Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259I07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.033AlaAla: 4.033 ± 0.197
0.556AlaCys: 0.556 ± 0.051
3.119AlaAsp: 3.119 ± 0.149
5.592AlaGlu: 5.592 ± 0.2
2.384AlaPhe: 2.384 ± 0.116
4.562AlaGly: 4.562 ± 0.211
0.927AlaHis: 0.927 ± 0.083
4.005AlaIle: 4.005 ± 0.187
3.902AlaLys: 3.902 ± 0.207
5.613AlaLeu: 5.613 ± 0.212
1.559AlaMet: 1.559 ± 0.107
1.58AlaAsn: 1.58 ± 0.112
1.711AlaPro: 1.711 ± 0.094
1.34AlaGln: 1.34 ± 0.102
3.215AlaArg: 3.215 ± 0.151
3.456AlaSer: 3.456 ± 0.149
2.631AlaThr: 2.631 ± 0.142
4.211AlaVal: 4.211 ± 0.187
0.694AlaTrp: 0.694 ± 0.076
1.724AlaTyr: 1.724 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.488CysAla: 0.488 ± 0.053
0.076CysCys: 0.076 ± 0.024
0.57CysAsp: 0.57 ± 0.06
1.01CysGlu: 1.01 ± 0.082
0.371CysPhe: 0.371 ± 0.054
1.017CysGly: 1.017 ± 0.096
0.192CysHis: 0.192 ± 0.034
0.488CysIle: 0.488 ± 0.057
0.577CysLys: 0.577 ± 0.055
0.818CysLeu: 0.818 ± 0.072
0.206CysMet: 0.206 ± 0.034
0.343CysAsn: 0.343 ± 0.043
0.735CysPro: 0.735 ± 0.068
0.24CysGln: 0.24 ± 0.035
0.708CysArg: 0.708 ± 0.072
0.673CysSer: 0.673 ± 0.068
0.398CysThr: 0.398 ± 0.045
0.447CysVal: 0.447 ± 0.05
0.131CysTrp: 0.131 ± 0.033
0.24CysTyr: 0.24 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
2.933AspAla: 2.933 ± 0.144
0.666AspCys: 0.666 ± 0.052
2.741AspAsp: 2.741 ± 0.12
6.059AspGlu: 6.059 ± 0.214
2.624AspPhe: 2.624 ± 0.138
3.641AspGly: 3.641 ± 0.176
0.9AspHis: 0.9 ± 0.075
4.301AspIle: 4.301 ± 0.184
3.614AspLys: 3.614 ± 0.163
6.272AspLeu: 6.272 ± 0.215
1.298AspMet: 1.298 ± 0.112
1.711AspAsn: 1.711 ± 0.103
2.439AspPro: 2.439 ± 0.135
1.168AspGln: 1.168 ± 0.094
3.833AspArg: 3.833 ± 0.171
3.243AspSer: 3.243 ± 0.162
2.329AspThr: 2.329 ± 0.112
4.191AspVal: 4.191 ± 0.152
0.783AspTrp: 0.783 ± 0.08
2.226AspTyr: 2.226 ± 0.131
0.0AspXaa: 0.0 ± 0.0
Glu
5.62GluAla: 5.62 ± 0.27
0.776GluCys: 0.776 ± 0.087
6.204GluAsp: 6.204 ± 0.26
13.383GluGlu: 13.383 ± 0.427
3.634GluPhe: 3.634 ± 0.141
6.478GluGly: 6.478 ± 0.239
1.443GluHis: 1.443 ± 0.105
8.471GluIle: 8.471 ± 0.274
11.892GluLys: 11.892 ± 0.367
8.319GluLeu: 8.319 ± 0.267
2.508GluMet: 2.508 ± 0.151
5.194GluAsn: 5.194 ± 0.236
2.975GluPro: 2.975 ± 0.163
1.889GluGln: 1.889 ± 0.115
6.561GluArg: 6.561 ± 0.287
4.85GluSer: 4.85 ± 0.181
4.919GluThr: 4.919 ± 0.218
6.733GluVal: 6.733 ± 0.205
0.982GluTrp: 0.982 ± 0.09
2.48GluTyr: 2.48 ± 0.138
0.0GluXaa: 0.0 ± 0.0
Phe
2.171PheAla: 2.171 ± 0.136
0.611PheCys: 0.611 ± 0.071
2.631PheAsp: 2.631 ± 0.138
3.717PheGlu: 3.717 ± 0.173
2.157PhePhe: 2.157 ± 0.157
3.346PheGly: 3.346 ± 0.162
0.852PheHis: 0.852 ± 0.074
2.384PheIle: 2.384 ± 0.152
2.301PheLys: 2.301 ± 0.13
4.953PheLeu: 4.953 ± 0.258
0.872PheMet: 0.872 ± 0.089
1.264PheAsn: 1.264 ± 0.1
1.635PhePro: 1.635 ± 0.108
1.14PheGln: 1.14 ± 0.091
2.082PheArg: 2.082 ± 0.094
2.995PheSer: 2.995 ± 0.169
1.697PheThr: 1.697 ± 0.112
2.549PheVal: 2.549 ± 0.144
0.55PheTrp: 0.55 ± 0.07
1.498PheTyr: 1.498 ± 0.1
0.0PheXaa: 0.0 ± 0.0
Gly
4.356GlyAla: 4.356 ± 0.219
0.646GlyCys: 0.646 ± 0.067
3.675GlyAsp: 3.675 ± 0.173
7.639GlyGlu: 7.639 ± 0.267
3.332GlyPhe: 3.332 ± 0.159
5.606GlyGly: 5.606 ± 0.267
1.161GlyHis: 1.161 ± 0.103
5.152GlyIle: 5.152 ± 0.213
5.915GlyLys: 5.915 ± 0.211
6.348GlyLeu: 6.348 ± 0.219
1.855GlyMet: 1.855 ± 0.119
2.308GlyAsn: 2.308 ± 0.129
2.281GlyPro: 2.281 ± 0.133
1.305GlyGln: 1.305 ± 0.099
4.108GlyArg: 4.108 ± 0.194
4.328GlySer: 4.328 ± 0.18
3.284GlyThr: 3.284 ± 0.166
5.448GlyVal: 5.448 ± 0.224
0.9GlyTrp: 0.9 ± 0.089
2.638GlyTyr: 2.638 ± 0.128
0.0GlyXaa: 0.0 ± 0.0
His
0.742HisAla: 0.742 ± 0.061
0.185HisCys: 0.185 ± 0.037
0.831HisAsp: 0.831 ± 0.082
1.559HisGlu: 1.559 ± 0.125
0.632HisPhe: 0.632 ± 0.064
1.395HisGly: 1.395 ± 0.099
0.364HisHis: 0.364 ± 0.056
0.948HisIle: 0.948 ± 0.07
0.763HisLys: 0.763 ± 0.072
1.985HisLeu: 1.985 ± 0.116
0.378HisMet: 0.378 ± 0.047
0.46HisAsn: 0.46 ± 0.058
0.934HisPro: 0.934 ± 0.093
0.323HisGln: 0.323 ± 0.047
0.962HisArg: 0.962 ± 0.083
1.168HisSer: 1.168 ± 0.087
0.804HisThr: 0.804 ± 0.076
0.982HisVal: 0.982 ± 0.083
0.165HisTrp: 0.165 ± 0.034
0.639HisTyr: 0.639 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
4.541IleAla: 4.541 ± 0.195
0.714IleCys: 0.714 ± 0.079
4.149IleAsp: 4.149 ± 0.179
7.207IleGlu: 7.207 ± 0.241
3.146IlePhe: 3.146 ± 0.179
5.331IleGly: 5.331 ± 0.227
1.25IleHis: 1.25 ± 0.098
4.83IleIle: 4.83 ± 0.203
4.452IleLys: 4.452 ± 0.182
7.158IleLeu: 7.158 ± 0.264
1.305IleMet: 1.305 ± 0.1
2.205IleAsn: 2.205 ± 0.131
3.215IlePro: 3.215 ± 0.13
1.862IleGln: 1.862 ± 0.121
3.985IleArg: 3.985 ± 0.163
5.166IleSer: 5.166 ± 0.2
3.38IleThr: 3.38 ± 0.151
5.022IleVal: 5.022 ± 0.178
0.673IleTrp: 0.673 ± 0.065
1.869IleTyr: 1.869 ± 0.115
0.0IleXaa: 0.0 ± 0.0
Lys
4.397LysAla: 4.397 ± 0.182
0.66LysCys: 0.66 ± 0.063
4.28LysAsp: 4.28 ± 0.179
8.649LysGlu: 8.649 ± 0.29
2.528LysPhe: 2.528 ± 0.139
4.788LysGly: 4.788 ± 0.192
1.154LysHis: 1.154 ± 0.084
7.227LysIle: 7.227 ± 0.23
7.055LysLys: 7.055 ± 0.304
6.712LysLeu: 6.712 ± 0.237
1.724LysMet: 1.724 ± 0.113
3.82LysAsn: 3.82 ± 0.159
2.37LysPro: 2.37 ± 0.138
1.532LysGln: 1.532 ± 0.105
4.356LysArg: 4.356 ± 0.197
4.191LysSer: 4.191 ± 0.181
4.094LysThr: 4.094 ± 0.172
5.104LysVal: 5.104 ± 0.179
0.769LysTrp: 0.769 ± 0.069
2.274LysTyr: 2.274 ± 0.128
0.0LysXaa: 0.0 ± 0.0
Leu
6.121LeuAla: 6.121 ± 0.224
0.666LeuCys: 0.666 ± 0.069
6.197LeuAsp: 6.197 ± 0.255
10.305LeuGlu: 10.305 ± 0.309
3.737LeuPhe: 3.737 ± 0.202
6.781LeuGly: 6.781 ± 0.238
1.429LeuHis: 1.429 ± 0.091
6.059LeuIle: 6.059 ± 0.245
7.255LeuLys: 7.255 ± 0.227
8.271LeuLeu: 8.271 ± 0.312
2.013LeuMet: 2.013 ± 0.131
3.531LeuAsn: 3.531 ± 0.157
3.435LeuPro: 3.435 ± 0.134
2.226LeuGln: 2.226 ± 0.121
5.18LeuArg: 5.18 ± 0.205
6.478LeuSer: 6.478 ± 0.231
4.651LeuThr: 4.651 ± 0.152
6.341LeuVal: 6.341 ± 0.216
0.982LeuTrp: 0.982 ± 0.087
2.295LeuTyr: 2.295 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
1.401MetAla: 1.401 ± 0.099
0.24MetCys: 0.24 ± 0.037
1.415MetAsp: 1.415 ± 0.101
2.185MetGlu: 2.185 ± 0.132
0.694MetPhe: 0.694 ± 0.081
1.45MetGly: 1.45 ± 0.103
0.357MetHis: 0.357 ± 0.047
1.559MetIle: 1.559 ± 0.111
2.006MetLys: 2.006 ± 0.106
1.848MetLeu: 1.848 ± 0.102
0.467MetMet: 0.467 ± 0.064
1.058MetAsn: 1.058 ± 0.083
1.037MetPro: 1.037 ± 0.094
0.419MetGln: 0.419 ± 0.054
1.168MetArg: 1.168 ± 0.092
1.594MetSer: 1.594 ± 0.104
1.072MetThr: 1.072 ± 0.084
1.779MetVal: 1.779 ± 0.112
0.137MetTrp: 0.137 ± 0.032
0.412MetTyr: 0.412 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
2.02AsnAla: 2.02 ± 0.13
0.515AsnCys: 0.515 ± 0.055
1.525AsnAsp: 1.525 ± 0.114
2.741AsnGlu: 2.741 ± 0.153
1.772AsnPhe: 1.772 ± 0.115
2.384AsnGly: 2.384 ± 0.143
0.625AsnHis: 0.625 ± 0.059
2.872AsnIle: 2.872 ± 0.138
2.514AsnLys: 2.514 ± 0.183
4.39AsnLeu: 4.39 ± 0.171
0.714AsnMet: 0.714 ± 0.074
1.161AsnAsn: 1.161 ± 0.095
2.391AsnPro: 2.391 ± 0.121
1.12AsnGln: 1.12 ± 0.093
2.308AsnArg: 2.308 ± 0.118
2.308AsnSer: 2.308 ± 0.138
1.546AsnThr: 1.546 ± 0.095
2.404AsnVal: 2.404 ± 0.126
0.508AsnTrp: 0.508 ± 0.055
1.395AsnTyr: 1.395 ± 0.115
0.0AsnXaa: 0.0 ± 0.0
Pro
1.869ProAla: 1.869 ± 0.117
0.447ProCys: 0.447 ± 0.057
2.569ProAsp: 2.569 ± 0.13
4.83ProGlu: 4.83 ± 0.187
1.477ProPhe: 1.477 ± 0.089
2.645ProGly: 2.645 ± 0.154
0.666ProHis: 0.666 ± 0.058
2.439ProIle: 2.439 ± 0.135
2.219ProLys: 2.219 ± 0.14
3.174ProLeu: 3.174 ± 0.154
0.866ProMet: 0.866 ± 0.071
1.353ProAsn: 1.353 ± 0.102
1.814ProPro: 1.814 ± 0.109
1.106ProGln: 1.106 ± 0.093
1.869ProArg: 1.869 ± 0.114
2.824ProSer: 2.824 ± 0.136
1.896ProThr: 1.896 ± 0.111
2.775ProVal: 2.775 ± 0.132
0.405ProTrp: 0.405 ± 0.053
1.25ProTyr: 1.25 ± 0.091
0.0ProXaa: 0.0 ± 0.0
Gln
1.381GlnAla: 1.381 ± 0.087
0.117GlnCys: 0.117 ± 0.023
1.024GlnAsp: 1.024 ± 0.081
2.295GlnGlu: 2.295 ± 0.113
0.852GlnPhe: 0.852 ± 0.081
1.587GlnGly: 1.587 ± 0.107
0.378GlnHis: 0.378 ± 0.046
1.972GlnIle: 1.972 ± 0.117
2.446GlnLys: 2.446 ± 0.125
1.882GlnLeu: 1.882 ± 0.106
0.57GlnMet: 0.57 ± 0.061
0.989GlnAsn: 0.989 ± 0.087
0.556GlnPro: 0.556 ± 0.064
0.495GlnGln: 0.495 ± 0.063
1.518GlnArg: 1.518 ± 0.094
1.271GlnSer: 1.271 ± 0.095
1.223GlnThr: 1.223 ± 0.084
1.456GlnVal: 1.456 ± 0.101
0.185GlnTrp: 0.185 ± 0.038
0.625GlnTyr: 0.625 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
3.181ArgAla: 3.181 ± 0.148
0.522ArgCys: 0.522 ± 0.063
3.414ArgAsp: 3.414 ± 0.167
7.0ArgGlu: 7.0 ± 0.27
2.226ArgPhe: 2.226 ± 0.129
4.198ArgGly: 4.198 ± 0.177
0.9ArgHis: 0.9 ± 0.082
4.136ArgIle: 4.136 ± 0.173
5.846ArgLys: 5.846 ± 0.247
5.091ArgLeu: 5.091 ± 0.235
1.415ArgMet: 1.415 ± 0.085
2.411ArgAsn: 2.411 ± 0.132
1.683ArgPro: 1.683 ± 0.115
1.099ArgGln: 1.099 ± 0.079
3.717ArgArg: 3.717 ± 0.194
3.174ArgSer: 3.174 ± 0.155
2.528ArgThr: 2.528 ± 0.146
3.902ArgVal: 3.902 ± 0.183
0.591ArgTrp: 0.591 ± 0.07
1.752ArgTyr: 1.752 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
3.353SerAla: 3.353 ± 0.143
0.639SerCys: 0.639 ± 0.076
3.366SerAsp: 3.366 ± 0.157
6.492SerGlu: 6.492 ± 0.226
2.686SerPhe: 2.686 ± 0.143
5.125SerGly: 5.125 ± 0.202
0.969SerHis: 0.969 ± 0.069
4.335SerIle: 4.335 ± 0.211
4.569SerLys: 4.569 ± 0.182
6.19SerLeu: 6.19 ± 0.222
1.367SerMet: 1.367 ± 0.098
2.459SerAsn: 2.459 ± 0.126
2.617SerPro: 2.617 ± 0.144
1.621SerGln: 1.621 ± 0.101
3.559SerArg: 3.559 ± 0.17
4.122SerSer: 4.122 ± 0.17
2.597SerThr: 2.597 ± 0.145
4.094SerVal: 4.094 ± 0.18
0.66SerTrp: 0.66 ± 0.066
1.93SerTyr: 1.93 ± 0.12
0.0SerXaa: 0.0 ± 0.0
Thr
2.645ThrAla: 2.645 ± 0.144
0.474ThrCys: 0.474 ± 0.054
2.59ThrAsp: 2.59 ± 0.137
4.115ThrGlu: 4.115 ± 0.161
2.054ThrPhe: 2.054 ± 0.127
3.998ThrGly: 3.998 ± 0.173
0.728ThrHis: 0.728 ± 0.074
3.098ThrIle: 3.098 ± 0.167
2.714ThrLys: 2.714 ± 0.154
4.431ThrLeu: 4.431 ± 0.186
0.976ThrMet: 0.976 ± 0.09
1.628ThrAsn: 1.628 ± 0.102
2.301ThrPro: 2.301 ± 0.123
1.175ThrGln: 1.175 ± 0.09
2.453ThrArg: 2.453 ± 0.124
2.906ThrSer: 2.906 ± 0.149
2.741ThrThr: 2.741 ± 0.162
3.854ThrVal: 3.854 ± 0.165
0.453ThrTrp: 0.453 ± 0.058
1.587ThrTyr: 1.587 ± 0.105
0.0ThrXaa: 0.0 ± 0.0
Val
3.545ValAla: 3.545 ± 0.156
0.756ValCys: 0.756 ± 0.072
4.266ValAsp: 4.266 ± 0.175
6.753ValGlu: 6.753 ± 0.223
3.222ValPhe: 3.222 ± 0.178
4.864ValGly: 4.864 ± 0.2
1.175ValHis: 1.175 ± 0.079
4.672ValIle: 4.672 ± 0.17
4.871ValLys: 4.871 ± 0.207
6.492ValLeu: 6.492 ± 0.231
1.47ValMet: 1.47 ± 0.102
2.226ValAsn: 2.226 ± 0.118
2.679ValPro: 2.679 ± 0.125
1.566ValGln: 1.566 ± 0.116
3.95ValArg: 3.95 ± 0.175
5.084ValSer: 5.084 ± 0.164
3.359ValThr: 3.359 ± 0.146
4.424ValVal: 4.424 ± 0.183
0.673ValTrp: 0.673 ± 0.075
1.944ValTyr: 1.944 ± 0.117
0.0ValXaa: 0.0 ± 0.0
Trp
0.55TrpAla: 0.55 ± 0.069
0.11TrpCys: 0.11 ± 0.026
0.618TrpAsp: 0.618 ± 0.07
0.893TrpGlu: 0.893 ± 0.086
0.371TrpPhe: 0.371 ± 0.058
0.673TrpGly: 0.673 ± 0.069
0.144TrpHis: 0.144 ± 0.029
0.756TrpIle: 0.756 ± 0.074
0.948TrpLys: 0.948 ± 0.084
0.969TrpLeu: 0.969 ± 0.079
0.213TrpMet: 0.213 ± 0.039
0.467TrpAsn: 0.467 ± 0.058
0.33TrpPro: 0.33 ± 0.05
0.282TrpGln: 0.282 ± 0.046
1.051TrpArg: 1.051 ± 0.107
0.728TrpSer: 0.728 ± 0.075
0.577TrpThr: 0.577 ± 0.06
0.694TrpVal: 0.694 ± 0.074
0.179TrpTrp: 0.179 ± 0.033
0.24TrpTyr: 0.24 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.47TyrAla: 1.47 ± 0.097
0.357TyrCys: 0.357 ± 0.062
1.786TyrAsp: 1.786 ± 0.117
2.885TyrGlu: 2.885 ± 0.142
1.505TyrPhe: 1.505 ± 0.104
2.418TyrGly: 2.418 ± 0.159
0.605TyrHis: 0.605 ± 0.059
1.759TyrIle: 1.759 ± 0.109
1.827TyrLys: 1.827 ± 0.113
3.037TyrLeu: 3.037 ± 0.154
0.515TyrMet: 0.515 ± 0.06
1.044TyrAsn: 1.044 ± 0.093
1.353TyrPro: 1.353 ± 0.091
0.914TyrGln: 0.914 ± 0.071
2.205TyrArg: 2.205 ± 0.144
2.192TyrSer: 2.192 ± 0.123
1.195TyrThr: 1.195 ± 0.091
1.58TyrVal: 1.58 ± 0.111
0.371TyrTrp: 0.371 ± 0.052
1.079TyrTyr: 1.079 ± 0.1
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 671 proteins (145563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski