Amino acid dipepetide frequency for Aneurinibacillus danicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.955AlaAla: 7.955 ± 0.109	0.821AlaCys: 0.821 ± 0.027	3.92AlaAsp: 3.92 ± 0.06	5.962AlaGlu: 5.962 ± 0.077	3.299AlaPhe: 3.299 ± 0.05	6.428AlaGly: 6.428 ± 0.075	1.591AlaHis: 1.591 ± 0.039	5.766AlaIle: 5.766 ± 0.079	4.671AlaLys: 4.671 ± 0.061	8.349AlaLeu: 8.349 ± 0.083	2.415AlaMet: 2.415 ± 0.047	2.617AlaAsn: 2.617 ± 0.049	2.724AlaPro: 2.724 ± 0.053	2.942AlaGln: 2.942 ± 0.058	4.407AlaArg: 4.407 ± 0.065	4.686AlaSer: 4.686 ± 0.063	3.559AlaThr: 3.559 ± 0.055	6.385AlaVal: 6.385 ± 0.082	0.77AlaTrp: 0.77 ± 0.023	2.634AlaTyr: 2.634 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.614CysAla: 0.614 ± 0.021	0.112CysCys: 0.112 ± 0.01	0.459CysAsp: 0.459 ± 0.023	0.496CysGlu: 0.496 ± 0.022	0.341CysPhe: 0.341 ± 0.017	0.867CysGly: 0.867 ± 0.03	0.201CysHis: 0.201 ± 0.013	0.559CysIle: 0.559 ± 0.019	0.367CysLys: 0.367 ± 0.016	0.776CysLeu: 0.776 ± 0.024	0.226CysMet: 0.226 ± 0.012	0.285CysAsn: 0.285 ± 0.014	0.449CysPro: 0.449 ± 0.022	0.266CysGln: 0.266 ± 0.015	0.525CysArg: 0.525 ± 0.02	0.529CysSer: 0.529 ± 0.023	0.466CysThr: 0.466 ± 0.02	0.534CysVal: 0.534 ± 0.021	0.08CysTrp: 0.08 ± 0.008	0.289CysTyr: 0.289 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.718AspAla: 3.718 ± 0.066	0.424AspCys: 0.424 ± 0.02	2.094AspAsp: 2.094 ± 0.05	4.079AspGlu: 4.079 ± 0.057	2.089AspPhe: 2.089 ± 0.044	3.35AspGly: 3.35 ± 0.057	0.852AspHis: 0.852 ± 0.028	4.046AspIle: 4.046 ± 0.057	2.807AspLys: 2.807 ± 0.054	4.263AspLeu: 4.263 ± 0.062	1.574AspMet: 1.574 ± 0.036	1.558AspAsn: 1.558 ± 0.035	1.969AspPro: 1.969 ± 0.047	1.408AspGln: 1.408 ± 0.035	2.503AspArg: 2.503 ± 0.047	2.155AspSer: 2.155 ± 0.043	2.517AspThr: 2.517 ± 0.047	3.787AspVal: 3.787 ± 0.061	0.613AspTrp: 0.613 ± 0.02	1.698AspTyr: 1.698 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.669GluAla: 6.669 ± 0.086	0.46GluCys: 0.46 ± 0.022	3.228GluAsp: 3.228 ± 0.057	7.435GluGlu: 7.435 ± 0.102	2.422GluPhe: 2.422 ± 0.048	4.68GluGly: 4.68 ± 0.065	1.571GluHis: 1.571 ± 0.037	5.27GluIle: 5.27 ± 0.073	6.142GluLys: 6.142 ± 0.074	6.818GluLeu: 6.818 ± 0.083	2.446GluMet: 2.446 ± 0.05	2.958GluAsn: 2.958 ± 0.049	2.079GluPro: 2.079 ± 0.046	3.736GluGln: 3.736 ± 0.069	4.724GluArg: 4.724 ± 0.081	3.174GluSer: 3.174 ± 0.055	3.705GluThr: 3.705 ± 0.062	5.183GluVal: 5.183 ± 0.064	0.947GluTrp: 0.947 ± 0.031	2.24GluTyr: 2.24 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.369PheAla: 3.369 ± 0.05	0.387PheCys: 0.387 ± 0.02	2.036PheAsp: 2.036 ± 0.042	2.381PheGlu: 2.381 ± 0.044	2.05PhePhe: 2.05 ± 0.053	3.156PheGly: 3.156 ± 0.051	0.903PheHis: 0.903 ± 0.027	3.077PheIle: 3.077 ± 0.061	1.781PheLys: 1.781 ± 0.044	4.201PheLeu: 4.201 ± 0.073	1.051PheMet: 1.051 ± 0.032	1.351PheAsn: 1.351 ± 0.036	1.681PhePro: 1.681 ± 0.039	1.197PheGln: 1.197 ± 0.026	1.812PheArg: 1.812 ± 0.039	2.809PheSer: 2.809 ± 0.049	2.469PheThr: 2.469 ± 0.045	2.976PheVal: 2.976 ± 0.054	0.464PheTrp: 0.464 ± 0.021	1.502PheTyr: 1.502 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.627GlyAla: 5.627 ± 0.074	0.764GlyCys: 0.764 ± 0.026	3.085GlyAsp: 3.085 ± 0.055	4.862GlyGlu: 4.862 ± 0.063	3.23GlyPhe: 3.23 ± 0.054	5.282GlyGly: 5.282 ± 0.072	1.435GlyHis: 1.435 ± 0.033	5.922GlyIle: 5.922 ± 0.079	4.974GlyLys: 4.974 ± 0.066	6.664GlyLeu: 6.664 ± 0.078	2.44GlyMet: 2.44 ± 0.047	2.439GlyAsn: 2.439 ± 0.048	1.937GlyPro: 1.937 ± 0.04	2.497GlyGln: 2.497 ± 0.05	3.615GlyArg: 3.615 ± 0.056	3.777GlySer: 3.777 ± 0.064	4.308GlyThr: 4.308 ± 0.059	5.514GlyVal: 5.514 ± 0.076	0.932GlyTrp: 0.932 ± 0.03	2.876GlyTyr: 2.876 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.562HisAla: 1.562 ± 0.033	0.2HisCys: 0.2 ± 0.012	0.971HisAsp: 0.971 ± 0.028	1.386HisGlu: 1.386 ± 0.033	0.955HisPhe: 0.955 ± 0.024	1.529HisGly: 1.529 ± 0.042	0.652HisHis: 0.652 ± 0.031	1.574HisIle: 1.574 ± 0.036	0.989HisLys: 0.989 ± 0.027	2.049HisLeu: 2.049 ± 0.043	0.615HisMet: 0.615 ± 0.023	0.775HisAsn: 0.775 ± 0.026	1.307HisPro: 1.307 ± 0.04	0.779HisGln: 0.779 ± 0.025	1.171HisArg: 1.171 ± 0.032	1.142HisSer: 1.142 ± 0.029	1.227HisThr: 1.227 ± 0.029	1.458HisVal: 1.458 ± 0.038	0.23HisTrp: 0.23 ± 0.014	0.848HisTyr: 0.848 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.251IleAla: 6.251 ± 0.075	0.695IleCys: 0.695 ± 0.024	3.802IleAsp: 3.802 ± 0.064	5.372IleGlu: 5.372 ± 0.071	2.567IlePhe: 2.567 ± 0.05	5.68IleGly: 5.68 ± 0.077	1.588IleHis: 1.588 ± 0.033	4.742IleIle: 4.742 ± 0.074	3.682IleLys: 3.682 ± 0.053	6.16IleLeu: 6.16 ± 0.076	1.713IleMet: 1.713 ± 0.043	2.524IleAsn: 2.524 ± 0.05	3.448IlePro: 3.448 ± 0.058	2.578IleGln: 2.578 ± 0.043	3.795IleArg: 3.795 ± 0.063	4.282IleSer: 4.282 ± 0.056	3.976IleThr: 3.976 ± 0.063	5.493IleVal: 5.493 ± 0.078	0.622IleTrp: 0.622 ± 0.023	2.114IleTyr: 2.114 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.711LysAla: 4.711 ± 0.069	0.32LysCys: 0.32 ± 0.017	2.906LysAsp: 2.906 ± 0.055	5.94LysGlu: 5.94 ± 0.079	1.643LysPhe: 1.643 ± 0.037	3.855LysGly: 3.855 ± 0.058	1.199LysHis: 1.199 ± 0.031	3.863LysIle: 3.863 ± 0.054	4.985LysLys: 4.985 ± 0.072	4.992LysLeu: 4.992 ± 0.057	1.981LysMet: 1.981 ± 0.04	2.576LysAsn: 2.576 ± 0.047	2.365LysPro: 2.365 ± 0.042	2.996LysGln: 2.996 ± 0.057	3.481LysArg: 3.481 ± 0.049	2.809LysSer: 2.809 ± 0.052	3.146LysThr: 3.146 ± 0.045	4.276LysVal: 4.276 ± 0.064	0.703LysTrp: 0.703 ± 0.026	1.961LysTyr: 1.961 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	8.561LeuAla: 8.561 ± 0.093	0.843LeuCys: 0.843 ± 0.031	4.651LeuAsp: 4.651 ± 0.071	6.547LeuGlu: 6.547 ± 0.087	4.282LeuPhe: 4.282 ± 0.083	6.65LeuGly: 6.65 ± 0.079	2.225LeuHis: 2.225 ± 0.047	6.068LeuIle: 6.068 ± 0.074	5.188LeuLys: 5.188 ± 0.071	10.318LeuLeu: 10.318 ± 0.127	2.38LeuMet: 2.38 ± 0.043	3.409LeuAsn: 3.409 ± 0.063	4.294LeuPro: 4.294 ± 0.06	3.524LeuGln: 3.524 ± 0.06	5.081LeuArg: 5.081 ± 0.066	6.338LeuSer: 6.338 ± 0.077	5.439LeuThr: 5.439 ± 0.067	6.434LeuVal: 6.434 ± 0.08	0.867LeuTrp: 0.867 ± 0.032	3.206LeuTyr: 3.206 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.484MetAla: 2.484 ± 0.052	0.166MetCys: 0.166 ± 0.012	1.455MetAsp: 1.455 ± 0.037	2.246MetGlu: 2.246 ± 0.041	1.017MetPhe: 1.017 ± 0.031	1.971MetGly: 1.971 ± 0.042	0.514MetHis: 0.514 ± 0.021	1.958MetIle: 1.958 ± 0.038	2.269MetLys: 2.269 ± 0.049	2.797MetLeu: 2.797 ± 0.058	0.952MetMet: 0.952 ± 0.03	1.431MetAsn: 1.431 ± 0.035	1.135MetPro: 1.135 ± 0.031	1.082MetGln: 1.082 ± 0.029	1.522MetArg: 1.522 ± 0.043	1.672MetSer: 1.672 ± 0.034	1.491MetThr: 1.491 ± 0.033	1.947MetVal: 1.947 ± 0.043	0.226MetTrp: 0.226 ± 0.013	0.849MetTyr: 0.849 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.592AsnAla: 2.592 ± 0.05	0.298AsnCys: 0.298 ± 0.015	1.573AsnAsp: 1.573 ± 0.04	2.68AsnGlu: 2.68 ± 0.046	1.276AsnPhe: 1.276 ± 0.033	2.866AsnGly: 2.866 ± 0.044	0.864AsnHis: 0.864 ± 0.027	2.8AsnIle: 2.8 ± 0.053	2.144AsnLys: 2.144 ± 0.047	3.207AsnLeu: 3.207 ± 0.049	1.065AsnMet: 1.065 ± 0.025	1.39AsnAsn: 1.39 ± 0.044	2.071AsnPro: 2.071 ± 0.039	1.603AsnGln: 1.603 ± 0.038	2.184AsnArg: 2.184 ± 0.044	1.674AsnSer: 1.674 ± 0.041	1.86AsnThr: 1.86 ± 0.043	2.752AsnVal: 2.752 ± 0.05	0.386AsnTrp: 0.386 ± 0.017	1.23AsnTyr: 1.23 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.054ProAla: 3.054 ± 0.054	0.259ProCys: 0.259 ± 0.015	2.434ProAsp: 2.434 ± 0.047	3.477ProGlu: 3.477 ± 0.053	1.837ProPhe: 1.837 ± 0.044	3.121ProGly: 3.121 ± 0.049	0.998ProHis: 0.998 ± 0.029	2.554ProIle: 2.554 ± 0.05	2.018ProLys: 2.018 ± 0.039	3.995ProLeu: 3.995 ± 0.068	0.9ProMet: 0.9 ± 0.027	1.458ProAsn: 1.458 ± 0.038	1.38ProPro: 1.38 ± 0.039	1.356ProGln: 1.356 ± 0.035	1.641ProArg: 1.641 ± 0.036	2.251ProSer: 2.251 ± 0.046	1.869ProThr: 1.869 ± 0.035	3.437ProVal: 3.437 ± 0.067	0.421ProTrp: 0.421 ± 0.018	1.542ProTyr: 1.542 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.538GlnAla: 3.538 ± 0.071	0.217GlnCys: 0.217 ± 0.014	1.592GlnAsp: 1.592 ± 0.035	3.125GlnGlu: 3.125 ± 0.056	1.303GlnPhe: 1.303 ± 0.036	2.454GlnGly: 2.454 ± 0.046	0.823GlnHis: 0.823 ± 0.027	2.59GlnIle: 2.59 ± 0.052	2.559GlnLys: 2.559 ± 0.053	3.617GlnLeu: 3.617 ± 0.061	1.258GlnMet: 1.258 ± 0.033	1.443GlnAsn: 1.443 ± 0.037	1.369GlnPro: 1.369 ± 0.033	1.88GlnGln: 1.88 ± 0.048	2.053GlnArg: 2.053 ± 0.043	1.903GlnSer: 1.903 ± 0.042	2.053GlnThr: 2.053 ± 0.045	2.715GlnVal: 2.715 ± 0.045	0.384GlnTrp: 0.384 ± 0.017	1.248GlnTyr: 1.248 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.717ArgAla: 3.717 ± 0.07	0.391ArgCys: 0.391 ± 0.018	2.527ArgAsp: 2.527 ± 0.043	4.536ArgGlu: 4.536 ± 0.068	2.247ArgPhe: 2.247 ± 0.046	3.213ArgGly: 3.213 ± 0.049	1.168ArgHis: 1.168 ± 0.032	4.006ArgIle: 4.006 ± 0.063	3.577ArgLys: 3.577 ± 0.05	5.383ArgLeu: 5.383 ± 0.072	1.805ArgMet: 1.805 ± 0.041	2.034ArgAsn: 2.034 ± 0.039	1.891ArgPro: 1.891 ± 0.037	2.297ArgGln: 2.297 ± 0.044	3.145ArgArg: 3.145 ± 0.061	2.668ArgSer: 2.668 ± 0.053	2.686ArgThr: 2.686 ± 0.045	3.595ArgVal: 3.595 ± 0.056	0.638ArgTrp: 0.638 ± 0.022	2.058ArgTyr: 2.058 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.177SerAla: 4.177 ± 0.064	0.501SerCys: 0.501 ± 0.019	2.493SerAsp: 2.493 ± 0.045	3.463SerGlu: 3.463 ± 0.062	2.758SerPhe: 2.758 ± 0.046	4.404SerGly: 4.404 ± 0.062	1.231SerHis: 1.231 ± 0.033	4.034SerIle: 4.034 ± 0.057	2.858SerLys: 2.858 ± 0.051	5.715SerLeu: 5.715 ± 0.071	1.641SerMet: 1.641 ± 0.036	1.797SerAsn: 1.797 ± 0.045	2.296SerPro: 2.296 ± 0.042	1.907SerGln: 1.907 ± 0.039	2.942SerArg: 2.942 ± 0.053	3.35SerSer: 3.35 ± 0.06	2.825SerThr: 2.825 ± 0.047	4.096SerVal: 4.096 ± 0.056	0.614SerTrp: 0.614 ± 0.024	1.992SerTyr: 1.992 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.255ThrAla: 4.255 ± 0.06	0.421ThrCys: 0.421 ± 0.018	2.451ThrAsp: 2.451 ± 0.043	3.6ThrGlu: 3.6 ± 0.058	2.306ThrPhe: 2.306 ± 0.049	4.565ThrGly: 4.565 ± 0.06	1.047ThrHis: 1.047 ± 0.029	3.868ThrIle: 3.868 ± 0.054	2.717ThrLys: 2.717 ± 0.044	5.339ThrLeu: 5.339 ± 0.062	1.425ThrMet: 1.425 ± 0.033	1.87ThrAsn: 1.87 ± 0.036	2.507ThrPro: 2.507 ± 0.044	1.557ThrGln: 1.557 ± 0.04	2.485ThrArg: 2.485 ± 0.045	2.95ThrSer: 2.95 ± 0.055	2.69ThrThr: 2.69 ± 0.05	4.506ThrVal: 4.506 ± 0.067	0.523ThrTrp: 0.523 ± 0.022	1.844ThrTyr: 1.844 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.884ValAla: 5.884 ± 0.075	0.705ValCys: 0.705 ± 0.022	3.598ValAsp: 3.598 ± 0.046	5.054ValGlu: 5.054 ± 0.062	3.059ValPhe: 3.059 ± 0.056	4.818ValGly: 4.818 ± 0.071	1.52ValHis: 1.52 ± 0.038	5.37ValIle: 5.37 ± 0.073	4.348ValLys: 4.348 ± 0.062	7.166ValLeu: 7.166 ± 0.078	2.049ValMet: 2.049 ± 0.041	2.752ValAsn: 2.752 ± 0.042	3.266ValPro: 3.266 ± 0.054	2.769ValGln: 2.769 ± 0.052	3.856ValArg: 3.856 ± 0.061	4.469ValSer: 4.469 ± 0.06	4.206ValThr: 4.206 ± 0.063	5.476ValVal: 5.476 ± 0.079	0.74ValTrp: 0.74 ± 0.029	2.46ValTyr: 2.46 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.714TrpAla: 0.714 ± 0.023	0.09TrpCys: 0.09 ± 0.009	0.511TrpAsp: 0.511 ± 0.021	0.727TrpGlu: 0.727 ± 0.026	0.46TrpPhe: 0.46 ± 0.021	0.695TrpGly: 0.695 ± 0.025	0.234TrpHis: 0.234 ± 0.015	0.76TrpIle: 0.76 ± 0.024	0.792TrpLys: 0.792 ± 0.025	1.218TrpLeu: 1.218 ± 0.034	0.406TrpMet: 0.406 ± 0.017	0.537TrpAsn: 0.537 ± 0.023	0.313TrpPro: 0.313 ± 0.015	0.41TrpGln: 0.41 ± 0.018	0.544TrpArg: 0.544 ± 0.023	0.53TrpSer: 0.53 ± 0.024	0.554TrpThr: 0.554 ± 0.021	0.683TrpVal: 0.683 ± 0.021	0.142TrpTrp: 0.142 ± 0.011	0.345TrpTyr: 0.345 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.448TyrAla: 2.448 ± 0.053	0.365TyrCys: 0.365 ± 0.018	1.72TyrAsp: 1.72 ± 0.037	2.52TyrGlu: 2.52 ± 0.047	1.513TyrPhe: 1.513 ± 0.039	2.597TyrGly: 2.597 ± 0.046	0.8TyrHis: 0.8 ± 0.026	2.256TyrIle: 2.256 ± 0.044	1.84TyrLys: 1.84 ± 0.034	3.279TyrLeu: 3.279 ± 0.062	0.842TyrMet: 0.842 ± 0.027	1.309TyrAsn: 1.309 ± 0.035	1.519TyrPro: 1.519 ± 0.039	1.342TyrGln: 1.342 ± 0.036	2.096TyrArg: 2.096 ± 0.045	1.927TyrSer: 1.927 ± 0.041	1.883TyrThr: 1.883 ± 0.041	2.319TyrVal: 2.319 ± 0.041	0.362TyrTrp: 0.362 ± 0.017	1.326TyrTyr: 1.326 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4349 proteins (1227664 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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