Amino acid dipepetide frequency for Ruminiclostridium cellobioparum subsp. termitidis CT1112

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.12AlaAla: 7.12 ± 0.093	0.887AlaCys: 0.887 ± 0.024	3.879AlaAsp: 3.879 ± 0.05	4.617AlaGlu: 4.617 ± 0.054	3.053AlaPhe: 3.053 ± 0.042	6.277AlaGly: 6.277 ± 0.072	0.908AlaHis: 0.908 ± 0.025	5.159AlaIle: 5.159 ± 0.06	4.13AlaLys: 4.13 ± 0.056	6.494AlaLeu: 6.494 ± 0.077	1.892AlaMet: 1.892 ± 0.032	2.802AlaAsn: 2.802 ± 0.045	1.947AlaPro: 1.947 ± 0.039	2.045AlaGln: 2.045 ± 0.036	2.791AlaArg: 2.791 ± 0.042	3.973AlaSer: 3.973 ± 0.055	2.938AlaThr: 2.938 ± 0.061	6.119AlaVal: 6.119 ± 0.067	0.619AlaTrp: 0.619 ± 0.02	2.502AlaTyr: 2.502 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.732CysAla: 0.732 ± 0.021	0.212CysCys: 0.212 ± 0.013	0.642CysAsp: 0.642 ± 0.018	0.675CysGlu: 0.675 ± 0.019	0.545CysPhe: 0.545 ± 0.018	1.142CysGly: 1.142 ± 0.03	0.262CysHis: 0.262 ± 0.014	1.006CysIle: 1.006 ± 0.024	0.7CysLys: 0.7 ± 0.02	0.983CysLeu: 0.983 ± 0.021	0.353CysMet: 0.353 ± 0.014	0.584CysAsn: 0.584 ± 0.02	0.474CysPro: 0.474 ± 0.019	0.28CysGln: 0.28 ± 0.012	0.625CysArg: 0.625 ± 0.021	0.868CysSer: 0.868 ± 0.026	0.616CysThr: 0.616 ± 0.02	0.689CysVal: 0.689 ± 0.02	0.131CysTrp: 0.131 ± 0.008	0.445CysTyr: 0.445 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.284AspAla: 3.284 ± 0.048	0.64AspCys: 0.64 ± 0.021	2.422AspAsp: 2.422 ± 0.042	3.79AspGlu: 3.79 ± 0.049	2.789AspPhe: 2.789 ± 0.039	4.061AspGly: 4.061 ± 0.063	0.634AspHis: 0.634 ± 0.021	5.493AspIle: 5.493 ± 0.059	3.999AspLys: 3.999 ± 0.054	4.287AspLeu: 4.287 ± 0.046	1.639AspMet: 1.639 ± 0.031	2.975AspAsn: 2.975 ± 0.046	1.753AspPro: 1.753 ± 0.036	1.195AspGln: 1.195 ± 0.026	2.504AspArg: 2.504 ± 0.04	3.484AspSer: 3.484 ± 0.046	3.042AspThr: 3.042 ± 0.044	3.283AspVal: 3.283 ± 0.043	0.65AspTrp: 0.65 ± 0.023	2.532AspTyr: 2.532 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.788GluAla: 4.788 ± 0.06	0.664GluCys: 0.664 ± 0.02	3.286GluAsp: 3.286 ± 0.05	4.865GluGlu: 4.865 ± 0.065	2.703GluPhe: 2.703 ± 0.039	3.835GluGly: 3.835 ± 0.049	1.029GluHis: 1.029 ± 0.026	5.843GluIle: 5.843 ± 0.065	5.883GluLys: 5.883 ± 0.075	6.538GluLeu: 6.538 ± 0.078	1.854GluMet: 1.854 ± 0.035	4.143GluAsn: 4.143 ± 0.049	1.692GluPro: 1.692 ± 0.033	2.271GluGln: 2.271 ± 0.038	2.55GluArg: 2.55 ± 0.046	3.239GluSer: 3.239 ± 0.04	3.198GluThr: 3.198 ± 0.038	4.087GluVal: 4.087 ± 0.048	0.588GluTrp: 0.588 ± 0.018	2.927GluTyr: 2.927 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.803PheAla: 2.803 ± 0.042	0.591PheCys: 0.591 ± 0.02	2.767PheAsp: 2.767 ± 0.038	2.857PheGlu: 2.857 ± 0.04	2.037PhePhe: 2.037 ± 0.042	3.102PheGly: 3.102 ± 0.044	0.644PheHis: 0.644 ± 0.02	3.817PheIle: 3.817 ± 0.049	3.085PheLys: 3.085 ± 0.043	3.83PheLeu: 3.83 ± 0.062	1.162PheMet: 1.162 ± 0.026	2.465PheAsn: 2.465 ± 0.043	1.423PhePro: 1.423 ± 0.034	1.094PheGln: 1.094 ± 0.023	1.661PheArg: 1.661 ± 0.029	3.472PheSer: 3.472 ± 0.047	2.626PheThr: 2.626 ± 0.04	2.734PheVal: 2.734 ± 0.038	0.467PheTrp: 0.467 ± 0.017	1.822PheTyr: 1.822 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.656GlyAla: 4.656 ± 0.059	1.03GlyCys: 1.03 ± 0.028	3.54GlyAsp: 3.54 ± 0.043	4.238GlyGlu: 4.238 ± 0.048	3.317GlyPhe: 3.317 ± 0.047	4.91GlyGly: 4.91 ± 0.066	1.126GlyHis: 1.126 ± 0.032	6.706GlyIle: 6.706 ± 0.062	5.219GlyLys: 5.219 ± 0.06	6.166GlyLeu: 6.166 ± 0.066	2.19GlyMet: 2.19 ± 0.036	3.606GlyAsn: 3.606 ± 0.065	1.516GlyPro: 1.516 ± 0.036	2.123GlyGln: 2.123 ± 0.037	3.008GlyArg: 3.008 ± 0.042	4.554GlySer: 4.554 ± 0.059	4.271GlyThr: 4.271 ± 0.069	4.601GlyVal: 4.601 ± 0.054	0.79GlyTrp: 0.79 ± 0.021	3.178GlyTyr: 3.178 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.829HisAla: 0.829 ± 0.021	0.234HisCys: 0.234 ± 0.013	0.76HisAsp: 0.76 ± 0.021	0.901HisGlu: 0.901 ± 0.022	0.758HisPhe: 0.758 ± 0.022	1.106HisGly: 1.106 ± 0.024	0.31HisHis: 0.31 ± 0.015	1.321HisIle: 1.321 ± 0.028	0.949HisLys: 0.949 ± 0.025	1.241HisLeu: 1.241 ± 0.023	0.415HisMet: 0.415 ± 0.015	0.728HisAsn: 0.728 ± 0.019	0.672HisPro: 0.672 ± 0.017	0.43HisGln: 0.43 ± 0.015	0.692HisArg: 0.692 ± 0.02	0.99HisSer: 0.99 ± 0.025	0.787HisThr: 0.787 ± 0.024	0.816HisVal: 0.816 ± 0.023	0.191HisTrp: 0.191 ± 0.01	0.636HisTyr: 0.636 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.623IleAla: 5.623 ± 0.065	1.102IleCys: 1.102 ± 0.023	4.862IleAsp: 4.862 ± 0.05	5.062IleGlu: 5.062 ± 0.063	3.776IlePhe: 3.776 ± 0.056	5.149IleGly: 5.149 ± 0.058	1.2IleHis: 1.2 ± 0.027	7.013IleIle: 7.013 ± 0.072	5.958IleLys: 5.958 ± 0.062	7.571IleLeu: 7.571 ± 0.08	2.044IleMet: 2.044 ± 0.032	4.892IleAsn: 4.892 ± 0.058	3.549IlePro: 3.549 ± 0.044	2.303IleGln: 2.303 ± 0.037	3.339IleArg: 3.339 ± 0.044	6.38IleSer: 6.38 ± 0.067	4.815IleThr: 4.815 ± 0.066	5.095IleVal: 5.095 ± 0.06	0.69IleTrp: 0.69 ± 0.022	3.072IleTyr: 3.072 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	5.176LysAla: 5.176 ± 0.058	0.617LysCys: 0.617 ± 0.023	4.01LysAsp: 4.01 ± 0.058	5.237LysGlu: 5.237 ± 0.068	2.438LysPhe: 2.438 ± 0.038	4.397LysGly: 4.397 ± 0.042	1.015LysHis: 1.015 ± 0.023	5.764LysIle: 5.764 ± 0.059	5.678LysLys: 5.678 ± 0.068	6.574LysLeu: 6.574 ± 0.072	2.018LysMet: 2.018 ± 0.034	4.392LysAsn: 4.392 ± 0.057	2.285LysPro: 2.285 ± 0.038	2.319LysGln: 2.319 ± 0.039	2.693LysArg: 2.693 ± 0.045	4.292LysSer: 4.292 ± 0.046	3.947LysThr: 3.947 ± 0.051	4.54LysVal: 4.54 ± 0.05	0.679LysTrp: 0.679 ± 0.019	3.28LysTyr: 3.28 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.291LeuAla: 6.291 ± 0.069	1.147LeuCys: 1.147 ± 0.025	4.89LeuAsp: 4.89 ± 0.048	6.037LeuGlu: 6.037 ± 0.066	4.098LeuPhe: 4.098 ± 0.063	5.83LeuGly: 5.83 ± 0.06	1.28LeuHis: 1.28 ± 0.028	6.92LeuIle: 6.92 ± 0.084	7.215LeuLys: 7.215 ± 0.067	8.735LeuLeu: 8.735 ± 0.104	2.397LeuMet: 2.397 ± 0.038	4.867LeuAsn: 4.867 ± 0.059	3.464LeuPro: 3.464 ± 0.043	2.736LeuGln: 2.736 ± 0.039	3.442LeuArg: 3.442 ± 0.053	6.747LeuSer: 6.747 ± 0.075	4.994LeuThr: 4.994 ± 0.058	5.551LeuVal: 5.551 ± 0.054	0.821LeuTrp: 0.821 ± 0.024	3.348LeuTyr: 3.348 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.044MetAla: 2.044 ± 0.033	0.272MetCys: 0.272 ± 0.012	1.584MetAsp: 1.584 ± 0.024	1.898MetGlu: 1.898 ± 0.032	1.055MetPhe: 1.055 ± 0.023	1.915MetGly: 1.915 ± 0.038	0.388MetHis: 0.388 ± 0.015	1.916MetIle: 1.916 ± 0.032	2.244MetLys: 2.244 ± 0.039	2.704MetLeu: 2.704 ± 0.042	0.647MetMet: 0.647 ± 0.021	1.512MetAsn: 1.512 ± 0.03	1.017MetPro: 1.017 ± 0.026	0.842MetGln: 0.842 ± 0.021	0.972MetArg: 0.972 ± 0.022	1.756MetSer: 1.756 ± 0.037	1.399MetThr: 1.399 ± 0.027	1.81MetVal: 1.81 ± 0.033	0.214MetTrp: 0.214 ± 0.01	0.858MetTyr: 0.858 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.389AsnAla: 3.389 ± 0.048	0.627AsnCys: 0.627 ± 0.019	2.616AsnAsp: 2.616 ± 0.043	3.333AsnGlu: 3.333 ± 0.045	2.197AsnPhe: 2.197 ± 0.037	3.961AsnGly: 3.961 ± 0.066	0.722AsnHis: 0.722 ± 0.018	5.125AsnIle: 5.125 ± 0.061	3.761AsnLys: 3.761 ± 0.053	4.408AsnLeu: 4.408 ± 0.054	1.466AsnMet: 1.466 ± 0.03	3.217AsnAsn: 3.217 ± 0.058	2.284AsnPro: 2.284 ± 0.033	1.5AsnGln: 1.5 ± 0.032	2.2AsnArg: 2.2 ± 0.039	3.87AsnSer: 3.87 ± 0.052	3.207AsnThr: 3.207 ± 0.05	3.267AsnVal: 3.267 ± 0.043	0.59AsnTrp: 0.59 ± 0.022	2.339AsnTyr: 2.339 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.696ProAla: 2.696 ± 0.048	0.37ProCys: 0.37 ± 0.017	2.41ProAsp: 2.41 ± 0.036	2.927ProGlu: 2.927 ± 0.039	1.566ProPhe: 1.566 ± 0.027	2.693ProGly: 2.693 ± 0.042	0.598ProHis: 0.598 ± 0.017	2.055ProIle: 2.055 ± 0.038	1.779ProLys: 1.779 ± 0.029	2.803ProLeu: 2.803 ± 0.042	0.807ProMet: 0.807 ± 0.022	1.388ProAsn: 1.388 ± 0.035	0.844ProPro: 0.844 ± 0.025	1.11ProGln: 1.11 ± 0.025	1.061ProArg: 1.061 ± 0.026	1.918ProSer: 1.918 ± 0.034	1.54ProThr: 1.54 ± 0.037	3.214ProVal: 3.214 ± 0.046	0.388ProTrp: 0.388 ± 0.016	1.391ProTyr: 1.391 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.056GlnAla: 2.056 ± 0.039	0.29GlnCys: 0.29 ± 0.014	1.391GlnAsp: 1.391 ± 0.032	2.015GlnGlu: 2.015 ± 0.034	1.186GlnPhe: 1.186 ± 0.027	1.741GlnGly: 1.741 ± 0.033	0.421GlnHis: 0.421 ± 0.017	2.348GlnIle: 2.348 ± 0.031	2.52GlnLys: 2.52 ± 0.044	2.937GlnLeu: 2.937 ± 0.041	0.84GlnMet: 0.84 ± 0.019	1.753GlnAsn: 1.753 ± 0.034	1.012GlnPro: 1.012 ± 0.024	1.16GlnGln: 1.16 ± 0.03	1.195GlnArg: 1.195 ± 0.027	1.749GlnSer: 1.749 ± 0.037	1.544GlnThr: 1.544 ± 0.03	1.865GlnVal: 1.865 ± 0.032	0.342GlnTrp: 0.342 ± 0.014	1.368GlnTyr: 1.368 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.49ArgAla: 2.49 ± 0.035	0.436ArgCys: 0.436 ± 0.018	2.211ArgAsp: 2.211 ± 0.035	3.199ArgGlu: 3.199 ± 0.047	1.744ArgPhe: 1.744 ± 0.032	2.252ArgGly: 2.252 ± 0.034	0.689ArgHis: 0.689 ± 0.022	3.53ArgIle: 3.53 ± 0.059	2.999ArgLys: 2.999 ± 0.041	3.894ArgLeu: 3.894 ± 0.057	1.154ArgMet: 1.154 ± 0.023	2.314ArgAsn: 2.314 ± 0.036	1.197ArgPro: 1.197 ± 0.03	1.424ArgGln: 1.424 ± 0.027	1.63ArgArg: 1.63 ± 0.035	2.084ArgSer: 2.084 ± 0.032	2.036ArgThr: 2.036 ± 0.032	2.603ArgVal: 2.603 ± 0.033	0.386ArgTrp: 0.386 ± 0.015	1.729ArgTyr: 1.729 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.585SerAla: 4.585 ± 0.054	0.712SerCys: 0.712 ± 0.024	3.537SerAsp: 3.537 ± 0.055	4.094SerGlu: 4.094 ± 0.052	3.129SerPhe: 3.129 ± 0.043	5.682SerGly: 5.682 ± 0.081	0.948SerHis: 0.948 ± 0.022	5.561SerIle: 5.561 ± 0.064	4.179SerLys: 4.179 ± 0.049	5.796SerLeu: 5.796 ± 0.058	1.69SerMet: 1.69 ± 0.029	3.315SerAsn: 3.315 ± 0.053	2.045SerPro: 2.045 ± 0.033	2.012SerGln: 2.012 ± 0.034	2.837SerArg: 2.837 ± 0.044	4.646SerSer: 4.646 ± 0.059	3.31SerThr: 3.31 ± 0.046	4.494SerVal: 4.494 ± 0.057	0.705SerTrp: 0.705 ± 0.024	2.571SerTyr: 2.571 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.49ThrAla: 4.49 ± 0.065	0.567ThrCys: 0.567 ± 0.019	3.061ThrAsp: 3.061 ± 0.045	3.005ThrGlu: 3.005 ± 0.041	2.32ThrPhe: 2.32 ± 0.039	5.178ThrGly: 5.178 ± 0.075	0.818ThrHis: 0.818 ± 0.022	4.207ThrIle: 4.207 ± 0.049	2.897ThrLys: 2.897 ± 0.041	4.825ThrLeu: 4.825 ± 0.054	1.214ThrMet: 1.214 ± 0.026	2.413ThrAsn: 2.413 ± 0.044	2.135ThrPro: 2.135 ± 0.037	1.45ThrGln: 1.45 ± 0.03	1.995ThrArg: 1.995 ± 0.038	3.344ThrSer: 3.344 ± 0.056	2.695ThrThr: 2.695 ± 0.054	4.548ThrVal: 4.548 ± 0.076	0.536ThrTrp: 0.536 ± 0.02	2.206ThrTyr: 2.206 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	4.144ValAla: 4.144 ± 0.049	0.867ValCys: 0.867 ± 0.024	3.575ValAsp: 3.575 ± 0.048	4.121ValGlu: 4.121 ± 0.054	3.265ValPhe: 3.265 ± 0.048	3.981ValGly: 3.981 ± 0.048	0.922ValHis: 0.922 ± 0.024	5.681ValIle: 5.681 ± 0.063	4.765ValLys: 4.765 ± 0.056	6.427ValLeu: 6.427 ± 0.079	1.85ValMet: 1.85 ± 0.034	3.631ValAsn: 3.631 ± 0.05	2.452ValPro: 2.452 ± 0.044	1.866ValGln: 1.866 ± 0.032	2.607ValArg: 2.607 ± 0.037	4.781ValSer: 4.781 ± 0.049	3.998ValThr: 3.998 ± 0.076	4.319ValVal: 4.319 ± 0.056	0.64ValTrp: 0.64 ± 0.02	2.626ValTyr: 2.626 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.606TrpAla: 0.606 ± 0.022	0.157TrpCys: 0.157 ± 0.011	0.624TrpAsp: 0.624 ± 0.02	0.618TrpGlu: 0.618 ± 0.018	0.435TrpPhe: 0.435 ± 0.018	0.738TrpGly: 0.738 ± 0.024	0.187TrpHis: 0.187 ± 0.011	0.667TrpIle: 0.667 ± 0.021	0.693TrpLys: 0.693 ± 0.02	0.936TrpLeu: 0.936 ± 0.029	0.296TrpMet: 0.296 ± 0.013	0.661TrpAsn: 0.661 ± 0.022	0.264TrpPro: 0.264 ± 0.014	0.409TrpGln: 0.409 ± 0.014	0.363TrpArg: 0.363 ± 0.013	0.677TrpSer: 0.677 ± 0.025	0.522TrpThr: 0.522 ± 0.021	0.582TrpVal: 0.582 ± 0.017	0.148TrpTrp: 0.148 ± 0.009	0.44TrpTyr: 0.44 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.347TyrAla: 2.347 ± 0.037	0.543TyrCys: 0.543 ± 0.019	2.392TyrAsp: 2.392 ± 0.072	2.493TyrGlu: 2.493 ± 0.038	2.05TyrPhe: 2.05 ± 0.034	2.795TyrGly: 2.795 ± 0.044	0.667TyrHis: 0.667 ± 0.019	3.365TyrIle: 3.365 ± 0.044	2.696TyrLys: 2.696 ± 0.039	3.66TyrLeu: 3.66 ± 0.052	1.119TyrMet: 1.119 ± 0.024	2.419TyrAsn: 2.419 ± 0.047	1.531TyrPro: 1.531 ± 0.029	1.164TyrGln: 1.164 ± 0.024	1.837TyrArg: 1.837 ± 0.034	3.023TyrSer: 3.023 ± 0.04	2.421TyrThr: 2.421 ± 0.049	2.299TyrVal: 2.299 ± 0.031	0.448TyrTrp: 0.448 ± 0.018	1.833TyrTyr: 1.833 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5302 proteins (1861788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---