Amino acid dipepetide frequency for Escherichia phage K1E (Bacteriophage K1E)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.323AlaAla: 8.323 ± 1.056
0.431AlaCys: 0.431 ± 0.163
5.31AlaAsp: 5.31 ± 0.703
5.453AlaGlu: 5.453 ± 0.59
3.229AlaPhe: 3.229 ± 0.448
6.673AlaGly: 6.673 ± 0.945
1.22AlaHis: 1.22 ± 0.285
5.238AlaIle: 5.238 ± 0.412
5.094AlaLys: 5.094 ± 0.59
6.888AlaLeu: 6.888 ± 0.875
3.014AlaMet: 3.014 ± 0.512
3.516AlaAsn: 3.516 ± 0.459
3.372AlaPro: 3.372 ± 0.609
4.951AlaGln: 4.951 ± 0.791
5.381AlaArg: 5.381 ± 0.862
5.023AlaSer: 5.023 ± 0.588
5.023AlaThr: 5.023 ± 0.553
6.314AlaVal: 6.314 ± 0.824
1.292AlaTrp: 1.292 ± 0.365
2.583AlaTyr: 2.583 ± 0.471
0.0AlaXaa: 0.0 ± 0.0
Cys
0.646CysAla: 0.646 ± 0.222
0.144CysCys: 0.144 ± 0.089
0.861CysAsp: 0.861 ± 0.266
0.287CysGlu: 0.287 ± 0.163
0.502CysPhe: 0.502 ± 0.197
1.076CysGly: 1.076 ± 0.287
0.431CysHis: 0.431 ± 0.22
0.502CysIle: 0.502 ± 0.201
0.718CysLys: 0.718 ± 0.259
0.861CysLeu: 0.861 ± 0.255
0.502CysMet: 0.502 ± 0.175
0.287CysAsn: 0.287 ± 0.14
0.359CysPro: 0.359 ± 0.168
0.502CysGln: 0.502 ± 0.205
0.789CysArg: 0.789 ± 0.257
0.502CysSer: 0.502 ± 0.211
0.431CysThr: 0.431 ± 0.185
0.718CysVal: 0.718 ± 0.251
0.072CysTrp: 0.072 ± 0.061
0.861CysTyr: 0.861 ± 0.264
0.0CysXaa: 0.0 ± 0.0
Asp
6.242AspAla: 6.242 ± 0.586
0.502AspCys: 0.502 ± 0.206
3.157AspAsp: 3.157 ± 0.488
4.664AspGlu: 4.664 ± 0.683
2.009AspPhe: 2.009 ± 0.382
4.233AspGly: 4.233 ± 0.677
0.718AspHis: 0.718 ± 0.211
4.305AspIle: 4.305 ± 0.53
4.377AspLys: 4.377 ± 0.571
4.233AspLeu: 4.233 ± 0.557
2.368AspMet: 2.368 ± 0.401
2.942AspAsn: 2.942 ± 0.495
2.009AspPro: 2.009 ± 0.36
1.363AspGln: 1.363 ± 0.279
2.727AspArg: 2.727 ± 0.413
4.09AspSer: 4.09 ± 0.628
3.659AspThr: 3.659 ± 0.463
4.09AspVal: 4.09 ± 0.517
1.005AspTrp: 1.005 ± 0.319
2.44AspTyr: 2.44 ± 0.469
0.0AspXaa: 0.0 ± 0.0
Glu
7.606GluAla: 7.606 ± 0.913
0.861GluCys: 0.861 ± 0.308
4.951GluAsp: 4.951 ± 0.625
7.032GluGlu: 7.032 ± 0.81
2.655GluPhe: 2.655 ± 0.451
5.381GluGly: 5.381 ± 0.551
1.579GluHis: 1.579 ± 0.37
2.942GluIle: 2.942 ± 0.467
4.664GluLys: 4.664 ± 0.509
6.386GluLeu: 6.386 ± 0.672
2.081GluMet: 2.081 ± 0.4
1.722GluAsn: 1.722 ± 0.414
1.722GluPro: 1.722 ± 0.316
3.229GluGln: 3.229 ± 0.515
3.731GluArg: 3.731 ± 0.476
3.372GluSer: 3.372 ± 0.541
3.157GluThr: 3.157 ± 0.416
5.74GluVal: 5.74 ± 0.674
1.507GluTrp: 1.507 ± 0.31
2.081GluTyr: 2.081 ± 0.364
0.0GluXaa: 0.0 ± 0.0
Phe
2.798PheAla: 2.798 ± 0.373
0.287PheCys: 0.287 ± 0.154
3.229PheAsp: 3.229 ± 0.491
2.655PheGlu: 2.655 ± 0.393
1.22PhePhe: 1.22 ± 0.3
2.727PheGly: 2.727 ± 0.463
0.718PheHis: 0.718 ± 0.202
2.511PheIle: 2.511 ± 0.356
2.655PheLys: 2.655 ± 0.469
3.229PheLeu: 3.229 ± 0.48
1.794PheMet: 1.794 ± 0.332
1.794PheAsn: 1.794 ± 0.348
1.148PhePro: 1.148 ± 0.303
1.507PheGln: 1.507 ± 0.283
1.507PheArg: 1.507 ± 0.369
2.153PheSer: 2.153 ± 0.43
2.153PheThr: 2.153 ± 0.34
1.148PheVal: 1.148 ± 0.401
0.215PheTrp: 0.215 ± 0.115
0.933PheTyr: 0.933 ± 0.246
0.0PheXaa: 0.0 ± 0.0
Gly
6.458GlyAla: 6.458 ± 0.72
0.933GlyCys: 0.933 ± 0.269
5.525GlyAsp: 5.525 ± 0.615
5.023GlyGlu: 5.023 ± 0.547
2.798GlyPhe: 2.798 ± 0.531
4.879GlyGly: 4.879 ± 0.732
2.224GlyHis: 2.224 ± 0.359
4.736GlyIle: 4.736 ± 0.499
6.458GlyLys: 6.458 ± 0.727
5.668GlyLeu: 5.668 ± 0.931
1.937GlyMet: 1.937 ± 0.378
2.727GlyAsn: 2.727 ± 0.412
0.431GlyPro: 0.431 ± 0.174
3.157GlyGln: 3.157 ± 0.511
3.301GlyArg: 3.301 ± 0.494
4.449GlySer: 4.449 ± 0.724
3.946GlyThr: 3.946 ± 0.588
5.238GlyVal: 5.238 ± 0.63
1.579GlyTrp: 1.579 ± 0.342
2.727GlyTyr: 2.727 ± 0.401
0.0GlyXaa: 0.0 ± 0.0
His
1.148HisAla: 1.148 ± 0.302
0.431HisCys: 0.431 ± 0.2
1.65HisAsp: 1.65 ± 0.349
1.22HisGlu: 1.22 ± 0.286
1.005HisPhe: 1.005 ± 0.212
1.937HisGly: 1.937 ± 0.453
0.431HisHis: 0.431 ± 0.161
1.076HisIle: 1.076 ± 0.248
1.507HisLys: 1.507 ± 0.417
2.44HisLeu: 2.44 ± 0.365
0.574HisMet: 0.574 ± 0.26
1.076HisAsn: 1.076 ± 0.288
0.789HisPro: 0.789 ± 0.28
0.646HisGln: 0.646 ± 0.216
1.435HisArg: 1.435 ± 0.361
0.646HisSer: 0.646 ± 0.202
0.861HisThr: 0.861 ± 0.195
1.722HisVal: 1.722 ± 0.396
0.144HisTrp: 0.144 ± 0.113
1.076HisTyr: 1.076 ± 0.277
0.0HisXaa: 0.0 ± 0.0
Ile
4.592IleAla: 4.592 ± 0.6
0.215IleCys: 0.215 ± 0.119
3.803IleAsp: 3.803 ± 0.361
4.162IleGlu: 4.162 ± 0.544
1.937IlePhe: 1.937 ± 0.516
4.879IleGly: 4.879 ± 0.585
0.861IleHis: 0.861 ± 0.268
3.301IleIle: 3.301 ± 0.647
4.018IleLys: 4.018 ± 0.617
3.157IleLeu: 3.157 ± 0.446
1.507IleMet: 1.507 ± 0.304
2.009IleAsn: 2.009 ± 0.332
2.511IlePro: 2.511 ± 0.392
2.081IleGln: 2.081 ± 0.426
3.301IleArg: 3.301 ± 0.479
2.368IleSer: 2.368 ± 0.41
3.659IleThr: 3.659 ± 0.634
3.803IleVal: 3.803 ± 0.546
0.861IleTrp: 0.861 ± 0.201
1.579IleTyr: 1.579 ± 0.413
0.0IleXaa: 0.0 ± 0.0
Lys
7.606LysAla: 7.606 ± 0.818
1.005LysCys: 1.005 ± 0.255
3.301LysAsp: 3.301 ± 0.59
4.951LysGlu: 4.951 ± 0.569
1.363LysPhe: 1.363 ± 0.285
5.381LysGly: 5.381 ± 0.698
2.224LysHis: 2.224 ± 0.373
3.157LysIle: 3.157 ± 0.468
5.381LysLys: 5.381 ± 0.739
5.381LysLeu: 5.381 ± 0.709
1.65LysMet: 1.65 ± 0.384
2.081LysAsn: 2.081 ± 0.454
3.372LysPro: 3.372 ± 0.528
2.296LysGln: 2.296 ± 0.414
3.875LysArg: 3.875 ± 0.416
3.875LysSer: 3.875 ± 0.488
2.87LysThr: 2.87 ± 0.396
4.879LysVal: 4.879 ± 0.798
0.718LysTrp: 0.718 ± 0.217
2.44LysTyr: 2.44 ± 0.332
0.0LysXaa: 0.0 ± 0.0
Leu
5.955LeuAla: 5.955 ± 0.662
0.933LeuCys: 0.933 ± 0.246
5.74LeuAsp: 5.74 ± 0.538
4.879LeuGlu: 4.879 ± 0.637
3.085LeuPhe: 3.085 ± 0.445
6.027LeuGly: 6.027 ± 0.89
1.65LeuHis: 1.65 ± 0.459
4.162LeuIle: 4.162 ± 0.495
5.094LeuLys: 5.094 ± 0.559
5.955LeuLeu: 5.955 ± 0.851
2.727LeuMet: 2.727 ± 0.624
3.085LeuAsn: 3.085 ± 0.409
3.229LeuPro: 3.229 ± 0.48
3.444LeuGln: 3.444 ± 0.621
4.305LeuArg: 4.305 ± 0.691
4.233LeuSer: 4.233 ± 0.695
5.453LeuThr: 5.453 ± 0.604
5.238LeuVal: 5.238 ± 0.582
0.933LeuTrp: 0.933 ± 0.23
2.583LeuTyr: 2.583 ± 0.439
0.0LeuXaa: 0.0 ± 0.0
Met
3.372MetAla: 3.372 ± 0.292
0.144MetCys: 0.144 ± 0.095
1.363MetAsp: 1.363 ± 0.284
2.368MetGlu: 2.368 ± 0.362
0.861MetPhe: 0.861 ± 0.283
2.153MetGly: 2.153 ± 0.441
0.718MetHis: 0.718 ± 0.223
1.435MetIle: 1.435 ± 0.391
1.794MetLys: 1.794 ± 0.305
3.157MetLeu: 3.157 ± 0.559
0.861MetMet: 0.861 ± 0.283
1.22MetAsn: 1.22 ± 0.275
1.292MetPro: 1.292 ± 0.254
1.722MetGln: 1.722 ± 0.349
2.081MetArg: 2.081 ± 0.488
2.727MetSer: 2.727 ± 0.474
2.153MetThr: 2.153 ± 0.388
2.081MetVal: 2.081 ± 0.381
0.215MetTrp: 0.215 ± 0.1
1.076MetTyr: 1.076 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
3.516AsnAla: 3.516 ± 0.518
0.359AsnCys: 0.359 ± 0.129
2.009AsnAsp: 2.009 ± 0.308
2.511AsnGlu: 2.511 ± 0.388
1.579AsnPhe: 1.579 ± 0.296
2.727AsnGly: 2.727 ± 0.389
0.574AsnHis: 0.574 ± 0.189
1.937AsnIle: 1.937 ± 0.305
2.942AsnLys: 2.942 ± 0.378
3.301AsnLeu: 3.301 ± 0.427
1.363AsnMet: 1.363 ± 0.405
1.579AsnAsn: 1.579 ± 0.272
1.794AsnPro: 1.794 ± 0.299
1.65AsnGln: 1.65 ± 0.391
2.942AsnArg: 2.942 ± 0.433
2.44AsnSer: 2.44 ± 0.449
2.224AsnThr: 2.224 ± 0.538
2.511AsnVal: 2.511 ± 0.417
0.718AsnTrp: 0.718 ± 0.225
1.363AsnTyr: 1.363 ± 0.314
0.0AsnXaa: 0.0 ± 0.0
Pro
2.942ProAla: 2.942 ± 0.499
0.502ProCys: 0.502 ± 0.183
2.727ProAsp: 2.727 ± 0.563
3.301ProGlu: 3.301 ± 0.535
1.076ProPhe: 1.076 ± 0.241
0.861ProGly: 0.861 ± 0.28
1.148ProHis: 1.148 ± 0.355
0.933ProIle: 0.933 ± 0.271
1.866ProLys: 1.866 ± 0.301
2.727ProLeu: 2.727 ± 0.392
1.22ProMet: 1.22 ± 0.26
1.435ProAsn: 1.435 ± 0.315
0.861ProPro: 0.861 ± 0.242
2.081ProGln: 2.081 ± 0.354
1.435ProArg: 1.435 ± 0.309
2.44ProSer: 2.44 ± 0.376
2.655ProThr: 2.655 ± 0.431
3.229ProVal: 3.229 ± 0.478
0.789ProTrp: 0.789 ± 0.213
2.009ProTyr: 2.009 ± 0.339
0.0ProXaa: 0.0 ± 0.0
Gln
4.305GlnAla: 4.305 ± 0.469
0.574GlnCys: 0.574 ± 0.252
2.009GlnAsp: 2.009 ± 0.396
3.085GlnGlu: 3.085 ± 0.489
1.937GlnPhe: 1.937 ± 0.344
2.87GlnGly: 2.87 ± 0.404
0.933GlnHis: 0.933 ± 0.25
2.44GlnIle: 2.44 ± 0.316
1.866GlnLys: 1.866 ± 0.33
2.942GlnLeu: 2.942 ± 0.512
2.081GlnMet: 2.081 ± 0.33
1.866GlnAsn: 1.866 ± 0.4
1.148GlnPro: 1.148 ± 0.23
2.368GlnGln: 2.368 ± 0.411
2.727GlnArg: 2.727 ± 0.386
1.937GlnSer: 1.937 ± 0.395
1.937GlnThr: 1.937 ± 0.372
2.511GlnVal: 2.511 ± 0.36
0.718GlnTrp: 0.718 ± 0.19
1.866GlnTyr: 1.866 ± 0.421
0.0GlnXaa: 0.0 ± 0.0
Arg
4.736ArgAla: 4.736 ± 0.785
0.359ArgCys: 0.359 ± 0.177
2.942ArgAsp: 2.942 ± 0.438
4.736ArgGlu: 4.736 ± 0.52
2.081ArgPhe: 2.081 ± 0.388
4.664ArgGly: 4.664 ± 0.531
1.005ArgHis: 1.005 ± 0.287
3.803ArgIle: 3.803 ± 0.432
3.516ArgLys: 3.516 ± 0.452
4.449ArgLeu: 4.449 ± 0.584
2.224ArgMet: 2.224 ± 0.408
2.081ArgAsn: 2.081 ± 0.382
1.65ArgPro: 1.65 ± 0.343
2.583ArgGln: 2.583 ± 0.451
3.301ArgArg: 3.301 ± 0.506
1.937ArgSer: 1.937 ± 0.47
2.153ArgThr: 2.153 ± 0.465
3.229ArgVal: 3.229 ± 0.412
0.861ArgTrp: 0.861 ± 0.266
2.368ArgTyr: 2.368 ± 0.378
0.0ArgXaa: 0.0 ± 0.0
Ser
4.233SerAla: 4.233 ± 0.451
0.718SerCys: 0.718 ± 0.221
3.085SerAsp: 3.085 ± 0.471
3.803SerGlu: 3.803 ± 0.446
2.511SerPhe: 2.511 ± 0.367
5.166SerGly: 5.166 ± 0.513
1.148SerHis: 1.148 ± 0.278
2.87SerIle: 2.87 ± 0.657
4.09SerLys: 4.09 ± 0.486
5.094SerLeu: 5.094 ± 0.707
2.296SerMet: 2.296 ± 0.39
2.081SerAsn: 2.081 ± 0.373
1.722SerPro: 1.722 ± 0.369
2.081SerGln: 2.081 ± 0.466
3.085SerArg: 3.085 ± 0.468
2.727SerSer: 2.727 ± 0.654
2.798SerThr: 2.798 ± 0.411
3.731SerVal: 3.731 ± 0.529
0.789SerTrp: 0.789 ± 0.219
2.368SerTyr: 2.368 ± 0.637
0.0SerXaa: 0.0 ± 0.0
Thr
3.659ThrAla: 3.659 ± 0.655
0.861ThrCys: 0.861 ± 0.321
