Amino acid dipepetide frequency for Candidatus Enterovibrio luxaltus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.421AlaAla: 6.421 ± 0.143
1.006AlaCys: 1.006 ± 0.054
3.694AlaAsp: 3.694 ± 0.091
4.559AlaGlu: 4.559 ± 0.099
2.966AlaPhe: 2.966 ± 0.09
5.125AlaGly: 5.125 ± 0.135
1.467AlaHis: 1.467 ± 0.049
6.372AlaIle: 6.372 ± 0.144
4.72AlaLys: 4.72 ± 0.109
8.478AlaLeu: 8.478 ± 0.154
2.644AlaMet: 2.644 ± 0.078
3.392AlaAsn: 3.392 ± 0.085
2.237AlaPro: 2.237 ± 0.074
3.109AlaGln: 3.109 ± 0.091
3.531AlaArg: 3.531 ± 0.099
4.861AlaSer: 4.861 ± 0.107
3.95AlaThr: 3.95 ± 0.093
5.193AlaVal: 5.193 ± 0.125
0.809AlaTrp: 0.809 ± 0.045
2.354AlaTyr: 2.354 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.772CysAla: 0.772 ± 0.048
0.197CysCys: 0.197 ± 0.024
0.634CysAsp: 0.634 ± 0.041
0.604CysGlu: 0.604 ± 0.04
0.578CysPhe: 0.578 ± 0.04
0.96CysGly: 0.96 ± 0.052
0.378CysHis: 0.378 ± 0.034
1.182CysIle: 1.182 ± 0.059
0.648CysLys: 0.648 ± 0.042
1.116CysLeu: 1.116 ± 0.045
0.307CysMet: 0.307 ± 0.026
0.497CysAsn: 0.497 ± 0.03
0.636CysPro: 0.636 ± 0.044
0.482CysGln: 0.482 ± 0.038
0.58CysArg: 0.58 ± 0.033
0.892CysSer: 0.892 ± 0.044
0.517CysThr: 0.517 ± 0.038
0.87CysVal: 0.87 ± 0.05
0.173CysTrp: 0.173 ± 0.019
0.465CysTyr: 0.465 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
4.113AspAla: 4.113 ± 0.097
0.56AspCys: 0.56 ± 0.038
2.444AspAsp: 2.444 ± 0.096
3.251AspGlu: 3.251 ± 0.104
2.032AspPhe: 2.032 ± 0.071
3.619AspGly: 3.619 ± 0.099
0.977AspHis: 0.977 ± 0.047
4.384AspIle: 4.384 ± 0.104
2.778AspLys: 2.778 ± 0.088
4.501AspLeu: 4.501 ± 0.111
1.496AspMet: 1.496 ± 0.07
2.359AspAsn: 2.359 ± 0.086
1.681AspPro: 1.681 ± 0.074
1.486AspGln: 1.486 ± 0.07
2.127AspArg: 2.127 ± 0.077
2.953AspSer: 2.953 ± 0.089
2.702AspThr: 2.702 ± 0.088
3.714AspVal: 3.714 ± 0.102
0.636AspTrp: 0.636 ± 0.036
1.733AspTyr: 1.733 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.506GluAla: 4.506 ± 0.107
0.587GluCys: 0.587 ± 0.041
2.447GluAsp: 2.447 ± 0.086
3.139GluGlu: 3.139 ± 0.101
2.125GluPhe: 2.125 ± 0.073
3.268GluGly: 3.268 ± 0.089
1.445GluHis: 1.445 ± 0.064
4.306GluIle: 4.306 ± 0.12
3.57GluLys: 3.57 ± 0.098
6.107GluLeu: 6.107 ± 0.113
1.891GluMet: 1.891 ± 0.064
2.576GluAsn: 2.576 ± 0.071
1.725GluPro: 1.725 ± 0.074
2.932GluGln: 2.932 ± 0.097
3.304GluArg: 3.304 ± 0.099
3.0GluSer: 3.0 ± 0.099
3.066GluThr: 3.066 ± 0.088
4.116GluVal: 4.116 ± 0.123
0.697GluTrp: 0.697 ± 0.047
1.708GluTyr: 1.708 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.949PheAla: 2.949 ± 0.089
0.526PheCys: 0.526 ± 0.039
2.383PheAsp: 2.383 ± 0.078
2.2PheGlu: 2.2 ± 0.075
1.835PhePhe: 1.835 ± 0.086
2.81PheGly: 2.81 ± 0.098
0.926PheHis: 0.926 ± 0.05
3.589PheIle: 3.589 ± 0.099
2.649PheLys: 2.649 ± 0.077
3.399PheLeu: 3.399 ± 0.09
1.14PheMet: 1.14 ± 0.054
2.442PheAsn: 2.442 ± 0.073
1.289PhePro: 1.289 ± 0.063
1.235PheGln: 1.235 ± 0.051
1.674PheArg: 1.674 ± 0.067
3.229PheSer: 3.229 ± 0.096
2.551PheThr: 2.551 ± 0.073
2.432PheVal: 2.432 ± 0.08
0.524PheTrp: 0.524 ± 0.036
1.209PheTyr: 1.209 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.601GlyAla: 4.601 ± 0.122
0.821GlyCys: 0.821 ± 0.042
3.163GlyAsp: 3.163 ± 0.083
4.021GlyGlu: 4.021 ± 0.101
2.893GlyPhe: 2.893 ± 0.079
4.511GlyGly: 4.511 ± 0.141
1.655GlyHis: 1.655 ± 0.069
5.261GlyIle: 5.261 ± 0.127
4.155GlyLys: 4.155 ± 0.118
6.465GlyLeu: 6.465 ± 0.135
2.152GlyMet: 2.152 ± 0.07
2.824GlyAsn: 2.824 ± 0.096
1.538GlyPro: 1.538 ± 0.063
2.512GlyGln: 2.512 ± 0.077
3.061GlyArg: 3.061 ± 0.1
3.819GlySer: 3.819 ± 0.108
3.741GlyThr: 3.741 ± 0.097
4.433GlyVal: 4.433 ± 0.111
0.772GlyTrp: 0.772 ± 0.055
2.193GlyTyr: 2.193 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.84HisAla: 1.84 ± 0.076
0.39HisCys: 0.39 ± 0.033
1.201HisAsp: 1.201 ± 0.06
1.25HisGlu: 1.25 ± 0.06
1.002HisPhe: 1.002 ± 0.053
1.723HisGly: 1.723 ± 0.056
0.668HisHis: 0.668 ± 0.042
1.759HisIle: 1.759 ± 0.069
1.255HisLys: 1.255 ± 0.057
2.59HisLeu: 2.59 ± 0.089
0.636HisMet: 0.636 ± 0.04
1.167HisAsn: 1.167 ± 0.056
1.092HisPro: 1.092 ± 0.052
1.004HisGln: 1.004 ± 0.055
1.153HisArg: 1.153 ± 0.055
1.447HisSer: 1.447 ± 0.056
1.148HisThr: 1.148 ± 0.051
1.438HisVal: 1.438 ± 0.056
0.314HisTrp: 0.314 ± 0.026
1.097HisTyr: 1.097 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
6.55IleAla: 6.55 ± 0.119
0.882IleCys: 0.882 ± 0.049
4.701IleAsp: 4.701 ± 0.108
4.71IleGlu: 4.71 ± 0.119
3.027IlePhe: 3.027 ± 0.093
5.171IleGly: 5.171 ± 0.122
1.769IleHis: 1.769 ± 0.065
5.953IleIle: 5.953 ± 0.127
4.788IleLys: 4.788 ± 0.107
6.497IleLeu: 6.497 ± 0.131
2.11IleMet: 2.11 ± 0.075
4.749IleAsn: 4.749 ± 0.116
2.88IlePro: 2.88 ± 0.088
2.883IleGln: 2.883 ± 0.082
3.77IleArg: 3.77 ± 0.093
5.371IleSer: 5.371 ± 0.126
4.586IleThr: 4.586 ± 0.12
4.735IleVal: 4.735 ± 0.119
0.643IleTrp: 0.643 ± 0.04
2.122IleTyr: 2.122 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
4.386LysAla: 4.386 ± 0.113
0.629LysCys: 0.629 ± 0.039
2.427LysAsp: 2.427 ± 0.074
3.414LysGlu: 3.414 ± 0.096
2.249LysPhe: 2.249 ± 0.086
3.575LysGly: 3.575 ± 0.096
1.484LysHis: 1.484 ± 0.058
4.547LysIle: 4.547 ± 0.109
4.491LysLys: 4.491 ± 0.119
6.27LysLeu: 6.27 ± 0.126
1.976LysMet: 1.976 ± 0.072
3.665LysAsn: 3.665 ± 0.094
2.032LysPro: 2.032 ± 0.078
3.131LysGln: 3.131 ± 0.086
3.594LysArg: 3.594 ± 0.104
3.343LysSer: 3.343 ± 0.09
3.702LysThr: 3.702 ± 0.102
3.984LysVal: 3.984 ± 0.106
0.531LysTrp: 0.531 ± 0.046
1.664LysTyr: 1.664 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
8.473LeuAla: 8.473 ± 0.158
1.243LeuCys: 1.243 ± 0.052
5.032LeuAsp: 5.032 ± 0.125
5.405LeuGlu: 5.405 ± 0.118
4.028LeuPhe: 4.028 ± 0.117
6.092LeuGly: 6.092 ± 0.138
2.478LeuHis: 2.478 ± 0.081
6.999LeuIle: 6.999 ± 0.122
6.19LeuLys: 6.19 ± 0.117
10.244LeuLeu: 10.244 ± 0.192
3.085LeuMet: 3.085 ± 0.086
5.524LeuAsn: 5.524 ± 0.13
4.525LeuPro: 4.525 ± 0.111
3.626LeuGln: 3.626 ± 0.1
5.195LeuArg: 5.195 ± 0.101
7.893LeuSer: 7.893 ± 0.156
6.021LeuThr: 6.021 ± 0.116
6.611LeuVal: 6.611 ± 0.137
0.97LeuTrp: 0.97 ± 0.049
2.517LeuTyr: 2.517 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.527MetAla: 2.527 ± 0.086
0.292MetCys: 0.292 ± 0.027
1.289MetAsp: 1.289 ± 0.06
1.352MetGlu: 1.352 ± 0.053
1.119MetPhe: 1.119 ± 0.047
1.84MetGly: 1.84 ± 0.068
0.76MetHis: 0.76 ± 0.042
2.244MetIle: 2.244 ± 0.08
1.937MetLys: 1.937 ± 0.072
3.341MetLeu: 3.341 ± 0.09
0.919MetMet: 0.919 ± 0.048
1.491MetAsn: 1.491 ± 0.065
1.511MetPro: 1.511 ± 0.048
1.201MetGln: 1.201 ± 0.054
1.482MetArg: 1.482 ± 0.059
2.171MetSer: 2.171 ± 0.08
1.825MetThr: 1.825 ± 0.066
2.391MetVal: 2.391 ± 0.085
0.214MetTrp: 0.214 ± 0.023
0.58MetTyr: 0.58 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.738AsnAla: 3.738 ± 0.113
0.599AsnCys: 0.599 ± 0.043
2.293AsnAsp: 2.293 ± 0.083
2.888AsnGlu: 2.888 ± 0.093
2.157AsnPhe: 2.157 ± 0.082
3.158AsnGly: 3.158 ± 0.095
1.179AsnHis: 1.179 ± 0.055
4.394AsnIle: 4.394 ± 0.119
3.317AsnLys: 3.317 ± 0.085
4.645AsnLeu: 4.645 ± 0.101
1.43AsnMet: 1.43 ± 0.061
2.715AsnAsn: 2.715 ± 0.102
1.859AsnPro: 1.859 ± 0.063
2.01AsnGln: 2.01 ± 0.072
2.286AsnArg: 2.286 ± 0.08
2.888AsnSer: 2.888 ± 0.09
2.746AsnThr: 2.746 ± 0.086
3.789AsnVal: 3.789 ± 0.098
0.614AsnTrp: 0.614 ± 0.038
1.472AsnTyr: 1.472 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.466ProAla: 2.466 ± 0.073
0.434ProCys: 0.434 ± 0.036
1.928ProAsp: 1.928 ± 0.073
2.403ProGlu: 2.403 ± 0.077
1.533ProPhe: 1.533 ± 0.067
1.859ProGly: 1.859 ± 0.063
1.084ProHis: 1.084 ± 0.052
2.427ProIle: 2.427 ± 0.076
2.062ProLys: 2.062 ± 0.081
3.989ProLeu: 3.989 ± 0.094
0.975ProMet: 0.975 ± 0.053
1.745ProAsn: 1.745 ± 0.066
1.019ProPro: 1.019 ± 0.046
1.294ProGln: 1.294 ± 0.06
1.348ProArg: 1.348 ± 0.063
2.186ProSer: 2.186 ± 0.075
1.959ProThr: 1.959 ± 0.066
2.819ProVal: 2.819 ± 0.09
0.392ProTrp: 0.392 ± 0.028
1.194ProTyr: 1.194 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.0GlnAla: 3.0 ± 0.08
0.514GlnCys: 0.514 ± 0.035
1.574GlnAsp: 1.574 ± 0.06
2.052GlnGlu: 2.052 ± 0.068
1.625GlnPhe: 1.625 ± 0.061
2.403GlnGly: 2.403 ± 0.082
1.204GlnHis: 1.204 ± 0.052
2.888GlnIle: 2.888 ± 0.083
2.264GlnLys: 2.264 ± 0.084
4.518GlnLeu: 4.518 ± 0.117
1.101GlnMet: 1.101 ± 0.055
1.772GlnAsn: 1.772 ± 0.071
1.374GlnPro: 1.374 ± 0.05
2.015GlnGln: 2.015 ± 0.083
2.261GlnArg: 2.261 ± 0.072
2.313GlnSer: 2.313 ± 0.087
2.415GlnThr: 2.415 ± 0.073
2.8GlnVal: 2.8 ± 0.077
0.497GlnTrp: 0.497 ± 0.043
1.367GlnTyr: 1.367 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
3.643ArgAla: 3.643 ± 0.103
0.58ArgCys: 0.58 ± 0.04
2.522ArgAsp: 2.522 ± 0.085
2.905ArgGlu: 2.905 ± 0.081
2.166ArgPhe: 2.166 ± 0.073
2.975ArgGly: 2.975 ± 0.079
1.235ArgHis: 1.235 ± 0.052
4.06ArgIle: 4.06 ± 0.107
2.739ArgLys: 2.739 ± 0.093
5.171ArgLeu: 5.171 ± 0.115
1.477ArgMet: 1.477 ± 0.061
2.203ArgAsn: 2.203 ± 0.076
1.574ArgPro: 1.574 ± 0.062
2.176ArgGln: 2.176 ± 0.082
2.827ArgArg: 2.827 ± 0.091
2.724ArgSer: 2.724 ± 0.077
2.488ArgThr: 2.488 ± 0.083
3.429ArgVal: 3.429 ± 0.102
0.565ArgTrp: 0.565 ± 0.035
1.552ArgTyr: 1.552 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.52SerAla: 4.52 ± 0.105
1.155SerCys: 1.155 ± 0.062
3.229SerAsp: 3.229 ± 0.098
3.436SerGlu: 3.436 ± 0.083
2.542SerPhe: 2.542 ± 0.086
4.701SerGly: 4.701 ± 0.123
1.625SerHis: 1.625 ± 0.066
4.776SerIle: 4.776 ± 0.107
3.789SerLys: 3.789 ± 0.098
6.787SerLeu: 6.787 ± 0.162
2.254SerMet: 2.254 ± 0.083
3.046SerAsn: 3.046 ± 0.078
2.027SerPro: 2.027 ± 0.066
2.349SerGln: 2.349 ± 0.075
2.922SerArg: 2.922 ± 0.086
4.084SerSer: 4.084 ± 0.129
3.404SerThr: 3.404 ± 0.096
4.379SerVal: 4.379 ± 0.096
0.646SerTrp: 0.646 ± 0.038
2.023SerTyr: 2.023 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
4.184ThrAla: 4.184 ± 0.093
0.675ThrCys: 0.675 ± 0.039
2.849ThrAsp: 2.849 ± 0.08
3.087ThrGlu: 3.087 ± 0.091
2.383ThrPhe: 2.383 ± 0.081
3.94ThrGly: 3.94 ± 0.108
1.348ThrHis: 1.348 ± 0.06
4.484ThrIle: 4.484 ± 0.112
3.385ThrLys: 3.385 ± 0.106
6.25ThrLeu: 6.25 ± 0.134
1.547ThrMet: 1.547 ± 0.057
2.532ThrAsn: 2.532 ± 0.085
2.215ThrPro: 2.215 ± 0.076
2.157ThrGln: 2.157 ± 0.08
2.556ThrArg: 2.556 ± 0.077
3.2ThrSer: 3.2 ± 0.092
3.078ThrThr: 3.078 ± 0.1
4.201ThrVal: 4.201 ± 0.101
0.519ThrTrp: 0.519 ± 0.037
1.465ThrTyr: 1.465 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.329ValAla: 5.329 ± 0.125
0.792ValCys: 0.792 ± 0.048
3.65ValAsp: 3.65 ± 0.105
3.84ValGlu: 3.84 ± 0.105
2.973ValPhe: 2.973 ± 0.086
4.204ValGly: 4.204 ± 0.103
1.331ValHis: 1.331 ± 0.054
5.488ValIle: 5.488 ± 0.121
4.277ValLys: 4.277 ± 0.098
7.047ValLeu: 7.047 ± 0.154
2.237ValMet: 2.237 ± 0.068
3.502ValAsn: 3.502 ± 0.094
2.408ValPro: 2.408 ± 0.08
2.188ValGln: 2.188 ± 0.081
3.126ValArg: 3.126 ± 0.091
4.601ValSer: 4.601 ± 0.131
4.245ValThr: 4.245 ± 0.102
4.808ValVal: 4.808 ± 0.127
0.648ValTrp: 0.648 ± 0.039
1.852ValTyr: 1.852 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.641TrpAla: 0.641 ± 0.035
0.168TrpCys: 0.168 ± 0.02
0.48TrpAsp: 0.48 ± 0.037
0.485TrpGlu: 0.485 ± 0.039
0.507TrpPhe: 0.507 ± 0.04
0.526TrpGly: 0.526 ± 0.037
0.327TrpHis: 0.327 ± 0.031
0.712TrpIle: 0.712 ± 0.042
0.612TrpLys: 0.612 ± 0.035
1.555TrpLeu: 1.555 ± 0.066
0.341TrpMet: 0.341 ± 0.029
0.541TrpAsn: 0.541 ± 0.039
0.351TrpPro: 0.351 ± 0.03
0.677TrpGln: 0.677 ± 0.048
0.617TrpArg: 0.617 ± 0.04
0.5TrpSer: 0.5 ± 0.038
0.441TrpThr: 0.441 ± 0.035
0.66TrpVal: 0.66 ± 0.04
0.146TrpTrp: 0.146 ± 0.022
0.341TrpTyr: 0.341 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.23TyrAla: 2.23 ± 0.077
0.436TyrCys: 0.436 ± 0.032
1.608TyrAsp: 1.608 ± 0.058
1.511TyrGlu: 1.511 ± 0.063
1.255TyrPhe: 1.255 ± 0.061
2.13TyrGly: 2.13 ± 0.074
0.833TyrHis: 0.833 ± 0.049
2.074TyrIle: 2.074 ± 0.075
1.472TyrLys: 1.472 ± 0.061
3.183TyrLeu: 3.183 ± 0.097
0.765TyrMet: 0.765 ± 0.039
1.435TyrAsn: 1.435 ± 0.056
1.14TyrPro: 1.14 ± 0.06
1.489TyrGln: 1.489 ± 0.059
1.599TyrArg: 1.599 ± 0.06
2.22TyrSer: 2.22 ± 0.081
1.469TyrThr: 1.469 ± 0.068
1.745TyrVal: 1.745 ± 0.062
0.314TyrTrp: 0.314 ± 0.029
1.082TyrTyr: 1.082 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1986 proteins (410369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski