Amino acid dipepetide frequency for Coprobacillus cateniformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.107AlaAla: 3.107 ± 0.068	0.832AlaCys: 0.832 ± 0.031	2.625AlaAsp: 2.625 ± 0.049	2.627AlaGlu: 2.627 ± 0.056	2.655AlaPhe: 2.655 ± 0.06	3.596AlaGly: 3.596 ± 0.069	1.127AlaHis: 1.127 ± 0.037	5.32AlaIle: 5.32 ± 0.078	4.351AlaLys: 4.351 ± 0.063	5.75AlaLeu: 5.75 ± 0.07	1.917AlaMet: 1.917 ± 0.043	2.539AlaAsn: 2.539 ± 0.057	1.407AlaPro: 1.407 ± 0.036	1.87AlaGln: 1.87 ± 0.038	1.858AlaArg: 1.858 ± 0.044	3.494AlaSer: 3.494 ± 0.057	3.134AlaThr: 3.134 ± 0.082	3.624AlaVal: 3.624 ± 0.071	0.407AlaTrp: 0.407 ± 0.023	2.556AlaTyr: 2.556 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.695CysAla: 0.695 ± 0.027	0.283CysCys: 0.283 ± 0.017	0.851CysAsp: 0.851 ± 0.028	0.787CysGlu: 0.787 ± 0.03	0.767CysPhe: 0.767 ± 0.026	1.036CysGly: 1.036 ± 0.036	0.445CysHis: 0.445 ± 0.021	1.356CysIle: 1.356 ± 0.038	0.716CysLys: 0.716 ± 0.027	1.423CysLeu: 1.423 ± 0.038	0.401CysMet: 0.401 ± 0.021	0.524CysAsn: 0.524 ± 0.024	0.517CysPro: 0.517 ± 0.028	0.767CysGln: 0.767 ± 0.032	0.421CysArg: 0.421 ± 0.019	0.833CysSer: 0.833 ± 0.03	0.602CysThr: 0.602 ± 0.022	0.889CysVal: 0.889 ± 0.025	0.091CysTrp: 0.091 ± 0.01	0.701CysTyr: 0.701 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	2.964AspAla: 2.964 ± 0.052	0.824AspCys: 0.824 ± 0.031	3.486AspAsp: 3.486 ± 0.066	4.912AspGlu: 4.912 ± 0.075	2.965AspPhe: 2.965 ± 0.051	3.603AspGly: 3.603 ± 0.089	1.151AspHis: 1.151 ± 0.035	6.172AspIle: 6.172 ± 0.086	4.131AspLys: 4.131 ± 0.07	5.079AspLeu: 5.079 ± 0.064	1.94AspMet: 1.94 ± 0.038	2.968AspAsn: 2.968 ± 0.058	1.375AspPro: 1.375 ± 0.037	1.846AspGln: 1.846 ± 0.04	1.651AspArg: 1.651 ± 0.036	3.026AspSer: 3.026 ± 0.061	2.622AspThr: 2.622 ± 0.067	3.826AspVal: 3.826 ± 0.065	0.453AspTrp: 0.453 ± 0.022	3.649AspTyr: 3.649 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	3.598GluAla: 3.598 ± 0.057	0.844GluCys: 0.844 ± 0.026	4.163GluAsp: 4.163 ± 0.064	5.269GluGlu: 5.269 ± 0.083	2.72GluPhe: 2.72 ± 0.054	3.313GluGly: 3.313 ± 0.067	1.34GluHis: 1.34 ± 0.038	5.835GluIle: 5.835 ± 0.08	6.257GluLys: 6.257 ± 0.081	6.462GluLeu: 6.462 ± 0.091	2.352GluMet: 2.352 ± 0.054	4.446GluAsn: 4.446 ± 0.061	1.454GluPro: 1.454 ± 0.039	2.394GluGln: 2.394 ± 0.059	2.598GluArg: 2.598 ± 0.053	3.379GluSer: 3.379 ± 0.059	3.536GluThr: 3.536 ± 0.063	4.215GluVal: 4.215 ± 0.069	0.532GluTrp: 0.532 ± 0.024	3.304GluTyr: 3.304 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.475PheAla: 2.475 ± 0.047	0.626PheCys: 0.626 ± 0.024	2.966PheAsp: 2.966 ± 0.051	3.072PheGlu: 3.072 ± 0.051	2.098PhePhe: 2.098 ± 0.052	2.802PheGly: 2.802 ± 0.06	1.096PheHis: 1.096 ± 0.035	4.638PheIle: 4.638 ± 0.09	2.912PheLys: 2.912 ± 0.046	4.078PheLeu: 4.078 ± 0.073	1.397PheMet: 1.397 ± 0.04	2.284PheAsn: 2.284 ± 0.048	1.275PhePro: 1.275 ± 0.034	1.818PheGln: 1.818 ± 0.049	1.086PheArg: 1.086 ± 0.031	2.857PheSer: 2.857 ± 0.054	2.226PheThr: 2.226 ± 0.047	3.122PheVal: 3.122 ± 0.066	0.31PheTrp: 0.31 ± 0.016	2.294PheTyr: 2.294 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	3.627GlyAla: 3.627 ± 0.11	1.0GlyCys: 1.0 ± 0.033	2.978GlyAsp: 2.978 ± 0.067	3.355GlyGlu: 3.355 ± 0.057	3.003GlyPhe: 3.003 ± 0.051	3.72GlyGly: 3.72 ± 0.074	1.365GlyHis: 1.365 ± 0.037	5.798GlyIle: 5.798 ± 0.086	4.477GlyLys: 4.477 ± 0.076	5.334GlyLeu: 5.334 ± 0.079	1.919GlyMet: 1.919 ± 0.047	2.78GlyAsn: 2.78 ± 0.063	1.098GlyPro: 1.098 ± 0.063	2.073GlyGln: 2.073 ± 0.059	1.865GlyArg: 1.865 ± 0.046	3.242GlySer: 3.242 ± 0.064	3.358GlyThr: 3.358 ± 0.065	4.027GlyVal: 4.027 ± 0.062	0.547GlyTrp: 0.547 ± 0.022	3.406GlyTyr: 3.406 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.058HisAla: 1.058 ± 0.035	0.386HisCys: 0.386 ± 0.021	1.336HisAsp: 1.336 ± 0.035	1.367HisGlu: 1.367 ± 0.038	1.25HisPhe: 1.25 ± 0.036	1.236HisGly: 1.236 ± 0.031	0.798HisHis: 0.798 ± 0.027	2.317HisIle: 2.317 ± 0.051	1.437HisLys: 1.437 ± 0.047	2.193HisLeu: 2.193 ± 0.046	0.62HisMet: 0.62 ± 0.026	1.057HisAsn: 1.057 ± 0.03	0.88HisPro: 0.88 ± 0.029	1.138HisGln: 1.138 ± 0.034	0.726HisArg: 0.726 ± 0.024	1.224HisSer: 1.224 ± 0.033	1.066HisThr: 1.066 ± 0.028	1.295HisVal: 1.295 ± 0.033	0.164HisTrp: 0.164 ± 0.012	1.278HisTyr: 1.278 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.59IleAla: 5.59 ± 0.081	1.478IleCys: 1.478 ± 0.041	6.088IleAsp: 6.088 ± 0.084	6.467IleGlu: 6.467 ± 0.085	3.975IlePhe: 3.975 ± 0.075	5.489IleGly: 5.489 ± 0.085	2.19IleHis: 2.19 ± 0.048	7.893IleIle: 7.893 ± 0.115	6.143IleLys: 6.143 ± 0.083	8.164IleLeu: 8.164 ± 0.114	2.522IleMet: 2.522 ± 0.052	4.381IleAsn: 4.381 ± 0.079	3.322IlePro: 3.322 ± 0.071	3.915IleGln: 3.915 ± 0.058	2.608IleArg: 2.608 ± 0.045	5.914IleSer: 5.914 ± 0.077	4.433IleThr: 4.433 ± 0.071	6.064IleVal: 6.064 ± 0.08	0.511IleTrp: 0.511 ± 0.022	4.029IleTyr: 4.029 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	4.183LysAla: 4.183 ± 0.08	0.803LysCys: 0.803 ± 0.034	5.298LysAsp: 5.298 ± 0.068	7.438LysGlu: 7.438 ± 0.093	2.013LysPhe: 2.013 ± 0.045	4.038LysGly: 4.038 ± 0.066	1.447LysHis: 1.447 ± 0.036	6.067LysIle: 6.067 ± 0.089	7.042LysLys: 7.042 ± 0.093	5.529LysLeu: 5.529 ± 0.073	2.552LysMet: 2.552 ± 0.046	4.694LysAsn: 4.694 ± 0.072	1.871LysPro: 1.871 ± 0.049	3.128LysGln: 3.128 ± 0.059	3.019LysArg: 3.019 ± 0.063	4.002LysSer: 4.002 ± 0.061	4.232LysThr: 4.232 ± 0.07	4.727LysVal: 4.727 ± 0.066	0.566LysTrp: 0.566 ± 0.022	3.697LysTyr: 3.697 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.237LeuAla: 5.237 ± 0.072	1.462LeuCys: 1.462 ± 0.036	5.395LeuAsp: 5.395 ± 0.073	6.2LeuGlu: 6.2 ± 0.086	4.475LeuPhe: 4.475 ± 0.094	5.511LeuGly: 5.511 ± 0.084	1.722LeuHis: 1.722 ± 0.044	7.659LeuIle: 7.659 ± 0.098	7.812LeuLys: 7.812 ± 0.088	8.881LeuLeu: 8.881 ± 0.118	2.815LeuMet: 2.815 ± 0.055	5.116LeuAsn: 5.116 ± 0.071	2.994LeuPro: 2.994 ± 0.059	3.172LeuGln: 3.172 ± 0.055	3.122LeuArg: 3.122 ± 0.057	6.811LeuSer: 6.811 ± 0.092	5.018LeuThr: 5.018 ± 0.072	5.04LeuVal: 5.04 ± 0.078	0.652LeuTrp: 0.652 ± 0.025	3.868LeuTyr: 3.868 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.718MetAla: 1.718 ± 0.041	0.379MetCys: 0.379 ± 0.017	1.468MetAsp: 1.468 ± 0.039	1.709MetGlu: 1.709 ± 0.037	1.21MetPhe: 1.21 ± 0.04	1.664MetGly: 1.664 ± 0.042	0.528MetHis: 0.528 ± 0.022	3.201MetIle: 3.201 ± 0.057	3.303MetLys: 3.303 ± 0.057	2.596MetLeu: 2.596 ± 0.052	1.106MetMet: 1.106 ± 0.033	2.255MetAsn: 2.255 ± 0.049	0.967MetPro: 0.967 ± 0.032	1.032MetGln: 1.032 ± 0.032	1.061MetArg: 1.061 ± 0.026	2.023MetSer: 2.023 ± 0.04	1.789MetThr: 1.789 ± 0.039	1.587MetVal: 1.587 ± 0.04	0.163MetTrp: 0.163 ± 0.012	0.96MetTyr: 0.96 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.894AsnAla: 2.894 ± 0.055	0.653AsnCys: 0.653 ± 0.023	3.244AsnAsp: 3.244 ± 0.069	3.957AsnGlu: 3.957 ± 0.063	1.857AsnPhe: 1.857 ± 0.043	3.381AsnGly: 3.381 ± 0.081	1.495AsnHis: 1.495 ± 0.04	4.905AsnIle: 4.905 ± 0.074	4.029AsnLys: 4.029 ± 0.075	4.102AsnLeu: 4.102 ± 0.061	1.511AsnMet: 1.511 ± 0.034	2.92AsnAsn: 2.92 ± 0.072	1.92AsnPro: 1.92 ± 0.044	2.847AsnGln: 2.847 ± 0.057	1.689AsnArg: 1.689 ± 0.04	2.807AsnSer: 2.807 ± 0.062	2.563AsnThr: 2.563 ± 0.056	3.088AsnVal: 3.088 ± 0.052	0.392AsnTrp: 0.392 ± 0.023	2.56AsnTyr: 2.56 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.438ProAla: 1.438 ± 0.04	0.377ProCys: 0.377 ± 0.018	1.682ProAsp: 1.682 ± 0.042	1.968ProGlu: 1.968 ± 0.048	1.557ProPhe: 1.557 ± 0.046	1.347ProGly: 1.347 ± 0.046	0.772ProHis: 0.772 ± 0.027	2.71ProIle: 2.71 ± 0.059	1.694ProLys: 1.694 ± 0.043	2.806ProLeu: 2.806 ± 0.055	0.836ProMet: 0.836 ± 0.026	1.373ProAsn: 1.373 ± 0.04	0.535ProPro: 0.535 ± 0.025	1.19ProGln: 1.19 ± 0.034	0.817ProArg: 0.817 ± 0.03	1.73ProSer: 1.73 ± 0.04	1.778ProThr: 1.778 ± 0.064	2.009ProVal: 2.009 ± 0.045	0.235ProTrp: 0.235 ± 0.014	1.602ProTyr: 1.602 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.072GlnAla: 2.072 ± 0.045	0.48GlnCys: 0.48 ± 0.022	2.282GlnAsp: 2.282 ± 0.049	3.01GlnGlu: 3.01 ± 0.056	1.733GlnPhe: 1.733 ± 0.042	2.127GlnGly: 2.127 ± 0.049	0.732GlnHis: 0.732 ± 0.029	3.314GlnIle: 3.314 ± 0.053	3.468GlnLys: 3.468 ± 0.064	3.95GlnLeu: 3.95 ± 0.068	1.297GlnMet: 1.297 ± 0.035	2.436GlnAsn: 2.436 ± 0.049	0.966GlnPro: 0.966 ± 0.032	1.736GlnGln: 1.736 ± 0.042	1.551GlnArg: 1.551 ± 0.042	2.299GlnSer: 2.299 ± 0.054	2.118GlnThr: 2.118 ± 0.051	2.297GlnVal: 2.297 ± 0.051	0.341GlnTrp: 0.341 ± 0.02	2.172GlnTyr: 2.172 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	1.529ArgAla: 1.529 ± 0.039	0.441ArgCys: 0.441 ± 0.02	1.768ArgAsp: 1.768 ± 0.043	2.408ArgGlu: 2.408 ± 0.046	1.596ArgPhe: 1.596 ± 0.036	1.677ArgGly: 1.677 ± 0.039	0.739ArgHis: 0.739 ± 0.029	3.04ArgIle: 3.04 ± 0.059	2.782ArgLys: 2.782 ± 0.057	3.158ArgLeu: 3.158 ± 0.059	1.107ArgMet: 1.107 ± 0.031	1.812ArgAsn: 1.812 ± 0.044	0.79ArgPro: 0.79 ± 0.029	1.376ArgGln: 1.376 ± 0.037	1.286ArgArg: 1.286 ± 0.035	1.592ArgSer: 1.592 ± 0.04	1.553ArgThr: 1.553 ± 0.04	2.04ArgVal: 2.04 ± 0.045	0.264ArgTrp: 0.264 ± 0.016	1.885ArgTyr: 1.885 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.072SerAla: 3.072 ± 0.058	0.732SerCys: 0.732 ± 0.029	3.127SerAsp: 3.127 ± 0.066	3.357SerGlu: 3.357 ± 0.061	3.267SerPhe: 3.267 ± 0.062	3.768SerGly: 3.768 ± 0.069	1.717SerHis: 1.717 ± 0.042	5.434SerIle: 5.434 ± 0.076	3.944SerLys: 3.944 ± 0.067	6.658SerLeu: 6.658 ± 0.092	1.711SerMet: 1.711 ± 0.041	2.523SerAsn: 2.523 ± 0.067	1.528SerPro: 1.528 ± 0.035	3.033SerGln: 3.033 ± 0.063	2.061SerArg: 2.061 ± 0.04	4.154SerSer: 4.154 ± 0.081	3.041SerThr: 3.041 ± 0.062	3.576SerVal: 3.576 ± 0.069	0.474SerTrp: 0.474 ± 0.022	3.047SerTyr: 3.047 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	2.819ThrAla: 2.819 ± 0.058	0.661ThrCys: 0.661 ± 0.024	2.706ThrAsp: 2.706 ± 0.067	2.496ThrGlu: 2.496 ± 0.052	2.564ThrPhe: 2.564 ± 0.054	3.532ThrGly: 3.532 ± 0.16	1.286ThrHis: 1.286 ± 0.034	4.92ThrIle: 4.92 ± 0.079	3.566ThrLys: 3.566 ± 0.057	5.455ThrLeu: 5.455 ± 0.077	1.457ThrMet: 1.457 ± 0.037	2.506ThrAsn: 2.506 ± 0.072	1.915ThrPro: 1.915 ± 0.047	1.902ThrGln: 1.902 ± 0.041	1.616ThrArg: 1.616 ± 0.039	3.38ThrSer: 3.38 ± 0.073	2.911ThrThr: 2.911 ± 0.068	3.516ThrVal: 3.516 ± 0.061	0.385ThrTrp: 0.385 ± 0.023	2.591ThrTyr: 2.591 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.735ValAla: 3.735 ± 0.068	0.988ValCys: 0.988 ± 0.035	3.686ValAsp: 3.686 ± 0.069	4.108ValGlu: 4.108 ± 0.06	2.945ValPhe: 2.945 ± 0.053	3.845ValGly: 3.845 ± 0.066	1.219ValHis: 1.219 ± 0.036	5.782ValIle: 5.782 ± 0.093	4.479ValLys: 4.479 ± 0.061	5.949ValLeu: 5.949 ± 0.085	1.773ValMet: 1.773 ± 0.046	3.164ValAsn: 3.164 ± 0.059	1.876ValPro: 1.876 ± 0.041	1.996ValGln: 1.996 ± 0.047	1.84ValArg: 1.84 ± 0.041	4.24ValSer: 4.24 ± 0.065	3.306ValThr: 3.306 ± 0.065	4.326ValVal: 4.326 ± 0.081	0.457ValTrp: 0.457 ± 0.019	2.753ValTyr: 2.753 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.393TrpAla: 0.393 ± 0.017	0.134TrpCys: 0.134 ± 0.012	0.364TrpAsp: 0.364 ± 0.022	0.399TrpGlu: 0.399 ± 0.02	0.393TrpPhe: 0.393 ± 0.022	0.545TrpGly: 0.545 ± 0.023	0.186TrpHis: 0.186 ± 0.013	0.636TrpIle: 0.636 ± 0.028	0.541TrpLys: 0.541 ± 0.024	0.777TrpLeu: 0.777 ± 0.026	0.216TrpMet: 0.216 ± 0.014	0.447TrpAsn: 0.447 ± 0.023	0.139TrpPro: 0.139 ± 0.011	0.319TrpGln: 0.319 ± 0.018	0.22TrpArg: 0.22 ± 0.015	0.436TrpSer: 0.436 ± 0.023	0.407TrpThr: 0.407 ± 0.02	0.396TrpVal: 0.396 ± 0.018	0.083TrpTrp: 0.083 ± 0.01	0.369TrpTyr: 0.369 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.593TyrAla: 2.593 ± 0.045	0.722TyrCys: 0.722 ± 0.026	3.13TyrAsp: 3.13 ± 0.078	3.107TyrGlu: 3.107 ± 0.066	2.39TyrPhe: 2.39 ± 0.055	2.742TyrGly: 2.742 ± 0.054	1.474TyrHis: 1.474 ± 0.039	4.181TyrIle: 4.181 ± 0.064	3.261TyrLys: 3.261 ± 0.058	4.615TyrLeu: 4.615 ± 0.066	1.268TyrMet: 1.268 ± 0.032	2.591TyrAsn: 2.591 ± 0.058	1.623TyrPro: 1.623 ± 0.035	2.829TyrGln: 2.829 ± 0.064	1.752TyrArg: 1.752 ± 0.046	2.775TyrSer: 2.775 ± 0.052	2.491TyrThr: 2.491 ± 0.056	2.806TyrVal: 2.806 ± 0.051	0.373TyrTrp: 0.373 ± 0.023	2.526TyrTyr: 2.526 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3839 proteins (1123468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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