3.659ThrAsp: 3.659 ± 0.706
4.449ThrGlu: 4.449 ± 0.613
2.727ThrPhe: 2.727 ± 0.406
3.803ThrGly: 3.803 ± 0.469
1.22ThrHis: 1.22 ± 0.283
2.655ThrIle: 2.655 ± 0.496
4.162ThrLys: 4.162 ± 0.504
4.592ThrLeu: 4.592 ± 0.537
1.148ThrMet: 1.148 ± 0.287
2.368ThrAsn: 2.368 ± 0.549
2.942ThrPro: 2.942 ± 0.303
2.009ThrGln: 2.009 ± 0.475
2.942ThrArg: 2.942 ± 0.458
3.157ThrSer: 3.157 ± 0.518
3.014ThrThr: 3.014 ± 0.543
3.085ThrVal: 3.085 ± 0.555
0.789ThrTrp: 0.789 ± 0.208
1.507ThrTyr: 1.507 ± 0.317
0.0ThrXaa: 0.0 ± 0.0
Val
6.027ValAla: 6.027 ± 0.622
1.005ValCys: 1.005 ± 0.293
2.798ValAsp: 2.798 ± 0.462
4.09ValGlu: 4.09 ± 0.536
2.009ValPhe: 2.009 ± 0.335
4.736ValGly: 4.736 ± 0.609
1.435ValHis: 1.435 ± 0.357
3.803ValIle: 3.803 ± 0.482
4.736ValLys: 4.736 ± 0.576
4.449ValLeu: 4.449 ± 0.679
1.937ValMet: 1.937 ± 0.352
3.946ValAsn: 3.946 ± 0.581
3.301ValPro: 3.301 ± 0.503
2.727ValGln: 2.727 ± 0.546
2.942ValArg: 2.942 ± 0.453
5.094ValSer: 5.094 ± 0.599
4.377ValThr: 4.377 ± 0.624
4.162ValVal: 4.162 ± 0.614
0.718ValTrp: 0.718 ± 0.188
2.296ValTyr: 2.296 ± 0.409
0.0ValXaa: 0.0 ± 0.0
Trp
1.076TrpAla: 1.076 ± 0.289
0.215TrpCys: 0.215 ± 0.113
0.861TrpAsp: 0.861 ± 0.243
1.579TrpGlu: 1.579 ± 0.292
0.502TrpPhe: 0.502 ± 0.21
0.789TrpGly: 0.789 ± 0.198
0.359TrpHis: 0.359 ± 0.152
0.574TrpIle: 0.574 ± 0.166
0.933TrpLys: 0.933 ± 0.309
1.005TrpLeu: 1.005 ± 0.275
0.144TrpMet: 0.144 ± 0.11
0.431TrpAsn: 0.431 ± 0.166
1.076TrpPro: 1.076 ± 0.254
0.646TrpGln: 0.646 ± 0.188
0.574TrpArg: 0.574 ± 0.218
1.076TrpSer: 1.076 ± 0.321
0.646TrpThr: 0.646 ± 0.205
1.22TrpVal: 1.22 ± 0.276
0.072TrpTrp: 0.072 ± 0.079
0.431TrpTyr: 0.431 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.085TyrAla: 3.085 ± 0.408
0.574TyrCys: 0.574 ± 0.22
2.153TyrAsp: 2.153 ± 0.401
2.153TyrGlu: 2.153 ± 0.282
1.292TyrPhe: 1.292 ± 0.303
3.229TyrGly: 3.229 ± 0.551
1.22TyrHis: 1.22 ± 0.327
2.224TyrIle: 2.224 ± 0.349
1.937TyrLys: 1.937 ± 0.354
2.798TyrLeu: 2.798 ± 0.451
1.292TyrMet: 1.292 ± 0.257
1.794TyrAsn: 1.794 ± 0.355
1.507TyrPro: 1.507 ± 0.35
1.076TyrGln: 1.076 ± 0.195
2.296TyrArg: 2.296 ± 0.44
2.153TyrSer: 2.153 ± 0.436
1.579TyrThr: 1.579 ± 0.355
1.937TyrVal: 1.937 ± 0.351
0.287TyrTrp: 0.287 ± 0.163
1.22TyrTyr: 1.22 ± 0.357
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (13938 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski