Amino acid dipepetide frequency for Okeania hirsuta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.302AlaAla: 5.302 ± 0.075	0.689AlaCys: 0.689 ± 0.02	3.418AlaAsp: 3.418 ± 0.049	4.856AlaGlu: 4.856 ± 0.065	2.611AlaPhe: 2.611 ± 0.047	4.525AlaGly: 4.525 ± 0.07	1.051AlaHis: 1.051 ± 0.025	6.212AlaIle: 6.212 ± 0.073	4.272AlaLys: 4.272 ± 0.054	6.836AlaLeu: 6.836 ± 0.083	1.437AlaMet: 1.437 ± 0.03	3.33AlaAsn: 3.33 ± 0.063	2.206AlaPro: 2.206 ± 0.041	3.07AlaGln: 3.07 ± 0.048	2.752AlaArg: 2.752 ± 0.044	3.968AlaSer: 3.968 ± 0.053	4.116AlaThr: 4.116 ± 0.061	4.597AlaVal: 4.597 ± 0.061	0.831AlaTrp: 0.831 ± 0.026	2.185AlaTyr: 2.185 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.532CysAla: 0.532 ± 0.018	0.18CysCys: 0.18 ± 0.01	0.499CysAsp: 0.499 ± 0.018	0.555CysGlu: 0.555 ± 0.019	0.455CysPhe: 0.455 ± 0.022	0.836CysGly: 0.836 ± 0.024	0.273CysHis: 0.273 ± 0.011	0.631CysIle: 0.631 ± 0.018	0.39CysLys: 0.39 ± 0.015	1.214CysLeu: 1.214 ± 0.032	0.161CysMet: 0.161 ± 0.01	0.427CysAsn: 0.427 ± 0.015	0.511CysPro: 0.511 ± 0.017	0.668CysGln: 0.668 ± 0.018	0.52CysArg: 0.52 ± 0.018	0.706CysSer: 0.706 ± 0.021	0.472CysThr: 0.472 ± 0.015	0.523CysVal: 0.523 ± 0.019	0.15CysTrp: 0.15 ± 0.009	0.422CysTyr: 0.422 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.117AspAla: 3.117 ± 0.046	0.512AspCys: 0.512 ± 0.019	2.48AspAsp: 2.48 ± 0.068	3.177AspGlu: 3.177 ± 0.053	2.646AspPhe: 2.646 ± 0.044	3.6AspGly: 3.6 ± 0.071	0.666AspHis: 0.666 ± 0.025	3.906AspIle: 3.906 ± 0.058	2.628AspLys: 2.628 ± 0.045	5.571AspLeu: 5.571 ± 0.06	0.828AspMet: 0.828 ± 0.023	2.546AspAsn: 2.546 ± 0.052	2.127AspPro: 2.127 ± 0.039	1.653AspGln: 1.653 ± 0.035	2.956AspArg: 2.956 ± 0.045	3.18AspSer: 3.18 ± 0.056	2.538AspThr: 2.538 ± 0.059	2.916AspVal: 2.916 ± 0.049	0.857AspTrp: 0.857 ± 0.025	1.984AspTyr: 1.984 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.112GluAla: 5.112 ± 0.056	0.51GluCys: 0.51 ± 0.02	3.029GluAsp: 3.029 ± 0.047	4.927GluGlu: 4.927 ± 0.075	2.704GluPhe: 2.704 ± 0.043	3.605GluGly: 3.605 ± 0.062	0.929GluHis: 0.929 ± 0.025	5.884GluIle: 5.884 ± 0.062	5.294GluLys: 5.294 ± 0.067	7.073GluLeu: 7.073 ± 0.077	1.463GluMet: 1.463 ± 0.027	3.918GluAsn: 3.918 ± 0.059	2.111GluPro: 2.111 ± 0.039	3.33GluGln: 3.33 ± 0.055	2.974GluArg: 2.974 ± 0.041	3.861GluSer: 3.861 ± 0.052	4.011GluThr: 4.011 ± 0.052	4.744GluVal: 4.744 ± 0.058	0.891GluTrp: 0.891 ± 0.024	2.23GluTyr: 2.23 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.85PheAla: 2.85 ± 0.04	0.596PheCys: 0.596 ± 0.02	2.392PheAsp: 2.392 ± 0.039	2.407PheGlu: 2.407 ± 0.041	1.978PhePhe: 1.978 ± 0.041	2.924PheGly: 2.924 ± 0.044	0.753PheHis: 0.753 ± 0.024	2.835PheIle: 2.835 ± 0.051	1.802PheLys: 1.802 ± 0.039	4.522PheLeu: 4.522 ± 0.064	0.761PheMet: 0.761 ± 0.022	2.057PheAsn: 2.057 ± 0.035	2.013PhePro: 2.013 ± 0.039	1.982PheGln: 1.982 ± 0.035	1.77PheArg: 1.77 ± 0.032	3.368PheSer: 3.368 ± 0.053	2.352PheThr: 2.352 ± 0.039	2.465PheVal: 2.465 ± 0.04	0.746PheTrp: 0.746 ± 0.023	1.602PheTyr: 1.602 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.183GlyAla: 4.183 ± 0.074	0.789GlyCys: 0.789 ± 0.024	3.578GlyAsp: 3.578 ± 0.089	4.439GlyGlu: 4.439 ± 0.064	2.969GlyPhe: 2.969 ± 0.044	4.845GlyGly: 4.845 ± 0.117	1.196GlyHis: 1.196 ± 0.032	5.4GlyIle: 5.4 ± 0.067	4.63GlyLys: 4.63 ± 0.067	6.354GlyLeu: 6.354 ± 0.075	1.493GlyMet: 1.493 ± 0.037	3.551GlyAsn: 3.551 ± 0.121	1.37GlyPro: 1.37 ± 0.032	2.591GlyGln: 2.591 ± 0.044	2.945GlyArg: 2.945 ± 0.048	3.939GlySer: 3.939 ± 0.057	3.7GlyThr: 3.7 ± 0.069	4.397GlyVal: 4.397 ± 0.058	1.133GlyTrp: 1.133 ± 0.031	2.368GlyTyr: 2.368 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	0.852HisAla: 0.852 ± 0.021	0.26HisCys: 0.26 ± 0.012	0.618HisAsp: 0.618 ± 0.025	0.767HisGlu: 0.767 ± 0.022	0.788HisPhe: 0.788 ± 0.022	1.043HisGly: 1.043 ± 0.025	0.541HisHis: 0.541 ± 0.023	1.15HisIle: 1.15 ± 0.026	0.904HisLys: 0.904 ± 0.022	2.024HisLeu: 2.024 ± 0.04	0.174HisMet: 0.174 ± 0.008	0.831HisAsn: 0.831 ± 0.023	1.22HisPro: 1.22 ± 0.028	1.173HisGln: 1.173 ± 0.032	0.965HisArg: 0.965 ± 0.023	1.15HisSer: 1.15 ± 0.029	0.825HisThr: 0.825 ± 0.022	0.673HisVal: 0.673 ± 0.021	0.328HisTrp: 0.328 ± 0.013	0.683HisTyr: 0.683 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.171IleAla: 6.171 ± 0.054	0.884IleCys: 0.884 ± 0.025	4.218IleAsp: 4.218 ± 0.056	5.172IleGlu: 5.172 ± 0.064	3.365IlePhe: 3.365 ± 0.044	4.674IleGly: 4.674 ± 0.058	1.237IleHis: 1.237 ± 0.026	5.166IleIle: 5.166 ± 0.071	4.017IleLys: 4.017 ± 0.064	7.418IleLeu: 7.418 ± 0.07	1.138IleMet: 1.138 ± 0.027	4.131IleAsn: 4.131 ± 0.064	3.787IlePro: 3.787 ± 0.053	3.031IleGln: 3.031 ± 0.042	2.947IleArg: 2.947 ± 0.044	5.569IleSer: 5.569 ± 0.074	4.056IleThr: 4.056 ± 0.075	4.55IleVal: 4.55 ± 0.056	0.974IleTrp: 0.974 ± 0.026	2.492IleTyr: 2.492 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.88LysAla: 3.88 ± 0.063	0.454LysCys: 0.454 ± 0.016	2.446LysAsp: 2.446 ± 0.041	3.578LysGlu: 3.578 ± 0.056	2.391LysPhe: 2.391 ± 0.047	2.999LysGly: 2.999 ± 0.049	0.931LysHis: 0.931 ± 0.023	4.989LysIle: 4.989 ± 0.07	3.811LysLys: 3.811 ± 0.057	6.7LysLeu: 6.7 ± 0.072	1.192LysMet: 1.192 ± 0.025	3.33LysAsn: 3.33 ± 0.05	2.527LysPro: 2.527 ± 0.045	3.034LysGln: 3.034 ± 0.047	2.379LysArg: 2.379 ± 0.035	3.884LysSer: 3.884 ± 0.056	3.241LysThr: 3.241 ± 0.049	3.786LysVal: 3.786 ± 0.056	0.754LysTrp: 0.754 ± 0.024	2.058LysTyr: 2.058 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	8.096LeuAla: 8.096 ± 0.086	0.956LeuCys: 0.956 ± 0.025	5.291LeuAsp: 5.291 ± 0.06	7.858LeuGlu: 7.858 ± 0.075	3.971LeuPhe: 3.971 ± 0.06	7.208LeuGly: 7.208 ± 0.079	1.639LeuHis: 1.639 ± 0.031	7.308LeuIle: 7.308 ± 0.075	6.205LeuLys: 6.205 ± 0.069	10.465LeuLeu: 10.465 ± 0.108	2.072LeuMet: 2.072 ± 0.037	4.962LeuAsn: 4.962 ± 0.06	5.388LeuPro: 5.388 ± 0.078	4.889LeuGln: 4.889 ± 0.057	4.629LeuArg: 4.629 ± 0.057	7.461LeuSer: 7.461 ± 0.084	6.075LeuThr: 6.075 ± 0.055	6.498LeuVal: 6.498 ± 0.074	1.449LeuTrp: 1.449 ± 0.037	2.766LeuTyr: 2.766 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.633MetAla: 1.633 ± 0.033	0.123MetCys: 0.123 ± 0.009	0.772MetAsp: 0.772 ± 0.024	1.222MetGlu: 1.222 ± 0.029	0.645MetPhe: 0.645 ± 0.021	1.416MetGly: 1.416 ± 0.03	0.237MetHis: 0.237 ± 0.012	1.28MetIle: 1.28 ± 0.027	1.201MetLys: 1.201 ± 0.027	1.858MetLeu: 1.858 ± 0.032	0.466MetMet: 0.466 ± 0.017	0.943MetAsn: 0.943 ± 0.026	0.909MetPro: 0.909 ± 0.025	0.752MetGln: 0.752 ± 0.019	0.885MetArg: 0.885 ± 0.023	1.387MetSer: 1.387 ± 0.027	1.247MetThr: 1.247 ± 0.026	1.314MetVal: 1.314 ± 0.027	0.204MetTrp: 0.204 ± 0.011	0.39MetTyr: 0.39 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.677AsnAla: 2.677 ± 0.048	0.569AsnCys: 0.569 ± 0.02	2.233AsnAsp: 2.233 ± 0.064	2.233AsnGlu: 2.233 ± 0.042	2.56AsnPhe: 2.56 ± 0.049	2.959AsnGly: 2.959 ± 0.064	1.029AsnHis: 1.029 ± 0.028	4.102AsnIle: 4.102 ± 0.082	2.313AsnLys: 2.313 ± 0.045	6.385AsnLeu: 6.385 ± 0.086	0.842AsnMet: 0.842 ± 0.023	2.917AsnAsn: 2.917 ± 0.063	2.861AsnPro: 2.861 ± 0.045	3.205AsnGln: 3.205 ± 0.047	2.269AsnArg: 2.269 ± 0.038	3.985AsnSer: 3.985 ± 0.059	2.555AsnThr: 2.555 ± 0.05	2.333AsnVal: 2.333 ± 0.046	0.927AsnTrp: 0.927 ± 0.025	2.113AsnTyr: 2.113 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.42ProAla: 2.42 ± 0.043	0.338ProCys: 0.338 ± 0.013	2.734ProAsp: 2.734 ± 0.05	4.307ProGlu: 4.307 ± 0.057	1.703ProPhe: 1.703 ± 0.037	2.792ProGly: 2.792 ± 0.047	0.774ProHis: 0.774 ± 0.021	3.12ProIle: 3.12 ± 0.041	2.361ProLys: 2.361 ± 0.037	4.257ProLeu: 4.257 ± 0.06	0.715ProMet: 0.715 ± 0.02	2.343ProAsn: 2.343 ± 0.043	2.074ProPro: 2.074 ± 0.052	2.24ProGln: 2.24 ± 0.042	1.6ProArg: 1.6 ± 0.035	2.685ProSer: 2.685 ± 0.043	2.737ProThr: 2.737 ± 0.049	2.87ProVal: 2.87 ± 0.053	0.545ProTrp: 0.545 ± 0.018	1.324ProTyr: 1.324 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.594GlnAla: 3.594 ± 0.044	0.32GlnCys: 0.32 ± 0.013	2.087GlnAsp: 2.087 ± 0.034	3.94GlnGlu: 3.94 ± 0.055	1.653GlnPhe: 1.653 ± 0.031	2.924GlnGly: 2.924 ± 0.053	0.728GlnHis: 0.728 ± 0.019	3.71GlnIle: 3.71 ± 0.052	3.561GlnLys: 3.561 ± 0.049	5.332GlnLeu: 5.332 ± 0.066	0.964GlnMet: 0.964 ± 0.022	2.455GlnAsn: 2.455 ± 0.04	2.202GlnPro: 2.202 ± 0.042	3.223GlnGln: 3.223 ± 0.067	2.295GlnArg: 2.295 ± 0.038	2.535GlnSer: 2.535 ± 0.044	2.835GlnThr: 2.835 ± 0.045	3.37GlnVal: 3.37 ± 0.043	0.642GlnTrp: 0.642 ± 0.021	1.254GlnTyr: 1.254 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.512ArgAla: 2.512 ± 0.039	0.462ArgCys: 0.462 ± 0.018	2.261ArgAsp: 2.261 ± 0.041	3.196ArgGlu: 3.196 ± 0.044	1.979ArgPhe: 1.979 ± 0.034	2.84ArgGly: 2.84 ± 0.05	0.836ArgHis: 0.836 ± 0.022	3.069ArgIle: 3.069 ± 0.046	2.666ArgLys: 2.666 ± 0.042	4.806ArgLeu: 4.806 ± 0.065	0.941ArgMet: 0.941 ± 0.027	2.005ArgAsn: 2.005 ± 0.037	1.798ArgPro: 1.798 ± 0.036	2.664ArgGln: 2.664 ± 0.043	2.618ArgArg: 2.618 ± 0.056	2.869ArgSer: 2.869 ± 0.049	2.012ArgThr: 2.012 ± 0.035	2.876ArgVal: 2.876 ± 0.048	0.705ArgTrp: 0.705 ± 0.02	1.713ArgTyr: 1.713 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.766SerAla: 3.766 ± 0.052	0.753SerCys: 0.753 ± 0.023	3.38SerAsp: 3.38 ± 0.06	4.417SerGlu: 4.417 ± 0.056	2.866SerPhe: 2.866 ± 0.045	4.845SerGly: 4.845 ± 0.073	1.25SerHis: 1.25 ± 0.028	4.579SerIle: 4.579 ± 0.061	3.305SerLys: 3.305 ± 0.05	7.198SerLeu: 7.198 ± 0.066	1.258SerMet: 1.258 ± 0.025	3.234SerAsn: 3.234 ± 0.052	3.186SerPro: 3.186 ± 0.049	3.836SerGln: 3.836 ± 0.057	2.908SerArg: 2.908 ± 0.04	4.613SerSer: 4.613 ± 0.071	3.472SerThr: 3.472 ± 0.046	3.861SerVal: 3.861 ± 0.052	0.988SerTrp: 0.988 ± 0.024	2.078SerTyr: 2.078 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	3.94ThrAla: 3.94 ± 0.059	0.439ThrCys: 0.439 ± 0.016	2.774ThrAsp: 2.774 ± 0.054	3.847ThrGlu: 3.847 ± 0.061	2.239ThrPhe: 2.239 ± 0.041	4.145ThrGly: 4.145 ± 0.074	0.91ThrHis: 0.91 ± 0.026	4.362ThrIle: 4.362 ± 0.067	2.841ThrLys: 2.841 ± 0.048	5.63ThrLeu: 5.63 ± 0.07	0.822ThrMet: 0.822 ± 0.025	2.717ThrAsn: 2.717 ± 0.048	3.104ThrPro: 3.104 ± 0.059	2.503ThrGln: 2.503 ± 0.043	2.034ThrArg: 2.034 ± 0.034	3.332ThrSer: 3.332 ± 0.053	3.475ThrThr: 3.475 ± 0.074	3.783ThrVal: 3.783 ± 0.053	0.674ThrTrp: 0.674 ± 0.022	1.72ThrTyr: 1.72 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	4.998ValAla: 4.998 ± 0.062	0.691ValCys: 0.691 ± 0.019	3.415ValAsp: 3.415 ± 0.052	4.712ValGlu: 4.712 ± 0.056	2.427ValPhe: 2.427 ± 0.041	4.536ValGly: 4.536 ± 0.065	0.892ValHis: 0.892 ± 0.025	4.37ValIle: 4.37 ± 0.054	3.824ValLys: 3.824 ± 0.053	5.919ValLeu: 5.919 ± 0.065	1.327ValMet: 1.327 ± 0.029	3.157ValAsn: 3.157 ± 0.042	2.453ValPro: 2.453 ± 0.043	2.26ValGln: 2.26 ± 0.041	2.764ValArg: 2.764 ± 0.047	4.09ValSer: 4.09 ± 0.047	3.483ValThr: 3.483 ± 0.054	4.447ValVal: 4.447 ± 0.059	0.842ValTrp: 0.842 ± 0.029	1.935ValTyr: 1.935 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.767TrpAla: 0.767 ± 0.026	0.166TrpCys: 0.166 ± 0.011	0.679TrpAsp: 0.679 ± 0.027	1.043TrpGlu: 1.043 ± 0.027	0.603TrpPhe: 0.603 ± 0.021	0.989TrpGly: 0.989 ± 0.028	0.36TrpHis: 0.36 ± 0.014	0.9TrpIle: 0.9 ± 0.023	0.781TrpLys: 0.781 ± 0.023	1.754TrpLeu: 1.754 ± 0.038	0.348TrpMet: 0.348 ± 0.015	0.719TrpAsn: 0.719 ± 0.023	0.394TrpPro: 0.394 ± 0.015	1.15TrpGln: 1.15 ± 0.031	0.699TrpArg: 0.699 ± 0.021	0.939TrpSer: 0.939 ± 0.027	0.513TrpThr: 0.513 ± 0.023	0.939TrpVal: 0.939 ± 0.025	0.24TrpTrp: 0.24 ± 0.012	0.473TrpTyr: 0.473 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.862TyrAla: 1.862 ± 0.036	0.432TyrCys: 0.432 ± 0.016	1.585TyrAsp: 1.585 ± 0.032	1.946TyrGlu: 1.946 ± 0.041	1.622TyrPhe: 1.622 ± 0.034	2.162TyrGly: 2.162 ± 0.042	0.737TyrHis: 0.737 ± 0.026	2.025TyrIle: 2.025 ± 0.036	1.557TyrLys: 1.557 ± 0.035	3.872TyrLeu: 3.872 ± 0.054	0.481TyrMet: 0.481 ± 0.016	1.497TyrAsn: 1.497 ± 0.031	1.697TyrPro: 1.697 ± 0.031	2.371TyrGln: 2.371 ± 0.045	1.921TyrArg: 1.921 ± 0.038	2.275TyrSer: 2.275 ± 0.039	1.576TyrThr: 1.576 ± 0.034	1.601TyrVal: 1.601 ± 0.031	0.571TyrTrp: 0.571 ± 0.019	1.34TyrTyr: 1.34 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6134 proteins (1773741 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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