Amino acid dipepetide frequency for Mitsuaria sp. 7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.147AlaAla: 18.147 ± 0.156	1.108AlaCys: 1.108 ± 0.03	6.781AlaAsp: 6.781 ± 0.07	6.616AlaGlu: 6.616 ± 0.074	4.098AlaPhe: 4.098 ± 0.042	10.838AlaGly: 10.838 ± 0.108	2.515AlaHis: 2.515 ± 0.048	5.035AlaIle: 5.035 ± 0.065	3.975AlaLys: 3.975 ± 0.073	15.395AlaLeu: 15.395 ± 0.127	3.628AlaMet: 3.628 ± 0.049	2.718AlaAsn: 2.718 ± 0.051	6.469AlaPro: 6.469 ± 0.086	5.545AlaGln: 5.545 ± 0.074	8.972AlaArg: 8.972 ± 0.077	7.28AlaSer: 7.28 ± 0.075	6.454AlaThr: 6.454 ± 0.069	9.081AlaVal: 9.081 ± 0.089	2.034AlaTrp: 2.034 ± 0.04	2.334AlaTyr: 2.334 ± 0.041	0.002AlaXaa: 0.002 ± 0.002
Cys	1.024CysAla: 1.024 ± 0.026	0.083CysCys: 0.083 ± 0.007	0.497CysAsp: 0.497 ± 0.02	0.478CysGlu: 0.478 ± 0.019	0.265CysPhe: 0.265 ± 0.014	0.881CysGly: 0.881 ± 0.028	0.226CysHis: 0.226 ± 0.013	0.316CysIle: 0.316 ± 0.014	0.184CysLys: 0.184 ± 0.011	0.791CysLeu: 0.791 ± 0.027	0.153CysMet: 0.153 ± 0.009	0.185CysAsn: 0.185 ± 0.011	0.412CysPro: 0.412 ± 0.016	0.225CysGln: 0.225 ± 0.011	0.543CysArg: 0.543 ± 0.018	0.435CysSer: 0.435 ± 0.017	0.404CysThr: 0.404 ± 0.016	0.628CysVal: 0.628 ± 0.021	0.124CysTrp: 0.124 ± 0.009	0.163CysTyr: 0.163 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.871AspAla: 7.871 ± 0.082	0.441AspCys: 0.441 ± 0.017	3.217AspAsp: 3.217 ± 0.069	3.546AspGlu: 3.546 ± 0.061	2.093AspPhe: 2.093 ± 0.036	5.489AspGly: 5.489 ± 0.062	1.129AspHis: 1.129 ± 0.026	2.217AspIle: 2.217 ± 0.044	1.718AspLys: 1.718 ± 0.038	5.981AspLeu: 5.981 ± 0.07	1.082AspMet: 1.082 ± 0.026	1.194AspAsn: 1.194 ± 0.032	3.332AspPro: 3.332 ± 0.05	1.939AspGln: 1.939 ± 0.037	4.084AspArg: 4.084 ± 0.059	2.314AspSer: 2.314 ± 0.041	2.544AspThr: 2.544 ± 0.043	4.131AspVal: 4.131 ± 0.051	1.129AspTrp: 1.129 ± 0.029	1.355AspTyr: 1.355 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.956GluAla: 6.956 ± 0.075	0.357GluCys: 0.357 ± 0.013	2.523GluAsp: 2.523 ± 0.042	2.577GluGlu: 2.577 ± 0.049	1.685GluPhe: 1.685 ± 0.039	3.854GluGly: 3.854 ± 0.06	1.308GluHis: 1.308 ± 0.032	2.526GluIle: 2.526 ± 0.047	1.587GluLys: 1.587 ± 0.042	6.103GluLeu: 6.103 ± 0.08	1.155GluMet: 1.155 ± 0.032	1.043GluAsn: 1.043 ± 0.024	2.502GluPro: 2.502 ± 0.042	2.624GluGln: 2.624 ± 0.043	4.905GluArg: 4.905 ± 0.068	2.584GluSer: 2.584 ± 0.039	2.572GluThr: 2.572 ± 0.039	3.948GluVal: 3.948 ± 0.048	0.764GluTrp: 0.764 ± 0.021	0.928GluTyr: 0.928 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.068PheAla: 4.068 ± 0.054	0.33PheCys: 0.33 ± 0.014	2.512PheAsp: 2.512 ± 0.038	2.082PheGlu: 2.082 ± 0.039	1.26PhePhe: 1.26 ± 0.032	3.204PheGly: 3.204 ± 0.049	0.717PheHis: 0.717 ± 0.021	1.383PheIle: 1.383 ± 0.031	1.16PheLys: 1.16 ± 0.031	2.842PheLeu: 2.842 ± 0.046	0.713PheMet: 0.713 ± 0.021	1.114PheAsn: 1.114 ± 0.026	1.452PhePro: 1.452 ± 0.032	1.122PheGln: 1.122 ± 0.026	1.929PheArg: 1.929 ± 0.036	2.112PheSer: 2.112 ± 0.038	1.769PheThr: 1.769 ± 0.037	2.579PheVal: 2.579 ± 0.043	0.496PheTrp: 0.496 ± 0.019	0.776PheTyr: 0.776 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.856GlyAla: 9.856 ± 0.099	0.769GlyCys: 0.769 ± 0.021	4.538GlyAsp: 4.538 ± 0.059	4.53GlyGlu: 4.53 ± 0.063	3.217GlyPhe: 3.217 ± 0.045	7.513GlyGly: 7.513 ± 0.104	1.956GlyHis: 1.956 ± 0.04	3.44GlyIle: 3.44 ± 0.051	3.087GlyLys: 3.087 ± 0.055	9.319GlyLeu: 9.319 ± 0.079	2.031GlyMet: 2.031 ± 0.04	2.108GlyAsn: 2.108 ± 0.046	3.443GlyPro: 3.443 ± 0.055	3.554GlyGln: 3.554 ± 0.058	6.06GlyArg: 6.06 ± 0.064	4.719GlySer: 4.719 ± 0.065	4.647GlyThr: 4.647 ± 0.067	6.557GlyVal: 6.557 ± 0.061	1.556GlyTrp: 1.556 ± 0.038	2.188GlyTyr: 2.188 ± 0.039	0.003GlyXaa: 0.003 ± 0.002
His	2.767HisAla: 2.767 ± 0.046	0.234HisCys: 0.234 ± 0.013	1.187HisAsp: 1.187 ± 0.036	1.211HisGlu: 1.211 ± 0.035	0.838HisPhe: 0.838 ± 0.021	2.142HisGly: 2.142 ± 0.045	0.626HisHis: 0.626 ± 0.02	0.715HisIle: 0.715 ± 0.02	0.481HisLys: 0.481 ± 0.019	2.31HisLeu: 2.31 ± 0.043	0.401HisMet: 0.401 ± 0.015	0.402HisAsn: 0.402 ± 0.014	1.429HisPro: 1.429 ± 0.036	0.77HisGln: 0.77 ± 0.025	1.594HisArg: 1.594 ± 0.034	0.906HisSer: 0.906 ± 0.027	0.885HisThr: 0.885 ± 0.023	1.614HisVal: 1.614 ± 0.03	0.423HisTrp: 0.423 ± 0.016	0.557HisTyr: 0.557 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.067IleAla: 6.067 ± 0.065	0.34IleCys: 0.34 ± 0.014	3.058IleAsp: 3.058 ± 0.048	2.823IleGlu: 2.823 ± 0.048	1.018IlePhe: 1.018 ± 0.028	3.96IleGly: 3.96 ± 0.052	0.797IleHis: 0.797 ± 0.027	1.116IleIle: 1.116 ± 0.032	1.321IleLys: 1.321 ± 0.033	2.858IleLeu: 2.858 ± 0.043	0.547IleMet: 0.547 ± 0.019	1.243IleAsn: 1.243 ± 0.029	1.883IlePro: 1.883 ± 0.037	1.242IleGln: 1.242 ± 0.032	2.496IleArg: 2.496 ± 0.046	2.206IleSer: 2.206 ± 0.043	2.198IleThr: 2.198 ± 0.042	3.301IleVal: 3.301 ± 0.052	0.436IleTrp: 0.436 ± 0.017	0.767IleTyr: 0.767 ± 0.021	0.001IleXaa: 0.001 ± 0.001
Lys	3.985LysAla: 3.985 ± 0.062	0.138LysCys: 0.138 ± 0.01	1.844LysAsp: 1.844 ± 0.039	1.418LysGlu: 1.418 ± 0.036	0.833LysPhe: 0.833 ± 0.026	2.351LysGly: 2.351 ± 0.044	0.634LysHis: 0.634 ± 0.02	1.208LysIle: 1.208 ± 0.032	1.12LysLys: 1.12 ± 0.033	3.434LysLeu: 3.434 ± 0.062	0.663LysMet: 0.663 ± 0.023	0.797LysAsn: 0.797 ± 0.023	2.03LysPro: 2.03 ± 0.043	1.23LysGln: 1.23 ± 0.032	2.354LysArg: 2.354 ± 0.041	1.744LysSer: 1.744 ± 0.036	1.885LysThr: 1.885 ± 0.034	2.377LysVal: 2.377 ± 0.05	0.331LysTrp: 0.331 ± 0.016	0.578LysTyr: 0.578 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.338LeuAla: 14.338 ± 0.12	0.894LeuCys: 0.894 ± 0.025	6.498LeuAsp: 6.498 ± 0.064	5.018LeuGlu: 5.018 ± 0.056	3.318LeuPhe: 3.318 ± 0.045	8.743LeuGly: 8.743 ± 0.085	2.261LeuHis: 2.261 ± 0.047	4.468LeuIle: 4.468 ± 0.061	3.802LeuLys: 3.802 ± 0.053	11.327LeuLeu: 11.327 ± 0.127	2.644LeuMet: 2.644 ± 0.052	2.75LeuAsn: 2.75 ± 0.045	6.422LeuPro: 6.422 ± 0.074	4.19LeuGln: 4.19 ± 0.051	8.571LeuArg: 8.571 ± 0.103	6.887LeuSer: 6.887 ± 0.082	5.819LeuThr: 5.819 ± 0.075	7.645LeuVal: 7.645 ± 0.079	1.442LeuTrp: 1.442 ± 0.032	1.908LeuTyr: 1.908 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	2.955MetAla: 2.955 ± 0.04	0.148MetCys: 0.148 ± 0.011	1.202MetAsp: 1.202 ± 0.029	0.94MetGlu: 0.94 ± 0.028	0.657MetPhe: 0.657 ± 0.021	1.686MetGly: 1.686 ± 0.031	0.482MetHis: 0.482 ± 0.018	0.84MetIle: 0.84 ± 0.024	0.909MetLys: 0.909 ± 0.026	2.554MetLeu: 2.554 ± 0.053	0.499MetMet: 0.499 ± 0.019	0.772MetAsn: 0.772 ± 0.024	1.521MetPro: 1.521 ± 0.028	0.917MetGln: 0.917 ± 0.026	1.748MetArg: 1.748 ± 0.036	1.753MetSer: 1.753 ± 0.031	1.669MetThr: 1.669 ± 0.032	1.538MetVal: 1.538 ± 0.032	0.216MetTrp: 0.216 ± 0.012	0.329MetTyr: 0.329 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.294AsnAla: 3.294 ± 0.051	0.224AsnCys: 0.224 ± 0.013	1.332AsnAsp: 1.332 ± 0.029	1.219AsnGlu: 1.219 ± 0.028	0.887AsnPhe: 0.887 ± 0.024	2.404AsnGly: 2.404 ± 0.055	0.429AsnHis: 0.429 ± 0.016	0.956AsnIle: 0.956 ± 0.026	0.716AsnLys: 0.716 ± 0.024	2.338AsnLeu: 2.338 ± 0.035	0.451AsnMet: 0.451 ± 0.018	0.718AsnAsn: 0.718 ± 0.025	1.57AsnPro: 1.57 ± 0.033	0.79AsnGln: 0.79 ± 0.027	1.544AsnArg: 1.544 ± 0.032	1.161AsnSer: 1.161 ± 0.028	1.312AsnThr: 1.312 ± 0.035	1.832AsnVal: 1.832 ± 0.036	0.367AsnTrp: 0.367 ± 0.015	0.612AsnTyr: 0.612 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.227ProAla: 7.227 ± 0.085	0.302ProCys: 0.302 ± 0.013	3.564ProAsp: 3.564 ± 0.056	3.324ProGlu: 3.324 ± 0.052	1.713ProPhe: 1.713 ± 0.036	4.834ProGly: 4.834 ± 0.06	1.118ProHis: 1.118 ± 0.025	1.759ProIle: 1.759 ± 0.035	1.584ProLys: 1.584 ± 0.036	5.521ProLeu: 5.521 ± 0.07	1.375ProMet: 1.375 ± 0.031	1.144ProAsn: 1.144 ± 0.031	2.903ProPro: 2.903 ± 0.066	2.093ProGln: 2.093 ± 0.034	3.268ProArg: 3.268 ± 0.054	3.114ProSer: 3.114 ± 0.047	2.863ProThr: 2.863 ± 0.039	4.34ProVal: 4.34 ± 0.06	0.833ProTrp: 0.833 ± 0.026	1.072ProTyr: 1.072 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.511GlnAla: 5.511 ± 0.064	0.26GlnCys: 0.26 ± 0.013	1.803GlnAsp: 1.803 ± 0.036	1.573GlnGlu: 1.573 ± 0.035	1.225GlnPhe: 1.225 ± 0.029	3.148GlnGly: 3.148 ± 0.053	0.839GlnHis: 0.839 ± 0.023	1.612GlnIle: 1.612 ± 0.04	0.946GlnLys: 0.946 ± 0.024	4.504GlnLeu: 4.504 ± 0.065	0.93GlnMet: 0.93 ± 0.027	0.727GlnAsn: 0.727 ± 0.023	2.297GlnPro: 2.297 ± 0.042	1.901GlnGln: 1.901 ± 0.041	3.599GlnArg: 3.599 ± 0.056	1.997GlnSer: 1.997 ± 0.044	1.981GlnThr: 1.981 ± 0.04	3.096GlnVal: 3.096 ± 0.044	0.696GlnTrp: 0.696 ± 0.021	0.738GlnTyr: 0.738 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.347ArgAla: 8.347 ± 0.077	0.619ArgCys: 0.619 ± 0.02	4.133ArgAsp: 4.133 ± 0.056	4.439ArgGlu: 4.439 ± 0.058	2.947ArgPhe: 2.947 ± 0.042	5.071ArgGly: 5.071 ± 0.062	1.932ArgHis: 1.932 ± 0.04	3.284ArgIle: 3.284 ± 0.046	1.972ArgLys: 1.972 ± 0.036	8.502ArgLeu: 8.502 ± 0.101	1.939ArgMet: 1.939 ± 0.031	1.75ArgAsn: 1.75 ± 0.031	3.474ArgPro: 3.474 ± 0.061	3.134ArgGln: 3.134 ± 0.049	5.878ArgArg: 5.878 ± 0.075	3.764ArgSer: 3.764 ± 0.052	3.301ArgThr: 3.301 ± 0.049	5.47ArgVal: 5.47 ± 0.063	1.417ArgTrp: 1.417 ± 0.034	1.812ArgTyr: 1.812 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	6.88SerAla: 6.88 ± 0.076	0.42SerCys: 0.42 ± 0.018	2.928SerAsp: 2.928 ± 0.043	2.447SerGlu: 2.447 ± 0.045	2.072SerPhe: 2.072 ± 0.035	5.481SerGly: 5.481 ± 0.063	1.148SerHis: 1.148 ± 0.029	2.173SerIle: 2.173 ± 0.037	1.543SerLys: 1.543 ± 0.035	6.11SerLeu: 6.11 ± 0.073	1.288SerMet: 1.288 ± 0.028	1.313SerAsn: 1.313 ± 0.03	3.275SerPro: 3.275 ± 0.057	1.973SerGln: 1.973 ± 0.035	3.833SerArg: 3.833 ± 0.058	3.376SerSer: 3.376 ± 0.061	3.27SerThr: 3.27 ± 0.051	3.95SerVal: 3.95 ± 0.056	0.833SerTrp: 0.833 ± 0.025	1.226SerTyr: 1.226 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	6.476ThrAla: 6.476 ± 0.071	0.366ThrCys: 0.366 ± 0.016	2.683ThrAsp: 2.683 ± 0.041	2.361ThrGlu: 2.361 ± 0.04	1.605ThrPhe: 1.605 ± 0.033	4.821ThrGly: 4.821 ± 0.064	1.089ThrHis: 1.089 ± 0.026	2.068ThrIle: 2.068 ± 0.043	1.325ThrLys: 1.325 ± 0.033	6.354ThrLeu: 6.354 ± 0.067	1.164ThrMet: 1.164 ± 0.028	1.219ThrAsn: 1.219 ± 0.035	3.724ThrPro: 3.724 ± 0.063	1.901ThrGln: 1.901 ± 0.041	3.556ThrArg: 3.556 ± 0.054	3.011ThrSer: 3.011 ± 0.057	3.133ThrThr: 3.133 ± 0.059	4.271ThrVal: 4.271 ± 0.056	0.735ThrTrp: 0.735 ± 0.022	1.065ThrTyr: 1.065 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.264ValAla: 9.264 ± 0.076	0.634ValCys: 0.634 ± 0.02	4.571ValAsp: 4.571 ± 0.054	4.208ValGlu: 4.208 ± 0.054	2.531ValPhe: 2.531 ± 0.041	5.686ValGly: 5.686 ± 0.064	1.536ValHis: 1.536 ± 0.029	3.175ValIle: 3.175 ± 0.046	2.433ValLys: 2.433 ± 0.046	8.468ValLeu: 8.468 ± 0.074	1.861ValMet: 1.861 ± 0.037	1.956ValAsn: 1.956 ± 0.04	3.991ValPro: 3.991 ± 0.049	2.674ValGln: 2.674 ± 0.039	5.129ValArg: 5.129 ± 0.066	4.161ValSer: 4.161 ± 0.053	4.17ValThr: 4.17 ± 0.052	6.049ValVal: 6.049 ± 0.081	1.053ValTrp: 1.053 ± 0.028	1.509ValTyr: 1.509 ± 0.035	0.001ValXaa: 0.001 ± 0.001
Trp	1.481TrpAla: 1.481 ± 0.035	0.157TrpCys: 0.157 ± 0.009	0.717TrpAsp: 0.717 ± 0.023	0.576TrpGlu: 0.576 ± 0.019	0.537TrpPhe: 0.537 ± 0.02	1.042TrpGly: 1.042 ± 0.028	0.385TrpHis: 0.385 ± 0.016	0.717TrpIle: 0.717 ± 0.022	0.47TrpLys: 0.47 ± 0.017	2.046TrpLeu: 2.046 ± 0.047	0.461TrpMet: 0.461 ± 0.016	0.465TrpAsn: 0.465 ± 0.016	0.798TrpPro: 0.798 ± 0.025	0.766TrpGln: 0.766 ± 0.024	1.398TrpArg: 1.398 ± 0.032	0.934TrpSer: 0.934 ± 0.025	0.942TrpThr: 0.942 ± 0.03	1.054TrpVal: 1.054 ± 0.031	0.311TrpTrp: 0.311 ± 0.017	0.302TrpTyr: 0.302 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.509TyrAla: 2.509 ± 0.042	0.192TyrCys: 0.192 ± 0.012	1.216TyrAsp: 1.216 ± 0.038	1.115TyrGlu: 1.115 ± 0.026	0.823TyrPhe: 0.823 ± 0.023	1.945TyrGly: 1.945 ± 0.044	0.365TyrHis: 0.365 ± 0.017	0.667TyrIle: 0.667 ± 0.02	0.623TyrLys: 0.623 ± 0.023	2.186TyrLeu: 2.186 ± 0.038	0.348TyrMet: 0.348 ± 0.014	0.54TyrAsn: 0.54 ± 0.022	1.025TyrPro: 1.025 ± 0.03	0.792TyrGln: 0.792 ± 0.023	1.723TyrArg: 1.723 ± 0.033	1.081TyrSer: 1.081 ± 0.028	1.112TyrThr: 1.112 ± 0.027	1.596TyrVal: 1.596 ± 0.035	0.362TyrTrp: 0.362 ± 0.016	0.542TyrTyr: 0.542 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.008

Statistics based on 4769 proteins (1584249 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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