Amino acid dipepetide frequency for Plasmodium relictum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	0.582AlaAla: 0.582 ± 0.02	0.382AlaCys: 0.382 ± 0.011	0.844AlaAsp: 0.844 ± 0.016	1.093AlaGlu: 1.093 ± 0.022	1.033AlaPhe: 1.033 ± 0.018	0.576AlaGly: 0.576 ± 0.018	0.446AlaHis: 0.446 ± 0.011	1.755AlaIle: 1.755 ± 0.028	1.876AlaLys: 1.876 ± 0.027	1.971AlaLeu: 1.971 ± 0.033	0.319AlaMet: 0.319 ± 0.01	1.833AlaAsn: 1.833 ± 0.03	0.428AlaPro: 0.428 ± 0.014	0.512AlaGln: 0.512 ± 0.015	0.526AlaArg: 0.526 ± 0.017	1.446AlaSer: 1.446 ± 0.028	0.873AlaThr: 0.873 ± 0.02	0.782AlaVal: 0.782 ± 0.021	0.114AlaTrp: 0.114 ± 0.005	1.117AlaTyr: 1.117 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.418CysAla: 0.418 ± 0.014	0.317CysCys: 0.317 ± 0.009	1.014CysAsp: 1.014 ± 0.018	1.141CysGlu: 1.141 ± 0.019	1.034CysPhe: 1.034 ± 0.02	0.504CysGly: 0.504 ± 0.013	0.267CysHis: 0.267 ± 0.011	1.791CysIle: 1.791 ± 0.022	1.688CysLys: 1.688 ± 0.029	1.643CysLeu: 1.643 ± 0.021	0.277CysMet: 0.277 ± 0.008	1.864CysAsn: 1.864 ± 0.027	0.351CysPro: 0.351 ± 0.015	0.28CysGln: 0.28 ± 0.009	0.402CysArg: 0.402 ± 0.011	1.429CysSer: 1.429 ± 0.023	0.659CysThr: 0.659 ± 0.015	0.741CysVal: 0.741 ± 0.016	0.076CysTrp: 0.076 ± 0.005	0.858CysTyr: 0.858 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	1.092AspAla: 1.092 ± 0.021	0.64AspCys: 0.64 ± 0.013	3.879AspAsp: 3.879 ± 0.063	5.422AspGlu: 5.422 ± 0.069	2.714AspPhe: 2.714 ± 0.027	1.156AspGly: 1.156 ± 0.022	0.766AspHis: 0.766 ± 0.016	6.727AspIle: 6.727 ± 0.05	6.466AspLys: 6.466 ± 0.056	4.325AspLeu: 4.325 ± 0.037	0.992AspMet: 0.992 ± 0.019	7.102AspAsn: 7.102 ± 0.076	0.713AspPro: 0.713 ± 0.018	0.973AspGln: 0.973 ± 0.017	1.039AspArg: 1.039 ± 0.024	3.632AspSer: 3.632 ± 0.04	2.126AspThr: 2.126 ± 0.026	2.076AspVal: 2.076 ± 0.027	0.175AspTrp: 0.175 ± 0.007	2.812AspTyr: 2.812 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	1.361GluAla: 1.361 ± 0.024	1.024GluCys: 1.024 ± 0.017	4.53GluAsp: 4.53 ± 0.052	9.226GluGlu: 9.226 ± 0.158	2.513GluPhe: 2.513 ± 0.029	1.631GluGly: 1.631 ± 0.028	1.199GluHis: 1.199 ± 0.018	7.558GluIle: 7.558 ± 0.069	13.519GluLys: 13.519 ± 0.127	5.467GluLeu: 5.467 ± 0.054	1.365GluMet: 1.365 ± 0.022	12.227GluAsn: 12.227 ± 0.082	0.678GluPro: 0.678 ± 0.015	1.956GluGln: 1.956 ± 0.031	2.066GluArg: 2.066 ± 0.045	4.225GluSer: 4.225 ± 0.044	2.47GluThr: 2.47 ± 0.034	2.431GluVal: 2.431 ± 0.036	0.385GluTrp: 0.385 ± 0.019	3.604GluTyr: 3.604 ± 0.035	0.001GluXaa: 0.001 ± 0.0
Phe	0.853PheAla: 0.853 ± 0.015	1.037PheCys: 1.037 ± 0.019	2.811PheAsp: 2.811 ± 0.031	2.878PheGlu: 2.878 ± 0.03	4.46PhePhe: 4.46 ± 0.074	1.128PheGly: 1.128 ± 0.023	1.155PheHis: 1.155 ± 0.019	5.268PheIle: 5.268 ± 0.061	4.738PheLys: 4.738 ± 0.048	6.254PheLeu: 6.254 ± 0.072	0.883PheMet: 0.883 ± 0.015	5.633PheAsn: 5.633 ± 0.054	1.106PhePro: 1.106 ± 0.016	1.292PheGln: 1.292 ± 0.02	1.151PheArg: 1.151 ± 0.02	4.364PheSer: 4.364 ± 0.04	1.812PheThr: 1.812 ± 0.028	1.823PheVal: 1.823 ± 0.024	0.218PheTrp: 0.218 ± 0.008	3.541PheTyr: 3.541 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	0.613GlyAla: 0.613 ± 0.02	0.441GlyCys: 0.441 ± 0.013	1.31GlyAsp: 1.31 ± 0.023	1.641GlyGlu: 1.641 ± 0.027	1.12GlyPhe: 1.12 ± 0.02	0.99GlyGly: 0.99 ± 0.03	0.39GlyHis: 0.39 ± 0.013	2.445GlyIle: 2.445 ± 0.031	2.66GlyLys: 2.66 ± 0.033	1.729GlyLeu: 1.729 ± 0.027	0.41GlyMet: 0.41 ± 0.012	2.733GlyAsn: 2.733 ± 0.031	0.35GlyPro: 0.35 ± 0.014	0.422GlyGln: 0.422 ± 0.011	0.738GlyArg: 0.738 ± 0.019	1.638GlySer: 1.638 ± 0.028	1.028GlyThr: 1.028 ± 0.023	1.075GlyVal: 1.075 ± 0.025	0.145GlyTrp: 0.145 ± 0.007	1.272GlyTyr: 1.272 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	0.352HisAla: 0.352 ± 0.01	0.256HisCys: 0.256 ± 0.008	0.805HisAsp: 0.805 ± 0.015	1.1HisGlu: 1.1 ± 0.019	1.199HisPhe: 1.199 ± 0.021	0.423HisGly: 0.423 ± 0.013	0.327HisHis: 0.327 ± 0.01	2.086HisIle: 2.086 ± 0.027	1.912HisLys: 1.912 ± 0.023	1.778HisLeu: 1.778 ± 0.024	0.381HisMet: 0.381 ± 0.011	1.984HisAsn: 1.984 ± 0.025	0.411HisPro: 0.411 ± 0.011	0.347HisGln: 0.347 ± 0.01	0.427HisArg: 0.427 ± 0.01	1.206HisSer: 1.206 ± 0.02	0.653HisThr: 0.653 ± 0.015	0.652HisVal: 0.652 ± 0.015	0.087HisTrp: 0.087 ± 0.005	0.893HisTyr: 0.893 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	1.692IleAla: 1.692 ± 0.03	1.995IleCys: 1.995 ± 0.026	5.349IleAsp: 5.349 ± 0.051	6.994IleGlu: 6.994 ± 0.063	5.963IlePhe: 5.963 ± 0.07	2.253IleGly: 2.253 ± 0.031	1.989IleHis: 1.989 ± 0.026	9.238IleIle: 9.238 ± 0.088	12.43IleLys: 12.43 ± 0.082	9.545IleLeu: 9.545 ± 0.082	1.43IleMet: 1.43 ± 0.021	13.746IleAsn: 13.746 ± 0.111	2.209IlePro: 2.209 ± 0.03	2.459IleGln: 2.459 ± 0.034	2.445IleArg: 2.445 ± 0.024	7.396IleSer: 7.396 ± 0.039	3.443IleThr: 3.443 ± 0.031	3.035IleVal: 3.035 ± 0.034	0.501IleTrp: 0.501 ± 0.015	6.401IleTyr: 6.401 ± 0.069	0.001IleXaa: 0.001 ± 0.0
Lys	1.842LysAla: 1.842 ± 0.03	1.981LysCys: 1.981 ± 0.029	6.297LysAsp: 6.297 ± 0.055	12.28LysGlu: 12.28 ± 0.124	4.365LysPhe: 4.365 ± 0.044	2.844LysGly: 2.844 ± 0.034	1.863LysHis: 1.863 ± 0.019	12.674LysIle: 12.674 ± 0.091	24.227LysLys: 24.227 ± 0.208	9.032LysLeu: 9.032 ± 0.064	2.28LysMet: 2.28 ± 0.023	20.078LysAsn: 20.078 ± 0.139	1.291LysPro: 1.291 ± 0.023	2.584LysGln: 2.584 ± 0.031	4.114LysArg: 4.114 ± 0.044	7.474LysSer: 7.474 ± 0.062	4.07LysThr: 4.07 ± 0.035	3.703LysVal: 3.703 ± 0.038	0.646LysTrp: 0.646 ± 0.018	7.085LysTyr: 7.085 ± 0.066	0.001LysXaa: 0.001 ± 0.0
Leu	1.632LeuAla: 1.632 ± 0.028	1.836LeuCys: 1.836 ± 0.024	3.951LeuAsp: 3.951 ± 0.036	5.292LeuGlu: 5.292 ± 0.056	5.059LeuPhe: 5.059 ± 0.058	1.934LeuGly: 1.934 ± 0.029	1.766LeuHis: 1.766 ± 0.027	7.654LeuIle: 7.654 ± 0.062	11.668LeuLys: 11.668 ± 0.078	8.152LeuLeu: 8.152 ± 0.074	1.358LeuMet: 1.358 ± 0.02	11.312LeuAsn: 11.312 ± 0.076	1.866LeuPro: 1.866 ± 0.029	2.213LeuGln: 2.213 ± 0.029	2.523LeuArg: 2.523 ± 0.032	6.693LeuSer: 6.693 ± 0.056	2.955LeuThr: 2.955 ± 0.033	2.49LeuVal: 2.49 ± 0.034	0.414LeuTrp: 0.414 ± 0.013	4.918LeuTyr: 4.918 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	0.342MetAla: 0.342 ± 0.011	0.318MetCys: 0.318 ± 0.009	0.837MetAsp: 0.837 ± 0.016	1.189MetGlu: 1.189 ± 0.021	0.707MetPhe: 0.707 ± 0.016	0.416MetGly: 0.416 ± 0.012	0.444MetHis: 0.444 ± 0.011	1.367MetIle: 1.367 ± 0.018	2.488MetLys: 2.488 ± 0.026	1.343MetLeu: 1.343 ± 0.02	0.302MetMet: 0.302 ± 0.009	2.818MetAsn: 2.818 ± 0.043	0.361MetPro: 0.361 ± 0.012	0.493MetGln: 0.493 ± 0.014	0.488MetArg: 0.488 ± 0.012	1.023MetSer: 1.023 ± 0.016	0.51MetThr: 0.51 ± 0.01	0.428MetVal: 0.428 ± 0.012	0.106MetTrp: 0.106 ± 0.005	0.842MetTyr: 0.842 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.186AsnAla: 2.186 ± 0.031	1.865AsnCys: 1.865 ± 0.028	8.557AsnAsp: 8.557 ± 0.09	12.316AsnGlu: 12.316 ± 0.088	7.053AsnPhe: 7.053 ± 0.066	2.592AsnGly: 2.592 ± 0.031	1.734AsnHis: 1.734 ± 0.025	15.643AsnIle: 15.643 ± 0.097	16.304AsnLys: 16.304 ± 0.119	10.31AsnLeu: 10.31 ± 0.075	2.367AsnMet: 2.367 ± 0.043	22.65AsnAsn: 22.65 ± 0.378	1.518AsnPro: 1.518 ± 0.026	2.404AsnGln: 2.404 ± 0.037	2.621AsnArg: 2.621 ± 0.033	10.121AsnSer: 10.121 ± 0.105	4.907AsnThr: 4.907 ± 0.054	4.858AsnVal: 4.858 ± 0.042	0.338AsnTrp: 0.338 ± 0.011	7.677AsnTyr: 7.677 ± 0.075	0.001AsnXaa: 0.001 ± 0.001
Pro	0.318ProAla: 0.318 ± 0.012	0.301ProCys: 0.301 ± 0.012	0.713ProAsp: 0.713 ± 0.018	0.911ProGlu: 0.911 ± 0.024	1.229ProPhe: 1.229 ± 0.02	0.456ProGly: 0.456 ± 0.016	0.4ProHis: 0.4 ± 0.012	1.628ProIle: 1.628 ± 0.028	1.459ProLys: 1.459 ± 0.027	1.841ProLeu: 1.841 ± 0.025	0.256ProMet: 0.256 ± 0.008	1.601ProAsn: 1.601 ± 0.028	0.578ProPro: 0.578 ± 0.027	0.462ProGln: 0.462 ± 0.016	0.433ProArg: 0.433 ± 0.013	1.4ProSer: 1.4 ± 0.029	0.743ProThr: 0.743 ± 0.025	0.7ProVal: 0.7 ± 0.016	0.121ProTrp: 0.121 ± 0.006	1.036ProTyr: 1.036 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	0.475GlnAla: 0.475 ± 0.013	0.331GlnCys: 0.331 ± 0.01	0.876GlnAsp: 0.876 ± 0.015	1.681GlnGlu: 1.681 ± 0.029	0.897GlnPhe: 0.897 ± 0.017	0.521GlnGly: 0.521 ± 0.013	0.354GlnHis: 0.354 ± 0.01	2.353GlnIle: 2.353 ± 0.029	3.254GlnLys: 3.254 ± 0.032	1.842GlnLeu: 1.842 ± 0.027	0.488GlnMet: 0.488 ± 0.017	3.282GlnAsn: 3.282 ± 0.037	0.343GlnPro: 0.343 ± 0.013	0.683GlnGln: 0.683 ± 0.031	0.679GlnArg: 0.679 ± 0.015	1.298GlnSer: 1.298 ± 0.019	0.887GlnThr: 0.887 ± 0.021	0.707GlnVal: 0.707 ± 0.014	0.141GlnTrp: 0.141 ± 0.006	0.991GlnTyr: 0.991 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	0.589ArgAla: 0.589 ± 0.014	0.41ArgCys: 0.41 ± 0.011	1.263ArgAsp: 1.263 ± 0.023	2.103ArgGlu: 2.103 ± 0.035	0.938ArgPhe: 0.938 ± 0.018	0.762ArgGly: 0.762 ± 0.017	0.404ArgHis: 0.404 ± 0.011	2.418ArgIle: 2.418 ± 0.028	4.112ArgLys: 4.112 ± 0.051	1.752ArgLeu: 1.752 ± 0.023	0.411ArgMet: 0.411 ± 0.01	3.493ArgAsn: 3.493 ± 0.034	0.36ArgPro: 0.36 ± 0.012	0.56ArgGln: 0.56 ± 0.014	1.083ArgArg: 1.083 ± 0.024	1.614ArgSer: 1.614 ± 0.027	0.956ArgThr: 0.956 ± 0.018	0.823ArgVal: 0.823 ± 0.02	0.141ArgTrp: 0.141 ± 0.006	1.209ArgTyr: 1.209 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	1.328SerAla: 1.328 ± 0.024	1.286SerCys: 1.286 ± 0.022	4.07SerAsp: 4.07 ± 0.04	4.787SerGlu: 4.787 ± 0.042	4.373SerPhe: 4.373 ± 0.046	1.629SerGly: 1.629 ± 0.032	1.301SerHis: 1.301 ± 0.019	6.84SerIle: 6.84 ± 0.048	7.588SerLys: 7.588 ± 0.063	6.63SerLeu: 6.63 ± 0.049	1.091SerMet: 1.091 ± 0.018	9.425SerAsn: 9.425 ± 0.105	1.234SerPro: 1.234 ± 0.029	1.491SerGln: 1.491 ± 0.024	1.595SerArg: 1.595 ± 0.03	6.684SerSer: 6.684 ± 0.068	2.971SerThr: 2.971 ± 0.043	2.547SerVal: 2.547 ± 0.03	0.282SerTrp: 0.282 ± 0.01	4.175SerTyr: 4.175 ± 0.039	0.001SerXaa: 0.001 ± 0.0
Thr	0.766ThrAla: 0.766 ± 0.018	0.673ThrCys: 0.673 ± 0.015	1.782ThrAsp: 1.782 ± 0.022	2.327ThrGlu: 2.327 ± 0.03	2.05ThrPhe: 2.05 ± 0.024	0.934ThrGly: 0.934 ± 0.025	0.727ThrHis: 0.727 ± 0.014	3.295ThrIle: 3.295 ± 0.036	4.154ThrLys: 4.154 ± 0.042	3.266ThrLeu: 3.266 ± 0.036	0.526ThrMet: 0.526 ± 0.012	4.746ThrAsn: 4.746 ± 0.052	0.943ThrPro: 0.943 ± 0.026	0.917ThrGln: 0.917 ± 0.022	0.853ThrArg: 0.853 ± 0.016	2.82ThrSer: 2.82 ± 0.032	1.712ThrThr: 1.712 ± 0.044	1.325ThrVal: 1.325 ± 0.022	0.181ThrTrp: 0.181 ± 0.007	2.164ThrTyr: 2.164 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	0.817ValAla: 0.817 ± 0.02	0.69ValCys: 0.69 ± 0.014	2.108ValAsp: 2.108 ± 0.027	2.508ValGlu: 2.508 ± 0.04	1.764ValPhe: 1.764 ± 0.024	0.969ValGly: 0.969 ± 0.021	0.781ValHis: 0.781 ± 0.016	3.093ValIle: 3.093 ± 0.034	3.642ValLys: 3.642 ± 0.038	3.2ValLeu: 3.2 ± 0.039	0.504ValMet: 0.504 ± 0.012	4.105ValAsn: 4.105 ± 0.039	0.796ValPro: 0.796 ± 0.021	0.889ValGln: 0.889 ± 0.018	0.879ValArg: 0.879 ± 0.018	2.484ValSer: 2.484 ± 0.031	1.31ValThr: 1.31 ± 0.023	1.312ValVal: 1.312 ± 0.028	0.179ValTrp: 0.179 ± 0.007	1.85ValTyr: 1.85 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	0.123TrpAla: 0.123 ± 0.006	0.098TrpCys: 0.098 ± 0.005	0.228TrpAsp: 0.228 ± 0.008	0.267TrpGlu: 0.267 ± 0.013	0.246TrpPhe: 0.246 ± 0.011	0.187TrpGly: 0.187 ± 0.009	0.065TrpHis: 0.065 ± 0.005	0.473TrpIle: 0.473 ± 0.014	0.608TrpLys: 0.608 ± 0.02	0.411TrpLeu: 0.411 ± 0.012	0.092TrpMet: 0.092 ± 0.006	0.511TrpAsn: 0.511 ± 0.012	0.098TrpPro: 0.098 ± 0.007	0.086TrpGln: 0.086 ± 0.005	0.166TrpArg: 0.166 ± 0.007	0.289TrpSer: 0.289 ± 0.011	0.144TrpThr: 0.144 ± 0.007	0.192TrpVal: 0.192 ± 0.008	0.038TrpTrp: 0.038 ± 0.004	0.182TrpTyr: 0.182 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.128TyrAla: 1.128 ± 0.016	0.872TyrCys: 0.872 ± 0.015	3.603TyrAsp: 3.603 ± 0.036	4.28TyrGlu: 4.28 ± 0.042	3.689TyrPhe: 3.689 ± 0.053	1.245TyrGly: 1.245 ± 0.021	0.896TyrHis: 0.896 ± 0.016	6.206TyrIle: 6.206 ± 0.069	5.938TyrLys: 5.938 ± 0.059	5.193TyrLeu: 5.193 ± 0.051	1.087TyrMet: 1.087 ± 0.017	6.882TyrAsn: 6.882 ± 0.067	0.952TyrPro: 0.952 ± 0.019	1.061TyrGln: 1.061 ± 0.017	1.171TyrArg: 1.171 ± 0.018	4.09TyrSer: 4.09 ± 0.037	1.934TyrThr: 1.934 ± 0.028	2.179TyrVal: 2.179 ± 0.027	0.217TyrTrp: 0.217 ± 0.008	3.156TyrTyr: 3.156 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.143XaaXaa: 0.143 ± 0.056

Statistics based on 5136 proteins (3624278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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