Amino acid dipepetide frequency for Bondarzewia mesenterica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.361AlaAla: 8.361 ± 0.049	1.068AlaCys: 1.068 ± 0.015	4.398AlaAsp: 4.398 ± 0.028	4.846AlaGlu: 4.846 ± 0.036	3.281AlaPhe: 3.281 ± 0.026	5.286AlaGly: 5.286 ± 0.038	2.238AlaHis: 2.238 ± 0.018	4.117AlaIle: 4.117 ± 0.03	3.693AlaLys: 3.693 ± 0.03	8.455AlaLeu: 8.455 ± 0.048	1.928AlaMet: 1.928 ± 0.018	2.746AlaAsn: 2.746 ± 0.021	5.145AlaPro: 5.145 ± 0.043	3.236AlaGln: 3.236 ± 0.026	5.506AlaArg: 5.506 ± 0.038	8.078AlaSer: 8.078 ± 0.046	4.883AlaThr: 4.883 ± 0.035	5.429AlaVal: 5.429 ± 0.039	1.144AlaTrp: 1.144 ± 0.015	2.139AlaTyr: 2.139 ± 0.021	0.244AlaXaa: 0.244 ± 0.014
Cys	0.981CysAla: 0.981 ± 0.015	0.232CysCys: 0.232 ± 0.007	0.648CysAsp: 0.648 ± 0.011	0.556CysGlu: 0.556 ± 0.009	0.506CysPhe: 0.506 ± 0.01	0.819CysGly: 0.819 ± 0.015	0.332CysHis: 0.332 ± 0.007	0.692CysIle: 0.692 ± 0.012	0.461CysLys: 0.461 ± 0.01	1.246CysLeu: 1.246 ± 0.016	0.27CysMet: 0.27 ± 0.007	0.38CysAsn: 0.38 ± 0.01	0.762CysPro: 0.762 ± 0.013	0.407CysGln: 0.407 ± 0.009	0.766CysArg: 0.766 ± 0.012	0.996CysSer: 0.996 ± 0.014	0.736CysThr: 0.736 ± 0.012	0.768CysVal: 0.768 ± 0.012	0.184CysTrp: 0.184 ± 0.005	0.304CysTyr: 0.304 ± 0.008	0.045CysXaa: 0.045 ± 0.004
Asp	5.086AspAla: 5.086 ± 0.037	0.589AspCys: 0.589 ± 0.013	4.242AspAsp: 4.242 ± 0.038	4.428AspGlu: 4.428 ± 0.031	2.122AspPhe: 2.122 ± 0.022	3.934AspGly: 3.934 ± 0.028	1.294AspHis: 1.294 ± 0.015	3.107AspIle: 3.107 ± 0.027	2.075AspLys: 2.075 ± 0.021	5.094AspLeu: 5.094 ± 0.037	1.274AspMet: 1.274 ± 0.015	1.649AspAsn: 1.649 ± 0.017	3.323AspPro: 3.323 ± 0.025	1.597AspGln: 1.597 ± 0.017	2.999AspArg: 2.999 ± 0.027	4.103AspSer: 4.103 ± 0.032	2.906AspThr: 2.906 ± 0.025	4.14AspVal: 4.14 ± 0.031	0.863AspTrp: 0.863 ± 0.014	1.387AspTyr: 1.387 ± 0.017	0.153AspXaa: 0.153 ± 0.008
Glu	4.908GluAla: 4.908 ± 0.039	0.618GluCys: 0.618 ± 0.012	4.119GluAsp: 4.119 ± 0.033	5.393GluGlu: 5.393 ± 0.058	1.806GluPhe: 1.806 ± 0.018	3.845GluGly: 3.845 ± 0.03	1.503GluHis: 1.503 ± 0.018	2.703GluIle: 2.703 ± 0.026	3.133GluLys: 3.133 ± 0.031	5.192GluLeu: 5.192 ± 0.035	1.384GluMet: 1.384 ± 0.016	1.895GluAsn: 1.895 ± 0.02	2.67GluPro: 2.67 ± 0.027	2.221GluGln: 2.221 ± 0.023	4.112GluArg: 4.112 ± 0.035	3.97GluSer: 3.97 ± 0.033	2.934GluThr: 2.934 ± 0.026	3.642GluVal: 3.642 ± 0.029	0.922GluTrp: 0.922 ± 0.013	1.472GluTyr: 1.472 ± 0.018	0.159GluXaa: 0.159 ± 0.009
Phe	3.092PheAla: 3.092 ± 0.023	0.549PheCys: 0.549 ± 0.011	2.268PheAsp: 2.268 ± 0.023	2.044PheGlu: 2.044 ± 0.021	1.66PhePhe: 1.66 ± 0.022	2.583PheGly: 2.583 ± 0.029	0.98PheHis: 0.98 ± 0.013	1.882PheIle: 1.882 ± 0.024	1.424PheLys: 1.424 ± 0.018	3.58PheLeu: 3.58 ± 0.027	0.749PheMet: 0.749 ± 0.011	1.307PheAsn: 1.307 ± 0.018	2.178PhePro: 2.178 ± 0.024	1.208PheGln: 1.208 ± 0.015	2.015PheArg: 2.015 ± 0.02	3.303PheSer: 3.303 ± 0.027	2.18PheThr: 2.18 ± 0.02	2.6PheVal: 2.6 ± 0.02	0.552PheTrp: 0.552 ± 0.011	1.007PheTyr: 1.007 ± 0.015	0.114PheXaa: 0.114 ± 0.007
Gly	4.844GlyAla: 4.844 ± 0.035	0.769GlyCys: 0.769 ± 0.012	3.382GlyAsp: 3.382 ± 0.023	3.535GlyGlu: 3.535 ± 0.028	2.434GlyPhe: 2.434 ± 0.022	5.084GlyGly: 5.084 ± 0.045	1.683GlyHis: 1.683 ± 0.019	3.186GlyIle: 3.186 ± 0.026	3.297GlyLys: 3.297 ± 0.03	5.449GlyLeu: 5.449 ± 0.033	1.479GlyMet: 1.479 ± 0.022	2.105GlyAsn: 2.105 ± 0.02	3.153GlyPro: 3.153 ± 0.026	2.277GlyGln: 2.277 ± 0.024	4.13GlyArg: 4.13 ± 0.03	5.287GlySer: 5.287 ± 0.041	3.753GlyThr: 3.753 ± 0.029	4.053GlyVal: 4.053 ± 0.031	1.062GlyTrp: 1.062 ± 0.016	1.712GlyTyr: 1.712 ± 0.019	0.161GlyXaa: 0.161 ± 0.009
His	2.326HisAla: 2.326 ± 0.022	0.375HisCys: 0.375 ± 0.008	1.432HisAsp: 1.432 ± 0.019	1.331HisGlu: 1.331 ± 0.016	1.061HisPhe: 1.061 ± 0.012	1.636HisGly: 1.636 ± 0.017	0.973HisHis: 0.973 ± 0.017	1.407HisIle: 1.407 ± 0.017	0.872HisLys: 0.872 ± 0.013	2.704HisLeu: 2.704 ± 0.021	0.473HisMet: 0.473 ± 0.011	0.799HisAsn: 0.799 ± 0.011	2.135HisPro: 2.135 ± 0.02	0.919HisGln: 0.919 ± 0.014	1.81HisArg: 1.81 ± 0.022	2.238HisSer: 2.238 ± 0.025	1.514HisThr: 1.514 ± 0.018	1.703HisVal: 1.703 ± 0.018	0.352HisTrp: 0.352 ± 0.008	0.663HisTyr: 0.663 ± 0.012	0.075HisXaa: 0.075 ± 0.005
Ile	4.2IleAla: 4.2 ± 0.029	0.702IleCys: 0.702 ± 0.015	2.797IleAsp: 2.797 ± 0.028	2.659IleGlu: 2.659 ± 0.024	1.952IlePhe: 1.952 ± 0.022	2.822IleGly: 2.822 ± 0.025	1.352IleHis: 1.352 ± 0.017	2.515IleIle: 2.515 ± 0.025	1.967IleLys: 1.967 ± 0.022	4.565IleLeu: 4.565 ± 0.035	0.996IleMet: 0.996 ± 0.015	1.541IleAsn: 1.541 ± 0.018	3.342IlePro: 3.342 ± 0.029	1.728IleGln: 1.728 ± 0.02	2.821IleArg: 2.821 ± 0.023	4.145IleSer: 4.145 ± 0.031	2.745IleThr: 2.745 ± 0.021	3.357IleVal: 3.357 ± 0.028	0.692IleTrp: 0.692 ± 0.012	1.297IleTyr: 1.297 ± 0.016	0.153IleXaa: 0.153 ± 0.01
Lys	3.951LysAla: 3.951 ± 0.031	0.46LysCys: 0.46 ± 0.01	2.419LysAsp: 2.419 ± 0.025	3.084LysGlu: 3.084 ± 0.033	1.274LysPhe: 1.274 ± 0.018	2.832LysGly: 2.832 ± 0.026	1.052LysHis: 1.052 ± 0.015	1.932LysIle: 1.932 ± 0.022	2.934LysLys: 2.934 ± 0.039	3.678LysLeu: 3.678 ± 0.028	0.925LysMet: 0.925 ± 0.013	1.405LysAsn: 1.405 ± 0.018	2.455LysPro: 2.455 ± 0.024	1.521LysGln: 1.521 ± 0.018	3.33LysArg: 3.33 ± 0.028	3.186LysSer: 3.186 ± 0.028	2.4LysThr: 2.4 ± 0.023	2.736LysVal: 2.736 ± 0.024	0.633LysTrp: 0.633 ± 0.01	1.173LysTyr: 1.173 ± 0.015	0.118LysXaa: 0.118 ± 0.007
Leu	8.023LeuAla: 8.023 ± 0.037	1.238LeuCys: 1.238 ± 0.016	5.197LeuAsp: 5.197 ± 0.033	5.3LeuGlu: 5.3 ± 0.038	3.496LeuPhe: 3.496 ± 0.028	5.332LeuGly: 5.332 ± 0.03	2.61LeuHis: 2.61 ± 0.023	4.006LeuIle: 4.006 ± 0.03	3.914LeuLys: 3.914 ± 0.035	8.692LeuLeu: 8.692 ± 0.06	1.738LeuMet: 1.738 ± 0.019	3.109LeuAsn: 3.109 ± 0.026	6.524LeuPro: 6.524 ± 0.041	3.584LeuGln: 3.584 ± 0.026	6.085LeuArg: 6.085 ± 0.04	8.551LeuSer: 8.551 ± 0.053	5.414LeuThr: 5.414 ± 0.032	5.608LeuVal: 5.608 ± 0.036	1.202LeuTrp: 1.202 ± 0.018	2.316LeuTyr: 2.316 ± 0.024	0.287LeuXaa: 0.287 ± 0.015
Met	1.839MetAla: 1.839 ± 0.018	0.222MetCys: 0.222 ± 0.006	1.264MetAsp: 1.264 ± 0.017	1.203MetGlu: 1.203 ± 0.016	0.73MetPhe: 0.73 ± 0.011	1.274MetGly: 1.274 ± 0.017	0.595MetHis: 0.595 ± 0.01	0.917MetIle: 0.917 ± 0.012	0.953MetLys: 0.953 ± 0.015	1.899MetLeu: 1.899 ± 0.019	0.523MetMet: 0.523 ± 0.011	0.755MetAsn: 0.755 ± 0.012	1.41MetPro: 1.41 ± 0.017	0.837MetGln: 0.837 ± 0.013	1.351MetArg: 1.351 ± 0.016	2.012MetSer: 2.012 ± 0.021	1.254MetThr: 1.254 ± 0.018	1.205MetVal: 1.205 ± 0.017	0.252MetTrp: 0.252 ± 0.007	0.508MetTyr: 0.508 ± 0.01	0.059MetXaa: 0.059 ± 0.004
Asn	3.11AsnAla: 3.11 ± 0.026	0.359AsnCys: 0.359 ± 0.008	1.737AsnAsp: 1.737 ± 0.02	1.741AsnGlu: 1.741 ± 0.019	1.266AsnPhe: 1.266 ± 0.014	2.473AsnGly: 2.473 ± 0.026	0.757AsnHis: 0.757 ± 0.011	1.79AsnIle: 1.79 ± 0.019	1.232AsnLys: 1.232 ± 0.016	3.058AsnLeu: 3.058 ± 0.027	0.728AsnMet: 0.728 ± 0.013	1.146AsnAsn: 1.146 ± 0.018	2.233AsnPro: 2.233 ± 0.023	1.023AsnGln: 1.023 ± 0.014	1.682AsnArg: 1.682 ± 0.02	2.571AsnSer: 2.571 ± 0.026	1.932AsnThr: 1.932 ± 0.02	2.333AsnVal: 2.333 ± 0.019	0.476AsnTrp: 0.476 ± 0.011	0.849AsnTyr: 0.849 ± 0.012	0.097AsnXaa: 0.097 ± 0.006
Pro	5.527ProAla: 5.527 ± 0.048	0.588ProCys: 0.588 ± 0.011	3.272ProAsp: 3.272 ± 0.027	3.406ProGlu: 3.406 ± 0.027	2.416ProPhe: 2.416 ± 0.025	3.478ProGly: 3.478 ± 0.026	1.788ProHis: 1.788 ± 0.021	2.907ProIle: 2.907 ± 0.025	2.344ProLys: 2.344 ± 0.024	5.618ProLeu: 5.618 ± 0.035	1.117ProMet: 1.117 ± 0.015	2.081ProAsn: 2.081 ± 0.02	6.711ProPro: 6.711 ± 0.065	2.331ProGln: 2.331 ± 0.025	3.745ProArg: 3.745 ± 0.033	8.059ProSer: 8.059 ± 0.07	4.447ProThr: 4.447 ± 0.031	3.868ProVal: 3.868 ± 0.028	0.68ProTrp: 0.68 ± 0.011	1.579ProTyr: 1.579 ± 0.018	0.205ProXaa: 0.205 ± 0.013
Gln	3.218GlnAla: 3.218 ± 0.031	0.452GlnCys: 0.452 ± 0.009	1.865GlnAsp: 1.865 ± 0.019	2.065GlnGlu: 2.065 ± 0.02	1.262GlnPhe: 1.262 ± 0.015	2.076GlnGly: 2.076 ± 0.023	1.06GlnHis: 1.06 ± 0.015	1.669GlnIle: 1.669 ± 0.016	1.548GlnLys: 1.548 ± 0.02	3.305GlnLeu: 3.305 ± 0.024	0.822GlnMet: 0.822 ± 0.012	1.267GlnAsn: 1.267 ± 0.015	2.371GlnPro: 2.371 ± 0.025	1.885GlnGln: 1.885 ± 0.034	2.485GlnArg: 2.485 ± 0.023	3.079GlnSer: 3.079 ± 0.028	2.195GlnThr: 2.195 ± 0.02	2.071GlnVal: 2.071 ± 0.022	0.525GlnTrp: 0.525 ± 0.011	1.028GlnTyr: 1.028 ± 0.015	0.094GlnXaa: 0.094 ± 0.006
Arg	5.484ArgAla: 5.484 ± 0.038	0.78ArgCys: 0.78 ± 0.011	3.352ArgAsp: 3.352 ± 0.026	3.834ArgGlu: 3.834 ± 0.034	2.185ArgPhe: 2.185 ± 0.021	3.657ArgGly: 3.657 ± 0.03	1.724ArgHis: 1.724 ± 0.02	2.989ArgIle: 2.989 ± 0.024	3.255ArgLys: 3.255 ± 0.031	5.791ArgLeu: 5.791 ± 0.041	1.356ArgMet: 1.356 ± 0.017	2.011ArgAsn: 2.011 ± 0.018	3.901ArgPro: 3.901 ± 0.032	2.388ArgGln: 2.388 ± 0.025	5.388ArgArg: 5.388 ± 0.044	5.323ArgSer: 5.323 ± 0.042	3.704ArgThr: 3.704 ± 0.026	3.778ArgVal: 3.778 ± 0.03	0.97ArgTrp: 0.97 ± 0.015	1.545ArgTyr: 1.545 ± 0.019	0.162ArgXaa: 0.162 ± 0.01
Ser	7.576SerAla: 7.576 ± 0.049	0.928SerCys: 0.928 ± 0.015	4.568SerAsp: 4.568 ± 0.034	4.095SerGlu: 4.095 ± 0.032	3.347SerPhe: 3.347 ± 0.032	5.432SerGly: 5.432 ± 0.041	2.321SerHis: 2.321 ± 0.023	4.243SerIle: 4.243 ± 0.031	3.472SerLys: 3.472 ± 0.031	8.226SerLeu: 8.226 ± 0.048	1.812SerMet: 1.812 ± 0.018	2.83SerAsn: 2.83 ± 0.025	6.864SerPro: 6.864 ± 0.063	3.304SerGln: 3.304 ± 0.03	5.434SerArg: 5.434 ± 0.04	11.102SerSer: 11.102 ± 0.104	6.242SerThr: 6.242 ± 0.047	5.263SerVal: 5.263 ± 0.036	1.04SerTrp: 1.04 ± 0.013	2.032SerTyr: 2.032 ± 0.021	0.251SerXaa: 0.251 ± 0.015
Thr	5.042ThrAla: 5.042 ± 0.031	0.717ThrCys: 0.717 ± 0.011	2.829ThrAsp: 2.829 ± 0.024	2.81ThrGlu: 2.81 ± 0.025	2.347ThrPhe: 2.347 ± 0.024	3.669ThrGly: 3.669 ± 0.029	1.589ThrHis: 1.589 ± 0.017	3.056ThrIle: 3.056 ± 0.024	2.235ThrLys: 2.235 ± 0.023	5.634ThrLeu: 5.634 ± 0.035	1.218ThrMet: 1.218 ± 0.014	1.907ThrAsn: 1.907 ± 0.022	4.573ThrPro: 4.573 ± 0.033	1.963ThrGln: 1.963 ± 0.018	3.401ThrArg: 3.401 ± 0.028	5.948ThrSer: 5.948 ± 0.042	3.98ThrThr: 3.98 ± 0.03	3.83ThrVal: 3.83 ± 0.028	0.759ThrTrp: 0.759 ± 0.013	1.543ThrTyr: 1.543 ± 0.018	0.161ThrXaa: 0.161 ± 0.009
Val	5.172ValAla: 5.172 ± 0.03	0.82ValCys: 0.82 ± 0.013	3.944ValAsp: 3.944 ± 0.027	3.921ValGlu: 3.921 ± 0.028	2.464ValPhe: 2.464 ± 0.023	3.862ValGly: 3.862 ± 0.029	1.74ValHis: 1.74 ± 0.017	3.025ValIle: 3.025 ± 0.024	2.866ValLys: 2.866 ± 0.023	6.089ValLeu: 6.089 ± 0.043	1.322ValMet: 1.322 ± 0.015	2.088ValAsn: 2.088 ± 0.021	4.099ValPro: 4.099 ± 0.03	2.408ValGln: 2.408 ± 0.023	3.875ValArg: 3.875 ± 0.029	5.152ValSer: 5.152 ± 0.032	3.451ValThr: 3.451 ± 0.026	4.437ValVal: 4.437 ± 0.036	0.908ValTrp: 0.908 ± 0.013	1.651ValTyr: 1.651 ± 0.016	0.179ValXaa: 0.179 ± 0.009
Trp	1.077TrpAla: 1.077 ± 0.016	0.206TrpCys: 0.206 ± 0.007	0.873TrpAsp: 0.873 ± 0.014	0.83TrpGlu: 0.83 ± 0.012	0.519TrpPhe: 0.519 ± 0.01	0.822TrpGly: 0.822 ± 0.013	0.382TrpHis: 0.382 ± 0.008	0.713TrpIle: 0.713 ± 0.01	0.731TrpLys: 0.731 ± 0.012	1.237TrpLeu: 1.237 ± 0.016	0.357TrpMet: 0.357 ± 0.009	0.567TrpAsn: 0.567 ± 0.011	0.612TrpPro: 0.612 ± 0.013	0.496TrpGln: 0.496 ± 0.01	0.972TrpArg: 0.972 ± 0.014	1.09TrpSer: 1.09 ± 0.015	0.878TrpThr: 0.878 ± 0.014	0.842TrpVal: 0.842 ± 0.013	0.259TrpTrp: 0.259 ± 0.007	0.375TrpTyr: 0.375 ± 0.01	0.036TrpXaa: 0.036 ± 0.003
Tyr	2.142TyrAla: 2.142 ± 0.019	0.375TyrCys: 0.375 ± 0.01	1.58TyrAsp: 1.58 ± 0.017	1.337TyrGlu: 1.337 ± 0.016	1.045TyrPhe: 1.045 ± 0.016	1.75TyrGly: 1.75 ± 0.023	0.744TyrHis: 0.744 ± 0.011	1.359TyrIle: 1.359 ± 0.018	0.97TyrLys: 0.97 ± 0.014	2.452TyrLeu: 2.452 ± 0.022	0.533TyrMet: 0.533 ± 0.01	0.916TyrAsn: 0.916 ± 0.014	1.529TyrPro: 1.529 ± 0.017	0.906TyrGln: 0.906 ± 0.013	1.512TyrArg: 1.512 ± 0.017	1.937TyrSer: 1.937 ± 0.018	1.502TyrThr: 1.502 ± 0.017	1.633TyrVal: 1.633 ± 0.017	0.359TyrTrp: 0.359 ± 0.008	0.779TyrTyr: 0.779 ± 0.014	0.07TyrXaa: 0.07 ± 0.005
Xaa	0.26XaaAla: 0.26 ± 0.014	0.044XaaCys: 0.044 ± 0.004	0.179XaaAsp: 0.179 ± 0.01	0.182XaaGlu: 0.182 ± 0.01	0.102XaaPhe: 0.102 ± 0.006	0.167XaaGly: 0.167 ± 0.009	0.084XaaHis: 0.084 ± 0.006	0.134XaaIle: 0.134 ± 0.008	0.123XaaLys: 0.123 ± 0.008	0.261XaaLeu: 0.261 ± 0.016	0.058XaaMet: 0.058 ± 0.004	0.09XaaAsn: 0.09 ± 0.005	0.177XaaPro: 0.177 ± 0.01	0.104XaaGln: 0.104 ± 0.006	0.158XaaArg: 0.158 ± 0.01	0.254XaaSer: 0.254 ± 0.015	0.159XaaThr: 0.159 ± 0.01	0.175XaaVal: 0.175 ± 0.009	0.039XaaTrp: 0.039 ± 0.003	0.07XaaTyr: 0.07 ± 0.005	0.815XaaXaa: 0.815 ± 0.07

Statistics based on 10514 proteins (5388005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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