Amino acid dipepetide frequency for Microcaecilia unicolor

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.25AlaAla: 5.25 ± 0.034	1.216AlaCys: 1.216 ± 0.009	2.777AlaAsp: 2.777 ± 0.013	4.335AlaGlu: 4.335 ± 0.02	2.372AlaPhe: 2.372 ± 0.014	3.691AlaGly: 3.691 ± 0.021	1.309AlaHis: 1.309 ± 0.008	2.892AlaIle: 2.892 ± 0.012	3.432AlaLys: 3.432 ± 0.017	5.911AlaLeu: 5.911 ± 0.024	1.433AlaMet: 1.433 ± 0.01	2.09AlaAsn: 2.09 ± 0.011	2.821AlaPro: 2.821 ± 0.022	2.625AlaGln: 2.625 ± 0.014	2.742AlaArg: 2.742 ± 0.015	5.153AlaSer: 5.153 ± 0.025	3.345AlaThr: 3.345 ± 0.028	4.496AlaVal: 4.496 ± 0.019	0.613AlaTrp: 0.613 ± 0.006	1.472AlaTyr: 1.472 ± 0.009	0.006AlaXaa: 0.006 ± 0.001
Cys	1.134CysAla: 1.134 ± 0.012	0.608CysCys: 0.608 ± 0.009	1.19CysAsp: 1.19 ± 0.014	1.328CysGlu: 1.328 ± 0.013	0.968CysPhe: 0.968 ± 0.012	1.593CysGly: 1.593 ± 0.021	0.603CysHis: 0.603 ± 0.007	1.188CysIle: 1.188 ± 0.009	1.288CysLys: 1.288 ± 0.012	2.07CysLeu: 2.07 ± 0.012	0.457CysMet: 0.457 ± 0.005	1.094CysAsn: 1.094 ± 0.016	1.158CysPro: 1.158 ± 0.013	1.014CysGln: 1.014 ± 0.011	1.171CysArg: 1.171 ± 0.01	2.34CysSer: 2.34 ± 0.021	1.451CysThr: 1.451 ± 0.017	1.217CysVal: 1.217 ± 0.012	0.276CysTrp: 0.276 ± 0.004	0.621CysTyr: 0.621 ± 0.007	0.003CysXaa: 0.003 ± 0.0
Asp	2.626AspAla: 2.626 ± 0.015	1.131AspCys: 1.131 ± 0.011	2.747AspAsp: 2.747 ± 0.018	3.619AspGlu: 3.619 ± 0.019	2.104AspPhe: 2.104 ± 0.011	3.126AspGly: 3.126 ± 0.02	1.184AspHis: 1.184 ± 0.009	2.931AspIle: 2.931 ± 0.019	2.838AspLys: 2.838 ± 0.016	4.927AspLeu: 4.927 ± 0.024	1.221AspMet: 1.221 ± 0.009	1.861AspAsn: 1.861 ± 0.012	2.655AspPro: 2.655 ± 0.016	1.93AspGln: 1.93 ± 0.011	2.377AspArg: 2.377 ± 0.015	4.358AspSer: 4.358 ± 0.022	2.585AspThr: 2.585 ± 0.014	3.07AspVal: 3.07 ± 0.016	0.62AspTrp: 0.62 ± 0.008	1.55AspTyr: 1.55 ± 0.01	0.006AspXaa: 0.006 ± 0.001
Glu	4.378GluAla: 4.378 ± 0.024	1.704GluCys: 1.704 ± 0.024	4.455GluAsp: 4.455 ± 0.022	8.086GluGlu: 8.086 ± 0.047	2.118GluPhe: 2.118 ± 0.013	3.796GluGly: 3.796 ± 0.023	1.574GluHis: 1.574 ± 0.011	3.579GluIle: 3.579 ± 0.019	6.038GluLys: 6.038 ± 0.034	6.232GluLeu: 6.232 ± 0.032	1.838GluMet: 1.838 ± 0.011	3.527GluAsn: 3.527 ± 0.02	2.669GluPro: 2.669 ± 0.02	3.518GluGln: 3.518 ± 0.035	4.097GluArg: 4.097 ± 0.027	4.798GluSer: 4.798 ± 0.021	3.796GluThr: 3.796 ± 0.026	4.095GluVal: 4.095 ± 0.016	0.71GluTrp: 0.71 ± 0.007	1.71GluTyr: 1.71 ± 0.013	0.009GluXaa: 0.009 ± 0.001
Phe	1.907PheAla: 1.907 ± 0.013	1.013PheCys: 1.013 ± 0.009	1.71PheAsp: 1.71 ± 0.011	1.972PheGlu: 1.972 ± 0.013	1.669PhePhe: 1.669 ± 0.012	2.163PheGly: 2.163 ± 0.014	1.065PheHis: 1.065 ± 0.008	2.157PheIle: 2.157 ± 0.016	2.001PheLys: 2.001 ± 0.017	4.072PheLeu: 4.072 ± 0.023	0.827PheMet: 0.827 ± 0.006	1.512PheAsn: 1.512 ± 0.012	1.951PhePro: 1.951 ± 0.013	1.879PheGln: 1.879 ± 0.012	1.817PheArg: 1.817 ± 0.014	3.615PheSer: 3.615 ± 0.02	2.456PheThr: 2.456 ± 0.019	2.089PheVal: 2.089 ± 0.014	0.467PheTrp: 0.467 ± 0.006	1.237PheTyr: 1.237 ± 0.009	0.006PheXaa: 0.006 ± 0.001
Gly	3.249GlyAla: 3.249 ± 0.016	1.161GlyCys: 1.161 ± 0.011	2.921GlyAsp: 2.921 ± 0.02	3.892GlyGlu: 3.892 ± 0.031	2.377GlyPhe: 2.377 ± 0.015	3.991GlyGly: 3.991 ± 0.04	1.502GlyHis: 1.502 ± 0.012	3.02GlyIle: 3.02 ± 0.018	3.941GlyLys: 3.941 ± 0.022	4.845GlyLeu: 4.845 ± 0.024	1.381GlyMet: 1.381 ± 0.01	2.611GlyAsn: 2.611 ± 0.016	2.768GlyPro: 2.768 ± 0.04	2.611GlyGln: 2.611 ± 0.02	3.085GlyArg: 3.085 ± 0.018	5.34GlySer: 5.34 ± 0.028	3.437GlyThr: 3.437 ± 0.025	3.28GlyVal: 3.28 ± 0.021	0.671GlyTrp: 0.671 ± 0.007	1.781GlyTyr: 1.781 ± 0.013	0.009GlyXaa: 0.009 ± 0.001
His	1.235HisAla: 1.235 ± 0.009	0.718HisCys: 0.718 ± 0.008	0.939HisAsp: 0.939 ± 0.008	1.483HisGlu: 1.483 ± 0.013	1.101HisPhe: 1.101 ± 0.01	1.432HisGly: 1.432 ± 0.011	0.902HisHis: 0.902 ± 0.011	1.366HisIle: 1.366 ± 0.008	1.465HisLys: 1.465 ± 0.013	2.79HisLeu: 2.79 ± 0.016	0.611HisMet: 0.611 ± 0.007	0.987HisAsn: 0.987 ± 0.008	1.49HisPro: 1.49 ± 0.012	1.579HisGln: 1.579 ± 0.019	1.463HisArg: 1.463 ± 0.011	2.368HisSer: 2.368 ± 0.022	1.736HisThr: 1.736 ± 0.02	1.382HisVal: 1.382 ± 0.01	0.33HisTrp: 0.33 ± 0.005	0.843HisTyr: 0.843 ± 0.007	0.004HisXaa: 0.004 ± 0.0
Ile	2.759IleAla: 2.759 ± 0.013	1.314IleCys: 1.314 ± 0.013	2.201IleAsp: 2.201 ± 0.014	2.913IleGlu: 2.913 ± 0.015	2.061IlePhe: 2.061 ± 0.013	2.466IleGly: 2.466 ± 0.016	1.79IleHis: 1.79 ± 0.021	2.867IleIle: 2.867 ± 0.017	2.973IleLys: 2.973 ± 0.014	5.097IleLeu: 5.097 ± 0.022	1.116IleMet: 1.116 ± 0.009	2.16IleAsn: 2.16 ± 0.013	2.919IlePro: 2.919 ± 0.015	2.576IleGln: 2.576 ± 0.013	2.419IleArg: 2.419 ± 0.012	4.454IleSer: 4.454 ± 0.021	3.008IleThr: 3.008 ± 0.019	2.853IleVal: 2.853 ± 0.018	0.543IleTrp: 0.543 ± 0.006	1.546IleTyr: 1.546 ± 0.012	0.007IleXaa: 0.007 ± 0.001
Lys	3.827LysAla: 3.827 ± 0.018	1.425LysCys: 1.425 ± 0.021	3.459LysAsp: 3.459 ± 0.02	5.746LysGlu: 5.746 ± 0.031	1.768LysPhe: 1.768 ± 0.013	3.459LysGly: 3.459 ± 0.025	1.602LysHis: 1.602 ± 0.012	3.174LysIle: 3.174 ± 0.017	5.343LysLys: 5.343 ± 0.028	5.59LysLeu: 5.59 ± 0.026	1.685LysMet: 1.685 ± 0.011	2.798LysAsn: 2.798 ± 0.016	3.459LysPro: 3.459 ± 0.028	3.115LysGln: 3.115 ± 0.019	3.645LysArg: 3.645 ± 0.018	4.796LysSer: 4.796 ± 0.028	3.519LysThr: 3.519 ± 0.017	3.724LysVal: 3.724 ± 0.018	0.663LysTrp: 0.663 ± 0.008	1.741LysTyr: 1.741 ± 0.011	0.012LysXaa: 0.012 ± 0.001
Leu	5.656LeuAla: 5.656 ± 0.023	2.083LeuCys: 2.083 ± 0.014	4.629LeuAsp: 4.629 ± 0.021	6.839LeuGlu: 6.839 ± 0.034	3.354LeuPhe: 3.354 ± 0.02	4.908LeuGly: 4.908 ± 0.022	2.763LeuHis: 2.763 ± 0.016	4.25LeuIle: 4.25 ± 0.017	6.459LeuLys: 6.459 ± 0.031	9.758LeuLeu: 9.758 ± 0.04	2.13LeuMet: 2.13 ± 0.012	3.85LeuAsn: 3.85 ± 0.017	5.283LeuPro: 5.283 ± 0.027	5.839LeuGln: 5.839 ± 0.033	5.095LeuArg: 5.095 ± 0.025	7.97LeuSer: 7.97 ± 0.023	5.077LeuThr: 5.077 ± 0.022	5.052LeuVal: 5.052 ± 0.019	0.998LeuTrp: 0.998 ± 0.008	2.563LeuTyr: 2.563 ± 0.014	0.012LeuXaa: 0.012 ± 0.001
Met	1.792MetAla: 1.792 ± 0.01	0.449MetCys: 0.449 ± 0.005	1.368MetAsp: 1.368 ± 0.008	2.021MetGlu: 2.021 ± 0.013	0.784MetPhe: 0.784 ± 0.008	1.285MetGly: 1.285 ± 0.011	0.545MetHis: 0.545 ± 0.006	1.025MetIle: 1.025 ± 0.009	1.742MetLys: 1.742 ± 0.01	2.048MetLeu: 2.048 ± 0.013	0.634MetMet: 0.634 ± 0.006	1.052MetAsn: 1.052 ± 0.008	1.137MetPro: 1.137 ± 0.011	1.123MetGln: 1.123 ± 0.01	1.066MetArg: 1.066 ± 0.008	1.797MetSer: 1.797 ± 0.011	1.26MetThr: 1.26 ± 0.011	1.403MetVal: 1.403 ± 0.01	0.24MetTrp: 0.24 ± 0.004	0.688MetTyr: 0.688 ± 0.007	0.003MetXaa: 0.003 ± 0.0
Asn	2.215AsnAla: 2.215 ± 0.013	0.979AsnCys: 0.979 ± 0.01	1.716AsnAsp: 1.716 ± 0.013	2.663AsnGlu: 2.663 ± 0.014	1.563AsnPhe: 1.563 ± 0.011	2.677AsnGly: 2.677 ± 0.018	1.067AsnHis: 1.067 ± 0.009	2.489AsnIle: 2.489 ± 0.013	2.715AsnLys: 2.715 ± 0.015	4.148AsnLeu: 4.148 ± 0.021	1.069AsnMet: 1.069 ± 0.009	1.841AsnAsn: 1.841 ± 0.013	2.296AsnPro: 2.296 ± 0.014	1.969AsnGln: 1.969 ± 0.012	2.078AsnArg: 2.078 ± 0.011	3.634AsnSer: 3.634 ± 0.017	2.312AsnThr: 2.312 ± 0.022	2.454AsnVal: 2.454 ± 0.013	0.514AsnTrp: 0.514 ± 0.007	1.232AsnTyr: 1.232 ± 0.009	0.006AsnXaa: 0.006 ± 0.001
Pro	3.607ProAla: 3.607 ± 0.022	1.011ProCys: 1.011 ± 0.011	2.561ProAsp: 2.561 ± 0.016	3.816ProGlu: 3.816 ± 0.021	2.228ProPhe: 2.228 ± 0.019	3.734ProGly: 3.734 ± 0.052	1.243ProHis: 1.243 ± 0.01	2.057ProIle: 2.057 ± 0.018	2.821ProLys: 2.821 ± 0.023	4.63ProLeu: 4.63 ± 0.022	1.021ProMet: 1.021 ± 0.009	1.972ProAsn: 1.972 ± 0.011	4.433ProPro: 4.433 ± 0.046	2.53ProGln: 2.53 ± 0.02	2.462ProArg: 2.462 ± 0.017	5.163ProSer: 5.163 ± 0.029	2.849ProThr: 2.849 ± 0.029	3.743ProVal: 3.743 ± 0.022	0.536ProTrp: 0.536 ± 0.007	1.443ProTyr: 1.443 ± 0.01	0.009ProXaa: 0.009 ± 0.001
Gln	2.93GlnAla: 2.93 ± 0.014	1.028GlnCys: 1.028 ± 0.014	2.354GlnAsp: 2.354 ± 0.014	4.003GlnGlu: 4.003 ± 0.028	1.43GlnPhe: 1.43 ± 0.009	2.495GlnGly: 2.495 ± 0.016	1.399GlnHis: 1.399 ± 0.011	2.311GlnIle: 2.311 ± 0.012	3.576GlnLys: 3.576 ± 0.028	4.736GlnLeu: 4.736 ± 0.027	1.33GlnMet: 1.33 ± 0.017	2.212GlnAsn: 2.212 ± 0.013	2.504GlnPro: 2.504 ± 0.021	3.691GlnGln: 3.691 ± 0.052	2.972GlnArg: 2.972 ± 0.019	3.531GlnSer: 3.531 ± 0.021	2.624GlnThr: 2.624 ± 0.02	2.733GlnVal: 2.733 ± 0.021	0.525GlnTrp: 0.525 ± 0.006	1.265GlnTyr: 1.265 ± 0.008	0.007GlnXaa: 0.007 ± 0.001
Arg	2.882ArgAla: 2.882 ± 0.015	1.084ArgCys: 1.084 ± 0.01	2.577ArgAsp: 2.577 ± 0.014	3.738ArgGlu: 3.738 ± 0.023	1.818ArgPhe: 1.818 ± 0.012	2.804ArgGly: 2.804 ± 0.021	1.45ArgHis: 1.45 ± 0.012	2.759ArgIle: 2.759 ± 0.018	3.979ArgLys: 3.979 ± 0.021	4.672ArgLeu: 4.672 ± 0.022	1.223ArgMet: 1.223 ± 0.009	2.327ArgAsn: 2.327 ± 0.011	2.538ArgPro: 2.538 ± 0.015	2.527ArgGln: 2.527 ± 0.014	3.715ArgArg: 3.715 ± 0.022	4.263ArgSer: 4.263 ± 0.031	2.835ArgThr: 2.835 ± 0.021	2.697ArgVal: 2.697 ± 0.014	0.588ArgTrp: 0.588 ± 0.007	1.484ArgTyr: 1.484 ± 0.01	0.007ArgXaa: 0.007 ± 0.001
Ser	5.05SerAla: 5.05 ± 0.024	1.94SerCys: 1.94 ± 0.016	4.161SerAsp: 4.161 ± 0.018	5.635SerGlu: 5.635 ± 0.028	3.542SerPhe: 3.542 ± 0.022	5.162SerGly: 5.162 ± 0.026	2.238SerHis: 2.238 ± 0.026	3.776SerIle: 3.776 ± 0.016	4.635SerLys: 4.635 ± 0.023	8.107SerLeu: 8.107 ± 0.027	1.86SerMet: 1.86 ± 0.012	3.384SerAsn: 3.384 ± 0.016	5.431SerPro: 5.431 ± 0.039	4.057SerGln: 4.057 ± 0.027	4.379SerArg: 4.379 ± 0.026	10.316SerSer: 10.316 ± 0.071	5.347SerThr: 5.347 ± 0.079	5.132SerVal: 5.132 ± 0.017	0.985SerTrp: 0.985 ± 0.009	2.289SerTyr: 2.289 ± 0.014	0.008SerXaa: 0.008 ± 0.001
Thr	3.829ThrAla: 3.829 ± 0.051	1.495ThrCys: 1.495 ± 0.017	2.82ThrAsp: 2.82 ± 0.016	4.277ThrGlu: 4.277 ± 0.033	2.198ThrPhe: 2.198 ± 0.011	3.836ThrGly: 3.836 ± 0.027	1.359ThrHis: 1.359 ± 0.013	2.789ThrIle: 2.789 ± 0.024	2.963ThrLys: 2.963 ± 0.017	5.292ThrLeu: 5.292 ± 0.02	1.209ThrMet: 1.209 ± 0.008	2.006ThrAsn: 2.006 ± 0.012	3.275ThrPro: 3.275 ± 0.031	2.328ThrGln: 2.328 ± 0.018	2.41ThrArg: 2.41 ± 0.017	5.391ThrSer: 5.391 ± 0.057	3.555ThrThr: 3.555 ± 0.099	4.189ThrVal: 4.189 ± 0.022	0.649ThrTrp: 0.649 ± 0.007	1.495ThrTyr: 1.495 ± 0.009	0.007ThrXaa: 0.007 ± 0.001
Val	3.703ValAla: 3.703 ± 0.015	1.457ValCys: 1.457 ± 0.012	2.881ValAsp: 2.881 ± 0.017	3.878ValGlu: 3.878 ± 0.019	2.361ValPhe: 2.361 ± 0.015	3.027ValGly: 3.027 ± 0.018	1.569ValHis: 1.569 ± 0.011	3.167ValIle: 3.167 ± 0.016	3.839ValLys: 3.839 ± 0.02	5.848ValLeu: 5.848 ± 0.022	1.412ValMet: 1.412 ± 0.009	2.478ValAsn: 2.478 ± 0.015	3.344ValPro: 3.344 ± 0.018	2.904ValGln: 2.904 ± 0.022	2.749ValArg: 2.749 ± 0.013	4.901ValSer: 4.901 ± 0.023	3.876ValThr: 3.876 ± 0.024	3.76ValVal: 3.76 ± 0.017	0.677ValTrp: 0.677 ± 0.007	1.697ValTyr: 1.697 ± 0.012	0.006ValXaa: 0.006 ± 0.001
Trp	0.577TrpAla: 0.577 ± 0.005	0.223TrpCys: 0.223 ± 0.004	0.602TrpAsp: 0.602 ± 0.008	0.766TrpGlu: 0.766 ± 0.008	0.442TrpPhe: 0.442 ± 0.006	0.564TrpGly: 0.564 ± 0.007	0.288TrpHis: 0.288 ± 0.004	0.634TrpIle: 0.634 ± 0.007	0.873TrpLys: 0.873 ± 0.008	1.082TrpLeu: 1.082 ± 0.01	0.321TrpMet: 0.321 ± 0.004	0.601TrpAsn: 0.601 ± 0.007	0.416TrpPro: 0.416 ± 0.005	0.55TrpGln: 0.55 ± 0.009	0.628TrpArg: 0.628 ± 0.006	0.817TrpSer: 0.817 ± 0.009	0.648TrpThr: 0.648 ± 0.007	0.597TrpVal: 0.597 ± 0.006	0.177TrpTrp: 0.177 ± 0.004	0.347TrpTyr: 0.347 ± 0.005	0.003TrpXaa: 0.003 ± 0.0
Tyr	1.369TyrAla: 1.369 ± 0.008	0.727TyrCys: 0.727 ± 0.008	1.394TyrAsp: 1.394 ± 0.009	1.709TyrGlu: 1.709 ± 0.01	1.318TyrPhe: 1.318 ± 0.009	1.655TyrGly: 1.655 ± 0.013	0.766TyrHis: 0.766 ± 0.007	1.606TyrIle: 1.606 ± 0.011	1.619TyrLys: 1.619 ± 0.015	2.7TyrLeu: 2.7 ± 0.014	0.681TyrMet: 0.681 ± 0.007	1.266TyrAsn: 1.266 ± 0.009	1.315TyrPro: 1.315 ± 0.01	1.288TyrGln: 1.288 ± 0.008	1.589TyrArg: 1.589 ± 0.01	2.419TyrSer: 2.419 ± 0.015	1.647TyrThr: 1.647 ± 0.013	1.562TyrVal: 1.562 ± 0.009	0.374TyrTrp: 0.374 ± 0.006	0.994TyrTyr: 0.994 ± 0.009	0.004TyrXaa: 0.004 ± 0.0
Xaa	0.006XaaAla: 0.006 ± 0.0	0.004XaaCys: 0.004 ± 0.0	0.006XaaAsp: 0.006 ± 0.001	0.009XaaGlu: 0.009 ± 0.001	0.008XaaPhe: 0.008 ± 0.001	0.008XaaGly: 0.008 ± 0.001	0.004XaaHis: 0.004 ± 0.0	0.006XaaIle: 0.006 ± 0.001	0.012XaaLys: 0.012 ± 0.001	0.011XaaLeu: 0.011 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.007XaaAsn: 0.007 ± 0.001	0.008XaaPro: 0.008 ± 0.001	0.005XaaGln: 0.005 ± 0.001	0.007XaaArg: 0.007 ± 0.001	0.009XaaSer: 0.009 ± 0.001	0.007XaaThr: 0.007 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.004XaaTyr: 0.004 ± 0.0	0.001XaaXaa: 0.001 ± 0.0

Statistics based on 30305 proteins (18831892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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