Amino acid dipepetide frequency for Lysinimonas sp. KACC 19322

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.863AlaAla: 21.863 ± 0.314
0.559AlaCys: 0.559 ± 0.032
8.131AlaAsp: 8.131 ± 0.129
8.957AlaGlu: 8.957 ± 0.131
4.201AlaPhe: 4.201 ± 0.08
12.699AlaGly: 12.699 ± 0.22
2.453AlaHis: 2.453 ± 0.064
6.468AlaIle: 6.468 ± 0.11
2.581AlaLys: 2.581 ± 0.084
15.027AlaLeu: 15.027 ± 0.184
2.134AlaMet: 2.134 ± 0.06
2.37AlaAsn: 2.37 ± 0.072
7.046AlaPro: 7.046 ± 0.144
3.758AlaGln: 3.758 ± 0.075
10.148AlaArg: 10.148 ± 0.163
7.618AlaSer: 7.618 ± 0.165
7.64AlaThr: 7.64 ± 0.207
12.107AlaVal: 12.107 ± 0.178
1.947AlaTrp: 1.947 ± 0.064
2.432AlaTyr: 2.432 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.565CysAla: 0.565 ± 0.032
0.04CysCys: 0.04 ± 0.007
0.257CysAsp: 0.257 ± 0.017
0.202CysGlu: 0.202 ± 0.018
0.154CysPhe: 0.154 ± 0.016
0.487CysGly: 0.487 ± 0.024
0.075CysHis: 0.075 ± 0.01
0.174CysIle: 0.174 ± 0.014
0.049CysLys: 0.049 ± 0.008
0.385CysLeu: 0.385 ± 0.022
0.067CysMet: 0.067 ± 0.01
0.098CysAsn: 0.098 ± 0.012
0.273CysPro: 0.273 ± 0.021
0.095CysGln: 0.095 ± 0.012
0.295CysArg: 0.295 ± 0.02
0.304CysSer: 0.304 ± 0.019
0.305CysThr: 0.305 ± 0.021
0.372CysVal: 0.372 ± 0.023
0.064CysTrp: 0.064 ± 0.01
0.114CysTyr: 0.114 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
9.537AspAla: 9.537 ± 0.149
0.23AspCys: 0.23 ± 0.019
3.963AspAsp: 3.963 ± 0.072
4.217AspGlu: 4.217 ± 0.083
1.769AspPhe: 1.769 ± 0.056
6.099AspGly: 6.099 ± 0.111
1.132AspHis: 1.132 ± 0.043
2.225AspIle: 2.225 ± 0.058
0.934AspLys: 0.934 ± 0.044
5.106AspLeu: 5.106 ± 0.087
0.596AspMet: 0.596 ± 0.027
0.93AspAsn: 0.93 ± 0.037
4.579AspPro: 4.579 ± 0.093
1.313AspGln: 1.313 ± 0.044
4.396AspArg: 4.396 ± 0.094
2.288AspSer: 2.288 ± 0.057
2.821AspThr: 2.821 ± 0.073
4.749AspVal: 4.749 ± 0.089
0.952AspTrp: 0.952 ± 0.038
1.336AspTyr: 1.336 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
7.237GluAla: 7.237 ± 0.113
0.193GluCys: 0.193 ± 0.013
2.341GluAsp: 2.341 ± 0.062
2.978GluGlu: 2.978 ± 0.08
1.874GluPhe: 1.874 ± 0.05
4.064GluGly: 4.064 ± 0.084
1.451GluHis: 1.451 ± 0.048
2.458GluIle: 2.458 ± 0.065
1.352GluLys: 1.352 ± 0.062
8.606GluLeu: 8.606 ± 0.132
0.693GluMet: 0.693 ± 0.031
1.131GluAsn: 1.131 ± 0.04
3.167GluPro: 3.167 ± 0.085
2.187GluGln: 2.187 ± 0.064
5.48GluArg: 5.48 ± 0.116
2.644GluSer: 2.644 ± 0.059
2.845GluThr: 2.845 ± 0.066
5.276GluVal: 5.276 ± 0.102
0.803GluTrp: 0.803 ± 0.031
1.122GluTyr: 1.122 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
4.597PheAla: 4.597 ± 0.086
0.158PheCys: 0.158 ± 0.015
2.207PheAsp: 2.207 ± 0.064
1.807PheGlu: 1.807 ± 0.048
1.015PhePhe: 1.015 ± 0.04
3.527PheGly: 3.527 ± 0.072
0.53PheHis: 0.53 ± 0.024
1.097PheIle: 1.097 ± 0.04
0.418PheLys: 0.418 ± 0.027
2.899PheLeu: 2.899 ± 0.074
0.404PheMet: 0.404 ± 0.026
0.57PheAsn: 0.57 ± 0.03
1.532PhePro: 1.532 ± 0.055
0.764PheGln: 0.764 ± 0.035
1.965PheArg: 1.965 ± 0.06
1.763PheSer: 1.763 ± 0.044
2.086PheThr: 2.086 ± 0.055
2.841PheVal: 2.841 ± 0.064
0.467PheTrp: 0.467 ± 0.028
0.652PheTyr: 0.652 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
11.452GlyAla: 11.452 ± 0.22
0.54GlyCys: 0.54 ± 0.026
5.077GlyAsp: 5.077 ± 0.098
5.201GlyGlu: 5.201 ± 0.086
3.383GlyPhe: 3.383 ± 0.072
8.363GlyGly: 8.363 ± 0.244
1.79GlyHis: 1.79 ± 0.043
5.203GlyIle: 5.203 ± 0.079
2.042GlyLys: 2.042 ± 0.062
9.083GlyLeu: 9.083 ± 0.134
1.715GlyMet: 1.715 ± 0.054
1.617GlyAsn: 1.617 ± 0.054
3.775GlyPro: 3.775 ± 0.074
2.225GlyGln: 2.225 ± 0.058
6.54GlyArg: 6.54 ± 0.115
5.444GlySer: 5.444 ± 0.147
5.544GlyThr: 5.544 ± 0.124
8.499GlyVal: 8.499 ± 0.153
1.774GlyTrp: 1.774 ± 0.053
2.332GlyTyr: 2.332 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.325HisAla: 2.325 ± 0.058
0.093HisCys: 0.093 ± 0.011
1.227HisAsp: 1.227 ± 0.04
1.188HisGlu: 1.188 ± 0.048
0.494HisPhe: 0.494 ± 0.028
1.932HisGly: 1.932 ± 0.054
0.527HisHis: 0.527 ± 0.033
0.643HisIle: 0.643 ± 0.03
0.238HisLys: 0.238 ± 0.017
1.983HisLeu: 1.983 ± 0.055
0.23HisMet: 0.23 ± 0.019
0.334HisAsn: 0.334 ± 0.019
1.582HisPro: 1.582 ± 0.047
0.493HisGln: 0.493 ± 0.024
1.618HisArg: 1.618 ± 0.048
0.881HisSer: 0.881 ± 0.039
0.867HisThr: 0.867 ± 0.038
1.514HisVal: 1.514 ± 0.043
0.322HisTrp: 0.322 ± 0.023
0.462HisTyr: 0.462 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.035IleAla: 7.035 ± 0.108
0.179IleCys: 0.179 ± 0.014
3.295IleAsp: 3.295 ± 0.071
2.893IleGlu: 2.893 ± 0.061
1.038IlePhe: 1.038 ± 0.046
4.634IleGly: 4.634 ± 0.103
0.678IleHis: 0.678 ± 0.031
1.693IleIle: 1.693 ± 0.054
0.799IleLys: 0.799 ± 0.04
3.769IleLeu: 3.769 ± 0.074
0.484IleMet: 0.484 ± 0.03
0.827IleAsn: 0.827 ± 0.038
2.584IlePro: 2.584 ± 0.058
1.065IleGln: 1.065 ± 0.041
3.236IleArg: 3.236 ± 0.066
2.271IleSer: 2.271 ± 0.057
2.698IleThr: 2.698 ± 0.076
4.786IleVal: 4.786 ± 0.073
0.518IleTrp: 0.518 ± 0.029
0.725IleTyr: 0.725 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
2.387LysAla: 2.387 ± 0.082
0.046LysCys: 0.046 ± 0.008
0.999LysAsp: 0.999 ± 0.043
0.839LysGlu: 0.839 ± 0.041
0.462LysPhe: 0.462 ± 0.028
1.538LysGly: 1.538 ± 0.053
0.403LysHis: 0.403 ± 0.023
0.821LysIle: 0.821 ± 0.039
0.715LysLys: 0.715 ± 0.042
1.914LysLeu: 1.914 ± 0.056
0.284LysMet: 0.284 ± 0.02
0.469LysAsn: 0.469 ± 0.029
1.151LysPro: 1.151 ± 0.045
0.66LysGln: 0.66 ± 0.036
1.493LysArg: 1.493 ± 0.054
1.048LysSer: 1.048 ± 0.046
1.192LysThr: 1.192 ± 0.044
1.686LysVal: 1.686 ± 0.062
0.225LysTrp: 0.225 ± 0.019
0.409LysTyr: 0.409 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
16.457LeuAla: 16.457 ± 0.183
0.445LeuCys: 0.445 ± 0.024
6.853LeuAsp: 6.853 ± 0.112
5.781LeuGlu: 5.781 ± 0.109
2.873LeuPhe: 2.873 ± 0.07
9.936LeuGly: 9.936 ± 0.139
1.884LeuHis: 1.884 ± 0.054
4.306LeuIle: 4.306 ± 0.084
1.673LeuLys: 1.673 ± 0.06
10.726LeuLeu: 10.726 ± 0.19
1.286LeuMet: 1.286 ± 0.045
1.637LeuAsn: 1.637 ± 0.05
5.963LeuPro: 5.963 ± 0.11
2.4LeuGln: 2.4 ± 0.061
7.604LeuArg: 7.604 ± 0.125
5.518LeuSer: 5.518 ± 0.086
5.9LeuThr: 5.9 ± 0.102
10.467LeuVal: 10.467 ± 0.146
1.277LeuTrp: 1.277 ± 0.047
1.727LeuTyr: 1.727 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.787MetAla: 1.787 ± 0.058
0.087MetCys: 0.087 ± 0.011
0.647MetAsp: 0.647 ± 0.029
0.502MetGlu: 0.502 ± 0.026
0.455MetPhe: 0.455 ± 0.026
1.017MetGly: 1.017 ± 0.034
0.266MetHis: 0.266 ± 0.02
0.606MetIle: 0.606 ± 0.026
0.307MetLys: 0.307 ± 0.02
1.501MetLeu: 1.501 ± 0.048
0.189MetMet: 0.189 ± 0.021
0.428MetAsn: 0.428 ± 0.023
0.985MetPro: 0.985 ± 0.035
0.433MetGln: 0.433 ± 0.022
1.123MetArg: 1.123 ± 0.039
1.299MetSer: 1.299 ± 0.043
1.302MetThr: 1.302 ± 0.042
1.057MetVal: 1.057 ± 0.047
0.188MetTrp: 0.188 ± 0.016
0.202MetTyr: 0.202 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.408AsnAla: 2.408 ± 0.064
0.117AsnCys: 0.117 ± 0.011
1.025AsnAsp: 1.025 ± 0.044
0.839AsnGlu: 0.839 ± 0.035
0.592AsnPhe: 0.592 ± 0.033
1.834AsnGly: 1.834 ± 0.062
0.333AsnHis: 0.333 ± 0.023
0.803AsnIle: 0.803 ± 0.036
0.341AsnLys: 0.341 ± 0.024
1.821AsnLeu: 1.821 ± 0.049
0.248AsnMet: 0.248 ± 0.017
0.439AsnAsn: 0.439 ± 0.025
1.579AsnPro: 1.579 ± 0.047
0.525AsnGln: 0.525 ± 0.029
1.235AsnArg: 1.235 ± 0.04
0.845AsnSer: 0.845 ± 0.037
1.065AsnThr: 1.065 ± 0.046
1.582AsnVal: 1.582 ± 0.051
0.331AsnTrp: 0.331 ± 0.019
0.451AsnTyr: 0.451 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.855ProAla: 7.855 ± 0.12
0.18ProCys: 0.18 ± 0.016
3.955ProAsp: 3.955 ± 0.074
4.18ProGlu: 4.18 ± 0.08
1.676ProPhe: 1.676 ± 0.05
5.461ProGly: 5.461 ± 0.113
1.113ProHis: 1.113 ± 0.043
2.223ProIle: 2.223 ± 0.056
1.033ProLys: 1.033 ± 0.045
5.132ProLeu: 5.132 ± 0.103
0.743ProMet: 0.743 ± 0.031
0.996ProAsn: 0.996 ± 0.037
2.66ProPro: 2.66 ± 0.111
1.465ProGln: 1.465 ± 0.056
3.787ProArg: 3.787 ± 0.089
3.212ProSer: 3.212 ± 0.066
3.101ProThr: 3.101 ± 0.075
5.128ProVal: 5.128 ± 0.094
0.895ProTrp: 0.895 ± 0.033
1.119ProTyr: 1.119 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.43GlnAla: 3.43 ± 0.074
0.095GlnCys: 0.095 ± 0.011
1.143GlnAsp: 1.143 ± 0.039
1.206GlnGlu: 1.206 ± 0.04
0.835GlnPhe: 0.835 ± 0.038
1.866GlnGly: 1.866 ± 0.053
0.562GlnHis: 0.562 ± 0.026
1.163GlnIle: 1.163 ± 0.042
0.607GlnLys: 0.607 ± 0.03
3.713GlnLeu: 3.713 ± 0.08
0.343GlnMet: 0.343 ± 0.023
0.598GlnAsn: 0.598 ± 0.032
1.441GlnPro: 1.441 ± 0.051
1.086GlnGln: 1.086 ± 0.049
2.385GlnArg: 2.385 ± 0.06
1.342GlnSer: 1.342 ± 0.049
1.336GlnThr: 1.336 ± 0.04
2.248GlnVal: 2.248 ± 0.061
0.41GlnTrp: 0.41 ± 0.024
0.572GlnTyr: 0.572 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
9.628ArgAla: 9.628 ± 0.169
0.305ArgCys: 0.305 ± 0.023
4.268ArgAsp: 4.268 ± 0.097
4.736ArgGlu: 4.736 ± 0.089
2.566ArgPhe: 2.566 ± 0.068
5.905ArgGly: 5.905 ± 0.1
1.524ArgHis: 1.524 ± 0.052
4.1ArgIle: 4.1 ± 0.084
1.362ArgLys: 1.362 ± 0.052
7.901ArgLeu: 7.901 ± 0.142
1.572ArgMet: 1.572 ± 0.048
1.305ArgAsn: 1.305 ± 0.04
3.847ArgPro: 3.847 ± 0.094
1.889ArgGln: 1.889 ± 0.047
7.024ArgArg: 7.024 ± 0.155
3.929ArgSer: 3.929 ± 0.079
4.094ArgThr: 4.094 ± 0.08
6.503ArgVal: 6.503 ± 0.102
1.266ArgTrp: 1.266 ± 0.046
1.666ArgTyr: 1.666 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.926SerAla: 6.926 ± 0.171
0.297SerCys: 0.297 ± 0.022
2.948SerAsp: 2.948 ± 0.067
2.632SerGlu: 2.632 ± 0.056
1.95SerPhe: 1.95 ± 0.057
5.794SerGly: 5.794 ± 0.112
0.908SerHis: 0.908 ± 0.032
2.529SerIle: 2.529 ± 0.074
0.972SerLys: 0.972 ± 0.043
4.967SerLeu: 4.967 ± 0.078
0.934SerMet: 0.934 ± 0.033
1.008SerAsn: 1.008 ± 0.037
3.006SerPro: 3.006 ± 0.07
1.233SerGln: 1.233 ± 0.043
3.852SerArg: 3.852 ± 0.072
3.2SerSer: 3.2 ± 0.088
3.558SerThr: 3.558 ± 0.093
4.395SerVal: 4.395 ± 0.104
1.025SerTrp: 1.025 ± 0.041
1.42SerTyr: 1.42 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
7.827ThrAla: 7.827 ± 0.243
0.183ThrCys: 0.183 ± 0.017
3.068ThrAsp: 3.068 ± 0.068
2.867ThrGlu: 2.867 ± 0.06
1.766ThrPhe: 1.766 ± 0.046
5.942ThrGly: 5.942 ± 0.114
1.011ThrHis: 1.011 ± 0.038
2.984ThrIle: 2.984 ± 0.077
1.08ThrLys: 1.08 ± 0.049
5.875ThrLeu: 5.875 ± 0.089
0.785ThrMet: 0.785 ± 0.034
1.029ThrAsn: 1.029 ± 0.039
4.044ThrPro: 4.044 ± 0.082
1.437ThrGln: 1.437 ± 0.041
3.982ThrArg: 3.982 ± 0.086
3.191ThrSer: 3.191 ± 0.094
3.751ThrThr: 3.751 ± 0.13
5.793ThrVal: 5.793 ± 0.161
0.713ThrTrp: 0.713 ± 0.034
0.737ThrTyr: 0.737 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
12.517ValAla: 12.517 ± 0.16
0.421ValCys: 0.421 ± 0.027
5.695ValAsp: 5.695 ± 0.094
5.137ValGlu: 5.137 ± 0.08
2.97ValPhe: 2.97 ± 0.069
7.379ValGly: 7.379 ± 0.13
1.676ValHis: 1.676 ± 0.046
4.292ValIle: 4.292 ± 0.084
1.606ValLys: 1.606 ± 0.055
10.071ValLeu: 10.071 ± 0.148
1.194ValMet: 1.194 ± 0.04
1.765ValAsn: 1.765 ± 0.056
4.936ValPro: 4.936 ± 0.087
2.252ValGln: 2.252 ± 0.058
6.247ValArg: 6.247 ± 0.095
4.872ValSer: 4.872 ± 0.1
5.897ValThr: 5.897 ± 0.149
9.337ValVal: 9.337 ± 0.13
1.158ValTrp: 1.158 ± 0.042
1.591ValTyr: 1.591 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.758TrpAla: 1.758 ± 0.052
0.085TrpCys: 0.085 ± 0.011
0.813TrpAsp: 0.813 ± 0.036
0.66TrpGlu: 0.66 ± 0.03
0.563TrpPhe: 0.563 ± 0.029
1.192TrpGly: 1.192 ± 0.044
0.32TrpHis: 0.32 ± 0.021
0.749TrpIle: 0.749 ± 0.032
0.283TrpLys: 0.283 ± 0.018
1.752TrpLeu: 1.752 ± 0.058
0.291TrpMet: 0.291 ± 0.019
0.418TrpAsn: 0.418 ± 0.023
0.741TrpPro: 0.741 ± 0.033
0.493TrpGln: 0.493 ± 0.028
1.239TrpArg: 1.239 ± 0.047
0.867TrpSer: 0.867 ± 0.037
0.932TrpThr: 0.932 ± 0.037
1.199TrpVal: 1.199 ± 0.049
0.391TrpTrp: 0.391 ± 0.023
0.291TrpTyr: 0.291 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.548TyrAla: 2.548 ± 0.06
0.12TyrCys: 0.12 ± 0.012
1.259TyrAsp: 1.259 ± 0.045
1.079TyrGlu: 1.079 ± 0.036
0.665TyrPhe: 0.665 ± 0.033
1.928TyrGly: 1.928 ± 0.05
0.318TyrHis: 0.318 ± 0.022
0.673TyrIle: 0.673 ± 0.029
0.349TyrLys: 0.349 ± 0.022
2.484TyrLeu: 2.484 ± 0.064
0.19TyrMet: 0.19 ± 0.016
0.444TyrAsn: 0.444 ± 0.024
1.023TyrPro: 1.023 ± 0.043
0.61TyrGln: 0.61 ± 0.034
1.742TyrArg: 1.742 ± 0.052
1.017TyrSer: 1.017 ± 0.044
1.129TyrThr: 1.129 ± 0.041
1.474TyrVal: 1.474 ± 0.047
0.311TyrTrp: 0.311 ± 0.019
0.392TyrTyr: 0.392 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2341 proteins (777487 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski