Amino acid dipepetide frequency for Nonomuraea longispora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.759AlaAla: 19.759 ± 0.137	1.185AlaCys: 1.185 ± 0.024	7.502AlaAsp: 7.502 ± 0.052	8.282AlaGlu: 8.282 ± 0.063	3.726AlaPhe: 3.726 ± 0.04	13.468AlaGly: 13.468 ± 0.088	2.639AlaHis: 2.639 ± 0.034	4.274AlaIle: 4.274 ± 0.045	2.754AlaLys: 2.754 ± 0.046	13.946AlaLeu: 13.946 ± 0.103	2.862AlaMet: 2.862 ± 0.034	1.939AlaAsn: 1.939 ± 0.027	5.928AlaPro: 5.928 ± 0.052	3.492AlaGln: 3.492 ± 0.038	10.412AlaArg: 10.412 ± 0.071	5.516AlaSer: 5.516 ± 0.044	6.735AlaThr: 6.735 ± 0.057	11.648AlaVal: 11.648 ± 0.079	1.931AlaTrp: 1.931 ± 0.029	2.821AlaTyr: 2.821 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.034CysAla: 1.034 ± 0.021	0.109CysCys: 0.109 ± 0.007	0.524CysAsp: 0.524 ± 0.015	0.438CysGlu: 0.438 ± 0.014	0.223CysPhe: 0.223 ± 0.008	0.961CysGly: 0.961 ± 0.022	0.212CysHis: 0.212 ± 0.009	0.141CysIle: 0.141 ± 0.007	0.117CysLys: 0.117 ± 0.007	0.77CysLeu: 0.77 ± 0.017	0.135CysMet: 0.135 ± 0.007	0.126CysAsn: 0.126 ± 0.007	0.493CysPro: 0.493 ± 0.015	0.167CysGln: 0.167 ± 0.008	0.623CysArg: 0.623 ± 0.016	0.447CysSer: 0.447 ± 0.014	0.422CysThr: 0.422 ± 0.014	0.715CysVal: 0.715 ± 0.014	0.114CysTrp: 0.114 ± 0.007	0.183CysTyr: 0.183 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.759AspAla: 6.759 ± 0.06	0.362AspCys: 0.362 ± 0.012	3.753AspAsp: 3.753 ± 0.035	3.825AspGlu: 3.825 ± 0.037	1.57AspPhe: 1.57 ± 0.027	5.951AspGly: 5.951 ± 0.063	1.402AspHis: 1.402 ± 0.024	1.805AspIle: 1.805 ± 0.026	1.109AspLys: 1.109 ± 0.025	6.657AspLeu: 6.657 ± 0.062	0.879AspMet: 0.879 ± 0.017	0.929AspAsn: 0.929 ± 0.019	4.475AspPro: 4.475 ± 0.041	1.599AspGln: 1.599 ± 0.025	4.848AspArg: 4.848 ± 0.044	2.113AspSer: 2.113 ± 0.033	2.677AspThr: 2.677 ± 0.03	5.207AspVal: 5.207 ± 0.043	0.909AspTrp: 0.909 ± 0.021	1.239AspTyr: 1.239 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.97GluAla: 6.97 ± 0.069	0.374GluCys: 0.374 ± 0.011	2.451GluAsp: 2.451 ± 0.033	3.545GluGlu: 3.545 ± 0.044	1.481GluPhe: 1.481 ± 0.023	4.16GluGly: 4.16 ± 0.036	1.668GluHis: 1.668 ± 0.029	2.492GluIle: 2.492 ± 0.036	1.159GluLys: 1.159 ± 0.024	7.106GluLeu: 7.106 ± 0.061	0.953GluMet: 0.953 ± 0.022	0.929GluAsn: 0.929 ± 0.021	3.554GluPro: 3.554 ± 0.042	2.309GluGln: 2.309 ± 0.031	5.917GluArg: 5.917 ± 0.058	2.648GluSer: 2.648 ± 0.034	2.727GluThr: 2.727 ± 0.031	4.791GluVal: 4.791 ± 0.047	0.798GluTrp: 0.798 ± 0.018	1.0GluTyr: 1.0 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.845PheAla: 3.845 ± 0.044	0.27PheCys: 0.27 ± 0.011	2.102PheAsp: 2.102 ± 0.027	1.459PheGlu: 1.459 ± 0.025	0.916PhePhe: 0.916 ± 0.022	3.132PheGly: 3.132 ± 0.036	0.655PheHis: 0.655 ± 0.016	0.814PheIle: 0.814 ± 0.017	0.529PheLys: 0.529 ± 0.016	2.678PheLeu: 2.678 ± 0.042	0.462PheMet: 0.462 ± 0.013	0.574PheAsn: 0.574 ± 0.014	1.466PhePro: 1.466 ± 0.024	0.697PheGln: 0.697 ± 0.015	1.865PheArg: 1.865 ± 0.028	1.509PheSer: 1.509 ± 0.029	1.977PheThr: 1.977 ± 0.029	2.486PheVal: 2.486 ± 0.032	0.463PheTrp: 0.463 ± 0.012	0.642PheTyr: 0.642 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.224GlyAla: 10.224 ± 0.077	0.843GlyCys: 0.843 ± 0.017	5.353GlyAsp: 5.353 ± 0.049	5.492GlyGlu: 5.492 ± 0.052	2.949GlyPhe: 2.949 ± 0.033	8.646GlyGly: 8.646 ± 0.08	2.397GlyHis: 2.397 ± 0.031	3.355GlyIle: 3.355 ± 0.041	2.413GlyLys: 2.413 ± 0.043	9.943GlyLeu: 9.943 ± 0.08	2.173GlyMet: 2.173 ± 0.031	1.689GlyAsn: 1.689 ± 0.029	4.971GlyPro: 4.971 ± 0.056	2.705GlyGln: 2.705 ± 0.036	8.077GlyArg: 8.077 ± 0.057	4.939GlySer: 4.939 ± 0.04	5.559GlyThr: 5.559 ± 0.047	8.13GlyVal: 8.13 ± 0.058	1.739GlyTrp: 1.739 ± 0.028	2.37GlyTyr: 2.37 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.714HisAla: 2.714 ± 0.035	0.204HisCys: 0.204 ± 0.009	1.529HisAsp: 1.529 ± 0.025	1.267HisGlu: 1.267 ± 0.027	0.579HisPhe: 0.579 ± 0.016	2.343HisGly: 2.343 ± 0.032	0.695HisHis: 0.695 ± 0.017	0.668HisIle: 0.668 ± 0.016	0.333HisLys: 0.333 ± 0.011	2.465HisLeu: 2.465 ± 0.03	0.372HisMet: 0.372 ± 0.011	0.387HisAsn: 0.387 ± 0.012	1.718HisPro: 1.718 ± 0.028	0.625HisGln: 0.625 ± 0.016	1.991HisArg: 1.991 ± 0.029	0.884HisSer: 0.884 ± 0.022	1.163HisThr: 1.163 ± 0.023	2.023HisVal: 2.023 ± 0.027	0.347HisTrp: 0.347 ± 0.012	0.518HisTyr: 0.518 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.097IleAla: 5.097 ± 0.051	0.334IleCys: 0.334 ± 0.012	2.518IleAsp: 2.518 ± 0.031	2.252IleGlu: 2.252 ± 0.031	0.89IlePhe: 0.89 ± 0.02	3.688IleGly: 3.688 ± 0.042	0.64IleHis: 0.64 ± 0.016	1.154IleIle: 1.154 ± 0.026	0.826IleLys: 0.826 ± 0.021	2.716IleLeu: 2.716 ± 0.034	0.658IleMet: 0.658 ± 0.02	0.752IleAsn: 0.752 ± 0.02	1.903IlePro: 1.903 ± 0.026	0.756IleGln: 0.756 ± 0.016	2.496IleArg: 2.496 ± 0.035	1.965IleSer: 1.965 ± 0.028	2.395IleThr: 2.395 ± 0.03	3.388IleVal: 3.388 ± 0.041	0.442IleTrp: 0.442 ± 0.014	0.652IleTyr: 0.652 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.672LysAla: 2.672 ± 0.039	0.107LysCys: 0.107 ± 0.006	1.199LysAsp: 1.199 ± 0.027	1.275LysGlu: 1.275 ± 0.023	0.442LysPhe: 0.442 ± 0.013	1.831LysGly: 1.831 ± 0.031	0.428LysHis: 0.428 ± 0.012	0.96LysIle: 0.96 ± 0.021	0.705LysLys: 0.705 ± 0.023	2.052LysLeu: 2.052 ± 0.035	0.367LysMet: 0.367 ± 0.012	0.444LysAsn: 0.444 ± 0.015	1.328LysPro: 1.328 ± 0.026	0.664LysGln: 0.664 ± 0.018	1.478LysArg: 1.478 ± 0.026	1.043LysSer: 1.043 ± 0.025	1.161LysThr: 1.161 ± 0.022	2.009LysVal: 2.009 ± 0.033	0.277LysTrp: 0.277 ± 0.012	0.422LysTyr: 0.422 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.796LeuAla: 15.796 ± 0.111	0.806LeuCys: 0.806 ± 0.018	6.787LeuAsp: 6.787 ± 0.055	4.821LeuGlu: 4.821 ± 0.047	2.749LeuPhe: 2.749 ± 0.041	9.537LeuGly: 9.537 ± 0.071	2.178LeuHis: 2.178 ± 0.03	3.897LeuIle: 3.897 ± 0.049	1.962LeuLys: 1.962 ± 0.034	11.367LeuLeu: 11.367 ± 0.107	1.893LeuMet: 1.893 ± 0.029	1.736LeuAsn: 1.736 ± 0.025	6.41LeuPro: 6.41 ± 0.052	2.149LeuGln: 2.149 ± 0.026	9.013LeuArg: 9.013 ± 0.068	5.758LeuSer: 5.758 ± 0.054	6.722LeuThr: 6.722 ± 0.051	9.216LeuVal: 9.216 ± 0.061	1.334LeuTrp: 1.334 ± 0.026	1.887LeuTyr: 1.887 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.569MetAla: 2.569 ± 0.031	0.144MetCys: 0.144 ± 0.007	0.967MetAsp: 0.967 ± 0.02	0.88MetGlu: 0.88 ± 0.019	0.535MetPhe: 0.535 ± 0.015	1.503MetGly: 1.503 ± 0.023	0.359MetHis: 0.359 ± 0.013	0.884MetIle: 0.884 ± 0.017	0.487MetLys: 0.487 ± 0.015	2.047MetLeu: 2.047 ± 0.025	0.36MetMet: 0.36 ± 0.013	0.47MetAsn: 0.47 ± 0.013	1.233MetPro: 1.233 ± 0.024	0.437MetGln: 0.437 ± 0.014	1.803MetArg: 1.803 ± 0.026	1.389MetSer: 1.389 ± 0.022	1.614MetThr: 1.614 ± 0.026	1.552MetVal: 1.552 ± 0.027	0.244MetTrp: 0.244 ± 0.009	0.345MetTyr: 0.345 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.173AsnAla: 2.173 ± 0.036	0.153AsnCys: 0.153 ± 0.008	0.989AsnAsp: 0.989 ± 0.02	0.844AsnGlu: 0.844 ± 0.018	0.488AsnPhe: 0.488 ± 0.014	1.809AsnGly: 1.809 ± 0.03	0.398AsnHis: 0.398 ± 0.011	0.619AsnIle: 0.619 ± 0.017	0.389AsnLys: 0.389 ± 0.014	1.798AsnLeu: 1.798 ± 0.025	0.311AsnMet: 0.311 ± 0.012	0.398AsnAsn: 0.398 ± 0.016	1.36AsnPro: 1.36 ± 0.023	0.475AsnGln: 0.475 ± 0.015	1.279AsnArg: 1.279 ± 0.023	0.789AsnSer: 0.789 ± 0.019	1.017AsnThr: 1.017 ± 0.023	1.59AsnVal: 1.59 ± 0.027	0.286AsnTrp: 0.286 ± 0.012	0.387AsnTyr: 0.387 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.967ProAla: 7.967 ± 0.06	0.344ProCys: 0.344 ± 0.012	4.115ProAsp: 4.115 ± 0.045	4.124ProGlu: 4.124 ± 0.043	1.628ProPhe: 1.628 ± 0.02	6.759ProGly: 6.759 ± 0.064	1.301ProHis: 1.301 ± 0.024	1.725ProIle: 1.725 ± 0.026	1.197ProLys: 1.197 ± 0.02	5.265ProLeu: 5.265 ± 0.049	1.207ProMet: 1.207 ± 0.021	0.869ProAsn: 0.869 ± 0.019	3.711ProPro: 3.711 ± 0.048	1.534ProGln: 1.534 ± 0.026	3.944ProArg: 3.944 ± 0.04	3.234ProSer: 3.234 ± 0.037	2.757ProThr: 2.757 ± 0.033	5.264ProVal: 5.264 ± 0.042	0.966ProTrp: 0.966 ± 0.02	1.513ProTyr: 1.513 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.971GlnAla: 3.971 ± 0.047	0.163GlnCys: 0.163 ± 0.008	1.286GlnAsp: 1.286 ± 0.023	1.488GlnGlu: 1.488 ± 0.024	0.665GlnPhe: 0.665 ± 0.014	2.207GlnGly: 2.207 ± 0.037	0.583GlnHis: 0.583 ± 0.016	1.171GlnIle: 1.171 ± 0.022	0.528GlnLys: 0.528 ± 0.017	2.752GlnLeu: 2.752 ± 0.037	0.47GlnMet: 0.47 ± 0.014	0.464GlnAsn: 0.464 ± 0.013	1.651GlnPro: 1.651 ± 0.03	1.024GlnGln: 1.024 ± 0.038	2.379GlnArg: 2.379 ± 0.034	1.162GlnSer: 1.162 ± 0.023	1.233GlnThr: 1.233 ± 0.024	2.625GlnVal: 2.625 ± 0.036	0.442GlnTrp: 0.442 ± 0.014	0.505GlnTyr: 0.505 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.671ArgAla: 9.671 ± 0.071	0.611ArgCys: 0.611 ± 0.016	4.509ArgAsp: 4.509 ± 0.041	4.816ArgGlu: 4.816 ± 0.053	2.495ArgPhe: 2.495 ± 0.035	5.953ArgGly: 5.953 ± 0.048	2.316ArgHis: 2.316 ± 0.032	3.169ArgIle: 3.169 ± 0.035	1.644ArgLys: 1.644 ± 0.027	9.817ArgLeu: 9.817 ± 0.086	2.016ArgMet: 2.016 ± 0.028	1.427ArgAsn: 1.427 ± 0.024	5.098ArgPro: 5.098 ± 0.052	2.46ArgGln: 2.46 ± 0.033	8.191ArgArg: 8.191 ± 0.069	4.023ArgSer: 4.023 ± 0.042	4.738ArgThr: 4.738 ± 0.04	6.442ArgVal: 6.442 ± 0.049	1.454ArgTrp: 1.454 ± 0.026	1.871ArgTyr: 1.871 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.281SerAla: 6.281 ± 0.05	0.409SerCys: 0.409 ± 0.015	2.577SerAsp: 2.577 ± 0.032	2.493SerGlu: 2.493 ± 0.031	1.575SerPhe: 1.575 ± 0.025	5.808SerGly: 5.808 ± 0.054	1.014SerHis: 1.014 ± 0.022	1.729SerIle: 1.729 ± 0.025	1.014SerLys: 1.014 ± 0.024	4.872SerLeu: 4.872 ± 0.051	1.243SerMet: 1.243 ± 0.023	0.843SerAsn: 0.843 ± 0.019	3.147SerPro: 3.147 ± 0.038	1.216SerGln: 1.216 ± 0.02	3.829SerArg: 3.829 ± 0.041	2.763SerSer: 2.763 ± 0.037	2.806SerThr: 2.806 ± 0.035	4.142SerVal: 4.142 ± 0.045	0.924SerTrp: 0.924 ± 0.019	1.185SerTyr: 1.185 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.426ThrAla: 7.426 ± 0.057	0.45ThrCys: 0.45 ± 0.012	2.882ThrAsp: 2.882 ± 0.034	2.757ThrGlu: 2.757 ± 0.037	1.812ThrPhe: 1.812 ± 0.029	6.237ThrGly: 6.237 ± 0.054	1.102ThrHis: 1.102 ± 0.02	2.115ThrIle: 2.115 ± 0.027	1.121ThrLys: 1.121 ± 0.025	5.814ThrLeu: 5.814 ± 0.049	1.229ThrMet: 1.229 ± 0.023	0.926ThrAsn: 0.926 ± 0.019	3.745ThrPro: 3.745 ± 0.042	1.295ThrGln: 1.295 ± 0.025	4.014ThrArg: 4.014 ± 0.041	3.041ThrSer: 3.041 ± 0.033	3.467ThrThr: 3.467 ± 0.044	5.602ThrVal: 5.602 ± 0.054	0.933ThrTrp: 0.933 ± 0.02	1.344ThrTyr: 1.344 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.452ValAla: 11.452 ± 0.076	0.734ValCys: 0.734 ± 0.019	4.75ValAsp: 4.75 ± 0.043	5.006ValGlu: 5.006 ± 0.048	2.634ValPhe: 2.634 ± 0.042	6.655ValGly: 6.655 ± 0.054	1.948ValHis: 1.948 ± 0.03	3.443ValIle: 3.443 ± 0.041	1.859ValLys: 1.859 ± 0.031	9.802ValLeu: 9.802 ± 0.072	1.609ValMet: 1.609 ± 0.026	1.813ValAsn: 1.813 ± 0.028	5.261ValPro: 5.261 ± 0.044	1.994ValGln: 1.994 ± 0.031	7.237ValArg: 7.237 ± 0.06	4.739ValSer: 4.739 ± 0.046	5.947ValThr: 5.947 ± 0.059	8.339ValVal: 8.339 ± 0.069	1.156ValTrp: 1.156 ± 0.023	1.682ValTyr: 1.682 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.647TrpAla: 1.647 ± 0.028	0.166TrpCys: 0.166 ± 0.008	0.779TrpAsp: 0.779 ± 0.018	0.764TrpGlu: 0.764 ± 0.017	0.512TrpPhe: 0.512 ± 0.015	1.043TrpGly: 1.043 ± 0.022	0.426TrpHis: 0.426 ± 0.012	0.575TrpIle: 0.575 ± 0.015	0.344TrpLys: 0.344 ± 0.012	1.889TrpLeu: 1.889 ± 0.03	0.332TrpMet: 0.332 ± 0.011	0.425TrpAsn: 0.425 ± 0.016	0.884TrpPro: 0.884 ± 0.018	0.585TrpGln: 0.585 ± 0.016	1.472TrpArg: 1.472 ± 0.027	0.956TrpSer: 0.956 ± 0.018	0.961TrpThr: 0.961 ± 0.02	1.007TrpVal: 1.007 ± 0.022	0.367TrpTrp: 0.367 ± 0.016	0.341TrpTyr: 0.341 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.794TyrAla: 2.794 ± 0.031	0.185TyrCys: 0.185 ± 0.008	1.498TyrAsp: 1.498 ± 0.029	1.204TyrGlu: 1.204 ± 0.023	0.672TyrPhe: 0.672 ± 0.016	2.277TyrGly: 2.277 ± 0.033	0.464TyrHis: 0.464 ± 0.015	0.531TyrIle: 0.531 ± 0.013	0.373TyrLys: 0.373 ± 0.013	2.262TyrLeu: 2.262 ± 0.028	0.291TyrMet: 0.291 ± 0.01	0.412TyrAsn: 0.412 ± 0.013	1.088TyrPro: 1.088 ± 0.02	0.586TyrGln: 0.586 ± 0.016	1.853TyrArg: 1.853 ± 0.03	0.951TyrSer: 0.951 ± 0.02	1.23TyrThr: 1.23 ± 0.023	1.884TyrVal: 1.884 ± 0.026	0.347TyrTrp: 0.347 ± 0.012	0.48TyrTyr: 0.48 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8278 proteins (2640208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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