Amino acid dipepetide frequency for Prevotella bergensis DSM 17361

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.577AlaAla: 5.577 ± 0.106	0.946AlaCys: 0.946 ± 0.033	4.601AlaAsp: 4.601 ± 0.072	4.525AlaGlu: 4.525 ± 0.093	3.034AlaPhe: 3.034 ± 0.059	5.012AlaGly: 5.012 ± 0.091	1.435AlaHis: 1.435 ± 0.04	4.569AlaIle: 4.569 ± 0.076	4.513AlaLys: 4.513 ± 0.077	6.524AlaLeu: 6.524 ± 0.086	2.311AlaMet: 2.311 ± 0.054	3.5AlaAsn: 3.5 ± 0.066	2.276AlaPro: 2.276 ± 0.054	2.963AlaGln: 2.963 ± 0.059	3.423AlaArg: 3.423 ± 0.065	4.225AlaSer: 4.225 ± 0.066	4.133AlaThr: 4.133 ± 0.072	4.833AlaVal: 4.833 ± 0.069	0.907AlaTrp: 0.907 ± 0.03	2.947AlaTyr: 2.947 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.766CysAla: 0.766 ± 0.031	0.212CysCys: 0.212 ± 0.017	0.726CysAsp: 0.726 ± 0.027	0.644CysGlu: 0.644 ± 0.028	0.593CysPhe: 0.593 ± 0.025	1.041CysGly: 1.041 ± 0.033	0.349CysHis: 0.349 ± 0.02	0.81CysIle: 0.81 ± 0.033	0.73CysLys: 0.73 ± 0.029	1.041CysLeu: 1.041 ± 0.038	0.338CysMet: 0.338 ± 0.018	0.616CysAsn: 0.616 ± 0.024	0.513CysPro: 0.513 ± 0.024	0.372CysGln: 0.372 ± 0.02	0.651CysArg: 0.651 ± 0.025	0.718CysSer: 0.718 ± 0.027	0.657CysThr: 0.657 ± 0.026	0.781CysVal: 0.781 ± 0.028	0.155CysTrp: 0.155 ± 0.012	0.533CysTyr: 0.533 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.36AspAla: 4.36 ± 0.08	0.665AspCys: 0.665 ± 0.027	3.209AspAsp: 3.209 ± 0.062	3.937AspGlu: 3.937 ± 0.073	3.055AspPhe: 3.055 ± 0.058	4.542AspGly: 4.542 ± 0.095	1.129AspHis: 1.129 ± 0.034	4.092AspIle: 4.092 ± 0.067	4.004AspLys: 4.004 ± 0.067	4.654AspLeu: 4.654 ± 0.068	1.795AspMet: 1.795 ± 0.041	3.083AspAsn: 3.083 ± 0.066	1.977AspPro: 1.977 ± 0.045	1.577AspGln: 1.577 ± 0.044	2.897AspArg: 2.897 ± 0.067	3.221AspSer: 3.221 ± 0.069	2.899AspThr: 2.899 ± 0.061	3.915AspVal: 3.915 ± 0.078	0.869AspTrp: 0.869 ± 0.037	2.884AspTyr: 2.884 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.547GluAla: 4.547 ± 0.082	0.593GluCys: 0.593 ± 0.029	3.293GluAsp: 3.293 ± 0.066	4.147GluGlu: 4.147 ± 0.087	2.284GluPhe: 2.284 ± 0.051	3.851GluGly: 3.851 ± 0.072	1.278GluHis: 1.278 ± 0.039	3.681GluIle: 3.681 ± 0.075	4.353GluLys: 4.353 ± 0.083	5.248GluLeu: 5.248 ± 0.08	1.986GluMet: 1.986 ± 0.049	3.193GluAsn: 3.193 ± 0.062	1.775GluPro: 1.775 ± 0.046	2.646GluGln: 2.646 ± 0.063	3.268GluArg: 3.268 ± 0.064	2.982GluSer: 2.982 ± 0.057	3.164GluThr: 3.164 ± 0.058	3.903GluVal: 3.903 ± 0.076	0.768GluTrp: 0.768 ± 0.033	2.346GluTyr: 2.346 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.044PheAla: 3.044 ± 0.059	0.703PheCys: 0.703 ± 0.028	2.966PheAsp: 2.966 ± 0.064	2.342PheGlu: 2.342 ± 0.048	2.083PhePhe: 2.083 ± 0.058	3.207PheGly: 3.207 ± 0.061	0.957PheHis: 0.957 ± 0.034	2.638PheIle: 2.638 ± 0.068	2.5PheLys: 2.5 ± 0.052	3.64PheLeu: 3.64 ± 0.079	1.296PheMet: 1.296 ± 0.039	2.334PheAsn: 2.334 ± 0.06	1.634PhePro: 1.634 ± 0.04	1.217PheGln: 1.217 ± 0.035	2.186PheArg: 2.186 ± 0.049	3.055PheSer: 3.055 ± 0.068	2.673PheThr: 2.673 ± 0.063	3.056PheVal: 3.056 ± 0.054	0.516PheTrp: 0.516 ± 0.025	1.865PheTyr: 1.865 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.49GlyAla: 4.49 ± 0.079	0.989GlyCys: 0.989 ± 0.038	3.758GlyAsp: 3.758 ± 0.072	3.904GlyGlu: 3.904 ± 0.068	3.083GlyPhe: 3.083 ± 0.067	4.865GlyGly: 4.865 ± 0.106	1.479GlyHis: 1.479 ± 0.041	4.972GlyIle: 4.972 ± 0.09	5.44GlyLys: 5.44 ± 0.086	5.739GlyLeu: 5.739 ± 0.081	2.307GlyMet: 2.307 ± 0.045	3.642GlyAsn: 3.642 ± 0.067	1.262GlyPro: 1.262 ± 0.043	2.443GlyGln: 2.443 ± 0.062	3.543GlyArg: 3.543 ± 0.066	4.151GlySer: 4.151 ± 0.08	4.317GlyThr: 4.317 ± 0.094	4.964GlyVal: 4.964 ± 0.084	1.045GlyTrp: 1.045 ± 0.035	3.299GlyTyr: 3.299 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.483HisAla: 1.483 ± 0.041	0.322HisCys: 0.322 ± 0.019	1.204HisAsp: 1.204 ± 0.04	1.175HisGlu: 1.175 ± 0.036	1.013HisPhe: 1.013 ± 0.032	1.479HisGly: 1.479 ± 0.04	0.669HisHis: 0.669 ± 0.031	1.471HisIle: 1.471 ± 0.041	1.052HisLys: 1.052 ± 0.031	1.849HisLeu: 1.849 ± 0.048	0.396HisMet: 0.396 ± 0.02	1.064HisAsn: 1.064 ± 0.033	1.029HisPro: 1.029 ± 0.035	0.848HisGln: 0.848 ± 0.033	1.156HisArg: 1.156 ± 0.042	1.165HisSer: 1.165 ± 0.032	1.154HisThr: 1.154 ± 0.037	1.389HisVal: 1.389 ± 0.041	0.282HisTrp: 0.282 ± 0.02	0.95HisTyr: 0.95 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	4.813IleAla: 4.813 ± 0.079	0.823IleCys: 0.823 ± 0.033	4.498IleAsp: 4.498 ± 0.075	3.887IleGlu: 3.887 ± 0.073	2.544IlePhe: 2.544 ± 0.056	4.382IleGly: 4.382 ± 0.076	1.266IleHis: 1.266 ± 0.043	4.156IleIle: 4.156 ± 0.083	3.91IleLys: 3.91 ± 0.07	5.063IleLeu: 5.063 ± 0.086	1.6IleMet: 1.6 ± 0.046	3.335IleAsn: 3.335 ± 0.068	2.808IlePro: 2.808 ± 0.05	1.974IleGln: 1.974 ± 0.047	3.34IleArg: 3.34 ± 0.062	4.155IleSer: 4.155 ± 0.067	3.873IleThr: 3.873 ± 0.065	4.257IleVal: 4.257 ± 0.086	0.674IleTrp: 0.674 ± 0.028	2.523IleTyr: 2.523 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.052LysAla: 5.052 ± 0.07	0.548LysCys: 0.548 ± 0.027	3.909LysAsp: 3.909 ± 0.074	4.404LysGlu: 4.404 ± 0.084	2.235LysPhe: 2.235 ± 0.046	4.351LysGly: 4.351 ± 0.078	1.378LysHis: 1.378 ± 0.036	4.047LysIle: 4.047 ± 0.063	4.658LysLys: 4.658 ± 0.093	5.311LysLeu: 5.311 ± 0.076	2.152LysMet: 2.152 ± 0.043	3.588LysAsn: 3.588 ± 0.074	2.355LysPro: 2.355 ± 0.052	2.773LysGln: 2.773 ± 0.058	3.281LysArg: 3.281 ± 0.066	3.423LysSer: 3.423 ± 0.058	3.994LysThr: 3.994 ± 0.068	4.099LysVal: 4.099 ± 0.068	0.852LysTrp: 0.852 ± 0.03	2.921LysTyr: 2.921 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.28LeuAla: 6.28 ± 0.091	1.281LeuCys: 1.281 ± 0.04	4.68LeuAsp: 4.68 ± 0.078	4.21LeuGlu: 4.21 ± 0.081	3.968LeuPhe: 3.968 ± 0.078	5.677LeuGly: 5.677 ± 0.094	1.833LeuHis: 1.833 ± 0.05	4.875LeuIle: 4.875 ± 0.083	5.654LeuLys: 5.654 ± 0.086	7.898LeuLeu: 7.898 ± 0.121	2.618LeuMet: 2.618 ± 0.051	4.436LeuAsn: 4.436 ± 0.08	3.818LeuPro: 3.818 ± 0.065	3.372LeuGln: 3.372 ± 0.063	4.615LeuArg: 4.615 ± 0.076	6.505LeuSer: 6.505 ± 0.093	5.24LeuThr: 5.24 ± 0.074	5.205LeuVal: 5.205 ± 0.091	1.078LeuTrp: 1.078 ± 0.037	3.457LeuTyr: 3.457 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.515MetAla: 2.515 ± 0.053	0.3MetCys: 0.3 ± 0.017	1.598MetAsp: 1.598 ± 0.045	1.847MetGlu: 1.847 ± 0.045	1.111MetPhe: 1.111 ± 0.044	2.088MetGly: 2.088 ± 0.048	0.568MetHis: 0.568 ± 0.026	1.656MetIle: 1.656 ± 0.042	2.649MetLys: 2.649 ± 0.059	2.7MetLeu: 2.7 ± 0.045	1.083MetMet: 1.083 ± 0.038	1.654MetAsn: 1.654 ± 0.043	1.29MetPro: 1.29 ± 0.035	1.257MetGln: 1.257 ± 0.038	1.546MetArg: 1.546 ± 0.04	1.773MetSer: 1.773 ± 0.048	1.791MetThr: 1.791 ± 0.045	1.823MetVal: 1.823 ± 0.046	0.273MetTrp: 0.273 ± 0.019	0.854MetTyr: 0.854 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.661AsnAla: 3.661 ± 0.067	0.573AsnCys: 0.573 ± 0.027	2.902AsnAsp: 2.902 ± 0.058	2.797AsnGlu: 2.797 ± 0.056	2.281AsnPhe: 2.281 ± 0.051	4.136AsnGly: 4.136 ± 0.081	1.142AsnHis: 1.142 ± 0.036	3.731AsnIle: 3.731 ± 0.081	3.277AsnLys: 3.277 ± 0.064	4.351AsnLeu: 4.351 ± 0.067	1.453AsnMet: 1.453 ± 0.037	2.856AsnAsn: 2.856 ± 0.07	2.426AsnPro: 2.426 ± 0.048	1.66AsnGln: 1.66 ± 0.048	2.67AsnArg: 2.67 ± 0.06	2.89AsnSer: 2.89 ± 0.057	2.904AsnThr: 2.904 ± 0.066	3.309AsnVal: 3.309 ± 0.062	0.647AsnTrp: 0.647 ± 0.03	2.374AsnTyr: 2.374 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.514ProAla: 2.514 ± 0.058	0.367ProCys: 0.367 ± 0.018	2.53ProAsp: 2.53 ± 0.063	2.846ProGlu: 2.846 ± 0.053	1.692ProPhe: 1.692 ± 0.044	2.333ProGly: 2.333 ± 0.052	0.774ProHis: 0.774 ± 0.033	2.259ProIle: 2.259 ± 0.054	2.197ProLys: 2.197 ± 0.042	3.093ProLeu: 3.093 ± 0.052	1.165ProMet: 1.165 ± 0.032	1.864ProAsn: 1.864 ± 0.043	0.731ProPro: 0.731 ± 0.03	1.439ProGln: 1.439 ± 0.041	1.499ProArg: 1.499 ± 0.04	2.231ProSer: 2.231 ± 0.051	2.245ProThr: 2.245 ± 0.049	2.661ProVal: 2.661 ± 0.059	0.506ProTrp: 0.506 ± 0.028	1.774ProTyr: 1.774 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.676GlnAla: 2.676 ± 0.062	0.33GlnCys: 0.33 ± 0.021	1.817GlnAsp: 1.817 ± 0.042	2.262GlnGlu: 2.262 ± 0.057	1.52GlnPhe: 1.52 ± 0.038	2.5GlnGly: 2.5 ± 0.06	0.783GlnHis: 0.783 ± 0.032	2.345GlnIle: 2.345 ± 0.055	2.476GlnLys: 2.476 ± 0.053	3.436GlnLeu: 3.436 ± 0.068	1.224GlnMet: 1.224 ± 0.041	1.923GlnAsn: 1.923 ± 0.052	1.342GlnPro: 1.342 ± 0.04	1.861GlnGln: 1.861 ± 0.053	1.97GlnArg: 1.97 ± 0.05	1.959GlnSer: 1.959 ± 0.053	2.067GlnThr: 2.067 ± 0.047	2.346GlnVal: 2.346 ± 0.049	0.551GlnTrp: 0.551 ± 0.025	1.535GlnTyr: 1.535 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.197ArgAla: 3.197 ± 0.07	0.528ArgCys: 0.528 ± 0.02	2.53ArgAsp: 2.53 ± 0.055	3.173ArgGlu: 3.173 ± 0.073	2.329ArgPhe: 2.329 ± 0.048	2.983ArgGly: 2.983 ± 0.06	1.251ArgHis: 1.251 ± 0.036	3.41ArgIle: 3.41 ± 0.06	3.598ArgLys: 3.598 ± 0.072	4.741ArgLeu: 4.741 ± 0.079	1.776ArgMet: 1.776 ± 0.046	2.719ArgAsn: 2.719 ± 0.062	1.759ArgPro: 1.759 ± 0.045	2.291ArgGln: 2.291 ± 0.051	2.853ArgArg: 2.853 ± 0.064	2.629ArgSer: 2.629 ± 0.055	2.615ArgThr: 2.615 ± 0.054	2.962ArgVal: 2.962 ± 0.06	0.756ArgTrp: 0.756 ± 0.028	2.357ArgTyr: 2.357 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.339SerAla: 4.339 ± 0.076	0.828SerCys: 0.828 ± 0.034	3.358SerAsp: 3.358 ± 0.068	3.18SerGlu: 3.18 ± 0.058	3.038SerPhe: 3.038 ± 0.065	4.357SerGly: 4.357 ± 0.081	1.259SerHis: 1.259 ± 0.036	3.933SerIle: 3.933 ± 0.061	3.531SerLys: 3.531 ± 0.058	5.62SerLeu: 5.62 ± 0.083	1.736SerMet: 1.736 ± 0.046	2.926SerAsn: 2.926 ± 0.067	2.35SerPro: 2.35 ± 0.042	2.114SerGln: 2.114 ± 0.047	2.831SerArg: 2.831 ± 0.051	3.762SerSer: 3.762 ± 0.085	3.288SerThr: 3.288 ± 0.069	4.189SerVal: 4.189 ± 0.069	0.789SerTrp: 0.789 ± 0.03	2.701SerTyr: 2.701 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.21ThrAla: 4.21 ± 0.078	0.595ThrCys: 0.595 ± 0.026	3.633ThrAsp: 3.633 ± 0.063	3.096ThrGlu: 3.096 ± 0.06	2.677ThrPhe: 2.677 ± 0.059	4.274ThrGly: 4.274 ± 0.082	1.154ThrHis: 1.154 ± 0.037	3.842ThrIle: 3.842 ± 0.069	3.108ThrLys: 3.108 ± 0.064	5.539ThrLeu: 5.539 ± 0.079	1.534ThrMet: 1.534 ± 0.043	2.652ThrAsn: 2.652 ± 0.056	2.826ThrPro: 2.826 ± 0.059	1.96ThrGln: 1.96 ± 0.053	2.437ThrArg: 2.437 ± 0.052	3.43ThrSer: 3.43 ± 0.067	3.562ThrThr: 3.562 ± 0.071	4.087ThrVal: 4.087 ± 0.074	0.77ThrTrp: 0.77 ± 0.035	2.443ThrTyr: 2.443 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.793ValAla: 4.793 ± 0.071	0.921ValCys: 0.921 ± 0.031	4.013ValAsp: 4.013 ± 0.07	3.965ValGlu: 3.965 ± 0.061	2.89ValPhe: 2.89 ± 0.056	4.547ValGly: 4.547 ± 0.067	1.155ValHis: 1.155 ± 0.032	4.025ValIle: 4.025 ± 0.072	4.268ValLys: 4.268 ± 0.072	5.553ValLeu: 5.553 ± 0.082	1.953ValMet: 1.953 ± 0.046	3.349ValAsn: 3.349 ± 0.062	2.538ValPro: 2.538 ± 0.061	2.003ValGln: 2.003 ± 0.053	3.269ValArg: 3.269 ± 0.061	4.608ValSer: 4.608 ± 0.075	3.859ValThr: 3.859 ± 0.072	5.012ValVal: 5.012 ± 0.098	0.791ValTrp: 0.791 ± 0.028	2.683ValTyr: 2.683 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.852TrpAla: 0.852 ± 0.031	0.171TrpCys: 0.171 ± 0.015	0.774TrpAsp: 0.774 ± 0.032	0.681TrpGlu: 0.681 ± 0.027	0.536TrpPhe: 0.536 ± 0.025	0.972TrpGly: 0.972 ± 0.034	0.303TrpHis: 0.303 ± 0.016	0.736TrpIle: 0.736 ± 0.031	0.917TrpLys: 0.917 ± 0.031	1.181TrpLeu: 1.181 ± 0.037	0.456TrpMet: 0.456 ± 0.02	0.848TrpAsn: 0.848 ± 0.032	0.316TrpPro: 0.316 ± 0.019	0.577TrpGln: 0.577 ± 0.026	0.68TrpArg: 0.68 ± 0.028	0.727TrpSer: 0.727 ± 0.028	0.755TrpThr: 0.755 ± 0.028	0.754TrpVal: 0.754 ± 0.027	0.237TrpTrp: 0.237 ± 0.015	0.546TrpTyr: 0.546 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.085TyrAla: 3.085 ± 0.062	0.548TyrCys: 0.548 ± 0.025	2.765TyrAsp: 2.765 ± 0.054	2.282TyrGlu: 2.282 ± 0.05	1.947TyrPhe: 1.947 ± 0.044	3.096TyrGly: 3.096 ± 0.069	0.989TyrHis: 0.989 ± 0.033	2.629TyrIle: 2.629 ± 0.055	2.498TyrLys: 2.498 ± 0.048	3.523TyrLeu: 3.523 ± 0.07	1.191TyrMet: 1.191 ± 0.042	2.461TyrAsn: 2.461 ± 0.071	1.695TyrPro: 1.695 ± 0.043	1.576TyrGln: 1.576 ± 0.035	2.34TyrArg: 2.34 ± 0.055	2.525TyrSer: 2.525 ± 0.057	2.639TyrThr: 2.639 ± 0.061	2.649TyrVal: 2.649 ± 0.058	0.554TyrTrp: 0.554 ± 0.024	2.089TyrTyr: 2.089 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2824 proteins (942703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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