Amino acid dipepetide frequency for Roseobacter virus SIO1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.024AlaAla: 12.024 ± 3.164
0.505AlaCys: 0.505 ± 0.258
5.86AlaAsp: 5.86 ± 0.977
6.163AlaGlu: 6.163 ± 1.04
2.728AlaPhe: 2.728 ± 0.395
7.174AlaGly: 7.174 ± 0.858
1.111AlaHis: 1.111 ± 0.365
3.739AlaIle: 3.739 ± 0.696
6.467AlaLys: 6.467 ± 0.794
6.265AlaLeu: 6.265 ± 0.924
2.223AlaMet: 2.223 ± 0.425
3.739AlaAsn: 3.739 ± 0.587
2.122AlaPro: 2.122 ± 0.328
3.637AlaGln: 3.637 ± 0.602
4.244AlaArg: 4.244 ± 0.874
8.386AlaSer: 8.386 ± 2.376
8.588AlaThr: 8.588 ± 2.766
5.961AlaVal: 5.961 ± 0.756
1.01AlaTrp: 1.01 ± 0.395
3.536AlaTyr: 3.536 ± 0.429
0.0AlaXaa: 0.0 ± 0.0
Cys
0.505CysAla: 0.505 ± 0.251
0.101CysCys: 0.101 ± 0.109
0.505CysAsp: 0.505 ± 0.269
0.101CysGlu: 0.101 ± 0.097
0.303CysPhe: 0.303 ± 0.231
0.707CysGly: 0.707 ± 0.34
0.101CysHis: 0.101 ± 0.087
0.101CysIle: 0.101 ± 0.109
1.111CysLys: 1.111 ± 0.395
0.909CysLeu: 0.909 ± 0.288
0.101CysMet: 0.101 ± 0.098
0.606CysAsn: 0.606 ± 0.266
0.303CysPro: 0.303 ± 0.206
0.303CysGln: 0.303 ± 0.17
0.404CysArg: 0.404 ± 0.251
0.505CysSer: 0.505 ± 0.246
0.404CysThr: 0.404 ± 0.218
0.404CysVal: 0.404 ± 0.213
0.202CysTrp: 0.202 ± 0.142
0.404CysTyr: 0.404 ± 0.181
0.0CysXaa: 0.0 ± 0.0
Asp
5.153AspAla: 5.153 ± 0.773
1.01AspCys: 1.01 ± 0.433
3.536AspAsp: 3.536 ± 0.681
3.435AspGlu: 3.435 ± 0.494
3.536AspPhe: 3.536 ± 0.548
6.366AspGly: 6.366 ± 1.212
1.111AspHis: 1.111 ± 0.438
4.85AspIle: 4.85 ± 0.676
2.829AspLys: 2.829 ± 0.55
5.052AspLeu: 5.052 ± 0.622
0.707AspMet: 0.707 ± 0.278
2.829AspAsn: 2.829 ± 0.541
3.637AspPro: 3.637 ± 0.503
1.314AspGln: 1.314 ± 0.345
2.425AspArg: 2.425 ± 0.611
3.435AspSer: 3.435 ± 0.536
4.446AspThr: 4.446 ± 0.592
5.658AspVal: 5.658 ± 0.803
1.111AspTrp: 1.111 ± 0.449
2.425AspTyr: 2.425 ± 0.508
0.0AspXaa: 0.0 ± 0.0
Glu
6.467GluAla: 6.467 ± 0.903
0.505GluCys: 0.505 ± 0.25
4.446GluAsp: 4.446 ± 0.738
4.446GluGlu: 4.446 ± 0.793
2.93GluPhe: 2.93 ± 0.466
5.557GluGly: 5.557 ± 0.708
1.111GluHis: 1.111 ± 0.29
3.435GluIle: 3.435 ± 0.457
3.739GluLys: 3.739 ± 0.661
5.456GluLeu: 5.456 ± 0.866
1.111GluMet: 1.111 ± 0.338
3.435GluAsn: 3.435 ± 0.582
1.617GluPro: 1.617 ± 0.42
2.728GluGln: 2.728 ± 0.579
3.739GluArg: 3.739 ± 0.632
2.425GluSer: 2.425 ± 0.496
4.85GluThr: 4.85 ± 0.904
3.739GluVal: 3.739 ± 0.666
1.111GluTrp: 1.111 ± 0.352
1.819GluTyr: 1.819 ± 0.408
0.0GluXaa: 0.0 ± 0.0
Phe
1.92PheAla: 1.92 ± 0.561
0.404PheCys: 0.404 ± 0.197
4.143PheAsp: 4.143 ± 0.689
3.132PheGlu: 3.132 ± 0.608
1.212PhePhe: 1.212 ± 0.323
3.435PheGly: 3.435 ± 0.602
0.606PheHis: 0.606 ± 0.213
1.819PheIle: 1.819 ± 0.365
2.93PheLys: 2.93 ± 0.469
3.132PheLeu: 3.132 ± 0.494
1.111PheMet: 1.111 ± 0.369
2.526PheAsn: 2.526 ± 0.368
0.707PhePro: 0.707 ± 0.283
1.01PheGln: 1.01 ± 0.433
1.718PheArg: 1.718 ± 0.492
2.93PheSer: 2.93 ± 0.614
2.122PheThr: 2.122 ± 0.369
2.021PheVal: 2.021 ± 0.511
0.404PheTrp: 0.404 ± 0.147
1.819PheTyr: 1.819 ± 0.549
0.0PheXaa: 0.0 ± 0.0
Gly
5.153GlyAla: 5.153 ± 0.656
0.909GlyCys: 0.909 ± 0.408
3.435GlyAsp: 3.435 ± 0.506
4.547GlyGlu: 4.547 ± 0.83
3.84GlyPhe: 3.84 ± 0.63
6.366GlyGly: 6.366 ± 1.109
1.212GlyHis: 1.212 ± 0.417
3.132GlyIle: 3.132 ± 0.409
5.557GlyLys: 5.557 ± 0.612
6.568GlyLeu: 6.568 ± 0.657
1.718GlyMet: 1.718 ± 0.334
2.829GlyAsn: 2.829 ± 0.432
1.314GlyPro: 1.314 ± 0.297
2.93GlyGln: 2.93 ± 0.513
4.446GlyArg: 4.446 ± 0.572
7.174GlySer: 7.174 ± 1.389
6.265GlyThr: 6.265 ± 0.934
4.85GlyVal: 4.85 ± 0.769
1.01GlyTrp: 1.01 ± 0.281
2.526GlyTyr: 2.526 ± 0.59
0.0GlyXaa: 0.0 ± 0.0
His
0.707HisAla: 0.707 ± 0.258
0.202HisCys: 0.202 ± 0.149
0.707HisAsp: 0.707 ± 0.246
0.505HisGlu: 0.505 ± 0.179
0.404HisPhe: 0.404 ± 0.254
0.707HisGly: 0.707 ± 0.273
0.0HisHis: 0.0 ± 0.0
0.606HisIle: 0.606 ± 0.194
1.314HisLys: 1.314 ± 0.378
2.021HisLeu: 2.021 ± 0.527
0.808HisMet: 0.808 ± 0.281
0.909HisAsn: 0.909 ± 0.203
0.505HisPro: 0.505 ± 0.226
0.909HisGln: 0.909 ± 0.285
0.808HisArg: 0.808 ± 0.244
1.01HisSer: 1.01 ± 0.268
0.404HisThr: 0.404 ± 0.195
1.617HisVal: 1.617 ± 0.369
0.0HisTrp: 0.0 ± 0.0
0.606HisTyr: 0.606 ± 0.176
0.0HisXaa: 0.0 ± 0.0
Ile
4.547IleAla: 4.547 ± 0.749
0.404IleCys: 0.404 ± 0.163
3.435IleAsp: 3.435 ± 0.656
2.93IleGlu: 2.93 ± 0.513
0.909IlePhe: 0.909 ± 0.261
2.93IleGly: 2.93 ± 0.461
0.505IleHis: 0.505 ± 0.243
2.324IleIle: 2.324 ± 0.482
3.031IleLys: 3.031 ± 0.539
4.446IleLeu: 4.446 ± 0.631
0.909IleMet: 0.909 ± 0.257
1.819IleAsn: 1.819 ± 0.456
1.718IlePro: 1.718 ± 0.603
1.617IleGln: 1.617 ± 0.485
2.324IleArg: 2.324 ± 0.416
4.042IleSer: 4.042 ± 0.688
2.526IleThr: 2.526 ± 0.402
2.526IleVal: 2.526 ± 0.385
0.505IleTrp: 0.505 ± 0.265
2.627IleTyr: 2.627 ± 0.511
0.0IleXaa: 0.0 ± 0.0
Lys
7.578LysAla: 7.578 ± 1.237
0.101LysCys: 0.101 ± 0.095
3.84LysAsp: 3.84 ± 0.511
4.951LysGlu: 4.951 ± 0.877
3.132LysPhe: 3.132 ± 0.535
4.143LysGly: 4.143 ± 0.499
1.314LysHis: 1.314 ± 0.49
3.536LysIle: 3.536 ± 0.61
3.84LysLys: 3.84 ± 0.508
4.648LysLeu: 4.648 ± 0.636
1.617LysMet: 1.617 ± 0.375
1.516LysAsn: 1.516 ± 0.357
2.627LysPro: 2.627 ± 0.651
2.122LysGln: 2.122 ± 0.462
3.941LysArg: 3.941 ± 0.852
4.143LysSer: 4.143 ± 0.544
3.637LysThr: 3.637 ± 0.687
3.739LysVal: 3.739 ± 0.642
0.707LysTrp: 0.707 ± 0.241
1.617LysTyr: 1.617 ± 0.276
0.0LysXaa: 0.0 ± 0.0
Leu
6.871LeuAla: 6.871 ± 0.886
0.202LeuCys: 0.202 ± 0.143
6.265LeuAsp: 6.265 ± 0.964
5.355LeuGlu: 5.355 ± 0.819
2.829LeuPhe: 2.829 ± 0.66
6.163LeuGly: 6.163 ± 0.776
0.909LeuHis: 0.909 ± 0.293
2.526LeuIle: 2.526 ± 0.516
4.85LeuLys: 4.85 ± 0.645
5.658LeuLeu: 5.658 ± 0.599
2.223LeuMet: 2.223 ± 0.407
5.557LeuAsn: 5.557 ± 0.661
1.819LeuPro: 1.819 ± 0.499
3.233LeuGln: 3.233 ± 0.734
3.84LeuArg: 3.84 ± 0.719
6.77LeuSer: 6.77 ± 0.645
5.355LeuThr: 5.355 ± 0.794
4.648LeuVal: 4.648 ± 0.665
1.617LeuTrp: 1.617 ± 0.47
2.93LeuTyr: 2.93 ± 0.655
0.0LeuXaa: 0.0 ± 0.0
Met
2.728MetAla: 2.728 ± 0.56
0.303MetCys: 0.303 ± 0.177
1.516MetAsp: 1.516 ± 0.343
1.516MetGlu: 1.516 ± 0.479
0.606MetPhe: 0.606 ± 0.219
3.132MetGly: 3.132 ± 0.625
0.404MetHis: 0.404 ± 0.216
0.404MetIle: 0.404 ± 0.186
1.617MetLys: 1.617 ± 0.355
1.516MetLeu: 1.516 ± 0.394
0.404MetMet: 0.404 ± 0.203
0.606MetAsn: 0.606 ± 0.181
0.606MetPro: 0.606 ± 0.237
0.707MetGln: 0.707 ± 0.308
1.01MetArg: 1.01 ± 0.218
1.819MetSer: 1.819 ± 0.434
2.021MetThr: 2.021 ± 0.509
1.01MetVal: 1.01 ± 0.311
0.0MetTrp: 0.0 ± 0.0
0.808MetTyr: 0.808 ± 0.311
0.0MetXaa: 0.0 ± 0.0
Asn
4.446AsnAla: 4.446 ± 1.433
0.909AsnCys: 0.909 ± 0.317
3.233AsnAsp: 3.233 ± 0.377
2.122AsnGlu: 2.122 ± 0.429
1.718AsnPhe: 1.718 ± 0.494
3.435AsnGly: 3.435 ± 0.727
0.505AsnHis: 0.505 ± 0.17
3.435AsnIle: 3.435 ± 0.586
3.233AsnLys: 3.233 ± 0.674
3.739AsnLeu: 3.739 ± 0.678
0.909AsnMet: 0.909 ± 0.316
3.334AsnAsn: 3.334 ± 0.581
1.92AsnPro: 1.92 ± 0.353
1.415AsnGln: 1.415 ± 0.362
2.324AsnArg: 2.324 ± 0.55
2.425AsnSer: 2.425 ± 0.556
3.334AsnThr: 3.334 ± 0.612
3.941AsnVal: 3.941 ± 0.615
0.303AsnTrp: 0.303 ± 0.181
1.819AsnTyr: 1.819 ± 0.483
0.101AsnXaa: 0.101 ± 0.1
Pro
1.819ProAla: 1.819 ± 0.381
0.404ProCys: 0.404 ± 0.209
2.728ProAsp: 2.728 ± 0.71
2.627ProGlu: 2.627 ± 0.537
1.415ProPhe: 1.415 ± 0.355
0.101ProGly: 0.101 ± 0.101
0.606ProHis: 0.606 ± 0.301
1.516ProIle: 1.516 ± 0.27
2.223ProLys: 2.223 ± 0.47
1.718ProLeu: 1.718 ± 0.347
1.212ProMet: 1.212 ± 0.212
2.021ProAsn: 2.021 ± 0.411
0.707ProPro: 0.707 ± 0.334
1.314ProGln: 1.314 ± 0.313
1.415ProArg: 1.415 ± 0.41
3.233ProSer: 3.233 ± 0.742
2.93ProThr: 2.93 ± 0.58
1.718ProVal: 1.718 ± 0.398
0.404ProTrp: 0.404 ± 0.243
0.707ProTyr: 0.707 ± 0.303
0.0ProXaa: 0.0 ± 0.0
Gln
4.345GlnAla: 4.345 ± 1.029
0.101GlnCys: 0.101 ± 0.097
1.516GlnAsp: 1.516 ± 0.474
1.92GlnGlu: 1.92 ± 0.514
0.808GlnPhe: 0.808 ± 0.224
2.021GlnGly: 2.021 ± 0.384
0.606GlnHis: 0.606 ± 0.21
1.617GlnIle: 1.617 ± 0.561
2.021GlnLys: 2.021 ± 0.35
3.031GlnLeu: 3.031 ± 0.574
1.212GlnMet: 1.212 ± 0.316
1.314GlnAsn: 1.314 ± 0.472
0.808GlnPro: 0.808 ± 0.282
1.415GlnGln: 1.415 ± 0.36
2.122GlnArg: 2.122 ± 0.509
2.829GlnSer: 2.829 ± 0.428
2.425GlnThr: 2.425 ± 0.399
3.233GlnVal: 3.233 ± 0.675
0.606GlnTrp: 0.606 ± 0.227
1.617GlnTyr: 1.617 ± 0.566
0.0GlnXaa: 0.0 ± 0.0
Arg
4.85ArgAla: 4.85 ± 0.915
0.202ArgCys: 0.202 ± 0.148
2.93ArgAsp: 2.93 ± 0.545
2.324ArgGlu: 2.324 ± 0.538
1.819ArgPhe: 1.819 ± 0.455
3.941ArgGly: 3.941 ± 0.573
1.212ArgHis: 1.212 ± 0.367
2.324ArgIle: 2.324 ± 0.554
3.031ArgLys: 3.031 ± 0.57
4.143ArgLeu: 4.143 ± 0.676
1.516ArgMet: 1.516 ± 0.348
2.728ArgAsn: 2.728 ± 0.595
0.707ArgPro: 0.707 ± 0.227
1.819ArgGln: 1.819 ± 0.527
2.526ArgArg: 2.526 ± 0.758
3.233ArgSer: 3.233 ± 0.547
1.718ArgThr: 1.718 ± 0.336
3.941ArgVal: 3.941 ± 0.644
1.01ArgTrp: 1.01 ± 0.344
2.021ArgTyr: 2.021 ± 0.452
0.0ArgXaa: 0.0 ± 0.0
Ser
8.285SerAla: 8.285 ± 2.217
0.404SerCys: 0.404 ± 0.197
4.244SerAsp: 4.244 ± 0.555
5.86SerGlu: 5.86 ± 1.13
3.637SerPhe: 3.637 ± 0.559
6.366SerGly: 6.366 ± 1.139
0.707SerHis: 0.707 ± 0.207
3.132SerIle: 3.132 ± 0.515
4.648SerLys: 4.648 ± 0.782
6.062SerLeu: 6.062 ± 0.703
1.617SerMet: 1.617 ± 0.323
2.93SerAsn: 2.93 ± 0.698
3.031SerPro: 3.031 ± 0.515
2.526SerGln: 2.526 ± 0.521
2.526SerArg: 2.526 ± 0.544
6.163SerSer: 6.163 ± 1.031
4.547SerThr: 4.547 ± 1.024
5.658SerVal: 5.658 ± 0.696
0.909SerTrp: 0.909 ± 0.247
2.526SerTyr: 2.526 ± 0.409
0.0SerXaa: 0.0 ± 0.0
Thr
7.275ThrAla: 7.275 ± 1.348
0.404ThrCys: 0.404 ± 0.239
4.143ThrAsp: 4.143 ± 0.569
4.042ThrGlu: 4.042 ± 0.663
2.526ThrPhe: 2.526 ± 0.607
4.951ThrGly: 4.951 ± 0.667
1.01ThrHis: 1.01 ± 0.299
2.93ThrIle: 2.93 ± 0.48
3.739ThrLys: 3.739 ± 0.597
4.85ThrLeu: 4.85 ± 0.687
1.212ThrMet: 1.212 ± 0.332
3.435ThrAsn: 3.435 ± 1.172
2.728ThrPro: 2.728 ± 0.456
2.425ThrGln: 2.425 ± 0.424
2.627ThrArg: 2.627 ± 0.361
6.568ThrSer: 6.568 ± 1.826
4.648ThrThr: 4.648 ± 0.953
6.062ThrVal: 6.062 ± 0.635
0.909ThrTrp: 0.909 ± 0.41
2.122ThrTyr: 2.122 ± 0.674
0.0ThrXaa: 0.0 ± 0.0
Val
6.871ValAla: 6.871 ± 0.775
0.505ValCys: 0.505 ± 0.191
4.951ValAsp: 4.951 ± 0.764
5.254ValGlu: 5.254 ± 0.775
3.132ValPhe: 3.132 ± 0.584
5.355ValGly: 5.355 ± 0.696
0.909ValHis: 0.909 ± 0.394
2.93ValIle: 2.93 ± 0.607
3.739ValLys: 3.739 ± 0.72
5.961ValLeu: 5.961 ± 0.578
1.01ValMet: 1.01 ± 0.324
3.435ValAsn: 3.435 ± 0.717
2.223ValPro: 2.223 ± 0.471
2.324ValGln: 2.324 ± 0.568
2.829ValArg: 2.829 ± 0.569
5.658ValSer: 5.658 ± 0.72
4.85ValThr: 4.85 ± 0.789
5.052ValVal: 5.052 ± 1.112
0.505ValTrp: 0.505 ± 0.256
2.021ValTyr: 2.021 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.314TrpAla: 1.314 ± 0.318
0.101TrpCys: 0.101 ± 0.108
0.606TrpAsp: 0.606 ± 0.225
0.707TrpGlu: 0.707 ± 0.426
0.707TrpPhe: 0.707 ± 0.267
0.606TrpGly: 0.606 ± 0.249
0.202TrpHis: 0.202 ± 0.143
0.505TrpIle: 0.505 ± 0.243
0.808TrpLys: 0.808 ± 0.473
1.415TrpLeu: 1.415 ± 0.425
0.202TrpMet: 0.202 ± 0.113
1.01TrpAsn: 1.01 ± 0.27
0.404TrpPro: 0.404 ± 0.195
0.606TrpGln: 0.606 ± 0.283
0.404TrpArg: 0.404 ± 0.226
0.404TrpSer: 0.404 ± 0.188
0.505TrpThr: 0.505 ± 0.227
1.212TrpVal: 1.212 ± 0.33
0.202TrpTrp: 0.202 ± 0.159
0.808TrpTyr: 0.808 ± 0.27
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.627TyrAla: 2.627 ± 0.484
0.404TyrCys: 0.404 ± 0.226
2.829TyrAsp: 2.829 ± 0.464
2.728TyrGlu: 2.728 ± 0.602
0.909TyrPhe: 0.909 ± 0.425
2.223TyrGly: 2.223 ± 0.447
0.606TyrHis: 0.606 ± 0.286
1.212TyrIle: 1.212 ± 0.327
2.021TyrLys: 2.021 ± 0.495
3.031TyrLeu: 3.031 ± 0.621
0.808TyrMet: 0.808 ± 0.298
2.021TyrAsn: 2.021 ± 0.406
1.314TyrPro: 1.314 ± 0.457
1.314TyrGln: 1.314 ± 0.367
2.324TyrArg: 2.324 ± 0.428
2.627TyrSer: 2.627 ± 0.681
3.031TyrThr: 3.031 ± 0.719
2.526TyrVal: 2.526 ± 0.487
0.202TyrTrp: 0.202 ± 0.142
1.617TyrTyr: 1.617 ± 0.584
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.101XaaGly: 0.101 ± 0.1
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 32 proteins (9898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski