.051	2.856ThrPro: 2.856 ± 0.106	1.433ThrGln: 1.433 ± 0.044	2.527ThrArg: 2.527 ± 0.056	3.18ThrSer: 3.18 ± 0.073	2.902ThrThr: 2.902 ± 0.091	4.002ThrVal: 4.002 ± 0.076	0.585ThrTrp: 0.585 ± 0.043	1.8ThrTyr: 1.8 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.694ValAla: 4.694 ± 0.08	0.786ValCys: 0.786 ± 0.033	3.86ValAsp: 3.86 ± 0.067	4.422ValGlu: 4.422 ± 0.075	2.884ValPhe: 2.884 ± 0.061	4.06ValGly: 4.06 ± 0.07	1.269ValHis: 1.269 ± 0.045	5.904ValIle: 5.904 ± 0.099	4.032ValLys: 4.032 ± 0.072	6.511ValLeu: 6.511 ± 0.098	1.823ValMet: 1.823 ± 0.047	2.776ValAsn: 2.776 ± 0.065	2.882ValPro: 2.882 ± 0.059	1.614ValGln: 1.614 ± 0.04	3.464ValArg: 3.464 ± 0.064	4.537ValSer: 4.537 ± 0.082	3.659ValThr: 3.659 ± 0.063	4.81ValVal: 4.81 ± 0.091	0.627ValTrp: 0.627 ± 0.034	2.217ValTyr: 2.217 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.596TrpAla: 0.596 ± 0.025	0.116TrpCys: 0.116 ± 0.012	0.631TrpAsp: 0.631 ± 0.033	0.619TrpGlu: 0.619 ± 0.031	0.378TrpPhe: 0.378 ± 0.023	0.686TrpGly: 0.686 ± 0.03	0.197TrpHis: 0.197 ± 0.015	0.807TrpIle: 0.807 ± 0.032	0.598TrpLys: 0.598 ± 0.023	0.987TrpLeu: 0.987 ± 0.034	0.362TrpMet: 0.362 ± 0.021	0.581TrpAsn: 0.581 ± 0.032	0.238TrpPro: 0.238 ± 0.016	0.297TrpGln: 0.297 ± 0.018	0.539TrpArg: 0.539 ± 0.022	0.625TrpSer: 0.625 ± 0.031	0.48TrpThr: 0.48 ± 0.026	0.65TrpVal: 0.65 ± 0.028	0.14TrpTrp: 0.14 ± 0.013	0.412TrpTyr: 0.412 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.235TyrAla: 2.235 ± 0.051	0.415TyrCys: 0.415 ± 0.019	1.978TyrAsp: 1.978 ± 0.047	2.148TyrGlu: 2.148 ± 0.047	1.567TyrPhe: 1.567 ± 0.047	2.589TyrGly: 2.589 ± 0.057	0.703TyrHis: 0.703 ± 0.028	2.885TyrIle: 2.885 ± 0.065	1.884TyrLys: 1.884 ± 0.044	3.312TyrLeu: 3.312 ± 0.061	0.782TyrMet: 0.782 ± 0.028	1.74TyrAsn: 1.74 ± 0.056	1.557TyrPro: 1.557 ± 0.04	0.933TyrGln: 0.933 ± 0.037	1.96TyrArg: 1.96 ± 0.045	2.519TyrSer: 2.519 ± 0.056	2.019TyrThr: 2.019 ± 0.049	2.01TyrVal: 2.01 ± 0.049	0.375TyrTrp: 0.375 ± 0.019	1.538TyrTyr: 1.538 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3430 proteins (941967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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