Amino acid dipepetide frequency for Hydrogenoanaerobacterium saccharovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.827AlaAla: 7.827 ± 0.121	1.093AlaCys: 1.093 ± 0.036	4.526AlaAsp: 4.526 ± 0.074	5.215AlaGlu: 5.215 ± 0.087	3.048AlaPhe: 3.048 ± 0.06	5.943AlaGly: 5.943 ± 0.103	1.245AlaHis: 1.245 ± 0.039	5.861AlaIle: 5.861 ± 0.088	5.544AlaLys: 5.544 ± 0.087	7.794AlaLeu: 7.794 ± 0.111	2.377AlaMet: 2.377 ± 0.054	3.293AlaAsn: 3.293 ± 0.058	2.526AlaPro: 2.526 ± 0.056	3.24AlaGln: 3.24 ± 0.07	2.807AlaArg: 2.807 ± 0.061	4.194AlaSer: 4.194 ± 0.071	3.918AlaThr: 3.918 ± 0.082	6.945AlaVal: 6.945 ± 0.11	0.536AlaTrp: 0.536 ± 0.022	2.576AlaTyr: 2.576 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.236CysAla: 1.236 ± 0.04	0.32CysCys: 0.32 ± 0.021	0.995CysAsp: 0.995 ± 0.039	0.981CysGlu: 0.981 ± 0.032	0.693CysPhe: 0.693 ± 0.03	1.534CysGly: 1.534 ± 0.048	0.295CysHis: 0.295 ± 0.017	1.221CysIle: 1.221 ± 0.038	1.078CysLys: 1.078 ± 0.035	1.054CysLeu: 1.054 ± 0.036	0.388CysMet: 0.388 ± 0.021	0.763CysAsn: 0.763 ± 0.03	0.631CysPro: 0.631 ± 0.033	0.352CysGln: 0.352 ± 0.018	0.625CysArg: 0.625 ± 0.027	1.015CysSer: 1.015 ± 0.042	0.839CysThr: 0.839 ± 0.033	0.987CysVal: 0.987 ± 0.032	0.101CysTrp: 0.101 ± 0.01	0.536CysTyr: 0.536 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.331AspAla: 4.331 ± 0.083	0.866AspCys: 0.866 ± 0.033	3.023AspAsp: 3.023 ± 0.078	4.325AspGlu: 4.325 ± 0.088	2.612AspPhe: 2.612 ± 0.053	4.018AspGly: 4.018 ± 0.072	0.78AspHis: 0.78 ± 0.032	4.73AspIle: 4.73 ± 0.077	3.894AspLys: 3.894 ± 0.066	4.334AspLeu: 4.334 ± 0.071	1.586AspMet: 1.586 ± 0.046	2.502AspAsn: 2.502 ± 0.057	1.561AspPro: 1.561 ± 0.036	1.062AspGln: 1.062 ± 0.033	1.996AspArg: 1.996 ± 0.04	3.059AspSer: 3.059 ± 0.074	3.142AspThr: 3.142 ± 0.072	3.957AspVal: 3.957 ± 0.069	0.554AspTrp: 0.554 ± 0.027	2.526AspTyr: 2.526 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.307GluAla: 4.307 ± 0.074	0.832GluCys: 0.832 ± 0.027	3.24GluAsp: 3.24 ± 0.063	4.202GluGlu: 4.202 ± 0.087	2.537GluPhe: 2.537 ± 0.061	3.474GluGly: 3.474 ± 0.058	1.314GluHis: 1.314 ± 0.044	5.174GluIle: 5.174 ± 0.091	5.128GluLys: 5.128 ± 0.083	6.366GluLeu: 6.366 ± 0.097	2.085GluMet: 2.085 ± 0.059	3.808GluAsn: 3.808 ± 0.067	1.875GluPro: 1.875 ± 0.054	3.311GluGln: 3.311 ± 0.069	2.794GluArg: 2.794 ± 0.067	3.03GluSer: 3.03 ± 0.057	3.148GluThr: 3.148 ± 0.058	3.862GluVal: 3.862 ± 0.071	0.485GluTrp: 0.485 ± 0.026	2.564GluTyr: 2.564 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.609PheAla: 3.609 ± 0.067	0.772PheCys: 0.772 ± 0.031	2.705PheAsp: 2.705 ± 0.062	2.751PheGlu: 2.751 ± 0.063	1.888PhePhe: 1.888 ± 0.053	3.189PheGly: 3.189 ± 0.067	0.742PheHis: 0.742 ± 0.029	3.106PheIle: 3.106 ± 0.06	2.314PheLys: 2.314 ± 0.058	3.542PheLeu: 3.542 ± 0.071	1.067PheMet: 1.067 ± 0.033	1.796PheAsn: 1.796 ± 0.046	1.288PhePro: 1.288 ± 0.036	1.049PheGln: 1.049 ± 0.035	1.457PheArg: 1.457 ± 0.04	3.03PheSer: 3.03 ± 0.067	2.782PheThr: 2.782 ± 0.054	2.89PheVal: 2.89 ± 0.062	0.38PheTrp: 0.38 ± 0.023	1.67PheTyr: 1.67 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.599GlyAla: 5.599 ± 0.096	1.336GlyCys: 1.336 ± 0.047	3.472GlyAsp: 3.472 ± 0.066	4.262GlyGlu: 4.262 ± 0.073	3.218GlyPhe: 3.218 ± 0.062	5.123GlyGly: 5.123 ± 0.095	1.069GlyHis: 1.069 ± 0.037	5.864GlyIle: 5.864 ± 0.097	5.307GlyLys: 5.307 ± 0.078	5.878GlyLeu: 5.878 ± 0.099	2.201GlyMet: 2.201 ± 0.059	3.124GlyAsn: 3.124 ± 0.074	1.153GlyPro: 1.153 ± 0.034	1.709GlyGln: 1.709 ± 0.048	2.614GlyArg: 2.614 ± 0.065	4.003GlySer: 4.003 ± 0.075	4.098GlyThr: 4.098 ± 0.08	5.466GlyVal: 5.466 ± 0.093	0.662GlyTrp: 0.662 ± 0.031	3.004GlyTyr: 3.004 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.15HisAla: 1.15 ± 0.039	0.381HisCys: 0.381 ± 0.021	0.813HisAsp: 0.813 ± 0.028	0.918HisGlu: 0.918 ± 0.034	0.912HisPhe: 0.912 ± 0.032	1.186HisGly: 1.186 ± 0.037	0.399HisHis: 0.399 ± 0.024	1.416HisIle: 1.416 ± 0.039	1.034HisLys: 1.034 ± 0.029	1.586HisLeu: 1.586 ± 0.043	0.442HisMet: 0.442 ± 0.02	0.892HisAsn: 0.892 ± 0.03	0.853HisPro: 0.853 ± 0.03	0.577HisGln: 0.577 ± 0.026	0.739HisArg: 0.739 ± 0.027	1.066HisSer: 1.066 ± 0.034	1.084HisThr: 1.084 ± 0.034	1.024HisVal: 1.024 ± 0.033	0.183HisTrp: 0.183 ± 0.015	0.691HisTyr: 0.691 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.548IleAla: 6.548 ± 0.102	1.271IleCys: 1.271 ± 0.038	4.621IleAsp: 4.621 ± 0.08	4.809IleGlu: 4.809 ± 0.066	2.879IlePhe: 2.879 ± 0.063	5.247IleGly: 5.247 ± 0.087	1.206IleHis: 1.206 ± 0.033	5.469IleIle: 5.469 ± 0.103	4.861IleLys: 4.861 ± 0.075	6.9IleLeu: 6.9 ± 0.102	1.897IleMet: 1.897 ± 0.056	3.576IleAsn: 3.576 ± 0.066	3.225IlePro: 3.225 ± 0.064	2.152IleGln: 2.152 ± 0.053	2.985IleArg: 2.985 ± 0.05	5.307IleSer: 5.307 ± 0.097	4.979IleThr: 4.979 ± 0.088	5.336IleVal: 5.336 ± 0.077	0.531IleTrp: 0.531 ± 0.023	2.608IleTyr: 2.608 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.359LysAla: 5.359 ± 0.095	0.769LysCys: 0.769 ± 0.03	3.693LysAsp: 3.693 ± 0.071	4.728LysGlu: 4.728 ± 0.077	1.983LysPhe: 1.983 ± 0.051	4.154LysGly: 4.154 ± 0.065	1.12LysHis: 1.12 ± 0.039	5.13LysIle: 5.13 ± 0.077	5.065LysLys: 5.065 ± 0.094	6.206LysLeu: 6.206 ± 0.098	2.27LysMet: 2.27 ± 0.05	3.901LysAsn: 3.901 ± 0.066	2.448LysPro: 2.448 ± 0.055	3.006LysGln: 3.006 ± 0.063	2.84LysArg: 2.84 ± 0.059	3.681LysSer: 3.681 ± 0.067	4.103LysThr: 4.103 ± 0.08	4.146LysVal: 4.146 ± 0.069	0.515LysTrp: 0.515 ± 0.027	2.508LysTyr: 2.508 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.503LeuAla: 7.503 ± 0.111	1.731LeuCys: 1.731 ± 0.051	4.958LeuAsp: 4.958 ± 0.084	5.294LeuGlu: 5.294 ± 0.068	4.086LeuPhe: 4.086 ± 0.087	6.122LeuGly: 6.122 ± 0.1	1.622LeuHis: 1.622 ± 0.04	6.326LeuIle: 6.326 ± 0.098	6.159LeuLys: 6.159 ± 0.078	8.851LeuLeu: 8.851 ± 0.141	2.662LeuMet: 2.662 ± 0.05	4.142LeuAsn: 4.142 ± 0.075	3.904LeuPro: 3.904 ± 0.065	3.229LeuGln: 3.229 ± 0.054	3.725LeuArg: 3.725 ± 0.073	6.448LeuSer: 6.448 ± 0.104	5.486LeuThr: 5.486 ± 0.077	5.623LeuVal: 5.623 ± 0.086	0.73LeuTrp: 0.73 ± 0.026	3.12LeuTyr: 3.12 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.323MetAla: 2.323 ± 0.059	0.357MetCys: 0.357 ± 0.019	1.548MetAsp: 1.548 ± 0.041	1.728MetGlu: 1.728 ± 0.045	1.144MetPhe: 1.144 ± 0.041	2.078MetGly: 2.078 ± 0.058	0.448MetHis: 0.448 ± 0.024	1.961MetIle: 1.961 ± 0.056	2.102MetLys: 2.102 ± 0.046	2.879MetLeu: 2.879 ± 0.063	0.909MetMet: 0.909 ± 0.037	1.429MetAsn: 1.429 ± 0.04	1.281MetPro: 1.281 ± 0.036	1.19MetGln: 1.19 ± 0.034	1.154MetArg: 1.154 ± 0.034	1.766MetSer: 1.766 ± 0.05	1.477MetThr: 1.477 ± 0.046	1.97MetVal: 1.97 ± 0.045	0.208MetTrp: 0.208 ± 0.016	0.793MetTyr: 0.793 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.593AsnAla: 3.593 ± 0.064	0.72AsnCys: 0.72 ± 0.031	2.326AsnAsp: 2.326 ± 0.051	2.794AsnGlu: 2.794 ± 0.064	1.837AsnPhe: 1.837 ± 0.049	3.663AsnGly: 3.663 ± 0.081	0.856AsnHis: 0.856 ± 0.034	4.049AsnIle: 4.049 ± 0.086	3.122AsnLys: 3.122 ± 0.063	4.25AsnLeu: 4.25 ± 0.072	1.316AsnMet: 1.316 ± 0.039	2.443AsnAsn: 2.443 ± 0.083	2.315AsnPro: 2.315 ± 0.051	1.647AsnGln: 1.647 ± 0.05	2.035AsnArg: 2.035 ± 0.05	2.815AsnSer: 2.815 ± 0.064	2.763AsnThr: 2.763 ± 0.07	3.041AsnVal: 3.041 ± 0.06	0.457AsnTrp: 0.457 ± 0.025	1.887AsnTyr: 1.887 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.833ProAla: 2.833 ± 0.057	0.486ProCys: 0.486 ± 0.023	2.237ProAsp: 2.237 ± 0.055	2.692ProGlu: 2.692 ± 0.06	1.621ProPhe: 1.621 ± 0.043	1.743ProGly: 1.743 ± 0.057	0.698ProHis: 0.698 ± 0.029	2.649ProIle: 2.649 ± 0.051	2.184ProLys: 2.184 ± 0.063	2.973ProLeu: 2.973 ± 0.066	0.946ProMet: 0.946 ± 0.034	1.771ProAsn: 1.771 ± 0.045	1.13ProPro: 1.13 ± 0.041	1.643ProGln: 1.643 ± 0.04	1.132ProArg: 1.132 ± 0.035	2.14ProSer: 2.14 ± 0.045	2.056ProThr: 2.056 ± 0.061	2.965ProVal: 2.965 ± 0.066	0.288ProTrp: 0.288 ± 0.015	1.422ProTyr: 1.422 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.741GlnAla: 2.741 ± 0.061	0.43GlnCys: 0.43 ± 0.023	1.51GlnAsp: 1.51 ± 0.041	2.007GlnGlu: 2.007 ± 0.048	1.339GlnPhe: 1.339 ± 0.038	2.194GlnGly: 2.194 ± 0.049	0.699GlnHis: 0.699 ± 0.026	2.717GlnIle: 2.717 ± 0.055	2.748GlnLys: 2.748 ± 0.056	3.33GlnLeu: 3.33 ± 0.063	1.123GlnMet: 1.123 ± 0.032	2.163GlnAsn: 2.163 ± 0.049	1.219GlnPro: 1.219 ± 0.041	1.684GlnGln: 1.684 ± 0.053	1.543GlnArg: 1.543 ± 0.042	2.029GlnSer: 2.029 ± 0.053	1.923GlnThr: 1.923 ± 0.047	2.089GlnVal: 2.089 ± 0.043	0.335GlnTrp: 0.335 ± 0.022	1.336GlnTyr: 1.336 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.645ArgAla: 2.645 ± 0.052	0.666ArgCys: 0.666 ± 0.035	2.037ArgAsp: 2.037 ± 0.049	2.783ArgGlu: 2.783 ± 0.053	1.842ArgPhe: 1.842 ± 0.044	2.443ArgGly: 2.443 ± 0.048	0.757ArgHis: 0.757 ± 0.031	3.303ArgIle: 3.303 ± 0.059	2.654ArgLys: 2.654 ± 0.055	3.858ArgLeu: 3.858 ± 0.07	1.286ArgMet: 1.286 ± 0.036	1.747ArgAsn: 1.747 ± 0.048	1.258ArgPro: 1.258 ± 0.041	1.334ArgGln: 1.334 ± 0.037	1.867ArgArg: 1.867 ± 0.056	2.031ArgSer: 2.031 ± 0.053	2.087ArgThr: 2.087 ± 0.046	2.615ArgVal: 2.615 ± 0.059	0.328ArgTrp: 0.328 ± 0.021	1.719ArgTyr: 1.719 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.947SerAla: 4.947 ± 0.084	0.898SerCys: 0.898 ± 0.035	3.289SerAsp: 3.289 ± 0.064	3.611SerGlu: 3.611 ± 0.068	2.802SerPhe: 2.802 ± 0.06	4.873SerGly: 4.873 ± 0.068	1.012SerHis: 1.012 ± 0.036	4.625SerIle: 4.625 ± 0.081	3.787SerLys: 3.787 ± 0.071	5.36SerLeu: 5.36 ± 0.081	1.637SerMet: 1.637 ± 0.036	2.715SerAsn: 2.715 ± 0.072	2.122SerPro: 2.122 ± 0.054	1.907SerGln: 1.907 ± 0.052	2.278SerArg: 2.278 ± 0.053	4.34SerSer: 4.34 ± 0.129	3.335SerThr: 3.335 ± 0.077	4.535SerVal: 4.535 ± 0.068	0.512SerTrp: 0.512 ± 0.026	2.22SerTyr: 2.22 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.317ThrAla: 5.317 ± 0.09	0.708ThrCys: 0.708 ± 0.026	3.259ThrAsp: 3.259 ± 0.08	3.475ThrGlu: 3.475 ± 0.069	2.286ThrPhe: 2.286 ± 0.055	4.392ThrGly: 4.392 ± 0.076	0.973ThrHis: 0.973 ± 0.033	4.313ThrIle: 4.313 ± 0.078	3.216ThrLys: 3.216 ± 0.062	5.336ThrLeu: 5.336 ± 0.082	1.453ThrMet: 1.453 ± 0.044	2.42ThrAsn: 2.42 ± 0.058	2.586ThrPro: 2.586 ± 0.063	2.016ThrGln: 2.016 ± 0.048	1.853ThrArg: 1.853 ± 0.044	3.258ThrSer: 3.258 ± 0.065	3.175ThrThr: 3.175 ± 0.077	4.897ThrVal: 4.897 ± 0.105	0.437ThrTrp: 0.437 ± 0.025	2.035ThrTyr: 2.035 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.397ValAla: 5.397 ± 0.089	1.25ValCys: 1.25 ± 0.043	3.839ValAsp: 3.839 ± 0.079	4.176ValGlu: 4.176 ± 0.071	3.179ValPhe: 3.179 ± 0.066	4.498ValGly: 4.498 ± 0.077	1.114ValHis: 1.114 ± 0.035	5.205ValIle: 5.205 ± 0.091	4.516ValLys: 4.516 ± 0.076	7.061ValLeu: 7.061 ± 0.092	1.982ValMet: 1.982 ± 0.052	2.957ValAsn: 2.957 ± 0.068	2.642ValPro: 2.642 ± 0.051	2.3ValGln: 2.3 ± 0.049	2.742ValArg: 2.742 ± 0.053	4.702ValSer: 4.702 ± 0.073	4.341ValThr: 4.341 ± 0.086	5.239ValVal: 5.239 ± 0.093	0.596ValTrp: 0.596 ± 0.026	2.597ValTyr: 2.597 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.565TrpAla: 0.565 ± 0.028	0.163TrpCys: 0.163 ± 0.014	0.504TrpAsp: 0.504 ± 0.028	0.485TrpGlu: 0.485 ± 0.025	0.365TrpPhe: 0.365 ± 0.019	0.602TrpGly: 0.602 ± 0.025	0.202TrpHis: 0.202 ± 0.016	0.514TrpIle: 0.514 ± 0.025	0.482TrpLys: 0.482 ± 0.022	0.835TrpLeu: 0.835 ± 0.033	0.259TrpMet: 0.259 ± 0.016	0.463TrpAsn: 0.463 ± 0.025	0.166TrpPro: 0.166 ± 0.015	0.408TrpGln: 0.408 ± 0.021	0.328TrpArg: 0.328 ± 0.019	0.478TrpSer: 0.478 ± 0.027	0.398TrpThr: 0.398 ± 0.023	0.582TrpVal: 0.582 ± 0.028	0.111TrpTrp: 0.111 ± 0.01	0.339TrpTyr: 0.339 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.676TyrAla: 2.676 ± 0.058	0.597TyrCys: 0.597 ± 0.027	2.267TyrAsp: 2.267 ± 0.061	2.298TyrGlu: 2.298 ± 0.052	1.757TyrPhe: 1.757 ± 0.048	2.686TyrGly: 2.686 ± 0.061	0.791TyrHis: 0.791 ± 0.027	2.777TyrIle: 2.777 ± 0.059	2.432TyrLys: 2.432 ± 0.055	3.327TyrLeu: 3.327 ± 0.066	0.861TyrMet: 0.861 ± 0.032	2.022TyrAsn: 2.022 ± 0.057	1.427TyrPro: 1.427 ± 0.039	1.342TyrGln: 1.342 ± 0.044	1.747TyrArg: 1.747 ± 0.045	2.412TyrSer: 2.412 ± 0.059	2.27TyrThr: 2.27 ± 0.062	2.164TyrVal: 2.164 ± 0.051	0.299TyrTrp: 0.299 ± 0.019	1.524TyrTyr: 1.524 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2929 proteins (935315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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