Amino acid dipepetide frequency for Acidianus spindle-shaped virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.267AlaAla: 1.267 ± 0.351
0.38AlaCys: 0.38 ± 0.232
2.027AlaAsp: 2.027 ± 0.5
3.801AlaGlu: 3.801 ± 0.59
2.787AlaPhe: 2.787 ± 0.489
2.407AlaGly: 2.407 ± 0.548
0.76AlaHis: 0.76 ± 0.311
4.434AlaIle: 4.434 ± 0.894
3.294AlaLys: 3.294 ± 0.827
6.081AlaLeu: 6.081 ± 0.834
1.647AlaMet: 1.647 ± 0.378
3.041AlaAsn: 3.041 ± 0.551
2.534AlaPro: 2.534 ± 0.482
1.267AlaGln: 1.267 ± 0.396
2.027AlaArg: 2.027 ± 0.652
3.041AlaSer: 3.041 ± 0.653
3.674AlaThr: 3.674 ± 0.559
4.054AlaVal: 4.054 ± 0.803
1.647AlaTrp: 1.647 ± 0.486
3.421AlaTyr: 3.421 ± 0.765
0.0AlaXaa: 0.0 ± 0.0
Cys
0.38CysAla: 0.38 ± 0.236
0.0CysCys: 0.0 ± 0.0
0.507CysAsp: 0.507 ± 0.257
0.633CysGlu: 0.633 ± 0.282
0.253CysPhe: 0.253 ± 0.172
0.887CysGly: 0.887 ± 0.412
0.0CysHis: 0.0 ± 0.0
0.253CysIle: 0.253 ± 0.159
0.507CysLys: 0.507 ± 0.338
0.887CysLeu: 0.887 ± 0.315
0.253CysMet: 0.253 ± 0.2
0.253CysAsn: 0.253 ± 0.181
0.887CysPro: 0.887 ± 0.521
0.253CysGln: 0.253 ± 0.164
0.253CysArg: 0.253 ± 0.176
0.253CysSer: 0.253 ± 0.18
0.38CysThr: 0.38 ± 0.173
0.633CysVal: 0.633 ± 0.28
0.127CysTrp: 0.127 ± 0.146
0.253CysTyr: 0.253 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
3.167AspAla: 3.167 ± 0.628
0.127AspCys: 0.127 ± 0.148
2.281AspAsp: 2.281 ± 0.533
3.674AspGlu: 3.674 ± 1.096
1.774AspPhe: 1.774 ± 0.556
3.294AspGly: 3.294 ± 0.728
1.14AspHis: 1.14 ± 0.444
3.801AspIle: 3.801 ± 0.707
2.407AspLys: 2.407 ± 0.725
2.787AspLeu: 2.787 ± 0.699
0.76AspMet: 0.76 ± 0.243
2.154AspAsn: 2.154 ± 0.423
1.9AspPro: 1.9 ± 0.402
0.38AspGln: 0.38 ± 0.223
1.014AspArg: 1.014 ± 0.419
1.52AspSer: 1.52 ± 0.378
1.9AspThr: 1.9 ± 0.508
3.547AspVal: 3.547 ± 0.538
1.14AspTrp: 1.14 ± 0.35
2.154AspTyr: 2.154 ± 0.713
0.0AspXaa: 0.0 ± 0.0
Glu
2.154GluAla: 2.154 ± 0.473
0.507GluCys: 0.507 ± 0.252
2.661GluAsp: 2.661 ± 0.733
6.588GluGlu: 6.588 ± 1.537
2.787GluPhe: 2.787 ± 0.55
4.054GluGly: 4.054 ± 0.891
0.633GluHis: 0.633 ± 0.255
4.181GluIle: 4.181 ± 0.888
4.688GluLys: 4.688 ± 1.391
5.701GluLeu: 5.701 ± 0.967
1.394GluMet: 1.394 ± 0.404
3.167GluAsn: 3.167 ± 0.682
1.14GluPro: 1.14 ± 0.422
2.154GluGln: 2.154 ± 0.474
2.787GluArg: 2.787 ± 0.946
2.027GluSer: 2.027 ± 0.53
3.421GluThr: 3.421 ± 0.637
4.688GluVal: 4.688 ± 0.861
0.633GluTrp: 0.633 ± 0.227
2.787GluTyr: 2.787 ± 0.607
0.0GluXaa: 0.0 ± 0.0
Phe
2.661PheAla: 2.661 ± 0.466
0.38PheCys: 0.38 ± 0.21
2.154PheAsp: 2.154 ± 0.507
2.787PheGlu: 2.787 ± 0.556
3.421PhePhe: 3.421 ± 0.85
3.928PheGly: 3.928 ± 0.698
1.52PheHis: 1.52 ± 0.531
4.434PheIle: 4.434 ± 0.742
2.661PheLys: 2.661 ± 0.698
5.068PheLeu: 5.068 ± 0.91
0.76PheMet: 0.76 ± 0.373
2.661PheAsn: 2.661 ± 0.55
1.774PhePro: 1.774 ± 0.447
1.267PheGln: 1.267 ± 0.388
1.394PheArg: 1.394 ± 0.331
3.928PheSer: 3.928 ± 0.73
3.041PheThr: 3.041 ± 0.692
4.054PheVal: 4.054 ± 0.801
0.76PheTrp: 0.76 ± 0.272
3.928PheTyr: 3.928 ± 0.695
0.0PheXaa: 0.0 ± 0.0
Gly
3.167GlyAla: 3.167 ± 0.609
0.38GlyCys: 0.38 ± 0.182
2.281GlyAsp: 2.281 ± 0.503
3.167GlyGlu: 3.167 ± 0.481
3.801GlyPhe: 3.801 ± 0.663
4.181GlyGly: 4.181 ± 1.012
0.253GlyHis: 0.253 ± 0.155
5.068GlyIle: 5.068 ± 0.625
4.308GlyLys: 4.308 ± 1.037
6.461GlyLeu: 6.461 ± 0.814
0.76GlyMet: 0.76 ± 0.299
4.941GlyAsn: 4.941 ± 1.069
1.9GlyPro: 1.9 ± 0.449
3.041GlyGln: 3.041 ± 0.59
1.774GlyArg: 1.774 ± 0.574
4.434GlySer: 4.434 ± 0.68
5.701GlyThr: 5.701 ± 0.876
4.688GlyVal: 4.688 ± 0.738
0.507GlyTrp: 0.507 ± 0.2
4.688GlyTyr: 4.688 ± 1.169
0.0GlyXaa: 0.0 ± 0.0
His
0.38HisAla: 0.38 ± 0.218
0.253HisCys: 0.253 ± 0.181
0.76HisAsp: 0.76 ± 0.372
0.76HisGlu: 0.76 ± 0.319
1.014HisPhe: 1.014 ± 0.424
1.14HisGly: 1.14 ± 0.348
0.38HisHis: 0.38 ± 0.27
1.14HisIle: 1.14 ± 0.446
0.887HisLys: 0.887 ± 0.297
1.9HisLeu: 1.9 ± 0.573
0.253HisMet: 0.253 ± 0.133
1.394HisAsn: 1.394 ± 0.43
0.127HisPro: 0.127 ± 0.102
0.76HisGln: 0.76 ± 0.292
0.633HisArg: 0.633 ± 0.344
1.267HisSer: 1.267 ± 0.52
0.76HisThr: 0.76 ± 0.313
0.887HisVal: 0.887 ± 0.403
0.0HisTrp: 0.0 ± 0.0
0.76HisTyr: 0.76 ± 0.221
0.0HisXaa: 0.0 ± 0.0
Ile
4.814IleAla: 4.814 ± 0.843
1.14IleCys: 1.14 ± 0.508
3.167IleAsp: 3.167 ± 0.575
4.688IleGlu: 4.688 ± 1.065
4.688IlePhe: 4.688 ± 1.253
5.321IleGly: 5.321 ± 0.803
1.014IleHis: 1.014 ± 0.312
6.715IleIle: 6.715 ± 0.99
4.054IleLys: 4.054 ± 1.112
7.222IleLeu: 7.222 ± 1.081
1.394IleMet: 1.394 ± 0.426
4.688IleAsn: 4.688 ± 0.746
3.294IlePro: 3.294 ± 0.663
2.787IleGln: 2.787 ± 0.629
3.801IleArg: 3.801 ± 0.821
5.194IleSer: 5.194 ± 1.206
5.701IleThr: 5.701 ± 0.735
5.575IleVal: 5.575 ± 0.762
1.394IleTrp: 1.394 ± 0.516
3.801IleTyr: 3.801 ± 0.539
0.0IleXaa: 0.0 ± 0.0
Lys
4.054LysAla: 4.054 ± 0.911
0.507LysCys: 0.507 ± 0.268
3.801LysAsp: 3.801 ± 0.967
4.941LysGlu: 4.941 ± 1.482
2.281LysPhe: 2.281 ± 0.543
3.294LysGly: 3.294 ± 0.723
1.267LysHis: 1.267 ± 0.429
3.801LysIle: 3.801 ± 0.887
6.588LysLys: 6.588 ± 2.022
6.081LysLeu: 6.081 ± 1.359
2.661LysMet: 2.661 ± 0.753
2.281LysAsn: 2.281 ± 0.558
0.887LysPro: 0.887 ± 0.364
2.027LysGln: 2.027 ± 0.587
3.167LysArg: 3.167 ± 0.989
3.041LysSer: 3.041 ± 0.63
4.941LysThr: 4.941 ± 1.266
4.308LysVal: 4.308 ± 0.955
1.014LysTrp: 1.014 ± 0.306
3.294LysTyr: 3.294 ± 0.67
0.0LysXaa: 0.0 ± 0.0
Leu
5.448LeuAla: 5.448 ± 0.912
0.76LeuCys: 0.76 ± 0.37
4.181LeuAsp: 4.181 ± 0.837
5.321LeuGlu: 5.321 ± 0.929
4.561LeuPhe: 4.561 ± 0.881
4.561LeuGly: 4.561 ± 0.777
1.14LeuHis: 1.14 ± 0.561
7.855LeuIle: 7.855 ± 1.298
6.208LeuLys: 6.208 ± 1.693
10.642LeuLeu: 10.642 ± 1.264
3.421LeuMet: 3.421 ± 0.612
5.701LeuAsn: 5.701 ± 0.817
3.547LeuPro: 3.547 ± 0.524
2.534LeuGln: 2.534 ± 0.511
4.434LeuArg: 4.434 ± 1.166
8.108LeuSer: 8.108 ± 0.788
5.701LeuThr: 5.701 ± 0.956
5.068LeuVal: 5.068 ± 0.903
1.267LeuTrp: 1.267 ± 0.377
4.941LeuTyr: 4.941 ± 0.72
0.0LeuXaa: 0.0 ± 0.0
Met
1.52MetAla: 1.52 ± 0.357
0.127MetCys: 0.127 ± 0.121
0.76MetAsp: 0.76 ± 0.243
1.647MetGlu: 1.647 ± 0.573
1.394MetPhe: 1.394 ± 0.351
2.027MetGly: 2.027 ± 0.604
0.253MetHis: 0.253 ± 0.211
1.52MetIle: 1.52 ± 0.445
2.407MetLys: 2.407 ± 0.664
2.027MetLeu: 2.027 ± 0.614
1.14MetMet: 1.14 ± 0.357
0.507MetAsn: 0.507 ± 0.215
1.52MetPro: 1.52 ± 0.391
0.253MetGln: 0.253 ± 0.194
1.14MetArg: 1.14 ± 0.441
1.267MetSer: 1.267 ± 0.463
1.14MetThr: 1.14 ± 0.428
1.14MetVal: 1.14 ± 0.386
0.507MetTrp: 0.507 ± 0.214
0.507MetTyr: 0.507 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
3.294AsnAla: 3.294 ± 0.774
0.38AsnCys: 0.38 ± 0.271
3.167AsnAsp: 3.167 ± 0.613
2.661AsnGlu: 2.661 ± 0.484
3.801AsnPhe: 3.801 ± 0.825
6.461AsnGly: 6.461 ± 1.592
1.14AsnHis: 1.14 ± 0.27
4.181AsnIle: 4.181 ± 0.881
2.534AsnLys: 2.534 ± 0.561
5.321AsnLeu: 5.321 ± 0.822
0.76AsnMet: 0.76 ± 0.25
3.421AsnAsn: 3.421 ± 0.543
3.421AsnPro: 3.421 ± 0.824
2.027AsnGln: 2.027 ± 0.466
1.14AsnArg: 1.14 ± 0.275
3.928AsnSer: 3.928 ± 0.875
3.294AsnThr: 3.294 ± 0.941
3.674AsnVal: 3.674 ± 0.581
1.014AsnTrp: 1.014 ± 0.307
2.787AsnTyr: 2.787 ± 0.527
0.0AsnXaa: 0.0 ± 0.0
Pro
1.9ProAla: 1.9 ± 0.488
0.0ProCys: 0.0 ± 0.0
1.647ProAsp: 1.647 ± 0.477
2.027ProGlu: 2.027 ± 0.561
1.9ProPhe: 1.9 ± 0.534
2.027ProGly: 2.027 ± 0.545
0.507ProHis: 0.507 ± 0.208
2.787ProIle: 2.787 ± 0.541
1.52ProLys: 1.52 ± 0.473
4.054ProLeu: 4.054 ± 0.708
1.014ProMet: 1.014 ± 0.319
2.281ProAsn: 2.281 ± 0.52
2.407ProPro: 2.407 ± 0.541
2.281ProGln: 2.281 ± 0.59
0.0ProArg: 0.0 ± 0.0
3.928ProSer: 3.928 ± 0.964
3.674ProThr: 3.674 ± 0.847
3.801ProVal: 3.801 ± 0.846
0.76ProTrp: 0.76 ± 0.325
2.407ProTyr: 2.407 ± 0.448
0.0ProXaa: 0.0 ± 0.0
Gln
1.9GlnAla: 1.9 ± 0.394
0.0GlnCys: 0.0 ± 0.0
1.267GlnAsp: 1.267 ± 0.45
1.52GlnGlu: 1.52 ± 0.307
1.52GlnPhe: 1.52 ± 0.464
1.774GlnGly: 1.774 ± 0.351
0.633GlnHis: 0.633 ± 0.27
3.041GlnIle: 3.041 ± 0.489
1.9GlnLys: 1.9 ± 0.571
3.294GlnLeu: 3.294 ± 0.666
0.633GlnMet: 0.633 ± 0.239
2.407GlnAsn: 2.407 ± 0.76
1.394GlnPro: 1.394 ± 0.423
1.14GlnGln: 1.14 ± 0.309
1.14GlnArg: 1.14 ± 0.4
1.774GlnSer: 1.774 ± 0.423
2.154GlnThr: 2.154 ± 0.528
1.647GlnVal: 1.647 ± 0.501
1.14GlnTrp: 1.14 ± 0.319
1.647GlnTyr: 1.647 ± 0.426
0.0GlnXaa: 0.0 ± 0.0
Arg
2.281ArgAla: 2.281 ± 0.72
0.507ArgCys: 0.507 ± 0.251
1.52ArgAsp: 1.52 ± 0.576
1.9ArgGlu: 1.9 ± 0.602
1.774ArgPhe: 1.774 ± 0.552
1.52ArgGly: 1.52 ± 0.422
0.633ArgHis: 0.633 ± 0.358
2.661ArgIle: 2.661 ± 0.752
4.688ArgLys: 4.688 ± 1.312
3.041ArgLeu: 3.041 ± 0.759
0.76ArgMet: 0.76 ± 0.397
2.914ArgAsn: 2.914 ± 0.804
0.76ArgPro: 0.76 ± 0.284
0.76ArgGln: 0.76 ± 0.386
2.027ArgArg: 2.027 ± 0.63
2.027ArgSer: 2.027 ± 0.462
0.633ArgThr: 0.633 ± 0.246
2.154ArgVal: 2.154 ± 0.698
0.38ArgTrp: 0.38 ± 0.25
1.9ArgTyr: 1.9 ± 0.57
0.0ArgXaa: 0.0 ± 0.0
Ser
4.181SerAla: 4.181 ± 0.812
0.38SerCys: 0.38 ± 0.198
2.281SerAsp: 2.281 ± 0.5
3.421SerGlu: 3.421 ± 0.524
2.661SerPhe: 2.661 ± 0.728
5.321SerGly: 5.321 ± 1.073
1.52SerHis: 1.52 ± 0.584
5.194SerIle: 5.194 ± 0.804
4.181SerLys: 4.181 ± 0.799
5.321SerLeu: 5.321 ± 0.811
1.394SerMet: 1.394 ± 0.377
3.294SerAsn: 3.294 ± 0.847
4.688SerPro: 4.688 ± 0.994
2.027SerGln: 2.027 ± 0.516
1.774SerArg: 1.774 ± 0.541
5.828SerSer: 5.828 ± 0.972
4.941SerThr: 4.941 ± 1.155
3.547SerVal: 3.547 ± 0.713
1.647SerTrp: 1.647 ± 0.402
4.561SerTyr: 4.561 ± 0.982
0.0SerXaa: 0.0 ± 0.0
Thr
2.534ThrAla: 2.534 ± 0.415
0.507ThrCys: 0.507 ± 0.246
2.154ThrAsp: 2.154 ± 0.382
2.787ThrGlu: 2.787 ± 0.464
3.294ThrPhe: 3.294 ± 0.714
4.181ThrGly: 4.181 ± 0.812
0.76ThrHis: 0.76 ± 0.422
6.081ThrIle: 6.081 ± 0.834
3.547ThrLys: 3.547 ± 0.723
6.842ThrLeu: 6.842 ± 0.82
1.774ThrMet: 1.774 ± 0.369
4.054ThrAsn: 4.054 ± 0.84
1.52ThrPro: 1.52 ± 0.413
2.281ThrGln: 2.281 ± 0.424
1.9ThrArg: 1.9 ± 0.576
5.448ThrSer: 5.448 ± 1.023
6.081ThrThr: 6.081 ± 1.221
5.321ThrVal: 5.321 ± 1.125
0.76ThrTrp: 0.76 ± 0.274
3.928ThrTyr: 3.928 ± 1.155
0.0ThrXaa: 0.0 ± 0.0
Val
3.294ValAla: 3.294 ± 0.695
1.14ValCys: 1.14 ± 0.64
2.027ValAsp: 2.027 ± 0.406
2.661ValGlu: 2.661 ± 0.499
4.434ValPhe: 4.434 ± 0.72
3.674ValGly: 3.674 ± 0.55
0.76ValHis: 0.76 ± 0.235
6.842ValIle: 6.842 ± 1.058
4.054ValLys: 4.054 ± 0.991
5.701ValLeu: 5.701 ± 0.656
1.14ValMet: 1.14 ± 0.36
5.194ValAsn: 5.194 ± 0.969
4.181ValPro: 4.181 ± 0.705
2.407ValGln: 2.407 ± 0.672
2.154ValArg: 2.154 ± 0.635
6.335ValSer: 6.335 ± 1.069
3.421ValThr: 3.421 ± 0.452
3.928ValVal: 3.928 ± 0.78
1.52ValTrp: 1.52 ± 0.29
3.801ValTyr: 3.801 ± 0.681
0.0ValXaa: 0.0 ± 0.0
Trp
0.887TrpAla: 0.887 ± 0.255
0.127TrpCys: 0.127 ± 0.148
0.76TrpAsp: 0.76 ± 0.264
1.14TrpGlu: 1.14 ± 0.307
0.887TrpPhe: 0.887 ± 0.345
1.14TrpGly: 1.14 ± 0.296
0.253TrpHis: 0.253 ± 0.156
1.9TrpIle: 1.9 ± 0.47
0.633TrpLys: 0.633 ± 0.249
1.52TrpLeu: 1.52 ± 0.386
0.127TrpMet: 0.127 ± 0.14
0.76TrpAsn: 0.76 ± 0.304
0.76TrpPro: 0.76 ± 0.358
1.394TrpGln: 1.394 ± 0.446
0.38TrpArg: 0.38 ± 0.173
1.267TrpSer: 1.267 ± 0.457
0.507TrpThr: 0.507 ± 0.181
1.52TrpVal: 1.52 ± 0.423
0.76TrpTrp: 0.76 ± 0.377
0.887TrpTyr: 0.887 ± 0.406
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.308TyrAla: 4.308 ± 0.776
0.253TyrCys: 0.253 ± 0.176
1.52TyrAsp: 1.52 ± 0.436
2.027TyrGlu: 2.027 ± 0.452
3.547TyrPhe: 3.547 ± 0.605
4.308TyrGly: 4.308 ± 1.101
0.887TyrHis: 0.887 ± 0.249
4.561TyrIle: 4.561 ± 0.804
3.167TyrLys: 3.167 ± 0.654
5.448TyrLeu: 5.448 ± 0.834
0.633TyrMet: 0.633 ± 0.367
3.294TyrAsn: 3.294 ± 1.051
2.281TyrPro: 2.281 ± 0.65
0.887TyrGln: 0.887 ± 0.244
2.027TyrArg: 2.027 ± 0.517
3.547TyrSer: 3.547 ± 0.739
4.688TyrThr: 4.688 ± 0.921
4.434TyrVal: 4.434 ± 0.729
0.633TyrTrp: 0.633 ± 0.376
4.308TyrTyr: 4.308 ± 1.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (7894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski