Amino acid dipepetide frequency for Nitrosomonas communis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.948AlaAla: 8.948 ± 0.119
1.131AlaCys: 1.131 ± 0.04
4.513AlaAsp: 4.513 ± 0.074
5.552AlaGlu: 5.552 ± 0.086
3.333AlaPhe: 3.333 ± 0.064
6.56AlaGly: 6.56 ± 0.103
2.183AlaHis: 2.183 ± 0.054
6.311AlaIle: 6.311 ± 0.101
4.204AlaLys: 4.204 ± 0.061
9.878AlaLeu: 9.878 ± 0.14
2.319AlaMet: 2.319 ± 0.051
3.329AlaAsn: 3.329 ± 0.072
3.118AlaPro: 3.118 ± 0.066
3.887AlaGln: 3.887 ± 0.072
5.224AlaArg: 5.224 ± 0.084
5.027AlaSer: 5.027 ± 0.072
4.444AlaThr: 4.444 ± 0.072
5.776AlaVal: 5.776 ± 0.093
1.197AlaTrp: 1.197 ± 0.036
2.594AlaTyr: 2.594 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.936CysAla: 0.936 ± 0.032
0.142CysCys: 0.142 ± 0.014
0.567CysAsp: 0.567 ± 0.029
0.595CysGlu: 0.595 ± 0.029
0.423CysPhe: 0.423 ± 0.023
0.9CysGly: 0.9 ± 0.036
0.456CysHis: 0.456 ± 0.028
0.621CysIle: 0.621 ± 0.029
0.423CysLys: 0.423 ± 0.023
0.928CysLeu: 0.928 ± 0.032
0.251CysMet: 0.251 ± 0.016
0.357CysAsn: 0.357 ± 0.018
0.522CysPro: 0.522 ± 0.024
0.408CysGln: 0.408 ± 0.021
0.599CysArg: 0.599 ± 0.027
0.655CysSer: 0.655 ± 0.028
0.525CysThr: 0.525 ± 0.022
0.65CysVal: 0.65 ± 0.028
0.159CysTrp: 0.159 ± 0.014
0.357CysTyr: 0.357 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.279AspAla: 4.279 ± 0.083
0.491AspCys: 0.491 ± 0.022
2.34AspAsp: 2.34 ± 0.061
3.427AspGlu: 3.427 ± 0.069
2.308AspPhe: 2.308 ± 0.054
3.184AspGly: 3.184 ± 0.077
1.298AspHis: 1.298 ± 0.038
3.726AspIle: 3.726 ± 0.063
2.592AspLys: 2.592 ± 0.062
5.175AspLeu: 5.175 ± 0.092
1.258AspMet: 1.258 ± 0.039
1.941AspAsn: 1.941 ± 0.052
2.493AspPro: 2.493 ± 0.06
2.069AspGln: 2.069 ± 0.052
2.802AspArg: 2.802 ± 0.059
2.723AspSer: 2.723 ± 0.056
2.654AspThr: 2.654 ± 0.07
3.095AspVal: 3.095 ± 0.074
0.914AspTrp: 0.914 ± 0.034
1.82AspTyr: 1.82 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.592GluAla: 5.592 ± 0.074
0.523GluCys: 0.523 ± 0.025
2.477GluAsp: 2.477 ± 0.055
3.854GluGlu: 3.854 ± 0.085
2.278GluPhe: 2.278 ± 0.058
3.55GluGly: 3.55 ± 0.067
1.544GluHis: 1.544 ± 0.046
5.008GluIle: 5.008 ± 0.084
3.643GluLys: 3.643 ± 0.068
6.444GluLeu: 6.444 ± 0.096
1.629GluMet: 1.629 ± 0.044
2.487GluAsn: 2.487 ± 0.059
2.121GluPro: 2.121 ± 0.049
3.279GluGln: 3.279 ± 0.069
3.899GluArg: 3.899 ± 0.078
3.426GluSer: 3.426 ± 0.061
3.166GluThr: 3.166 ± 0.063
3.914GluVal: 3.914 ± 0.082
0.906GluTrp: 0.906 ± 0.036
1.725GluTyr: 1.725 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.451PheAla: 3.451 ± 0.069
0.52PheCys: 0.52 ± 0.025
2.495PheAsp: 2.495 ± 0.055
2.294PheGlu: 2.294 ± 0.046
1.922PhePhe: 1.922 ± 0.066
3.001PheGly: 3.001 ± 0.06
0.968PheHis: 0.968 ± 0.03
2.759PheIle: 2.759 ± 0.059
1.622PheLys: 1.622 ± 0.045
3.851PheLeu: 3.851 ± 0.081
0.935PheMet: 0.935 ± 0.039
1.821PheAsn: 1.821 ± 0.047
1.797PhePro: 1.797 ± 0.048
1.327PheGln: 1.327 ± 0.039
1.961PheArg: 1.961 ± 0.047
2.877PheSer: 2.877 ± 0.056
2.148PheThr: 2.148 ± 0.049
2.51PheVal: 2.51 ± 0.051
0.574PheTrp: 0.574 ± 0.027
1.405PheTyr: 1.405 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.248GlyAla: 5.248 ± 0.092
0.888GlyCys: 0.888 ± 0.034
3.144GlyAsp: 3.144 ± 0.077
4.054GlyGlu: 4.054 ± 0.075
2.958GlyPhe: 2.958 ± 0.062
4.938GlyGly: 4.938 ± 0.104
1.729GlyHis: 1.729 ± 0.046
5.132GlyIle: 5.132 ± 0.074
4.035GlyLys: 4.035 ± 0.068
6.81GlyLeu: 6.81 ± 0.103
2.089GlyMet: 2.089 ± 0.049
2.726GlyAsn: 2.726 ± 0.086
1.891GlyPro: 1.891 ± 0.048
2.587GlyGln: 2.587 ± 0.057
3.876GlyArg: 3.876 ± 0.078
4.053GlySer: 4.053 ± 0.074
3.528GlyThr: 3.528 ± 0.073
4.846GlyVal: 4.846 ± 0.081
1.141GlyTrp: 1.141 ± 0.036
2.45GlyTyr: 2.45 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.275HisAla: 2.275 ± 0.054
0.323HisCys: 0.323 ± 0.019
1.323HisAsp: 1.323 ± 0.04
1.39HisGlu: 1.39 ± 0.047
1.161HisPhe: 1.161 ± 0.04
1.965HisGly: 1.965 ± 0.056
0.974HisHis: 0.974 ± 0.041
1.727HisIle: 1.727 ± 0.038
1.012HisLys: 1.012 ± 0.035
2.744HisLeu: 2.744 ± 0.061
0.568HisMet: 0.568 ± 0.026
0.929HisAsn: 0.929 ± 0.036
1.595HisPro: 1.595 ± 0.044
1.12HisGln: 1.12 ± 0.041
1.406HisArg: 1.406 ± 0.037
1.393HisSer: 1.393 ± 0.041
1.306HisThr: 1.306 ± 0.044
1.513HisVal: 1.513 ± 0.049
0.355HisTrp: 0.355 ± 0.022
0.999HisTyr: 0.999 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.833IleAla: 6.833 ± 0.097
0.745IleCys: 0.745 ± 0.031
4.059IleAsp: 4.059 ± 0.073
4.786IleGlu: 4.786 ± 0.078
2.566IlePhe: 2.566 ± 0.061
4.899IleGly: 4.899 ± 0.08
1.641IleHis: 1.641 ± 0.041
4.291IleIle: 4.291 ± 0.074
3.528IleLys: 3.528 ± 0.069
6.514IleLeu: 6.514 ± 0.1
1.505IleMet: 1.505 ± 0.039
3.099IleAsn: 3.099 ± 0.057
3.338IlePro: 3.338 ± 0.064
2.428IleGln: 2.428 ± 0.058
3.542IleArg: 3.542 ± 0.049
4.479IleSer: 4.479 ± 0.074
3.947IleThr: 3.947 ± 0.067
4.134IleVal: 4.134 ± 0.071
0.718IleTrp: 0.718 ± 0.03
1.88IleTyr: 1.88 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.015LysAla: 4.015 ± 0.08
0.34LysCys: 0.34 ± 0.02
2.211LysAsp: 2.211 ± 0.053
3.314LysGlu: 3.314 ± 0.066
1.519LysPhe: 1.519 ± 0.039
2.797LysGly: 2.797 ± 0.068
1.27LysHis: 1.27 ± 0.042
3.555LysIle: 3.555 ± 0.07
2.864LysLys: 2.864 ± 0.061
5.22LysLeu: 5.22 ± 0.073
1.261LysMet: 1.261 ± 0.046
2.232LysAsn: 2.232 ± 0.045
2.236LysPro: 2.236 ± 0.057
2.493LysGln: 2.493 ± 0.064
3.1LysArg: 3.1 ± 0.069
2.854LysSer: 2.854 ± 0.067
2.619LysThr: 2.619 ± 0.056
3.017LysVal: 3.017 ± 0.065
0.557LysTrp: 0.557 ± 0.027
1.187LysTyr: 1.187 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.402LeuAla: 10.402 ± 0.138
1.132LeuCys: 1.132 ± 0.037
5.379LeuAsp: 5.379 ± 0.087
6.155LeuGlu: 6.155 ± 0.098
4.257LeuPhe: 4.257 ± 0.066
6.804LeuGly: 6.804 ± 0.107
2.499LeuHis: 2.499 ± 0.061
6.969LeuIle: 6.969 ± 0.106
5.057LeuLys: 5.057 ± 0.078
11.583LeuLeu: 11.583 ± 0.194
2.502LeuMet: 2.502 ± 0.056
4.1LeuAsn: 4.1 ± 0.071
5.659LeuPro: 5.659 ± 0.089
4.355LeuGln: 4.355 ± 0.084
5.919LeuArg: 5.919 ± 0.076
7.113LeuSer: 7.113 ± 0.093
6.04LeuThr: 6.04 ± 0.085
6.581LeuVal: 6.581 ± 0.095
1.282LeuTrp: 1.282 ± 0.049
2.791LeuTyr: 2.791 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.287MetAla: 2.287 ± 0.059
0.187MetCys: 0.187 ± 0.013
1.179MetAsp: 1.179 ± 0.037
1.374MetGlu: 1.374 ± 0.038
0.765MetPhe: 0.765 ± 0.032
1.59MetGly: 1.59 ± 0.052
0.64MetHis: 0.64 ± 0.028
1.572MetIle: 1.572 ± 0.041
1.347MetLys: 1.347 ± 0.042
2.979MetLeu: 2.979 ± 0.066
0.651MetMet: 0.651 ± 0.029
1.155MetAsn: 1.155 ± 0.034
1.222MetPro: 1.222 ± 0.039
1.152MetGln: 1.152 ± 0.037
1.535MetArg: 1.535 ± 0.041
1.604MetSer: 1.604 ± 0.046
1.559MetThr: 1.559 ± 0.038
1.632MetVal: 1.632 ± 0.045
0.197MetTrp: 0.197 ± 0.014
0.44MetTyr: 0.44 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.372AsnAla: 3.372 ± 0.076
0.396AsnCys: 0.396 ± 0.02
2.032AsnAsp: 2.032 ± 0.074
2.264AsnGlu: 2.264 ± 0.044
1.567AsnPhe: 1.567 ± 0.041
2.652AsnGly: 2.652 ± 0.068
1.051AsnHis: 1.051 ± 0.035
2.723AsnIle: 2.723 ± 0.05
1.997AsnLys: 1.997 ± 0.042
4.224AsnLeu: 4.224 ± 0.077
0.973AsnMet: 0.973 ± 0.034
1.653AsnAsn: 1.653 ± 0.057
2.26AsnPro: 2.26 ± 0.054
1.791AsnGln: 1.791 ± 0.051
2.249AsnArg: 2.249 ± 0.041
2.141AsnSer: 2.141 ± 0.041
1.989AsnThr: 1.989 ± 0.055
2.294AsnVal: 2.294 ± 0.061
0.678AsnTrp: 0.678 ± 0.027
1.236AsnTyr: 1.236 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.864ProAla: 3.864 ± 0.069
0.431ProCys: 0.431 ± 0.018
2.821ProAsp: 2.821 ± 0.067
3.295ProGlu: 3.295 ± 0.059
1.926ProPhe: 1.926 ± 0.051
3.198ProGly: 3.198 ± 0.064
1.15ProHis: 1.15 ± 0.037
2.756ProIle: 2.756 ± 0.054
1.888ProLys: 1.888 ± 0.045
4.553ProLeu: 4.553 ± 0.083
0.988ProMet: 0.988 ± 0.031
1.666ProAsn: 1.666 ± 0.045
1.993ProPro: 1.993 ± 0.055
1.855ProGln: 1.855 ± 0.05
1.941ProArg: 1.941 ± 0.047
2.492ProSer: 2.492 ± 0.053
2.163ProThr: 2.163 ± 0.047
3.544ProVal: 3.544 ± 0.069
0.607ProTrp: 0.607 ± 0.03
1.334ProTyr: 1.334 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.302GlnAla: 4.302 ± 0.084
0.404GlnCys: 0.404 ± 0.021
1.788GlnAsp: 1.788 ± 0.054
2.573GlnGlu: 2.573 ± 0.064
1.535GlnPhe: 1.535 ± 0.044
2.686GlnGly: 2.686 ± 0.057
1.325GlnHis: 1.325 ± 0.041
2.941GlnIle: 2.941 ± 0.068
2.094GlnLys: 2.094 ± 0.06
4.822GlnLeu: 4.822 ± 0.085
1.015GlnMet: 1.015 ± 0.032
1.511GlnAsn: 1.511 ± 0.042
1.965GlnPro: 1.965 ± 0.047
2.482GlnGln: 2.482 ± 0.065
2.744GlnArg: 2.744 ± 0.062
2.402GlnSer: 2.402 ± 0.06
2.148GlnThr: 2.148 ± 0.053
2.613GlnVal: 2.613 ± 0.054
0.673GlnTrp: 0.673 ± 0.028
1.178GlnTyr: 1.178 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
4.727ArgAla: 4.727 ± 0.077
0.511ArgCys: 0.511 ± 0.022
2.891ArgAsp: 2.891 ± 0.058
3.778ArgGlu: 3.778 ± 0.068
2.58ArgPhe: 2.58 ± 0.053
3.256ArgGly: 3.256 ± 0.054
1.598ArgHis: 1.598 ± 0.042
4.128ArgIle: 4.128 ± 0.068
2.768ArgLys: 2.768 ± 0.065
6.342ArgLeu: 6.342 ± 0.096
1.565ArgMet: 1.565 ± 0.039
2.382ArgAsn: 2.382 ± 0.048
2.123ArgPro: 2.123 ± 0.046
2.593ArgGln: 2.593 ± 0.062
3.255ArgArg: 3.255 ± 0.067
3.032ArgSer: 3.032 ± 0.064
2.648ArgThr: 2.648 ± 0.063
3.539ArgVal: 3.539 ± 0.075
0.877ArgTrp: 0.877 ± 0.032
2.089ArgTyr: 2.089 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.96SerAla: 4.96 ± 0.074
0.615SerCys: 0.615 ± 0.026
2.963SerAsp: 2.963 ± 0.059
3.571SerGlu: 3.571 ± 0.065
2.486SerPhe: 2.486 ± 0.06
4.791SerGly: 4.791 ± 0.082
1.568SerHis: 1.568 ± 0.044
3.943SerIle: 3.943 ± 0.064
2.816SerLys: 2.816 ± 0.06
6.373SerLeu: 6.373 ± 0.083
1.556SerMet: 1.556 ± 0.044
2.367SerAsn: 2.367 ± 0.064
2.511SerPro: 2.511 ± 0.055
2.523SerGln: 2.523 ± 0.054
3.286SerArg: 3.286 ± 0.067
3.848SerSer: 3.848 ± 0.077
3.13SerThr: 3.13 ± 0.059
3.759SerVal: 3.759 ± 0.078
0.84SerTrp: 0.84 ± 0.032
1.824SerTyr: 1.824 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.659ThrAla: 4.659 ± 0.072
0.512ThrCys: 0.512 ± 0.027
2.791ThrAsp: 2.791 ± 0.058
3.047ThrGlu: 3.047 ± 0.057
2.094ThrPhe: 2.094 ± 0.052
4.037ThrGly: 4.037 ± 0.07
1.424ThrHis: 1.424 ± 0.044
3.474ThrIle: 3.474 ± 0.064
1.988ThrLys: 1.988 ± 0.05
6.154ThrLeu: 6.154 ± 0.097
1.238ThrMet: 1.238 ± 0.035
1.785ThrAsn: 1.785 ± 0.056
2.782ThrPro: 2.782 ± 0.053
2.254ThrGln: 2.254 ± 0.055
2.798ThrArg: 2.798 ± 0.046
3.081ThrSer: 3.081 ± 0.075
2.81ThrThr: 2.81 ± 0.059
3.646ThrVal: 3.646 ± 0.071
0.625ThrTrp: 0.625 ± 0.029
1.469ThrTyr: 1.469 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.839ValAla: 5.839 ± 0.089
0.647ValCys: 0.647 ± 0.025
3.391ValAsp: 3.391 ± 0.059
3.845ValGlu: 3.845 ± 0.079
2.557ValPhe: 2.557 ± 0.057
4.342ValGly: 4.342 ± 0.078
1.458ValHis: 1.458 ± 0.045
4.78ValIle: 4.78 ± 0.079
3.098ValLys: 3.098 ± 0.07
6.682ValLeu: 6.682 ± 0.1
1.842ValMet: 1.842 ± 0.047
2.494ValAsn: 2.494 ± 0.053
2.803ValPro: 2.803 ± 0.067
2.087ValGln: 2.087 ± 0.048
3.572ValArg: 3.572 ± 0.065
3.973ValSer: 3.973 ± 0.07
3.789ValThr: 3.789 ± 0.077
4.362ValVal: 4.362 ± 0.086
0.777ValTrp: 0.777 ± 0.032
1.775ValTyr: 1.775 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.038
0.17TrpCys: 0.17 ± 0.012
0.613TrpAsp: 0.613 ± 0.028
0.673TrpGlu: 0.673 ± 0.029
0.629TrpPhe: 0.629 ± 0.028
0.815TrpGly: 0.815 ± 0.034
0.453TrpHis: 0.453 ± 0.023
0.87TrpIle: 0.87 ± 0.031
0.581TrpLys: 0.581 ± 0.025
1.96TrpLeu: 1.96 ± 0.056
0.36TrpMet: 0.36 ± 0.021
0.516TrpAsn: 0.516 ± 0.023
0.524TrpPro: 0.524 ± 0.026
0.908TrpGln: 0.908 ± 0.032
0.955TrpArg: 0.955 ± 0.031
0.794TrpSer: 0.794 ± 0.032
0.558TrpThr: 0.558 ± 0.024
0.891TrpVal: 0.891 ± 0.035
0.225TrpTrp: 0.225 ± 0.015
0.407TrpTyr: 0.407 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.608TyrAla: 2.608 ± 0.059
0.366TyrCys: 0.366 ± 0.02
1.612TyrAsp: 1.612 ± 0.079
1.626TyrGlu: 1.626 ± 0.044
1.376TyrPhe: 1.376 ± 0.037
2.159TyrGly: 2.159 ± 0.047
0.849TyrHis: 0.849 ± 0.032
1.642TyrIle: 1.642 ± 0.046
1.102TyrLys: 1.102 ± 0.038
3.346TyrLeu: 3.346 ± 0.061
0.561TyrMet: 0.561 ± 0.023
0.991TyrAsn: 0.991 ± 0.041
1.512TyrPro: 1.512 ± 0.047
1.605TyrGln: 1.605 ± 0.046
2.016TyrArg: 2.016 ± 0.047
1.764TyrSer: 1.764 ± 0.045
1.496TyrThr: 1.496 ± 0.034
1.799TyrVal: 1.799 ± 0.039
0.531TyrTrp: 0.531 ± 0.024
1.069TyrTyr: 1.069 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3064 proteins (915887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski