Amino acid dipepetide frequency for Altererythrobacter soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.267AlaAla: 19.267 ± 0.239	1.086AlaCys: 1.086 ± 0.037	7.226AlaAsp: 7.226 ± 0.107	9.246AlaGlu: 9.246 ± 0.13	4.238AlaPhe: 4.238 ± 0.083	11.872AlaGly: 11.872 ± 0.178	2.202AlaHis: 2.202 ± 0.052	6.251AlaIle: 6.251 ± 0.093	3.611AlaLys: 3.611 ± 0.086	13.866AlaLeu: 13.866 ± 0.176	3.596AlaMet: 3.596 ± 0.066	2.991AlaAsn: 2.991 ± 0.073	6.27AlaPro: 6.27 ± 0.093	4.526AlaGln: 4.526 ± 0.074	9.536AlaArg: 9.536 ± 0.146	6.252AlaSer: 6.252 ± 0.093	5.707AlaThr: 5.707 ± 0.099	8.664AlaVal: 8.664 ± 0.111	1.609AlaTrp: 1.609 ± 0.046	2.458AlaTyr: 2.458 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.032CysAla: 1.032 ± 0.034	0.117CysCys: 0.117 ± 0.013	0.576CysAsp: 0.576 ± 0.026	0.533CysGlu: 0.533 ± 0.027	0.288CysPhe: 0.288 ± 0.019	0.928CysGly: 0.928 ± 0.034	0.22CysHis: 0.22 ± 0.017	0.324CysIle: 0.324 ± 0.018	0.162CysLys: 0.162 ± 0.015	0.654CysLeu: 0.654 ± 0.031	0.147CysMet: 0.147 ± 0.012	0.225CysAsn: 0.225 ± 0.017	0.417CysPro: 0.417 ± 0.025	0.193CysGln: 0.193 ± 0.015	0.572CysArg: 0.572 ± 0.03	0.491CysSer: 0.491 ± 0.024	0.424CysThr: 0.424 ± 0.02	0.598CysVal: 0.598 ± 0.024	0.105CysTrp: 0.105 ± 0.011	0.158CysTyr: 0.158 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.82AspAla: 6.82 ± 0.105	0.491AspCys: 0.491 ± 0.026	3.064AspAsp: 3.064 ± 0.063	3.87AspGlu: 3.87 ± 0.069	2.214AspPhe: 2.214 ± 0.052	5.532AspGly: 5.532 ± 0.129	1.189AspHis: 1.189 ± 0.035	2.631AspIle: 2.631 ± 0.053	1.652AspLys: 1.652 ± 0.048	5.707AspLeu: 5.707 ± 0.073	1.317AspMet: 1.317 ± 0.04	1.312AspAsn: 1.312 ± 0.04	4.027AspPro: 4.027 ± 0.066	1.673AspGln: 1.673 ± 0.048	4.765AspArg: 4.765 ± 0.08	2.459AspSer: 2.459 ± 0.061	2.543AspThr: 2.543 ± 0.063	3.971AspVal: 3.971 ± 0.074	1.12AspTrp: 1.12 ± 0.038	1.592AspTyr: 1.592 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.624GluAla: 8.624 ± 0.127	0.386GluCys: 0.386 ± 0.021	3.409GluAsp: 3.409 ± 0.078	4.135GluGlu: 4.135 ± 0.098	1.959GluPhe: 1.959 ± 0.045	5.414GluGly: 5.414 ± 0.088	1.364GluHis: 1.364 ± 0.041	3.24GluIle: 3.24 ± 0.063	2.063GluLys: 2.063 ± 0.062	6.323GluLeu: 6.323 ± 0.095	1.609GluMet: 1.609 ± 0.044	1.575GluAsn: 1.575 ± 0.042	3.222GluPro: 3.222 ± 0.068	2.605GluGln: 2.605 ± 0.057	5.937GluArg: 5.937 ± 0.092	2.619GluSer: 2.619 ± 0.054	3.209GluThr: 3.209 ± 0.066	4.245GluVal: 4.245 ± 0.078	0.969GluTrp: 0.969 ± 0.032	1.235GluTyr: 1.235 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.986PheAla: 4.986 ± 0.085	0.359PheCys: 0.359 ± 0.019	2.728PheAsp: 2.728 ± 0.051	2.295PheGlu: 2.295 ± 0.048	1.25PhePhe: 1.25 ± 0.049	3.722PheGly: 3.722 ± 0.078	0.667PheHis: 0.667 ± 0.027	1.293PheIle: 1.293 ± 0.036	0.771PheLys: 0.771 ± 0.028	3.008PheLeu: 3.008 ± 0.063	0.735PheMet: 0.735 ± 0.033	1.022PheAsn: 1.022 ± 0.038	1.57PhePro: 1.57 ± 0.047	0.921PheGln: 0.921 ± 0.032	2.328PheArg: 2.328 ± 0.048	1.94PheSer: 1.94 ± 0.048	2.024PheThr: 2.024 ± 0.061	2.614PheVal: 2.614 ± 0.057	0.475PheTrp: 0.475 ± 0.026	0.932PheTyr: 0.932 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.348GlyAla: 10.348 ± 0.167	0.888GlyCys: 0.888 ± 0.036	4.948GlyAsp: 4.948 ± 0.099	6.076GlyGlu: 6.076 ± 0.098	3.527GlyPhe: 3.527 ± 0.059	8.795GlyGly: 8.795 ± 0.19	1.85GlyHis: 1.85 ± 0.047	4.215GlyIle: 4.215 ± 0.08	3.228GlyLys: 3.228 ± 0.08	8.572GlyLeu: 8.572 ± 0.111	2.305GlyMet: 2.305 ± 0.055	2.387GlyAsn: 2.387 ± 0.082	4.014GlyPro: 4.014 ± 0.079	2.986GlyGln: 2.986 ± 0.054	6.665GlyArg: 6.665 ± 0.093	5.278GlySer: 5.278 ± 0.109	5.232GlyThr: 5.232 ± 0.241	6.038GlyVal: 6.038 ± 0.091	1.533GlyTrp: 1.533 ± 0.04	2.299GlyTyr: 2.299 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.222HisAla: 2.222 ± 0.05	0.233HisCys: 0.233 ± 0.016	1.176HisAsp: 1.176 ± 0.039	1.181HisGlu: 1.181 ± 0.045	0.8HisPhe: 0.8 ± 0.03	1.924HisGly: 1.924 ± 0.053	0.51HisHis: 0.51 ± 0.027	0.767HisIle: 0.767 ± 0.031	0.463HisLys: 0.463 ± 0.023	1.836HisLeu: 1.836 ± 0.058	0.416HisMet: 0.416 ± 0.02	0.397HisAsn: 0.397 ± 0.019	1.384HisPro: 1.384 ± 0.045	0.536HisGln: 0.536 ± 0.024	1.435HisArg: 1.435 ± 0.039	0.954HisSer: 0.954 ± 0.028	0.798HisThr: 0.798 ± 0.036	1.445HisVal: 1.445 ± 0.04	0.319HisTrp: 0.319 ± 0.021	0.527HisTyr: 0.527 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.068IleAla: 7.068 ± 0.093	0.406IleCys: 0.406 ± 0.024	3.689IleAsp: 3.689 ± 0.063	3.653IleGlu: 3.653 ± 0.071	1.358IlePhe: 1.358 ± 0.043	4.922IleGly: 4.922 ± 0.085	0.828IleHis: 0.828 ± 0.031	1.593IleIle: 1.593 ± 0.051	1.056IleLys: 1.056 ± 0.035	3.66IleLeu: 3.66 ± 0.069	0.802IleMet: 0.802 ± 0.029	1.227IleAsn: 1.227 ± 0.042	2.193IlePro: 2.193 ± 0.051	1.076IleGln: 1.076 ± 0.039	3.016IleArg: 3.016 ± 0.064	2.312IleSer: 2.312 ± 0.057	2.328IleThr: 2.328 ± 0.063	3.993IleVal: 3.993 ± 0.079	0.549IleTrp: 0.549 ± 0.028	0.89IleTyr: 0.89 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.658LysAla: 3.658 ± 0.081	0.149LysCys: 0.149 ± 0.013	1.406LysAsp: 1.406 ± 0.039	1.306LysGlu: 1.306 ± 0.046	0.813LysPhe: 0.813 ± 0.027	2.394LysGly: 2.394 ± 0.069	0.564LysHis: 0.564 ± 0.028	1.356LysIle: 1.356 ± 0.043	1.091LysLys: 1.091 ± 0.054	3.077LysLeu: 3.077 ± 0.065	0.632LysMet: 0.632 ± 0.028	0.666LysAsn: 0.666 ± 0.028	1.782LysPro: 1.782 ± 0.043	0.955LysGln: 0.955 ± 0.035	2.224LysArg: 2.224 ± 0.057	1.394LysSer: 1.394 ± 0.038	1.424LysThr: 1.424 ± 0.045	2.104LysVal: 2.104 ± 0.055	0.395LysTrp: 0.395 ± 0.024	0.585LysTyr: 0.585 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.704LeuAla: 14.704 ± 0.178	0.764LeuCys: 0.764 ± 0.028	5.973LeuAsp: 5.973 ± 0.089	5.832LeuGlu: 5.832 ± 0.092	3.448LeuPhe: 3.448 ± 0.077	8.4LeuGly: 8.4 ± 0.126	1.74LeuHis: 1.74 ± 0.044	4.319LeuIle: 4.319 ± 0.087	2.776LeuLys: 2.776 ± 0.055	9.728LeuLeu: 9.728 ± 0.15	2.036LeuMet: 2.036 ± 0.055	2.233LeuAsn: 2.233 ± 0.06	5.639LeuPro: 5.639 ± 0.084	2.866LeuGln: 2.866 ± 0.058	7.221LeuArg: 7.221 ± 0.102	5.845LeuSer: 5.845 ± 0.088	5.458LeuThr: 5.458 ± 0.112	7.358LeuVal: 7.358 ± 0.106	1.192LeuTrp: 1.192 ± 0.044	1.847LeuTyr: 1.847 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.031MetAla: 3.031 ± 0.061	0.134MetCys: 0.134 ± 0.011	1.115MetAsp: 1.115 ± 0.038	1.147MetGlu: 1.147 ± 0.04	0.676MetPhe: 0.676 ± 0.027	1.739MetGly: 1.739 ± 0.05	0.46MetHis: 0.46 ± 0.024	1.287MetIle: 1.287 ± 0.038	0.869MetLys: 0.869 ± 0.036	2.483MetLeu: 2.483 ± 0.053	0.536MetMet: 0.536 ± 0.026	0.681MetAsn: 0.681 ± 0.029	1.44MetPro: 1.44 ± 0.041	0.749MetGln: 0.749 ± 0.028	1.794MetArg: 1.794 ± 0.043	1.395MetSer: 1.395 ± 0.034	1.481MetThr: 1.481 ± 0.042	1.541MetVal: 1.541 ± 0.046	0.211MetTrp: 0.211 ± 0.015	0.282MetTyr: 0.282 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.014AsnAla: 3.014 ± 0.063	0.261AsnCys: 0.261 ± 0.018	1.3AsnAsp: 1.3 ± 0.052	1.2AsnGlu: 1.2 ± 0.034	0.901AsnPhe: 0.901 ± 0.032	2.413AsnGly: 2.413 ± 0.09	0.447AsnHis: 0.447 ± 0.025	1.199AsnIle: 1.199 ± 0.036	0.583AsnLys: 0.583 ± 0.026	2.409AsnLeu: 2.409 ± 0.054	0.51AsnMet: 0.51 ± 0.027	0.703AsnAsn: 0.703 ± 0.038	1.832AsnPro: 1.832 ± 0.056	0.749AsnGln: 0.749 ± 0.03	1.769AsnArg: 1.769 ± 0.051	1.335AsnSer: 1.335 ± 0.059	1.144AsnThr: 1.144 ± 0.043	1.905AsnVal: 1.905 ± 0.055	0.414AsnTrp: 0.414 ± 0.025	0.621AsnTyr: 0.621 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.162ProAla: 7.162 ± 0.115	0.336ProCys: 0.336 ± 0.02	3.584ProAsp: 3.584 ± 0.068	4.314ProGlu: 4.314 ± 0.077	1.986ProPhe: 1.986 ± 0.053	5.1ProGly: 5.1 ± 0.082	1.027ProHis: 1.027 ± 0.04	2.366ProIle: 2.366 ± 0.052	1.423ProLys: 1.423 ± 0.04	5.243ProLeu: 5.243 ± 0.086	1.111ProMet: 1.111 ± 0.032	1.344ProAsn: 1.344 ± 0.039	3.022ProPro: 3.022 ± 0.094	1.959ProGln: 1.959 ± 0.056	3.248ProArg: 3.248 ± 0.07	2.659ProSer: 2.659 ± 0.046	2.435ProThr: 2.435 ± 0.05	4.288ProVal: 4.288 ± 0.075	0.705ProTrp: 0.705 ± 0.029	1.121ProTyr: 1.121 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.415GlnAla: 4.415 ± 0.072	0.223GlnCys: 0.223 ± 0.016	1.615GlnAsp: 1.615 ± 0.046	1.714GlnGlu: 1.714 ± 0.049	1.161GlnPhe: 1.161 ± 0.04	2.72GlnGly: 2.72 ± 0.056	0.632GlnHis: 0.632 ± 0.029	1.572GlnIle: 1.572 ± 0.04	0.816GlnLys: 0.816 ± 0.03	3.251GlnLeu: 3.251 ± 0.066	0.79GlnMet: 0.79 ± 0.031	0.701GlnAsn: 0.701 ± 0.027	1.954GlnPro: 1.954 ± 0.053	1.357GlnGln: 1.357 ± 0.047	2.51GlnArg: 2.51 ± 0.061	1.654GlnSer: 1.654 ± 0.046	1.552GlnThr: 1.552 ± 0.047	2.493GlnVal: 2.493 ± 0.048	0.445GlnTrp: 0.445 ± 0.021	0.637GlnTyr: 0.637 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.661ArgAla: 8.661 ± 0.123	0.525ArgCys: 0.525 ± 0.023	3.987ArgAsp: 3.987 ± 0.075	5.121ArgGlu: 5.121 ± 0.103	3.192ArgPhe: 3.192 ± 0.062	5.351ArgGly: 5.351 ± 0.084	1.643ArgHis: 1.643 ± 0.045	4.022ArgIle: 4.022 ± 0.071	2.207ArgLys: 2.207 ± 0.056	8.136ArgLeu: 8.136 ± 0.134	2.011ArgMet: 2.011 ± 0.044	1.821ArgAsn: 1.821 ± 0.041	3.731ArgPro: 3.731 ± 0.075	2.674ArgGln: 2.674 ± 0.049	5.967ArgArg: 5.967 ± 0.101	3.863ArgSer: 3.863 ± 0.07	3.57ArgThr: 3.57 ± 0.068	4.857ArgVal: 4.857 ± 0.078	1.255ArgTrp: 1.255 ± 0.04	1.786ArgTyr: 1.786 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.517SerAla: 6.517 ± 0.091	0.461SerCys: 0.461 ± 0.023	2.914SerAsp: 2.914 ± 0.063	3.026SerGlu: 3.026 ± 0.064	2.138SerPhe: 2.138 ± 0.055	5.715SerGly: 5.715 ± 0.137	0.94SerHis: 0.94 ± 0.029	2.351SerIle: 2.351 ± 0.059	1.278SerLys: 1.278 ± 0.04	5.097SerLeu: 5.097 ± 0.077	1.171SerMet: 1.171 ± 0.038	1.299SerAsn: 1.299 ± 0.04	2.857SerPro: 2.857 ± 0.059	1.573SerGln: 1.573 ± 0.047	3.656SerArg: 3.656 ± 0.074	2.884SerSer: 2.884 ± 0.08	2.589SerThr: 2.589 ± 0.071	3.493SerVal: 3.493 ± 0.071	0.772SerTrp: 0.772 ± 0.03	1.364SerTyr: 1.364 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	6.204ThrAla: 6.204 ± 0.095	0.414ThrCys: 0.414 ± 0.024	2.742ThrAsp: 2.742 ± 0.068	2.595ThrGlu: 2.595 ± 0.059	1.813ThrPhe: 1.813 ± 0.049	5.452ThrGly: 5.452 ± 0.145	0.875ThrHis: 0.875 ± 0.033	2.788ThrIle: 2.788 ± 0.092	1.134ThrLys: 1.134 ± 0.04	5.384ThrLeu: 5.384 ± 0.165	1.125ThrMet: 1.125 ± 0.033	1.277ThrAsn: 1.277 ± 0.054	3.239ThrPro: 3.239 ± 0.058	1.347ThrGln: 1.347 ± 0.043	3.282ThrArg: 3.282 ± 0.066	2.62ThrSer: 2.62 ± 0.079	2.61ThrThr: 2.61 ± 0.084	4.19ThrVal: 4.19 ± 0.123	0.642ThrTrp: 0.642 ± 0.028	1.182ThrTyr: 1.182 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.806ValAla: 8.806 ± 0.1	0.573ValCys: 0.573 ± 0.027	4.156ValAsp: 4.156 ± 0.07	4.943ValGlu: 4.943 ± 0.086	2.416ValPhe: 2.416 ± 0.059	5.727ValGly: 5.727 ± 0.091	1.346ValHis: 1.346 ± 0.042	3.585ValIle: 3.585 ± 0.064	1.834ValLys: 1.834 ± 0.053	7.164ValLeu: 7.164 ± 0.095	1.492ValMet: 1.492 ± 0.047	1.858ValAsn: 1.858 ± 0.056	4.058ValPro: 4.058 ± 0.069	2.122ValGln: 2.122 ± 0.046	5.21ValArg: 5.21 ± 0.07	4.011ValSer: 4.011 ± 0.073	4.566ValThr: 4.566 ± 0.12	5.383ValVal: 5.383 ± 0.08	0.849ValTrp: 0.849 ± 0.031	1.374ValTyr: 1.374 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.409TrpAla: 1.409 ± 0.04	0.128TrpCys: 0.128 ± 0.012	0.778TrpAsp: 0.778 ± 0.029	0.652TrpGlu: 0.652 ± 0.025	0.609TrpPhe: 0.609 ± 0.027	0.936TrpGly: 0.936 ± 0.035	0.322TrpHis: 0.322 ± 0.02	0.672TrpIle: 0.672 ± 0.028	0.418TrpLys: 0.418 ± 0.022	1.741TrpLeu: 1.741 ± 0.054	0.314TrpMet: 0.314 ± 0.017	0.446TrpAsn: 0.446 ± 0.02	0.735TrpPro: 0.735 ± 0.031	0.666TrpGln: 0.666 ± 0.029	1.378TrpArg: 1.378 ± 0.039	0.912TrpSer: 0.912 ± 0.034	0.721TrpThr: 0.721 ± 0.031	0.785TrpVal: 0.785 ± 0.028	0.227TrpTrp: 0.227 ± 0.016	0.266TrpTyr: 0.266 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.052	0.231TyrCys: 0.231 ± 0.015	1.563TyrAsp: 1.563 ± 0.047	1.303TyrGlu: 1.303 ± 0.038	0.851TyrPhe: 0.851 ± 0.033	2.13TyrGly: 2.13 ± 0.051	0.498TyrHis: 0.498 ± 0.021	0.789TyrIle: 0.789 ± 0.03	0.54TyrLys: 0.54 ± 0.024	2.04TyrLeu: 2.04 ± 0.042	0.391TyrMet: 0.391 ± 0.022	0.543TyrAsn: 0.543 ± 0.029	1.043TyrPro: 1.043 ± 0.041	0.681TyrGln: 0.681 ± 0.024	1.866TyrArg: 1.866 ± 0.054	1.22TyrSer: 1.22 ± 0.044	1.103TyrThr: 1.103 ± 0.055	1.507TyrVal: 1.507 ± 0.037	0.33TyrTrp: 0.33 ± 0.024	0.609TyrTyr: 0.609 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2807 proteins (910999 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---