Amino acid dipepetide frequency for Pigmentiphaga aceris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.979AlaAla: 16.979 ± 0.149	1.129AlaCys: 1.129 ± 0.028	7.062AlaAsp: 7.062 ± 0.071	6.087AlaGlu: 6.087 ± 0.06	4.079AlaPhe: 4.079 ± 0.054	10.435AlaGly: 10.435 ± 0.093	2.411AlaHis: 2.411 ± 0.04	5.808AlaIle: 5.808 ± 0.064	3.594AlaLys: 3.594 ± 0.055	14.333AlaLeu: 14.333 ± 0.117	3.386AlaMet: 3.386 ± 0.052	3.215AlaAsn: 3.215 ± 0.047	5.852AlaPro: 5.852 ± 0.081	5.348AlaGln: 5.348 ± 0.064	8.619AlaArg: 8.619 ± 0.078	7.666AlaSer: 7.666 ± 0.073	6.543AlaThr: 6.543 ± 0.076	9.095AlaVal: 9.095 ± 0.073	1.837AlaTrp: 1.837 ± 0.041	2.657AlaTyr: 2.657 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.026	0.102CysCys: 0.102 ± 0.007	0.444CysAsp: 0.444 ± 0.017	0.394CysGlu: 0.394 ± 0.015	0.285CysPhe: 0.285 ± 0.012	0.811CysGly: 0.811 ± 0.024	0.205CysHis: 0.205 ± 0.012	0.355CysIle: 0.355 ± 0.015	0.198CysLys: 0.198 ± 0.01	0.778CysLeu: 0.778 ± 0.023	0.195CysMet: 0.195 ± 0.011	0.216CysAsn: 0.216 ± 0.012	0.383CysPro: 0.383 ± 0.015	0.221CysGln: 0.221 ± 0.011	0.481CysArg: 0.481 ± 0.016	0.414CysSer: 0.414 ± 0.016	0.415CysThr: 0.415 ± 0.017	0.687CysVal: 0.687 ± 0.021	0.121CysTrp: 0.121 ± 0.009	0.187CysTyr: 0.187 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.777AspAla: 7.777 ± 0.069	0.405AspCys: 0.405 ± 0.014	2.95AspAsp: 2.95 ± 0.048	3.04AspGlu: 3.04 ± 0.048	2.039AspPhe: 2.039 ± 0.037	4.72AspGly: 4.72 ± 0.059	1.106AspHis: 1.106 ± 0.029	2.857AspIle: 2.857 ± 0.043	1.659AspLys: 1.659 ± 0.036	5.384AspLeu: 5.384 ± 0.061	1.337AspMet: 1.337 ± 0.029	1.277AspAsn: 1.277 ± 0.025	3.069AspPro: 3.069 ± 0.046	1.819AspGln: 1.819 ± 0.038	3.61AspArg: 3.61 ± 0.043	2.615AspSer: 2.615 ± 0.04	3.175AspThr: 3.175 ± 0.046	4.516AspVal: 4.516 ± 0.056	0.954AspTrp: 0.954 ± 0.025	1.494AspTyr: 1.494 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.127GluAla: 6.127 ± 0.062	0.316GluCys: 0.316 ± 0.014	2.294GluAsp: 2.294 ± 0.034	2.162GluGlu: 2.162 ± 0.041	1.672GluPhe: 1.672 ± 0.033	3.327GluGly: 3.327 ± 0.05	1.272GluHis: 1.272 ± 0.028	2.675GluIle: 2.675 ± 0.044	1.646GluLys: 1.646 ± 0.039	5.268GluLeu: 5.268 ± 0.057	1.109GluMet: 1.109 ± 0.026	1.34GluAsn: 1.34 ± 0.027	2.255GluPro: 2.255 ± 0.036	2.339GluGln: 2.339 ± 0.046	4.059GluArg: 4.059 ± 0.051	2.625GluSer: 2.625 ± 0.034	2.655GluThr: 2.655 ± 0.04	3.719GluVal: 3.719 ± 0.044	0.627GluTrp: 0.627 ± 0.021	1.016GluTyr: 1.016 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.253PheAla: 4.253 ± 0.052	0.347PheCys: 0.347 ± 0.013	2.527PheAsp: 2.527 ± 0.04	1.831PheGlu: 1.831 ± 0.032	1.282PhePhe: 1.282 ± 0.03	3.304PheGly: 3.304 ± 0.046	0.683PheHis: 0.683 ± 0.019	1.605PheIle: 1.605 ± 0.032	1.074PheLys: 1.074 ± 0.026	3.168PheLeu: 3.168 ± 0.043	0.829PheMet: 0.829 ± 0.022	1.143PheAsn: 1.143 ± 0.028	1.538PhePro: 1.538 ± 0.029	1.119PheGln: 1.119 ± 0.022	1.886PheArg: 1.886 ± 0.033	2.332PheSer: 2.332 ± 0.039	2.037PheThr: 2.037 ± 0.037	2.762PheVal: 2.762 ± 0.042	0.546PheTrp: 0.546 ± 0.02	0.87PheTyr: 0.87 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	8.637GlyAla: 8.637 ± 0.088	0.694GlyCys: 0.694 ± 0.021	4.077GlyAsp: 4.077 ± 0.051	4.138GlyGlu: 4.138 ± 0.05	3.298GlyPhe: 3.298 ± 0.041	6.736GlyGly: 6.736 ± 0.102	1.765GlyHis: 1.765 ± 0.032	4.291GlyIle: 4.291 ± 0.052	3.301GlyLys: 3.301 ± 0.043	8.922GlyLeu: 8.922 ± 0.079	2.469GlyMet: 2.469 ± 0.04	2.378GlyAsn: 2.378 ± 0.052	2.983GlyPro: 2.983 ± 0.046	3.125GlyGln: 3.125 ± 0.042	5.166GlyArg: 5.166 ± 0.054	4.821GlySer: 4.821 ± 0.06	4.706GlyThr: 4.706 ± 0.07	6.756GlyVal: 6.756 ± 0.075	1.361GlyTrp: 1.361 ± 0.031	2.168GlyTyr: 2.168 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.823HisAla: 2.823 ± 0.042	0.207HisCys: 0.207 ± 0.01	1.33HisAsp: 1.33 ± 0.031	1.079HisGlu: 1.079 ± 0.024	0.784HisPhe: 0.784 ± 0.022	1.991HisGly: 1.991 ± 0.038	0.586HisHis: 0.586 ± 0.02	0.967HisIle: 0.967 ± 0.024	0.455HisLys: 0.455 ± 0.016	2.108HisLeu: 2.108 ± 0.036	0.478HisMet: 0.478 ± 0.016	0.497HisAsn: 0.497 ± 0.016	1.395HisPro: 1.395 ± 0.027	0.728HisGln: 0.728 ± 0.018	1.392HisArg: 1.392 ± 0.03	0.984HisSer: 0.984 ± 0.025	1.061HisThr: 1.061 ± 0.027	1.577HisVal: 1.577 ± 0.027	0.328HisTrp: 0.328 ± 0.016	0.561HisTyr: 0.561 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.89IleAla: 6.89 ± 0.071	0.414IleCys: 0.414 ± 0.015	3.528IleAsp: 3.528 ± 0.043	3.077IleGlu: 3.077 ± 0.043	1.438IlePhe: 1.438 ± 0.03	4.589IleGly: 4.589 ± 0.061	0.886IleHis: 0.886 ± 0.024	1.704IleIle: 1.704 ± 0.037	1.43IleLys: 1.43 ± 0.032	3.681IleLeu: 3.681 ± 0.055	0.826IleMet: 0.826 ± 0.02	1.564IleAsn: 1.564 ± 0.034	2.179IlePro: 2.179 ± 0.039	1.385IleGln: 1.385 ± 0.031	2.784IleArg: 2.784 ± 0.04	2.886IleSer: 2.886 ± 0.04	2.676IleThr: 2.676 ± 0.042	3.934IleVal: 3.934 ± 0.051	0.547IleTrp: 0.547 ± 0.02	1.014IleTyr: 1.014 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.362LysAla: 3.362 ± 0.051	0.122LysCys: 0.122 ± 0.009	1.41LysAsp: 1.41 ± 0.035	1.326LysGlu: 1.326 ± 0.031	0.896LysPhe: 0.896 ± 0.022	2.116LysGly: 2.116 ± 0.038	0.659LysHis: 0.659 ± 0.019	1.44LysIle: 1.44 ± 0.033	1.099LysLys: 1.099 ± 0.03	3.472LysLeu: 3.472 ± 0.047	0.734LysMet: 0.734 ± 0.02	0.833LysAsn: 0.833 ± 0.024	1.948LysPro: 1.948 ± 0.035	1.331LysGln: 1.331 ± 0.026	2.18LysArg: 2.18 ± 0.032	1.618LysSer: 1.618 ± 0.032	1.884LysThr: 1.884 ± 0.04	2.403LysVal: 2.403 ± 0.042	0.341LysTrp: 0.341 ± 0.015	0.555LysTyr: 0.555 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.686LeuAla: 14.686 ± 0.116	0.866LeuCys: 0.866 ± 0.022	6.243LeuAsp: 6.243 ± 0.069	4.591LeuGlu: 4.591 ± 0.059	3.506LeuPhe: 3.506 ± 0.056	8.776LeuGly: 8.776 ± 0.09	2.167LeuHis: 2.167 ± 0.04	4.898LeuIle: 4.898 ± 0.065	3.113LeuLys: 3.113 ± 0.047	11.087LeuLeu: 11.087 ± 0.133	2.411LeuMet: 2.411 ± 0.041	3.001LeuAsn: 3.001 ± 0.042	6.081LeuPro: 6.081 ± 0.067	3.636LeuGln: 3.636 ± 0.048	7.581LeuArg: 7.581 ± 0.083	7.115LeuSer: 7.115 ± 0.066	5.82LeuThr: 5.82 ± 0.062	7.936LeuVal: 7.936 ± 0.085	1.162LeuTrp: 1.162 ± 0.027	2.051LeuTyr: 2.051 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.837MetAla: 2.837 ± 0.047	0.16MetCys: 0.16 ± 0.01	1.053MetAsp: 1.053 ± 0.021	0.866MetGlu: 0.866 ± 0.025	0.744MetPhe: 0.744 ± 0.022	1.74MetGly: 1.74 ± 0.031	0.543MetHis: 0.543 ± 0.019	1.139MetIle: 1.139 ± 0.032	0.827MetLys: 0.827 ± 0.025	2.866MetLeu: 2.866 ± 0.044	0.597MetMet: 0.597 ± 0.021	0.815MetAsn: 0.815 ± 0.018	1.489MetPro: 1.489 ± 0.034	1.07MetGln: 1.07 ± 0.024	1.755MetArg: 1.755 ± 0.034	1.893MetSer: 1.893 ± 0.031	1.594MetThr: 1.594 ± 0.027	1.743MetVal: 1.743 ± 0.036	0.216MetTrp: 0.216 ± 0.01	0.409MetTyr: 0.409 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.523AsnAla: 3.523 ± 0.058	0.214AsnCys: 0.214 ± 0.011	1.468AsnAsp: 1.468 ± 0.028	1.214AsnGlu: 1.214 ± 0.028	0.956AsnPhe: 0.956 ± 0.026	2.348AsnGly: 2.348 ± 0.041	0.551AsnHis: 0.551 ± 0.017	1.346AsnIle: 1.346 ± 0.031	0.785AsnLys: 0.785 ± 0.023	2.9AsnLeu: 2.9 ± 0.047	0.57AsnMet: 0.57 ± 0.019	0.818AsnAsn: 0.818 ± 0.028	1.841AsnPro: 1.841 ± 0.03	0.954AsnGln: 0.954 ± 0.028	1.804AsnArg: 1.804 ± 0.032	1.344AsnSer: 1.344 ± 0.034	1.664AsnThr: 1.664 ± 0.029	2.23AsnVal: 2.23 ± 0.037	0.394AsnTrp: 0.394 ± 0.015	0.689AsnTyr: 0.689 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.939ProAla: 6.939 ± 0.081	0.278ProCys: 0.278 ± 0.014	3.476ProAsp: 3.476 ± 0.044	2.981ProGlu: 2.981 ± 0.042	1.739ProPhe: 1.739 ± 0.031	4.267ProGly: 4.267 ± 0.053	1.051ProHis: 1.051 ± 0.025	2.136ProIle: 2.136 ± 0.033	1.39ProLys: 1.39 ± 0.033	5.103ProLeu: 5.103 ± 0.054	1.229ProMet: 1.229 ± 0.025	1.376ProAsn: 1.376 ± 0.032	2.435ProPro: 2.435 ± 0.054	1.84ProGln: 1.84 ± 0.034	2.854ProArg: 2.854 ± 0.048	3.001ProSer: 3.001 ± 0.047	2.883ProThr: 2.883 ± 0.041	4.473ProVal: 4.473 ± 0.053	0.727ProTrp: 0.727 ± 0.02	1.146ProTyr: 1.146 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.379GlnAla: 5.379 ± 0.068	0.241GlnCys: 0.241 ± 0.013	1.739GlnAsp: 1.739 ± 0.032	1.545GlnGlu: 1.545 ± 0.032	1.206GlnPhe: 1.206 ± 0.026	2.883GlnGly: 2.883 ± 0.044	0.937GlnHis: 0.937 ± 0.023	1.941GlnIle: 1.941 ± 0.031	0.957GlnLys: 0.957 ± 0.024	3.979GlnLeu: 3.979 ± 0.054	0.899GlnMet: 0.899 ± 0.02	0.92GlnAsn: 0.92 ± 0.025	2.022GlnPro: 2.022 ± 0.036	1.85GlnGln: 1.85 ± 0.04	3.153GlnArg: 3.153 ± 0.048	2.126GlnSer: 2.126 ± 0.036	2.265GlnThr: 2.265 ± 0.041	3.028GlnVal: 3.028 ± 0.044	0.553GlnTrp: 0.553 ± 0.016	0.79GlnTyr: 0.79 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.778ArgAla: 7.778 ± 0.07	0.514ArgCys: 0.514 ± 0.019	3.881ArgAsp: 3.881 ± 0.049	3.744ArgGlu: 3.744 ± 0.053	2.697ArgPhe: 2.697 ± 0.039	4.557ArgGly: 4.557 ± 0.06	1.711ArgHis: 1.711 ± 0.036	3.69ArgIle: 3.69 ± 0.045	2.038ArgLys: 2.038 ± 0.032	7.534ArgLeu: 7.534 ± 0.079	1.808ArgMet: 1.808 ± 0.031	1.985ArgAsn: 1.985 ± 0.033	3.026ArgPro: 3.026 ± 0.044	2.945ArgGln: 2.945 ± 0.044	4.763ArgArg: 4.763 ± 0.066	3.557ArgSer: 3.557 ± 0.05	3.303ArgThr: 3.303 ± 0.045	5.174ArgVal: 5.174 ± 0.059	1.074ArgTrp: 1.074 ± 0.027	1.852ArgTyr: 1.852 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.079SerAla: 7.079 ± 0.073	0.395SerCys: 0.395 ± 0.013	2.907SerAsp: 2.907 ± 0.045	2.54SerGlu: 2.54 ± 0.038	2.299SerPhe: 2.299 ± 0.035	5.369SerGly: 5.369 ± 0.07	1.241SerHis: 1.241 ± 0.029	2.842SerIle: 2.842 ± 0.043	1.601SerLys: 1.601 ± 0.031	6.53SerLeu: 6.53 ± 0.061	1.494SerMet: 1.494 ± 0.031	1.625SerAsn: 1.625 ± 0.032	3.124SerPro: 3.124 ± 0.045	2.081SerGln: 2.081 ± 0.036	3.803SerArg: 3.803 ± 0.051	3.637SerSer: 3.637 ± 0.046	3.482SerThr: 3.482 ± 0.046	4.663SerVal: 4.663 ± 0.058	0.837SerTrp: 0.837 ± 0.022	1.38SerTyr: 1.38 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.637ThrAla: 6.637 ± 0.086	0.377ThrCys: 0.377 ± 0.016	2.865ThrAsp: 2.865 ± 0.047	2.451ThrGlu: 2.451 ± 0.039	1.811ThrPhe: 1.811 ± 0.036	4.922ThrGly: 4.922 ± 0.067	1.235ThrHis: 1.235 ± 0.028	2.532ThrIle: 2.532 ± 0.041	1.303ThrLys: 1.303 ± 0.031	6.595ThrLeu: 6.595 ± 0.064	1.165ThrMet: 1.165 ± 0.028	1.395ThrAsn: 1.395 ± 0.035	3.752ThrPro: 3.752 ± 0.054	2.114ThrGln: 2.114 ± 0.037	3.653ThrArg: 3.653 ± 0.049	3.241ThrSer: 3.241 ± 0.047	3.225ThrThr: 3.225 ± 0.054	4.648ThrVal: 4.648 ± 0.055	0.793ThrTrp: 0.793 ± 0.018	1.183ThrTyr: 1.183 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.432ValAla: 9.432 ± 0.082	0.706ValCys: 0.706 ± 0.019	4.597ValAsp: 4.597 ± 0.06	3.863ValGlu: 3.863 ± 0.048	2.953ValPhe: 2.953 ± 0.049	5.97ValGly: 5.97 ± 0.07	1.517ValHis: 1.517 ± 0.03	3.771ValIle: 3.771 ± 0.053	2.263ValLys: 2.263 ± 0.042	8.571ValLeu: 8.571 ± 0.072	1.989ValMet: 1.989 ± 0.035	2.265ValAsn: 2.265 ± 0.041	4.082ValPro: 4.082 ± 0.051	2.856ValGln: 2.856 ± 0.043	5.085ValArg: 5.085 ± 0.062	5.068ValSer: 5.068 ± 0.055	4.452ValThr: 4.452 ± 0.064	6.762ValVal: 6.762 ± 0.079	0.984ValTrp: 0.984 ± 0.024	1.657ValTyr: 1.657 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.298TrpAla: 1.298 ± 0.03	0.142TrpCys: 0.142 ± 0.009	0.643TrpAsp: 0.643 ± 0.018	0.519TrpGlu: 0.519 ± 0.016	0.552TrpPhe: 0.552 ± 0.021	0.88TrpGly: 0.88 ± 0.024	0.374TrpHis: 0.374 ± 0.017	0.637TrpIle: 0.637 ± 0.018	0.416TrpLys: 0.416 ± 0.017	1.959TrpLeu: 1.959 ± 0.042	0.421TrpMet: 0.421 ± 0.014	0.428TrpAsn: 0.428 ± 0.015	0.664TrpPro: 0.664 ± 0.02	0.741TrpGln: 0.741 ± 0.02	1.203TrpArg: 1.203 ± 0.029	0.791TrpSer: 0.791 ± 0.026	0.777TrpThr: 0.777 ± 0.022	0.969TrpVal: 0.969 ± 0.024	0.239TrpTrp: 0.239 ± 0.011	0.321TrpTyr: 0.321 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.736TyrAla: 2.736 ± 0.042	0.227TyrCys: 0.227 ± 0.011	1.307TyrAsp: 1.307 ± 0.027	1.055TyrGlu: 1.055 ± 0.025	0.901TyrPhe: 0.901 ± 0.021	2.05TyrGly: 2.05 ± 0.034	0.43TyrHis: 0.43 ± 0.015	0.798TyrIle: 0.798 ± 0.02	0.583TyrLys: 0.583 ± 0.02	2.487TyrLeu: 2.487 ± 0.039	0.413TyrMet: 0.413 ± 0.017	0.521TyrAsn: 0.521 ± 0.019	1.205TyrPro: 1.205 ± 0.025	0.913TyrGln: 0.913 ± 0.025	1.797TyrArg: 1.797 ± 0.031	1.193TyrSer: 1.193 ± 0.025	1.278TyrThr: 1.278 ± 0.027	1.768TyrVal: 1.768 ± 0.034	0.336TyrTrp: 0.336 ± 0.015	0.588TyrTyr: 0.588 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5191 proteins (1790400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---