Amino acid dipepetide frequency for Bromus-associated circular DNA virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.519AlaAla: 5.519 ± 1.895
1.104AlaCys: 1.104 ± 0.861
5.519AlaAsp: 5.519 ± 0.96
2.208AlaGlu: 2.208 ± 1.721
1.104AlaPhe: 1.104 ± 0.819
7.726AlaGly: 7.726 ± 0.666
1.104AlaHis: 1.104 ± 0.861
4.415AlaIle: 4.415 ± 2.04
4.415AlaLys: 4.415 ± 2.04
4.415AlaLeu: 4.415 ± 1.804
1.104AlaMet: 1.104 ± 1.163
2.208AlaAsn: 2.208 ± 1.637
1.104AlaPro: 1.104 ± 0.861
1.104AlaGln: 1.104 ± 0.861
7.726AlaArg: 7.726 ± 0.666
6.623AlaSer: 6.623 ± 1.945
5.519AlaThr: 5.519 ± 1.785
6.623AlaVal: 6.623 ± 2.524
0.0AlaTrp: 0.0 ± 0.0
1.104AlaTyr: 1.104 ± 0.861
0.0AlaXaa: 0.0 ± 0.0
Cys
2.208CysAla: 2.208 ± 1.297
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.104CysGlu: 1.104 ± 0.861
1.104CysPhe: 1.104 ± 0.861
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
2.208CysIle: 2.208 ± 1.309
0.0CysLys: 0.0 ± 0.0
2.208CysLeu: 2.208 ± 1.309
1.104CysMet: 1.104 ± 0.861
2.208CysAsn: 2.208 ± 1.721
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
2.208CysArg: 2.208 ± 1.721
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.208AspAla: 2.208 ± 1.3
1.104AspCys: 1.104 ± 1.163
4.415AspAsp: 4.415 ± 1.187
3.311AspGlu: 3.311 ± 2.378
1.104AspPhe: 1.104 ± 0.819
2.208AspGly: 2.208 ± 1.232
1.104AspHis: 1.104 ± 1.213
3.311AspIle: 3.311 ± 2.582
3.311AspLys: 3.311 ± 2.582
3.311AspLeu: 3.311 ± 2.359
1.104AspMet: 1.104 ± 1.163
2.208AspAsn: 2.208 ± 0.594
3.311AspPro: 3.311 ± 2.359
0.0AspGln: 0.0 ± 0.0
2.208AspArg: 2.208 ± 0.594
3.311AspSer: 3.311 ± 1.231
6.623AspThr: 6.623 ± 1.781
1.104AspVal: 1.104 ± 0.819
0.0AspTrp: 0.0 ± 0.0
3.311AspTyr: 3.311 ± 1.142
0.0AspXaa: 0.0 ± 0.0
Glu
3.311GluAla: 3.311 ± 1.885
1.104GluCys: 1.104 ± 0.861
0.0GluAsp: 0.0 ± 0.0
5.519GluGlu: 5.519 ± 3.346
4.415GluPhe: 4.415 ± 2.593
0.0GluGly: 0.0 ± 0.0
4.415GluHis: 4.415 ± 1.215
1.104GluIle: 1.104 ± 1.213
4.415GluLys: 4.415 ± 3.551
4.415GluLeu: 4.415 ± 1.266
0.0GluMet: 0.0 ± 1.027
0.0GluAsn: 0.0 ± 0.0
3.311GluPro: 3.311 ± 1.885
2.208GluGln: 2.208 ± 0.594
1.104GluArg: 1.104 ± 0.861
3.311GluSer: 3.311 ± 1.837
3.311GluThr: 3.311 ± 1.231
3.311GluVal: 3.311 ± 0.918
1.104GluTrp: 1.104 ± 0.861
1.104GluTyr: 1.104 ± 0.861
0.0GluXaa: 0.0 ± 0.0
Phe
3.311PheAla: 3.311 ± 1.142
0.0PheCys: 0.0 ± 0.0
4.415PheAsp: 4.415 ± 2.04
1.104PheGlu: 1.104 ± 0.861
0.0PhePhe: 0.0 ± 0.0
2.208PheGly: 2.208 ± 0.594
0.0PheHis: 0.0 ± 0.0
1.104PheIle: 1.104 ± 0.861
2.208PheLys: 2.208 ± 1.3
1.104PheLeu: 1.104 ± 0.819
1.104PheMet: 1.104 ± 0.819
1.104PheAsn: 1.104 ± 0.861
2.208PhePro: 2.208 ± 1.721
1.104PheGln: 1.104 ± 0.819
1.104PheArg: 1.104 ± 0.819
3.311PheSer: 3.311 ± 2.359
4.415PheThr: 4.415 ± 1.896
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
1.104PheTyr: 1.104 ± 0.819
0.0PheXaa: 0.0 ± 0.0
Gly
2.208GlyAla: 2.208 ± 1.232
0.0GlyCys: 0.0 ± 0.0
4.415GlyAsp: 4.415 ± 2.04
3.311GlyGlu: 3.311 ± 1.231
2.208GlyPhe: 2.208 ± 0.594
1.104GlyGly: 1.104 ± 0.819
1.104GlyHis: 1.104 ± 0.819
3.311GlyIle: 3.311 ± 1.739
5.519GlyLys: 5.519 ± 2.097
2.208GlyLeu: 2.208 ± 1.3
1.104GlyMet: 1.104 ± 0.861
3.311GlyAsn: 3.311 ± 0.906
4.415GlyPro: 4.415 ± 1.215
1.104GlyGln: 1.104 ± 0.819
2.208GlyArg: 2.208 ± 1.309
4.415GlySer: 4.415 ± 1.126
2.208GlyThr: 2.208 ± 0.594
3.311GlyVal: 3.311 ± 2.456
2.208GlyTrp: 2.208 ± 1.721
2.208GlyTyr: 2.208 ± 0.594
0.0GlyXaa: 0.0 ± 0.0
His
1.104HisAla: 1.104 ± 0.819
0.0HisCys: 0.0 ± 0.0
1.104HisAsp: 1.104 ± 1.163
1.104HisGlu: 1.104 ± 1.213
0.0HisPhe: 0.0 ± 0.0
1.104HisGly: 1.104 ± 0.819
0.0HisHis: 0.0 ± 0.0
4.415HisIle: 4.415 ± 1.126
0.0HisLys: 0.0 ± 0.0
2.208HisLeu: 2.208 ± 0.594
2.208HisMet: 2.208 ± 0.594
2.208HisAsn: 2.208 ± 1.297
1.104HisPro: 1.104 ± 1.163
0.0HisGln: 0.0 ± 0.0
3.311HisArg: 3.311 ± 0.918
1.104HisSer: 1.104 ± 0.819
0.0HisThr: 0.0 ± 0.0
2.208HisVal: 2.208 ± 0.594
2.208HisTrp: 2.208 ± 1.721
1.104HisTyr: 1.104 ± 0.819
0.0HisXaa: 0.0 ± 0.0
Ile
1.104IleAla: 1.104 ± 0.861
0.0IleCys: 0.0 ± 0.0
1.104IleAsp: 1.104 ± 0.861
5.519IleGlu: 5.519 ± 3.346
1.104IlePhe: 1.104 ± 0.861
1.104IleGly: 1.104 ± 1.163
0.0IleHis: 0.0 ± 0.0
2.208IleIle: 2.208 ± 1.297
1.104IleLys: 1.104 ± 0.861
4.415IleLeu: 4.415 ± 2.325
0.0IleMet: 0.0 ± 0.0
2.208IleAsn: 2.208 ± 0.594
3.311IlePro: 3.311 ± 1.142
2.208IleGln: 2.208 ± 1.232
3.311IleArg: 3.311 ± 2.321
4.415IleSer: 4.415 ± 1.16
4.415IleThr: 4.415 ± 2.423
4.415IleVal: 4.415 ± 2.622
1.104IleTrp: 1.104 ± 1.213
3.311IleTyr: 3.311 ± 1.142
0.0IleXaa: 0.0 ± 0.0
Lys
4.415LysAla: 4.415 ± 1.187
1.104LysCys: 1.104 ± 0.861
3.311LysAsp: 3.311 ± 1.52
5.519LysGlu: 5.519 ± 4.566
2.208LysPhe: 2.208 ± 0.594
9.934LysGly: 9.934 ± 5.266
3.311LysHis: 3.311 ± 1.739
4.415LysIle: 4.415 ± 1.896
2.208LysLys: 2.208 ± 1.721
3.311LysLeu: 3.311 ± 0.906
0.0LysMet: 0.0 ± 0.0
2.208LysAsn: 2.208 ± 1.637
2.208LysPro: 2.208 ± 0.594
2.208LysGln: 2.208 ± 2.325
6.623LysArg: 6.623 ± 1.812
6.623LysSer: 6.623 ± 0.405
1.104LysThr: 1.104 ± 0.861
1.104LysVal: 1.104 ± 1.163
1.104LysTrp: 1.104 ± 0.861
3.311LysTyr: 3.311 ± 1.231
0.0LysXaa: 0.0 ± 0.0
Leu
4.415LeuAla: 4.415 ± 1.16
1.104LeuCys: 1.104 ± 0.861
4.415LeuAsp: 4.415 ± 3.544
2.208LeuGlu: 2.208 ± 1.232
3.311LeuPhe: 3.311 ± 1.231
3.311LeuGly: 3.311 ± 1.231
1.104LeuHis: 1.104 ± 1.213
4.415LeuIle: 4.415 ± 1.266
4.415LeuLys: 4.415 ± 2.423
4.415LeuLeu: 4.415 ± 2.419
1.104LeuMet: 1.104 ± 0.819
2.208LeuAsn: 2.208 ± 1.232
4.415LeuPro: 4.415 ± 2.419
4.415LeuGln: 4.415 ± 0.985
6.623LeuArg: 6.623 ± 1.815
9.934LeuSer: 9.934 ± 3.94
5.519LeuThr: 5.519 ± 1.106
9.934LeuVal: 9.934 ± 2.584
1.104LeuTrp: 1.104 ± 1.213
2.208LeuTyr: 2.208 ± 1.637
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.104MetGly: 1.104 ± 0.861
0.0MetHis: 0.0 ± 0.0
1.104MetIle: 1.104 ± 1.163
0.0MetLys: 0.0 ± 0.0
1.104MetLeu: 1.104 ± 1.163
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.104MetPro: 1.104 ± 0.861
1.104MetGln: 1.104 ± 0.819
1.104MetArg: 1.104 ± 0.819
3.311MetSer: 3.311 ± 1.482
3.311MetThr: 3.311 ± 0.906
1.104MetVal: 1.104 ± 0.819
0.0MetTrp: 0.0 ± 0.0
1.104MetTyr: 1.104 ± 0.861
0.0MetXaa: 0.0 ± 0.0
Asn
2.208AsnAla: 2.208 ± 0.594
0.0AsnCys: 0.0 ± 0.0
2.208AsnAsp: 2.208 ± 0.594
1.104AsnGlu: 1.104 ± 0.861
2.208AsnPhe: 2.208 ± 1.637
0.0AsnGly: 0.0 ± 0.0
2.208AsnHis: 2.208 ± 1.637
2.208AsnIle: 2.208 ± 1.3
4.415AsnLys: 4.415 ± 1.896
2.208AsnLeu: 2.208 ± 1.297
0.0AsnMet: 0.0 ± 0.0
2.208AsnAsn: 2.208 ± 1.637
2.208AsnPro: 2.208 ± 0.594
2.208AsnGln: 2.208 ± 1.637
0.0AsnArg: 0.0 ± 0.0
8.83AsnSer: 8.83 ± 3.0
4.415AsnThr: 4.415 ± 2.423
5.519AsnVal: 5.519 ± 1.731
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
1.104ProAla: 1.104 ± 0.861
0.0ProCys: 0.0 ± 0.0
1.104ProAsp: 1.104 ± 1.213
2.208ProGlu: 2.208 ± 1.297
2.208ProPhe: 2.208 ± 0.594
3.311ProGly: 3.311 ± 1.482
0.0ProHis: 0.0 ± 0.0
3.311ProIle: 3.311 ± 1.482
4.415ProLys: 4.415 ± 2.622
6.623ProLeu: 6.623 ± 3.813
1.104ProMet: 1.104 ± 0.732
0.0ProAsn: 0.0 ± 0.0
7.726ProPro: 7.726 ± 3.784
2.208ProGln: 2.208 ± 0.594
2.208ProArg: 2.208 ± 0.594
7.726ProSer: 7.726 ± 2.961
4.415ProThr: 4.415 ± 1.126
3.311ProVal: 3.311 ± 2.378
1.104ProTrp: 1.104 ± 0.861
1.104ProTyr: 1.104 ± 0.861
0.0ProXaa: 0.0 ± 0.0
Gln
5.519GlnAla: 5.519 ± 1.748
1.104GlnCys: 1.104 ± 0.861
1.104GlnAsp: 1.104 ± 1.213
1.104GlnGlu: 1.104 ± 0.861
1.104GlnPhe: 1.104 ± 1.213
3.311GlnGly: 3.311 ± 1.142
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.104GlnLys: 1.104 ± 0.861
3.311GlnLeu: 3.311 ± 0.906
1.104GlnMet: 1.104 ± 0.752
1.104GlnAsn: 1.104 ± 0.819
1.104GlnPro: 1.104 ± 1.213
0.0GlnGln: 0.0 ± 0.0
4.415GlnArg: 4.415 ± 1.126
5.519GlnSer: 5.519 ± 1.785
3.311GlnThr: 3.311 ± 1.739
1.104GlnVal: 1.104 ± 0.861
1.104GlnTrp: 1.104 ± 0.861
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.415ArgAla: 4.415 ± 2.412
1.104ArgCys: 1.104 ± 1.213
2.208ArgAsp: 2.208 ± 1.309
5.519ArgGlu: 5.519 ± 1.895
3.311ArgPhe: 3.311 ± 2.456
2.208ArgGly: 2.208 ± 1.721
3.311ArgHis: 3.311 ± 1.142
2.208ArgIle: 2.208 ± 1.309
11.038ArgLys: 11.038 ± 4.193
6.623ArgLeu: 6.623 ± 1.837
0.0ArgMet: 0.0 ± 0.0
4.415ArgAsn: 4.415 ± 1.896
6.623ArgPro: 6.623 ± 1.815
0.0ArgGln: 0.0 ± 0.0
11.038ArgArg: 11.038 ± 7.19
6.623ArgSer: 6.623 ± 2.487
2.208ArgThr: 2.208 ± 0.594
3.311ArgVal: 3.311 ± 2.456
2.208ArgTrp: 2.208 ± 0.594
2.208ArgTyr: 2.208 ± 1.3
0.0ArgXaa: 0.0 ± 0.0
Ser
6.623SerAla: 6.623 ± 4.163
0.0SerCys: 0.0 ± 0.0
4.415SerAsp: 4.415 ± 2.48
5.519SerGlu: 5.519 ± 2.565
4.415SerPhe: 4.415 ± 1.187
1.104SerGly: 1.104 ± 0.861
3.311SerHis: 3.311 ± 0.906
4.415SerIle: 4.415 ± 2.558
3.311SerLys: 3.311 ± 1.142
9.934SerLeu: 9.934 ± 2.931
0.0SerMet: 0.0 ± 0.0
2.208SerAsn: 2.208 ± 1.3
6.623SerPro: 6.623 ± 2.893
3.311SerGln: 3.311 ± 0.918
13.245SerArg: 13.245 ± 5.07
8.83SerSer: 8.83 ± 1.373
6.623SerThr: 6.623 ± 2.965
7.726SerVal: 7.726 ± 3.572
0.0SerTrp: 0.0 ± 0.0
2.208SerTyr: 2.208 ± 0.594
0.0SerXaa: 0.0 ± 0.0
Thr
5.519ThrAla: 5.519 ± 0.997
2.208ThrCys: 2.208 ± 1.309
4.415ThrAsp: 4.415 ± 1.187
0.0ThrGlu: 0.0 ± 0.0
0.0ThrPhe: 0.0 ± 0.0
7.726ThrGly: 7.726 ± 4.738
3.311ThrHis: 3.311 ± 1.885
1.104ThrIle: 1.104 ± 1.163
3.311ThrLys: 3.311 ± 0.906
6.623ThrLeu: 6.623 ± 3.064
1.104ThrMet: 1.104 ± 0.819
6.623ThrAsn: 6.623 ± 2.524
1.104ThrPro: 1.104 ± 0.819
7.726ThrGln: 7.726 ± 1.975
5.519ThrArg: 5.519 ± 2.689
3.311ThrSer: 3.311 ± 0.906
8.83ThrThr: 8.83 ± 3.103
4.415ThrVal: 4.415 ± 1.896
1.104ThrTrp: 1.104 ± 0.861
3.311ThrTyr: 3.311 ± 2.456
0.0ThrXaa: 0.0 ± 0.0
Val
8.83ValAla: 8.83 ± 2.32
1.104ValCys: 1.104 ± 0.861
1.104ValAsp: 1.104 ± 0.861
2.208ValGlu: 2.208 ± 0.594
1.104ValPhe: 1.104 ± 0.861
4.415ValGly: 4.415 ± 1.126
1.104ValHis: 1.104 ± 0.861
1.104ValIle: 1.104 ± 0.819
4.415ValLys: 4.415 ± 1.998
7.726ValLeu: 7.726 ± 0.666
1.104ValMet: 1.104 ± 1.163
4.415ValAsn: 4.415 ± 1.896
3.311ValPro: 3.311 ± 2.56
1.104ValGln: 1.104 ± 0.819
3.311ValArg: 3.311 ± 1.142
4.415ValSer: 4.415 ± 2.376
8.83ValThr: 8.83 ± 3.793
3.311ValVal: 3.311 ± 1.142
0.0ValTrp: 0.0 ± 0.0
2.208ValTyr: 2.208 ± 0.594
0.0ValXaa: 0.0 ± 0.0
Trp
3.311TrpAla: 3.311 ± 1.231
2.208TrpCys: 2.208 ± 1.721
1.104TrpAsp: 1.104 ± 0.861
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
2.208TrpLys: 2.208 ± 1.721
0.0TrpLeu: 0.0 ± 0.0
1.104TrpMet: 1.104 ± 0.929
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
2.208TrpGln: 2.208 ± 1.721
1.104TrpArg: 1.104 ± 0.861
1.104TrpSer: 1.104 ± 1.213
0.0TrpThr: 0.0 ± 0.0
2.208TrpVal: 2.208 ± 1.721
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.311TyrAla: 3.311 ± 1.142
1.104TyrCys: 1.104 ± 0.861
2.208TyrAsp: 2.208 ± 1.637
0.0TyrGlu: 0.0 ± 0.0
0.0TyrPhe: 0.0 ± 0.0
0.0TyrGly: 0.0 ± 0.0
1.104TyrHis: 1.104 ± 0.819
0.0TyrIle: 0.0 ± 0.0
4.415TyrLys: 4.415 ± 1.896
4.415TyrLeu: 4.415 ± 2.04
0.0TyrMet: 0.0 ± 0.0
3.311TyrAsn: 3.311 ± 2.456
0.0TyrPro: 0.0 ± 0.0
2.208TyrGln: 2.208 ± 0.594
2.208TyrArg: 2.208 ± 1.297
1.104TyrSer: 1.104 ± 0.819
2.208TyrThr: 2.208 ± 1.637
1.104TyrVal: 1.104 ± 0.861
2.208TyrTrp: 2.208 ± 1.721
1.104TyrTyr: 1.104 ± 0.819
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski