Amino acid dipepetide frequency for Phyllobacterium endophyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.941AlaAla: 13.941 ± 0.125	0.885AlaCys: 0.885 ± 0.022	6.163AlaAsp: 6.163 ± 0.067	6.487AlaGlu: 6.487 ± 0.066	4.345AlaPhe: 4.345 ± 0.058	9.711AlaGly: 9.711 ± 0.108	1.939AlaHis: 1.939 ± 0.035	6.943AlaIle: 6.943 ± 0.078	4.457AlaLys: 4.457 ± 0.075	11.83AlaLeu: 11.83 ± 0.102	3.178AlaMet: 3.178 ± 0.044	3.287AlaAsn: 3.287 ± 0.053	4.49AlaPro: 4.49 ± 0.059	3.501AlaGln: 3.501 ± 0.049	7.075AlaArg: 7.075 ± 0.066	6.587AlaSer: 6.587 ± 0.074	5.657AlaThr: 5.657 ± 0.07	8.038AlaVal: 8.038 ± 0.075	1.293AlaTrp: 1.293 ± 0.031	2.551AlaTyr: 2.551 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.793CysAla: 0.793 ± 0.024	0.096CysCys: 0.096 ± 0.007	0.458CysAsp: 0.458 ± 0.017	0.429CysGlu: 0.429 ± 0.016	0.332CysPhe: 0.332 ± 0.014	0.816CysGly: 0.816 ± 0.027	0.225CysHis: 0.225 ± 0.012	0.439CysIle: 0.439 ± 0.018	0.2CysLys: 0.2 ± 0.01	0.757CysLeu: 0.757 ± 0.024	0.161CysMet: 0.161 ± 0.01	0.227CysAsn: 0.227 ± 0.012	0.358CysPro: 0.358 ± 0.016	0.218CysGln: 0.218 ± 0.012	0.524CysArg: 0.524 ± 0.021	0.482CysSer: 0.482 ± 0.02	0.412CysThr: 0.412 ± 0.018	0.597CysVal: 0.597 ± 0.021	0.102CysTrp: 0.102 ± 0.009	0.196CysTyr: 0.196 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.228AspAla: 6.228 ± 0.078	0.426AspCys: 0.426 ± 0.017	3.182AspAsp: 3.182 ± 0.057	3.593AspGlu: 3.593 ± 0.048	2.294AspPhe: 2.294 ± 0.043	4.895AspGly: 4.895 ± 0.076	1.296AspHis: 1.296 ± 0.031	3.467AspIle: 3.467 ± 0.046	2.195AspLys: 2.195 ± 0.047	5.677AspLeu: 5.677 ± 0.058	1.359AspMet: 1.359 ± 0.027	1.668AspAsn: 1.668 ± 0.03	3.245AspPro: 3.245 ± 0.045	1.754AspGln: 1.754 ± 0.034	3.946AspArg: 3.946 ± 0.048	2.333AspSer: 2.333 ± 0.04	2.693AspThr: 2.693 ± 0.045	4.26AspVal: 4.26 ± 0.06	0.895AspTrp: 0.895 ± 0.023	1.549AspTyr: 1.549 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.667GluAla: 6.667 ± 0.072	0.354GluCys: 0.354 ± 0.017	2.74GluAsp: 2.74 ± 0.045	3.178GluGlu: 3.178 ± 0.05	1.979GluPhe: 1.979 ± 0.037	4.069GluGly: 4.069 ± 0.055	1.228GluHis: 1.228 ± 0.029	3.809GluIle: 3.809 ± 0.052	2.717GluLys: 2.717 ± 0.044	5.388GluLeu: 5.388 ± 0.056	1.539GluMet: 1.539 ± 0.031	1.961GluAsn: 1.961 ± 0.037	2.646GluPro: 2.646 ± 0.046	2.08GluGln: 2.08 ± 0.037	4.452GluArg: 4.452 ± 0.051	2.531GluSer: 2.531 ± 0.041	3.564GluThr: 3.564 ± 0.057	3.646GluVal: 3.646 ± 0.048	0.737GluTrp: 0.737 ± 0.019	1.199GluTyr: 1.199 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.471PheAla: 4.471 ± 0.064	0.37PheCys: 0.37 ± 0.014	2.711PheAsp: 2.711 ± 0.044	2.206PheGlu: 2.206 ± 0.033	1.609PhePhe: 1.609 ± 0.041	3.8PheGly: 3.8 ± 0.05	0.825PheHis: 0.825 ± 0.025	2.145PheIle: 2.145 ± 0.043	1.253PheLys: 1.253 ± 0.031	3.586PheLeu: 3.586 ± 0.048	0.873PheMet: 0.873 ± 0.025	1.334PheAsn: 1.334 ± 0.028	1.679PhePro: 1.679 ± 0.032	1.133PheGln: 1.133 ± 0.026	2.274PheArg: 2.274 ± 0.039	2.489PheSer: 2.489 ± 0.04	2.131PheThr: 2.131 ± 0.035	3.004PheVal: 3.004 ± 0.043	0.558PheTrp: 0.558 ± 0.02	1.017PheTyr: 1.017 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.089GlyAla: 8.089 ± 0.109	0.763GlyCys: 0.763 ± 0.022	4.377GlyAsp: 4.377 ± 0.075	4.561GlyGlu: 4.561 ± 0.053	3.661GlyPhe: 3.661 ± 0.052	7.042GlyGly: 7.042 ± 0.111	1.797GlyHis: 1.797 ± 0.03	5.21GlyIle: 5.21 ± 0.06	3.972GlyLys: 3.972 ± 0.063	8.297GlyLeu: 8.297 ± 0.084	2.142GlyMet: 2.142 ± 0.041	2.766GlyAsn: 2.766 ± 0.072	3.151GlyPro: 3.151 ± 0.045	2.79GlyGln: 2.79 ± 0.051	5.242GlyArg: 5.242 ± 0.058	5.136GlySer: 5.136 ± 0.064	4.893GlyThr: 4.893 ± 0.088	5.807GlyVal: 5.807 ± 0.06	1.25GlyTrp: 1.25 ± 0.032	2.321GlyTyr: 2.321 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.084HisAla: 2.084 ± 0.043	0.192HisCys: 0.192 ± 0.011	1.263HisAsp: 1.263 ± 0.033	1.113HisGlu: 1.113 ± 0.026	0.879HisPhe: 0.879 ± 0.027	1.799HisGly: 1.799 ± 0.035	0.564HisHis: 0.564 ± 0.019	1.097HisIle: 1.097 ± 0.027	0.596HisLys: 0.596 ± 0.021	2.05HisLeu: 2.05 ± 0.042	0.521HisMet: 0.521 ± 0.017	0.565HisAsn: 0.565 ± 0.017	1.248HisPro: 1.248 ± 0.029	0.576HisGln: 0.576 ± 0.021	1.319HisArg: 1.319 ± 0.028	1.108HisSer: 1.108 ± 0.026	0.855HisThr: 0.855 ± 0.021	1.513HisVal: 1.513 ± 0.027	0.318HisTrp: 0.318 ± 0.015	0.575HisTyr: 0.575 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.813IleAla: 7.813 ± 0.082	0.58IleCys: 0.58 ± 0.018	4.06IleAsp: 4.06 ± 0.052	3.906IleGlu: 3.906 ± 0.049	2.209IlePhe: 2.209 ± 0.043	5.437IleGly: 5.437 ± 0.066	1.037IleHis: 1.037 ± 0.031	3.267IleIle: 3.267 ± 0.05	1.889IleLys: 1.889 ± 0.039	5.191IleLeu: 5.191 ± 0.068	1.228IleMet: 1.228 ± 0.029	1.881IleAsn: 1.881 ± 0.036	2.601IlePro: 2.601 ± 0.04	1.454IleGln: 1.454 ± 0.03	3.494IleArg: 3.494 ± 0.053	3.768IleSer: 3.768 ± 0.047	3.091IleThr: 3.091 ± 0.052	4.795IleVal: 4.795 ± 0.053	0.653IleTrp: 0.653 ± 0.02	1.35IleTyr: 1.35 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.518LysAla: 4.518 ± 0.064	0.194LysCys: 0.194 ± 0.012	2.17LysAsp: 2.17 ± 0.045	1.963LysGlu: 1.963 ± 0.04	1.196LysPhe: 1.196 ± 0.03	2.974LysGly: 2.974 ± 0.058	0.75LysHis: 0.75 ± 0.025	2.317LysIle: 2.317 ± 0.049	1.72LysLys: 1.72 ± 0.044	3.946LysLeu: 3.946 ± 0.057	0.921LysMet: 0.921 ± 0.026	1.283LysAsn: 1.283 ± 0.033	2.329LysPro: 2.329 ± 0.046	1.329LysGln: 1.329 ± 0.028	2.61LysArg: 2.61 ± 0.041	2.499LysSer: 2.499 ± 0.046	2.378LysThr: 2.378 ± 0.046	2.718LysVal: 2.718 ± 0.049	0.426LysTrp: 0.426 ± 0.016	0.814LysTyr: 0.814 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	11.974LeuAla: 11.974 ± 0.114	0.833LeuCys: 0.833 ± 0.023	5.845LeuAsp: 5.845 ± 0.067	5.25LeuGlu: 5.25 ± 0.056	3.659LeuPhe: 3.659 ± 0.059	8.014LeuGly: 8.014 ± 0.083	1.784LeuHis: 1.784 ± 0.036	5.586LeuIle: 5.586 ± 0.068	4.128LeuLys: 4.128 ± 0.061	9.213LeuLeu: 9.213 ± 0.114	2.355LeuMet: 2.355 ± 0.039	2.939LeuAsn: 2.939 ± 0.044	5.146LeuPro: 5.146 ± 0.054	3.004LeuGln: 3.004 ± 0.049	6.107LeuArg: 6.107 ± 0.064	6.678LeuSer: 6.678 ± 0.072	5.566LeuThr: 5.566 ± 0.071	7.347LeuVal: 7.347 ± 0.076	1.091LeuTrp: 1.091 ± 0.028	2.185LeuTyr: 2.185 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.852MetAla: 2.852 ± 0.05	0.153MetCys: 0.153 ± 0.01	1.115MetAsp: 1.115 ± 0.026	1.125MetGlu: 1.125 ± 0.024	0.747MetPhe: 0.747 ± 0.024	1.754MetGly: 1.754 ± 0.041	0.509MetHis: 0.509 ± 0.019	1.615MetIle: 1.615 ± 0.032	1.157MetLys: 1.157 ± 0.03	2.496MetLeu: 2.496 ± 0.045	0.682MetMet: 0.682 ± 0.024	0.949MetAsn: 0.949 ± 0.026	1.379MetPro: 1.379 ± 0.03	0.916MetGln: 0.916 ± 0.024	1.775MetArg: 1.775 ± 0.031	1.723MetSer: 1.723 ± 0.031	1.88MetThr: 1.88 ± 0.036	1.712MetVal: 1.712 ± 0.032	0.207MetTrp: 0.207 ± 0.012	0.33MetTyr: 0.33 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.482AsnAla: 3.482 ± 0.049	0.264AsnCys: 0.264 ± 0.012	1.784AsnAsp: 1.784 ± 0.048	1.603AsnGlu: 1.603 ± 0.036	1.205AsnPhe: 1.205 ± 0.028	2.889AsnGly: 2.889 ± 0.065	0.604AsnHis: 0.604 ± 0.021	1.857AsnIle: 1.857 ± 0.038	1.011AsnLys: 1.011 ± 0.025	2.947AsnLeu: 2.947 ± 0.043	0.755AsnMet: 0.755 ± 0.022	0.976AsnAsn: 0.976 ± 0.029	2.051AsnPro: 2.051 ± 0.037	0.929AsnGln: 0.929 ± 0.022	2.051AsnArg: 2.051 ± 0.034	1.772AsnSer: 1.772 ± 0.038	1.472AsnThr: 1.472 ± 0.03	2.417AsnVal: 2.417 ± 0.046	0.513AsnTrp: 0.513 ± 0.019	0.842AsnTyr: 0.842 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.35ProAla: 5.35 ± 0.068	0.289ProCys: 0.289 ± 0.015	3.438ProAsp: 3.438 ± 0.048	3.48ProGlu: 3.48 ± 0.056	2.008ProPhe: 2.008 ± 0.036	4.049ProGly: 4.049 ± 0.059	1.029ProHis: 1.029 ± 0.028	2.534ProIle: 2.534 ± 0.043	1.798ProLys: 1.798 ± 0.034	4.654ProLeu: 4.654 ± 0.056	1.129ProMet: 1.129 ± 0.027	1.531ProAsn: 1.531 ± 0.034	2.024ProPro: 2.024 ± 0.042	1.638ProGln: 1.638 ± 0.036	2.53ProArg: 2.53 ± 0.045	2.857ProSer: 2.857 ± 0.042	2.317ProThr: 2.317 ± 0.033	4.088ProVal: 4.088 ± 0.051	0.648ProTrp: 0.648 ± 0.019	1.257ProTyr: 1.257 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.635GlnAla: 3.635 ± 0.046	0.2GlnCys: 0.2 ± 0.011	1.455GlnAsp: 1.455 ± 0.031	1.576GlnGlu: 1.576 ± 0.034	1.204GlnPhe: 1.204 ± 0.025	2.275GlnGly: 2.275 ± 0.038	0.661GlnHis: 0.661 ± 0.02	2.036GlnIle: 2.036 ± 0.033	1.298GlnLys: 1.298 ± 0.03	3.078GlnLeu: 3.078 ± 0.049	0.924GlnMet: 0.924 ± 0.024	1.026GlnAsn: 1.026 ± 0.025	1.659GlnPro: 1.659 ± 0.031	1.253GlnGln: 1.253 ± 0.035	2.326GlnArg: 2.326 ± 0.036	2.063GlnSer: 2.063 ± 0.031	1.868GlnThr: 1.868 ± 0.033	2.146GlnVal: 2.146 ± 0.034	0.409GlnTrp: 0.409 ± 0.017	0.696GlnTyr: 0.696 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.374ArgAla: 6.374 ± 0.069	0.421ArgCys: 0.421 ± 0.017	3.637ArgAsp: 3.637 ± 0.054	3.922ArgGlu: 3.922 ± 0.058	2.797ArgPhe: 2.797 ± 0.044	4.199ArgGly: 4.199 ± 0.058	1.494ArgHis: 1.494 ± 0.035	4.056ArgIle: 4.056 ± 0.051	2.578ArgLys: 2.578 ± 0.04	6.911ArgLeu: 6.911 ± 0.075	1.773ArgMet: 1.773 ± 0.032	2.17ArgAsn: 2.17 ± 0.034	2.997ArgPro: 2.997 ± 0.043	2.511ArgGln: 2.511 ± 0.043	4.676ArgArg: 4.676 ± 0.067	3.956ArgSer: 3.956 ± 0.051	3.257ArgThr: 3.257 ± 0.044	4.248ArgVal: 4.248 ± 0.051	0.859ArgTrp: 0.859 ± 0.022	1.755ArgTyr: 1.755 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.339SerAla: 6.339 ± 0.075	0.429SerCys: 0.429 ± 0.017	3.331SerAsp: 3.331 ± 0.049	3.086SerGlu: 3.086 ± 0.048	2.611SerPhe: 2.611 ± 0.043	5.997SerGly: 5.997 ± 0.077	1.175SerHis: 1.175 ± 0.028	3.574SerIle: 3.574 ± 0.047	2.101SerLys: 2.101 ± 0.04	5.93SerLeu: 5.93 ± 0.062	1.542SerMet: 1.542 ± 0.034	1.806SerAsn: 1.806 ± 0.03	2.946SerPro: 2.946 ± 0.044	1.79SerGln: 1.79 ± 0.034	3.736SerArg: 3.736 ± 0.057	3.647SerSer: 3.647 ± 0.057	3.092SerThr: 3.092 ± 0.046	4.435SerVal: 4.435 ± 0.053	0.807SerTrp: 0.807 ± 0.024	1.511SerTyr: 1.511 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.916ThrAla: 5.916 ± 0.072	0.414ThrCys: 0.414 ± 0.018	2.931ThrAsp: 2.931 ± 0.047	2.639ThrGlu: 2.639 ± 0.038	2.228ThrPhe: 2.228 ± 0.04	5.232ThrGly: 5.232 ± 0.075	1.064ThrHis: 1.064 ± 0.027	3.59ThrIle: 3.59 ± 0.054	1.843ThrLys: 1.843 ± 0.034	5.634ThrLeu: 5.634 ± 0.085	1.295ThrMet: 1.295 ± 0.028	1.563ThrAsn: 1.563 ± 0.035	3.133ThrPro: 3.133 ± 0.044	1.469ThrGln: 1.469 ± 0.035	3.236ThrArg: 3.236 ± 0.053	3.234ThrSer: 3.234 ± 0.045	3.005ThrThr: 3.005 ± 0.05	4.153ThrVal: 4.153 ± 0.057	0.64ThrTrp: 0.64 ± 0.021	1.322ThrTyr: 1.322 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.311ValAla: 8.311 ± 0.072	0.617ValCys: 0.617 ± 0.021	4.122ValAsp: 4.122 ± 0.05	4.438ValGlu: 4.438 ± 0.052	2.929ValPhe: 2.929 ± 0.052	5.231ValGly: 5.231 ± 0.059	1.406ValHis: 1.406 ± 0.029	4.337ValIle: 4.337 ± 0.057	2.805ValLys: 2.805 ± 0.047	7.181ValLeu: 7.181 ± 0.074	1.817ValMet: 1.817 ± 0.036	2.224ValAsn: 2.224 ± 0.041	3.733ValPro: 3.733 ± 0.049	2.11ValGln: 2.11 ± 0.035	4.479ValArg: 4.479 ± 0.06	4.722ValSer: 4.722 ± 0.057	4.448ValThr: 4.448 ± 0.059	5.76ValVal: 5.76 ± 0.071	0.875ValTrp: 0.875 ± 0.024	1.558ValTyr: 1.558 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.119TrpAla: 1.119 ± 0.032	0.102TrpCys: 0.102 ± 0.008	0.623TrpAsp: 0.623 ± 0.02	0.551TrpGlu: 0.551 ± 0.022	0.538TrpPhe: 0.538 ± 0.018	0.852TrpGly: 0.852 ± 0.022	0.323TrpHis: 0.323 ± 0.013	0.698TrpIle: 0.698 ± 0.021	0.541TrpLys: 0.541 ± 0.018	1.534TrpLeu: 1.534 ± 0.03	0.36TrpMet: 0.36 ± 0.014	0.524TrpAsn: 0.524 ± 0.018	0.646TrpPro: 0.646 ± 0.021	0.573TrpGln: 0.573 ± 0.021	1.008TrpArg: 1.008 ± 0.023	0.87TrpSer: 0.87 ± 0.023	0.738TrpThr: 0.738 ± 0.019	0.735TrpVal: 0.735 ± 0.022	0.204TrpTrp: 0.204 ± 0.012	0.329TrpTyr: 0.329 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.041	0.24TyrCys: 0.24 ± 0.013	1.548TyrAsp: 1.548 ± 0.031	1.38TyrGlu: 1.38 ± 0.032	1.037TyrPhe: 1.037 ± 0.024	2.23TyrGly: 2.23 ± 0.037	0.524TyrHis: 0.524 ± 0.018	1.13TyrIle: 1.13 ± 0.03	0.794TyrLys: 0.794 ± 0.023	2.405TyrLeu: 2.405 ± 0.038	0.522TyrMet: 0.522 ± 0.016	0.744TyrAsn: 0.744 ± 0.025	1.187TyrPro: 1.187 ± 0.032	0.761TyrGln: 0.761 ± 0.022	1.729TyrArg: 1.729 ± 0.037	1.431TyrSer: 1.431 ± 0.032	1.223TyrThr: 1.223 ± 0.032	1.683TyrVal: 1.683 ± 0.03	0.385TyrTrp: 0.385 ± 0.015	0.67TyrTyr: 0.67 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5125 proteins (1598008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---