Amino acid dipepetide frequency for Sphingomonas koreensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.853AlaAla: 20.853 ± 0.213	0.968AlaCys: 0.968 ± 0.027	7.629AlaAsp: 7.629 ± 0.077	7.862AlaGlu: 7.862 ± 0.105	4.479AlaPhe: 4.479 ± 0.051	12.202AlaGly: 12.202 ± 0.12	2.253AlaHis: 2.253 ± 0.04	7.106AlaIle: 7.106 ± 0.08	4.073AlaLys: 4.073 ± 0.073	13.997AlaLeu: 13.997 ± 0.131	3.868AlaMet: 3.868 ± 0.068	3.321AlaAsn: 3.321 ± 0.069	6.723AlaPro: 6.723 ± 0.086	4.665AlaGln: 4.665 ± 0.07	10.087AlaArg: 10.087 ± 0.105	6.822AlaSer: 6.822 ± 0.074	6.77AlaThr: 6.77 ± 0.083	8.85AlaVal: 8.85 ± 0.096	1.793AlaTrp: 1.793 ± 0.043	2.656AlaTyr: 2.656 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.94CysAla: 0.94 ± 0.025	0.086CysCys: 0.086 ± 0.009	0.463CysAsp: 0.463 ± 0.018	0.369CysGlu: 0.369 ± 0.018	0.273CysPhe: 0.273 ± 0.014	0.743CysGly: 0.743 ± 0.024	0.206CysHis: 0.206 ± 0.013	0.302CysIle: 0.302 ± 0.015	0.136CysLys: 0.136 ± 0.011	0.598CysLeu: 0.598 ± 0.021	0.133CysMet: 0.133 ± 0.009	0.176CysAsn: 0.176 ± 0.012	0.404CysPro: 0.404 ± 0.017	0.17CysGln: 0.17 ± 0.011	0.55CysArg: 0.55 ± 0.019	0.362CysSer: 0.362 ± 0.017	0.331CysThr: 0.331 ± 0.017	0.496CysVal: 0.496 ± 0.018	0.102CysTrp: 0.102 ± 0.008	0.145CysTyr: 0.145 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.926AspAla: 7.926 ± 0.088	0.433AspCys: 0.433 ± 0.018	3.09AspAsp: 3.09 ± 0.055	3.203AspGlu: 3.203 ± 0.049	2.022AspPhe: 2.022 ± 0.04	5.603AspGly: 5.603 ± 0.068	1.224AspHis: 1.224 ± 0.036	2.732AspIle: 2.732 ± 0.054	1.576AspLys: 1.576 ± 0.036	5.657AspLeu: 5.657 ± 0.057	1.243AspMet: 1.243 ± 0.028	1.254AspAsn: 1.254 ± 0.036	3.951AspPro: 3.951 ± 0.062	1.714AspGln: 1.714 ± 0.035	4.888AspArg: 4.888 ± 0.077	2.35AspSer: 2.35 ± 0.046	2.666AspThr: 2.666 ± 0.048	3.849AspVal: 3.849 ± 0.062	1.131AspTrp: 1.131 ± 0.033	1.598AspTyr: 1.598 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.868GluAla: 7.868 ± 0.098	0.268GluCys: 0.268 ± 0.016	2.479GluAsp: 2.479 ± 0.047	2.72GluGlu: 2.72 ± 0.052	1.52GluPhe: 1.52 ± 0.034	4.585GluGly: 4.585 ± 0.065	1.066GluHis: 1.066 ± 0.029	2.886GluIle: 2.886 ± 0.051	1.909GluLys: 1.909 ± 0.048	5.108GluLeu: 5.108 ± 0.07	1.386GluMet: 1.386 ± 0.034	1.287GluAsn: 1.287 ± 0.037	2.6GluPro: 2.6 ± 0.05	1.918GluGln: 1.918 ± 0.04	5.13GluArg: 5.13 ± 0.069	2.27GluSer: 2.27 ± 0.045	3.306GluThr: 3.306 ± 0.051	3.624GluVal: 3.624 ± 0.059	0.802GluTrp: 0.802 ± 0.026	0.939GluTyr: 0.939 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.926PheAla: 4.926 ± 0.066	0.287PheCys: 0.287 ± 0.014	2.723PheAsp: 2.723 ± 0.052	2.091PheGlu: 2.091 ± 0.044	1.24PhePhe: 1.24 ± 0.038	3.72PheGly: 3.72 ± 0.059	0.706PheHis: 0.706 ± 0.024	1.333PheIle: 1.333 ± 0.031	0.876PheLys: 0.876 ± 0.024	2.986PheLeu: 2.986 ± 0.056	0.705PheMet: 0.705 ± 0.025	1.017PheAsn: 1.017 ± 0.04	1.499PhePro: 1.499 ± 0.033	0.89PheGln: 0.89 ± 0.027	2.302PheArg: 2.302 ± 0.043	1.886PheSer: 1.886 ± 0.035	2.099PheThr: 2.099 ± 0.05	2.694PheVal: 2.694 ± 0.044	0.497PheTrp: 0.497 ± 0.02	0.858PheTyr: 0.858 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.406GlyAla: 10.406 ± 0.139	0.754GlyCys: 0.754 ± 0.024	4.858GlyAsp: 4.858 ± 0.061	5.187GlyGlu: 5.187 ± 0.069	3.7GlyPhe: 3.7 ± 0.058	8.565GlyGly: 8.565 ± 0.172	1.761GlyHis: 1.761 ± 0.043	4.677GlyIle: 4.677 ± 0.07	3.385GlyLys: 3.385 ± 0.058	8.606GlyLeu: 8.606 ± 0.083	2.376GlyMet: 2.376 ± 0.044	2.514GlyAsn: 2.514 ± 0.077	3.663GlyPro: 3.663 ± 0.049	2.972GlyGln: 2.972 ± 0.048	6.522GlyArg: 6.522 ± 0.066	4.969GlySer: 4.969 ± 0.097	5.263GlyThr: 5.263 ± 0.169	6.43GlyVal: 6.43 ± 0.081	1.757GlyTrp: 1.757 ± 0.04	2.449GlyTyr: 2.449 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.357HisAla: 2.357 ± 0.047	0.192HisCys: 0.192 ± 0.012	1.138HisAsp: 1.138 ± 0.03	0.919HisGlu: 0.919 ± 0.027	0.788HisPhe: 0.788 ± 0.024	1.897HisGly: 1.897 ± 0.045	0.512HisHis: 0.512 ± 0.023	0.826HisIle: 0.826 ± 0.023	0.401HisLys: 0.401 ± 0.016	1.81HisLeu: 1.81 ± 0.044	0.407HisMet: 0.407 ± 0.019	0.443HisAsn: 0.443 ± 0.017	1.246HisPro: 1.246 ± 0.032	0.555HisGln: 0.555 ± 0.021	1.514HisArg: 1.514 ± 0.041	0.909HisSer: 0.909 ± 0.029	0.693HisThr: 0.693 ± 0.025	1.369HisVal: 1.369 ± 0.032	0.343HisTrp: 0.343 ± 0.016	0.512HisTyr: 0.512 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.19IleAla: 8.19 ± 0.083	0.37IleCys: 0.37 ± 0.018	4.062IleAsp: 4.062 ± 0.052	3.656IleGlu: 3.656 ± 0.054	1.428IlePhe: 1.428 ± 0.035	5.115IleGly: 5.115 ± 0.065	0.808IleHis: 0.808 ± 0.025	1.729IleIle: 1.729 ± 0.039	1.152IleLys: 1.152 ± 0.027	4.033IleLeu: 4.033 ± 0.057	0.712IleMet: 0.712 ± 0.027	1.265IleAsn: 1.265 ± 0.043	2.296IlePro: 2.296 ± 0.046	1.148IleGln: 1.148 ± 0.028	3.31IleArg: 3.31 ± 0.047	2.368IleSer: 2.368 ± 0.047	2.508IleThr: 2.508 ± 0.065	4.184IleVal: 4.184 ± 0.049	0.62IleTrp: 0.62 ± 0.022	0.952IleTyr: 0.952 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.025LysAla: 4.025 ± 0.077	0.147LysCys: 0.147 ± 0.009	1.501LysAsp: 1.501 ± 0.037	1.188LysGlu: 1.188 ± 0.033	0.816LysPhe: 0.816 ± 0.026	2.554LysGly: 2.554 ± 0.055	0.536LysHis: 0.536 ± 0.018	1.345LysIle: 1.345 ± 0.032	0.99LysLys: 0.99 ± 0.032	3.246LysLeu: 3.246 ± 0.053	0.721LysMet: 0.721 ± 0.024	0.661LysAsn: 0.661 ± 0.022	2.108LysPro: 2.108 ± 0.042	0.871LysGln: 0.871 ± 0.027	2.31LysArg: 2.31 ± 0.046	1.388LysSer: 1.388 ± 0.036	1.675LysThr: 1.675 ± 0.036	2.15LysVal: 2.15 ± 0.049	0.406LysTrp: 0.406 ± 0.018	0.55LysTyr: 0.55 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.418LeuAla: 14.418 ± 0.142	0.666LeuCys: 0.666 ± 0.02	6.165LeuAsp: 6.165 ± 0.081	4.578LeuGlu: 4.578 ± 0.065	3.569LeuPhe: 3.569 ± 0.057	8.426LeuGly: 8.426 ± 0.084	1.712LeuHis: 1.712 ± 0.039	4.98LeuIle: 4.98 ± 0.067	2.974LeuLys: 2.974 ± 0.051	9.393LeuLeu: 9.393 ± 0.129	1.989LeuMet: 1.989 ± 0.043	2.597LeuAsn: 2.597 ± 0.067	5.528LeuPro: 5.528 ± 0.081	2.364LeuGln: 2.364 ± 0.042	6.947LeuArg: 6.947 ± 0.088	5.749LeuSer: 5.749 ± 0.075	5.839LeuThr: 5.839 ± 0.078	6.938LeuVal: 6.938 ± 0.085	1.257LeuTrp: 1.257 ± 0.034	1.992LeuTyr: 1.992 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.087MetAla: 3.087 ± 0.059	0.123MetCys: 0.123 ± 0.01	1.02MetAsp: 1.02 ± 0.026	0.927MetGlu: 0.927 ± 0.028	0.706MetPhe: 0.706 ± 0.024	1.8MetGly: 1.8 ± 0.037	0.412MetHis: 0.412 ± 0.017	1.322MetIle: 1.322 ± 0.035	0.887MetLys: 0.887 ± 0.024	2.569MetLeu: 2.569 ± 0.048	0.585MetMet: 0.585 ± 0.023	0.626MetAsn: 0.626 ± 0.02	1.476MetPro: 1.476 ± 0.036	0.732MetGln: 0.732 ± 0.024	1.916MetArg: 1.916 ± 0.042	1.305MetSer: 1.305 ± 0.031	1.732MetThr: 1.732 ± 0.039	1.514MetVal: 1.514 ± 0.034	0.244MetTrp: 0.244 ± 0.013	0.261MetTyr: 0.261 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.342AsnAla: 3.342 ± 0.071	0.208AsnCys: 0.208 ± 0.014	1.373AsnAsp: 1.373 ± 0.033	1.098AsnGlu: 1.098 ± 0.024	0.966AsnPhe: 0.966 ± 0.039	2.617AsnGly: 2.617 ± 0.081	0.458AsnHis: 0.458 ± 0.018	1.3AsnIle: 1.3 ± 0.038	0.621AsnLys: 0.621 ± 0.018	2.544AsnLeu: 2.544 ± 0.058	0.531AsnMet: 0.531 ± 0.018	0.694AsnAsn: 0.694 ± 0.048	1.811AsnPro: 1.811 ± 0.042	0.77AsnGln: 0.77 ± 0.025	1.866AsnArg: 1.866 ± 0.037	1.184AsnSer: 1.184 ± 0.049	1.171AsnThr: 1.171 ± 0.046	1.912AsnVal: 1.912 ± 0.055	0.471AsnTrp: 0.471 ± 0.02	0.742AsnTyr: 0.742 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.717ProAla: 7.717 ± 0.09	0.301ProCys: 0.301 ± 0.016	3.755ProAsp: 3.755 ± 0.059	3.559ProGlu: 3.559 ± 0.054	1.901ProPhe: 1.901 ± 0.034	5.365ProGly: 5.365 ± 0.068	0.977ProHis: 0.977 ± 0.03	2.238ProIle: 2.238 ± 0.039	1.47ProLys: 1.47 ± 0.035	4.943ProLeu: 4.943 ± 0.075	1.197ProMet: 1.197 ± 0.03	1.28ProAsn: 1.28 ± 0.032	2.846ProPro: 2.846 ± 0.079	1.671ProGln: 1.671 ± 0.031	3.208ProArg: 3.208 ± 0.056	2.703ProSer: 2.703 ± 0.044	2.359ProThr: 2.359 ± 0.047	4.603ProVal: 4.603 ± 0.061	0.741ProTrp: 0.741 ± 0.024	1.105ProTyr: 1.105 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.169GlnAla: 4.169 ± 0.058	0.202GlnCys: 0.202 ± 0.011	1.362GlnAsp: 1.362 ± 0.03	1.185GlnGlu: 1.185 ± 0.03	1.039GlnPhe: 1.039 ± 0.031	2.519GlnGly: 2.519 ± 0.04	0.576GlnHis: 0.576 ± 0.021	1.724GlnIle: 1.724 ± 0.04	0.813GlnLys: 0.813 ± 0.029	3.122GlnLeu: 3.122 ± 0.046	0.765GlnMet: 0.765 ± 0.021	0.755GlnAsn: 0.755 ± 0.022	1.854GlnPro: 1.854 ± 0.041	1.124GlnGln: 1.124 ± 0.034	2.552GlnArg: 2.552 ± 0.047	1.626GlnSer: 1.626 ± 0.038	1.599GlnThr: 1.599 ± 0.038	2.251GlnVal: 2.251 ± 0.046	0.422GlnTrp: 0.422 ± 0.015	0.586GlnTyr: 0.586 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.369ArgAla: 9.369 ± 0.12	0.462ArgCys: 0.462 ± 0.019	4.471ArgAsp: 4.471 ± 0.06	4.135ArgGlu: 4.135 ± 0.057	3.187ArgPhe: 3.187 ± 0.05	5.431ArgGly: 5.431 ± 0.07	1.665ArgHis: 1.665 ± 0.038	4.335ArgIle: 4.335 ± 0.062	2.121ArgLys: 2.121 ± 0.046	7.899ArgLeu: 7.899 ± 0.094	1.994ArgMet: 1.994 ± 0.035	1.913ArgAsn: 1.913 ± 0.038	3.781ArgPro: 3.781 ± 0.061	2.385ArgGln: 2.385 ± 0.039	5.899ArgArg: 5.899 ± 0.096	3.838ArgSer: 3.838 ± 0.055	3.847ArgThr: 3.847 ± 0.056	5.06ArgVal: 5.06 ± 0.073	1.291ArgTrp: 1.291 ± 0.034	2.0ArgTyr: 2.0 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.472SerAla: 6.472 ± 0.082	0.35SerCys: 0.35 ± 0.017	2.852SerAsp: 2.852 ± 0.045	2.416SerGlu: 2.416 ± 0.044	2.187SerPhe: 2.187 ± 0.046	5.568SerGly: 5.568 ± 0.107	0.9SerHis: 0.9 ± 0.028	2.708SerIle: 2.708 ± 0.056	1.411SerLys: 1.411 ± 0.035	4.896SerLeu: 4.896 ± 0.062	1.169SerMet: 1.169 ± 0.027	1.406SerAsn: 1.406 ± 0.043	2.799SerPro: 2.799 ± 0.044	1.428SerGln: 1.428 ± 0.036	3.566SerArg: 3.566 ± 0.052	2.635SerSer: 2.635 ± 0.042	2.63SerThr: 2.63 ± 0.056	3.702SerVal: 3.702 ± 0.062	0.815SerTrp: 0.815 ± 0.025	1.362SerTyr: 1.362 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.913ThrAla: 6.913 ± 0.082	0.365ThrCys: 0.365 ± 0.018	2.881ThrAsp: 2.881 ± 0.052	2.26ThrGlu: 2.26 ± 0.036	1.793ThrPhe: 1.793 ± 0.045	5.773ThrGly: 5.773 ± 0.162	0.937ThrHis: 0.937 ± 0.026	3.112ThrIle: 3.112 ± 0.074	1.248ThrLys: 1.248 ± 0.035	6.149ThrLeu: 6.149 ± 0.092	1.169ThrMet: 1.169 ± 0.031	1.361ThrAsn: 1.361 ± 0.045	3.529ThrPro: 3.529 ± 0.058	1.489ThrGln: 1.489 ± 0.037	3.634ThrArg: 3.634 ± 0.045	2.621ThrSer: 2.621 ± 0.057	2.749ThrThr: 2.749 ± 0.065	4.292ThrVal: 4.292 ± 0.072	0.593ThrTrp: 0.593 ± 0.022	1.177ThrTyr: 1.177 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.822ValAla: 9.822 ± 0.105	0.466ValCys: 0.466 ± 0.02	3.977ValAsp: 3.977 ± 0.059	4.572ValGlu: 4.572 ± 0.066	2.253ValPhe: 2.253 ± 0.044	5.179ValGly: 5.179 ± 0.069	1.315ValHis: 1.315 ± 0.034	3.729ValIle: 3.729 ± 0.051	2.106ValLys: 2.106 ± 0.047	6.566ValLeu: 6.566 ± 0.074	1.558ValMet: 1.558 ± 0.038	2.043ValAsn: 2.043 ± 0.053	4.051ValPro: 4.051 ± 0.059	2.071ValGln: 2.071 ± 0.039	5.446ValArg: 5.446 ± 0.071	4.153ValSer: 4.153 ± 0.055	4.882ValThr: 4.882 ± 0.08	5.245ValVal: 5.245 ± 0.073	0.858ValTrp: 0.858 ± 0.023	1.355ValTyr: 1.355 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.456TrpAla: 1.456 ± 0.039	0.125TrpCys: 0.125 ± 0.011	0.713TrpAsp: 0.713 ± 0.023	0.633TrpGlu: 0.633 ± 0.023	0.584TrpPhe: 0.584 ± 0.022	0.999TrpGly: 0.999 ± 0.027	0.353TrpHis: 0.353 ± 0.017	0.738TrpIle: 0.738 ± 0.025	0.484TrpLys: 0.484 ± 0.019	1.789TrpLeu: 1.789 ± 0.042	0.357TrpMet: 0.357 ± 0.015	0.454TrpAsn: 0.454 ± 0.019	0.719TrpPro: 0.719 ± 0.024	0.634TrpGln: 0.634 ± 0.02	1.427TrpArg: 1.427 ± 0.035	0.902TrpSer: 0.902 ± 0.028	0.891TrpThr: 0.891 ± 0.025	0.916TrpVal: 0.916 ± 0.03	0.285TrpTrp: 0.285 ± 0.015	0.31TrpTyr: 0.31 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.72TyrAla: 2.72 ± 0.042	0.21TyrCys: 0.21 ± 0.011	1.6TyrAsp: 1.6 ± 0.039	1.11TyrGlu: 1.11 ± 0.03	0.886TyrPhe: 0.886 ± 0.029	2.149TyrGly: 2.149 ± 0.044	0.453TyrHis: 0.453 ± 0.02	0.786TyrIle: 0.786 ± 0.027	0.555TyrLys: 0.555 ± 0.021	2.17TyrLeu: 2.17 ± 0.041	0.377TyrMet: 0.377 ± 0.014	0.611TyrAsn: 0.611 ± 0.026	1.056TyrPro: 1.056 ± 0.029	0.673TyrGln: 0.673 ± 0.024	2.009TyrArg: 2.009 ± 0.041	1.232TyrSer: 1.232 ± 0.031	1.038TyrThr: 1.038 ± 0.029	1.571TyrVal: 1.571 ± 0.037	0.341TyrTrp: 0.341 ± 0.016	0.635TyrTyr: 0.635 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4485 proteins (1424114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---