Amino acid dipepetide frequency for Rodentibacter trehalosifermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.649AlaAla: 6.649 ± 0.132
0.882AlaCys: 0.882 ± 0.039
4.098AlaAsp: 4.098 ± 0.093
6.056AlaGlu: 6.056 ± 0.116
3.56AlaPhe: 3.56 ± 0.078
5.454AlaGly: 5.454 ± 0.106
1.491AlaHis: 1.491 ± 0.041
6.008AlaIle: 6.008 ± 0.104
5.797AlaLys: 5.797 ± 0.088
10.019AlaLeu: 10.019 ± 0.143
2.45AlaMet: 2.45 ± 0.06
3.671AlaAsn: 3.671 ± 0.074
2.407AlaPro: 2.407 ± 0.069
4.042AlaGln: 4.042 ± 0.084
3.471AlaArg: 3.471 ± 0.078
3.771AlaSer: 3.771 ± 0.079
4.257AlaThr: 4.257 ± 0.088
5.92AlaVal: 5.92 ± 0.112
0.86AlaTrp: 0.86 ± 0.036
2.542AlaTyr: 2.542 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.752CysAla: 0.752 ± 0.037
0.162CysCys: 0.162 ± 0.014
0.525CysAsp: 0.525 ± 0.03
0.612CysGlu: 0.612 ± 0.031
0.492CysPhe: 0.492 ± 0.025
0.953CysGly: 0.953 ± 0.042
0.303CysHis: 0.303 ± 0.026
0.563CysIle: 0.563 ± 0.029
0.425CysLys: 0.425 ± 0.027
0.98CysLeu: 0.98 ± 0.034
0.159CysMet: 0.159 ± 0.015
0.36CysAsn: 0.36 ± 0.025
0.443CysPro: 0.443 ± 0.031
0.476CysGln: 0.476 ± 0.027
0.454CysArg: 0.454 ± 0.025
0.567CysSer: 0.567 ± 0.024
0.466CysThr: 0.466 ± 0.027
0.62CysVal: 0.62 ± 0.027
0.12CysTrp: 0.12 ± 0.012
0.349CysTyr: 0.349 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.316AspAla: 3.316 ± 0.064
0.542AspCys: 0.542 ± 0.027
2.359AspAsp: 2.359 ± 0.073
3.915AspGlu: 3.915 ± 0.088
2.698AspPhe: 2.698 ± 0.065
3.028AspGly: 3.028 ± 0.075
0.867AspHis: 0.867 ± 0.041
3.784AspIle: 3.784 ± 0.077
3.407AspLys: 3.407 ± 0.076
5.049AspLeu: 5.049 ± 0.091
1.131AspMet: 1.131 ± 0.042
2.371AspAsn: 2.371 ± 0.061
2.01AspPro: 2.01 ± 0.06
1.425AspGln: 1.425 ± 0.044
2.219AspArg: 2.219 ± 0.059
2.518AspSer: 2.518 ± 0.069
2.272AspThr: 2.272 ± 0.063
3.301AspVal: 3.301 ± 0.075
0.838AspTrp: 0.838 ± 0.035
2.276AspTyr: 2.276 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.779GluAla: 4.779 ± 0.1
0.463GluCys: 0.463 ± 0.028
2.581GluAsp: 2.581 ± 0.063
4.27GluGlu: 4.27 ± 0.115
2.561GluPhe: 2.561 ± 0.057
3.775GluGly: 3.775 ± 0.086
1.266GluHis: 1.266 ± 0.043
4.94GluIle: 4.94 ± 0.085
5.718GluLys: 5.718 ± 0.102
6.419GluLeu: 6.419 ± 0.102
1.915GluMet: 1.915 ± 0.051
4.185GluAsn: 4.185 ± 0.081
1.916GluPro: 1.916 ± 0.052
4.05GluGln: 4.05 ± 0.088
3.418GluArg: 3.418 ± 0.078
3.1GluSer: 3.1 ± 0.066
3.346GluThr: 3.346 ± 0.069
4.023GluVal: 4.023 ± 0.085
0.754GluTrp: 0.754 ± 0.039
1.777GluTyr: 1.777 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.686PheAla: 3.686 ± 0.071
0.553PheCys: 0.553 ± 0.029
2.807PheAsp: 2.807 ± 0.056
2.597PheGlu: 2.597 ± 0.067
2.155PhePhe: 2.155 ± 0.065
3.416PheGly: 3.416 ± 0.085
0.923PheHis: 0.923 ± 0.034
3.276PheIle: 3.276 ± 0.086
2.259PheLys: 2.259 ± 0.062
4.087PheLeu: 4.087 ± 0.108
0.981PheMet: 0.981 ± 0.035
2.458PheAsn: 2.458 ± 0.07
1.582PhePro: 1.582 ± 0.048
1.427PheGln: 1.427 ± 0.044
1.624PheArg: 1.624 ± 0.046
3.356PheSer: 3.356 ± 0.078
2.454PheThr: 2.454 ± 0.053
2.967PheVal: 2.967 ± 0.073
0.589PheTrp: 0.589 ± 0.028
1.611PheTyr: 1.611 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
5.124GlyAla: 5.124 ± 0.104
0.805GlyCys: 0.805 ± 0.036
3.181GlyAsp: 3.181 ± 0.08
4.591GlyGlu: 4.591 ± 0.097
3.189GlyPhe: 3.189 ± 0.076
4.723GlyGly: 4.723 ± 0.11
1.259GlyHis: 1.259 ± 0.046
5.33GlyIle: 5.33 ± 0.102
5.283GlyLys: 5.283 ± 0.096
6.878GlyLeu: 6.878 ± 0.108
1.904GlyMet: 1.904 ± 0.057
3.006GlyAsn: 3.006 ± 0.08
1.086GlyPro: 1.086 ± 0.042
2.445GlyGln: 2.445 ± 0.057
2.844GlyArg: 2.844 ± 0.069
3.663GlySer: 3.663 ± 0.095
3.305GlyThr: 3.305 ± 0.077
5.097GlyVal: 5.097 ± 0.087
0.932GlyTrp: 0.932 ± 0.036
2.597GlyTyr: 2.597 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.28HisAla: 1.28 ± 0.043
0.36HisCys: 0.36 ± 0.022
0.793HisAsp: 0.793 ± 0.039
0.886HisGlu: 0.886 ± 0.035
1.246HisPhe: 1.246 ± 0.05
1.216HisGly: 1.216 ± 0.04
0.715HisHis: 0.715 ± 0.034
1.548HisIle: 1.548 ± 0.046
1.078HisLys: 1.078 ± 0.036
2.431HisLeu: 2.431 ± 0.062
0.367HisMet: 0.367 ± 0.021
0.918HisAsn: 0.918 ± 0.035
1.137HisPro: 1.137 ± 0.042
1.237HisGln: 1.237 ± 0.043
1.064HisArg: 1.064 ± 0.031
1.338HisSer: 1.338 ± 0.045
0.973HisThr: 0.973 ± 0.039
0.839HisVal: 0.839 ± 0.034
0.327HisTrp: 0.327 ± 0.021
0.923HisTyr: 0.923 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.692IleAla: 6.692 ± 0.113
0.754IleCys: 0.754 ± 0.029
3.876IleAsp: 3.876 ± 0.076
4.697IleGlu: 4.697 ± 0.086
2.993IlePhe: 2.993 ± 0.088
5.189IleGly: 5.189 ± 0.092
1.454IleHis: 1.454 ± 0.053
4.388IleIle: 4.388 ± 0.114
3.897IleLys: 3.897 ± 0.07
6.513IleLeu: 6.513 ± 0.136
1.221IleMet: 1.221 ± 0.04
3.427IleAsn: 3.427 ± 0.075
2.874IlePro: 2.874 ± 0.062
2.696IleGln: 2.696 ± 0.066
2.952IleArg: 2.952 ± 0.063
4.65IleSer: 4.65 ± 0.084
3.862IleThr: 3.862 ± 0.075
4.4IleVal: 4.4 ± 0.075
0.7IleTrp: 0.7 ± 0.028
2.111IleTyr: 2.111 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.499LysAla: 5.499 ± 0.094
0.414LysCys: 0.414 ± 0.03
2.989LysAsp: 2.989 ± 0.077
4.383LysGlu: 4.383 ± 0.078
2.146LysPhe: 2.146 ± 0.06
4.234LysGly: 4.234 ± 0.082
1.18LysHis: 1.18 ± 0.042
4.279LysIle: 4.279 ± 0.086
4.197LysLys: 4.197 ± 0.086
6.142LysLeu: 6.142 ± 0.101
1.999LysMet: 1.999 ± 0.053
3.545LysAsn: 3.545 ± 0.076
2.499LysPro: 2.499 ± 0.061
3.282LysGln: 3.282 ± 0.077
2.969LysArg: 2.969 ± 0.067
3.569LysSer: 3.569 ± 0.07
3.678LysThr: 3.678 ± 0.081
4.019LysVal: 4.019 ± 0.075
0.747LysTrp: 0.747 ± 0.038
1.842LysTyr: 1.842 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
9.448LeuAla: 9.448 ± 0.133
1.101LeuCys: 1.101 ± 0.04
5.302LeuAsp: 5.302 ± 0.089
6.047LeuGlu: 6.047 ± 0.106
4.756LeuPhe: 4.756 ± 0.1
7.202LeuGly: 7.202 ± 0.112
1.894LeuHis: 1.894 ± 0.051
6.808LeuIle: 6.808 ± 0.125
6.134LeuLys: 6.134 ± 0.102
10.452LeuLeu: 10.452 ± 0.204
2.527LeuMet: 2.527 ± 0.07
5.161LeuAsn: 5.161 ± 0.101
4.806LeuPro: 4.806 ± 0.082
4.133LeuGln: 4.133 ± 0.09
4.568LeuArg: 4.568 ± 0.096
7.454LeuSer: 7.454 ± 0.111
6.09LeuThr: 6.09 ± 0.098
6.314LeuVal: 6.314 ± 0.107
1.085LeuTrp: 1.085 ± 0.044
2.844LeuTyr: 2.844 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.393MetAla: 2.393 ± 0.067
0.183MetCys: 0.183 ± 0.014
1.019MetAsp: 1.019 ± 0.038
1.274MetGlu: 1.274 ± 0.044
0.932MetPhe: 0.932 ± 0.037
1.641MetGly: 1.641 ± 0.052
0.353MetHis: 0.353 ± 0.02
1.569MetIle: 1.569 ± 0.046
1.814MetLys: 1.814 ± 0.053
2.593MetLeu: 2.593 ± 0.058
0.804MetMet: 0.804 ± 0.032
1.22MetAsn: 1.22 ± 0.042
1.115MetPro: 1.115 ± 0.045
1.198MetGln: 1.198 ± 0.044
1.064MetArg: 1.064 ± 0.042
1.51MetSer: 1.51 ± 0.042
1.513MetThr: 1.513 ± 0.047
1.551MetVal: 1.551 ± 0.051
0.23MetTrp: 0.23 ± 0.022
0.508MetTyr: 0.508 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.18AsnAla: 4.18 ± 0.086
0.388AsnCys: 0.388 ± 0.024
2.291AsnAsp: 2.291 ± 0.062
3.095AsnGlu: 3.095 ± 0.07
1.946AsnPhe: 1.946 ± 0.055
3.523AsnGly: 3.523 ± 0.088
1.134AsnHis: 1.134 ± 0.034
3.547AsnIle: 3.547 ± 0.09
2.877AsnLys: 2.877 ± 0.072
4.845AsnLeu: 4.845 ± 0.11
1.049AsnMet: 1.049 ± 0.036
2.238AsnAsn: 2.238 ± 0.074
2.457AsnPro: 2.457 ± 0.062
2.48AsnGln: 2.48 ± 0.063
2.243AsnArg: 2.243 ± 0.061
2.548AsnSer: 2.548 ± 0.074
2.418AsnThr: 2.418 ± 0.067
3.125AsnVal: 3.125 ± 0.08
0.7AsnTrp: 0.7 ± 0.031
1.593AsnTyr: 1.593 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.641ProAla: 2.641 ± 0.06
0.285ProCys: 0.285 ± 0.018
1.84ProAsp: 1.84 ± 0.058
2.965ProGlu: 2.965 ± 0.077
1.841ProPhe: 1.841 ± 0.054
1.533ProGly: 1.533 ± 0.05
1.064ProHis: 1.064 ± 0.036
2.661ProIle: 2.661 ± 0.055
2.42ProLys: 2.42 ± 0.054
3.968ProLeu: 3.968 ± 0.095
0.987ProMet: 0.987 ± 0.035
2.268ProAsn: 2.268 ± 0.059
1.138ProPro: 1.138 ± 0.043
1.896ProGln: 1.896 ± 0.056
1.355ProArg: 1.355 ± 0.047
2.101ProSer: 2.101 ± 0.056
2.284ProThr: 2.284 ± 0.061
2.63ProVal: 2.63 ± 0.07
0.405ProTrp: 0.405 ± 0.026
1.447ProTyr: 1.447 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.428GlnAla: 4.428 ± 0.086
0.39GlnCys: 0.39 ± 0.025
2.084GlnAsp: 2.084 ± 0.056
2.702GlnGlu: 2.702 ± 0.063
2.075GlnPhe: 2.075 ± 0.051
3.1GlnGly: 3.1 ± 0.079
1.062GlnHis: 1.062 ± 0.034
3.205GlnIle: 3.205 ± 0.074
3.042GlnLys: 3.042 ± 0.072
4.592GlnLeu: 4.592 ± 0.092
1.033GlnMet: 1.033 ± 0.036
2.258GlnAsn: 2.258 ± 0.057
1.706GlnPro: 1.706 ± 0.058
2.909GlnGln: 2.909 ± 0.077
2.298GlnArg: 2.298 ± 0.062
2.641GlnSer: 2.641 ± 0.072
2.363GlnThr: 2.363 ± 0.058
2.769GlnVal: 2.769 ± 0.073
0.62GlnTrp: 0.62 ± 0.027
1.533GlnTyr: 1.533 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.129ArgAla: 3.129 ± 0.068
0.414ArgCys: 0.414 ± 0.029
2.281ArgAsp: 2.281 ± 0.064
3.219ArgGlu: 3.219 ± 0.077
2.334ArgPhe: 2.334 ± 0.064
2.569ArgGly: 2.569 ± 0.063
1.067ArgHis: 1.067 ± 0.04
3.216ArgIle: 3.216 ± 0.071
2.671ArgLys: 2.671 ± 0.07
5.114ArgLeu: 5.114 ± 0.091
1.023ArgMet: 1.023 ± 0.037
1.99ArgAsn: 1.99 ± 0.048
1.601ArgPro: 1.601 ± 0.049
2.371ArgGln: 2.371 ± 0.062
2.153ArgArg: 2.153 ± 0.077
2.236ArgSer: 2.236 ± 0.066
2.219ArgThr: 2.219 ± 0.056
2.728ArgVal: 2.728 ± 0.072
0.567ArgTrp: 0.567 ± 0.026
1.842ArgTyr: 1.842 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.228SerAla: 5.228 ± 0.086
0.512SerCys: 0.512 ± 0.026
2.98SerAsp: 2.98 ± 0.066
3.61SerGlu: 3.61 ± 0.081
2.554SerPhe: 2.554 ± 0.067
4.402SerGly: 4.402 ± 0.081
1.344SerHis: 1.344 ± 0.039
3.7SerIle: 3.7 ± 0.074
2.983SerLys: 2.983 ± 0.074
6.19SerLeu: 6.19 ± 0.099
1.295SerMet: 1.295 ± 0.043
2.438SerAsn: 2.438 ± 0.073
2.353SerPro: 2.353 ± 0.054
2.745SerGln: 2.745 ± 0.067
2.554SerArg: 2.554 ± 0.066
3.38SerSer: 3.38 ± 0.096
3.001SerThr: 3.001 ± 0.062
3.908SerVal: 3.908 ± 0.082
0.668SerTrp: 0.668 ± 0.029
1.717SerTyr: 1.717 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.086ThrAla: 5.086 ± 0.097
0.416ThrCys: 0.416 ± 0.027
2.588ThrAsp: 2.588 ± 0.062
3.35ThrGlu: 3.35 ± 0.072
2.289ThrPhe: 2.289 ± 0.06
3.741ThrGly: 3.741 ± 0.086
1.15ThrHis: 1.15 ± 0.036
3.212ThrIle: 3.212 ± 0.071
2.904ThrLys: 2.904 ± 0.076
6.295ThrLeu: 6.295 ± 0.118
1.062ThrMet: 1.062 ± 0.034
2.19ThrAsn: 2.19 ± 0.067
2.582ThrPro: 2.582 ± 0.065
2.557ThrGln: 2.557 ± 0.059
2.033ThrArg: 2.033 ± 0.054
2.655ThrSer: 2.655 ± 0.067
2.871ThrThr: 2.871 ± 0.068
3.572ThrVal: 3.572 ± 0.092
0.534ThrTrp: 0.534 ± 0.025
1.555ThrTyr: 1.555 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.654ValAla: 5.654 ± 0.131
0.617ValCys: 0.617 ± 0.032
3.444ValAsp: 3.444 ± 0.085
4.61ValGlu: 4.61 ± 0.106
2.641ValPhe: 2.641 ± 0.073
4.548ValGly: 4.548 ± 0.095
1.002ValHis: 1.002 ± 0.04
4.708ValIle: 4.708 ± 0.095
4.498ValLys: 4.498 ± 0.087
6.337ValLeu: 6.337 ± 0.117
1.767ValMet: 1.767 ± 0.052
3.155ValAsn: 3.155 ± 0.086
2.389ValPro: 2.389 ± 0.057
2.464ValGln: 2.464 ± 0.047
2.926ValArg: 2.926 ± 0.069
4.095ValSer: 4.095 ± 0.084
3.272ValThr: 3.272 ± 0.086
4.706ValVal: 4.706 ± 0.098
0.638ValTrp: 0.638 ± 0.031
1.852ValTyr: 1.852 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.867TrpAla: 0.867 ± 0.037
0.131TrpCys: 0.131 ± 0.014
0.563TrpAsp: 0.563 ± 0.027
0.639TrpGlu: 0.639 ± 0.031
0.634TrpPhe: 0.634 ± 0.031
0.784TrpGly: 0.784 ± 0.033
0.32TrpHis: 0.32 ± 0.024
0.771TrpIle: 0.771 ± 0.033
0.688TrpLys: 0.688 ± 0.029
1.672TrpLeu: 1.672 ± 0.059
0.238TrpMet: 0.238 ± 0.016
0.522TrpAsn: 0.522 ± 0.027
0.158TrpPro: 0.158 ± 0.013
1.007TrpGln: 1.007 ± 0.04
0.643TrpArg: 0.643 ± 0.031
0.5TrpSer: 0.5 ± 0.025
0.476TrpThr: 0.476 ± 0.024
0.812TrpVal: 0.812 ± 0.029
0.179TrpTrp: 0.179 ± 0.017
0.357TrpTyr: 0.357 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.574TyrAla: 2.574 ± 0.059
0.406TyrCys: 0.406 ± 0.025
1.727TyrAsp: 1.727 ± 0.052
1.736TyrGlu: 1.736 ± 0.048
1.769TyrPhe: 1.769 ± 0.05
2.213TyrGly: 2.213 ± 0.056
0.829TyrHis: 0.829 ± 0.037
1.832TyrIle: 1.832 ± 0.057
1.518TyrLys: 1.518 ± 0.04
3.551TyrLeu: 3.551 ± 0.077
0.57TyrMet: 0.57 ± 0.03
1.296TyrAsn: 1.296 ± 0.051
1.469TyrPro: 1.469 ± 0.046
1.972TyrGln: 1.972 ± 0.056
1.896TyrArg: 1.896 ± 0.055
1.906TyrSer: 1.906 ± 0.057
1.522TyrThr: 1.522 ± 0.054
2.022TyrVal: 2.022 ± 0.054
0.469TyrTrp: 0.469 ± 0.026
1.217TyrTyr: 1.217 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2455 proteins (733808 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski