Amino acid dipepetide frequency for Gymnodraco acuticeps (Antarctic dragonfish)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.409AlaAla: 6.409 ± 0.031	1.178AlaCys: 1.178 ± 0.009	3.17AlaAsp: 3.17 ± 0.013	4.862AlaGlu: 4.862 ± 0.021	2.15AlaPhe: 2.15 ± 0.01	4.408AlaGly: 4.408 ± 0.025	1.438AlaHis: 1.438 ± 0.008	2.542AlaIle: 2.542 ± 0.01	3.424AlaLys: 3.424 ± 0.021	6.336AlaLeu: 6.336 ± 0.026	1.592AlaMet: 1.592 ± 0.009	2.24AlaAsn: 2.24 ± 0.01	3.776AlaPro: 3.776 ± 0.021	3.007AlaGln: 3.007 ± 0.015	3.004AlaArg: 3.004 ± 0.013	5.579AlaSer: 5.579 ± 0.02	3.498AlaThr: 3.498 ± 0.016	4.669AlaVal: 4.669 ± 0.015	0.587AlaTrp: 0.587 ± 0.005	1.399AlaTyr: 1.399 ± 0.009	0.003AlaXaa: 0.003 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.008	0.554CysCys: 0.554 ± 0.006	1.09CysAsp: 1.09 ± 0.01	1.296CysGlu: 1.296 ± 0.012	0.804CysPhe: 0.804 ± 0.005	1.453CysGly: 1.453 ± 0.012	0.578CysHis: 0.578 ± 0.005	0.873CysIle: 0.873 ± 0.006	1.097CysLys: 1.097 ± 0.008	1.978CysLeu: 1.978 ± 0.012	0.442CysMet: 0.442 ± 0.004	0.773CysAsn: 0.773 ± 0.007	1.183CysPro: 1.183 ± 0.013	0.963CysGln: 0.963 ± 0.009	1.249CysArg: 1.249 ± 0.009	2.157CysSer: 2.157 ± 0.016	1.094CysThr: 1.094 ± 0.009	1.419CysVal: 1.419 ± 0.01	0.273CysTrp: 0.273 ± 0.003	0.558CysTyr: 0.558 ± 0.005	0.001CysXaa: 0.001 ± 0.0
Asp	2.916AspAla: 2.916 ± 0.013	1.141AspCys: 1.141 ± 0.01	3.136AspAsp: 3.136 ± 0.02	3.876AspGlu: 3.876 ± 0.016	2.066AspPhe: 2.066 ± 0.009	3.638AspGly: 3.638 ± 0.016	1.213AspHis: 1.213 ± 0.009	2.714AspIle: 2.714 ± 0.015	2.77AspLys: 2.77 ± 0.014	5.095AspLeu: 5.095 ± 0.015	1.4AspMet: 1.4 ± 0.008	1.994AspAsn: 1.994 ± 0.012	2.975AspPro: 2.975 ± 0.014	2.08AspGln: 2.08 ± 0.009	2.759AspArg: 2.759 ± 0.012	4.81AspSer: 4.81 ± 0.024	2.785AspThr: 2.785 ± 0.014	3.281AspVal: 3.281 ± 0.014	0.651AspTrp: 0.651 ± 0.006	1.479AspTyr: 1.479 ± 0.01	0.002AspXaa: 0.002 ± 0.0
Glu	4.898GluAla: 4.898 ± 0.022	1.178GluCys: 1.178 ± 0.01	4.791GluAsp: 4.791 ± 0.017	8.787GluGlu: 8.787 ± 0.045	1.841GluPhe: 1.841 ± 0.009	4.4GluGly: 4.4 ± 0.018	1.534GluHis: 1.534 ± 0.008	2.843GluIle: 2.843 ± 0.014	4.961GluLys: 4.961 ± 0.028	6.11GluLeu: 6.11 ± 0.023	1.831GluMet: 1.831 ± 0.009	2.753GluAsn: 2.753 ± 0.011	3.06GluPro: 3.06 ± 0.018	3.253GluGln: 3.253 ± 0.015	4.548GluArg: 4.548 ± 0.024	4.825GluSer: 4.825 ± 0.019	3.77GluThr: 3.77 ± 0.019	4.539GluVal: 4.539 ± 0.019	0.649GluTrp: 0.649 ± 0.006	1.514GluTyr: 1.514 ± 0.01	0.003GluXaa: 0.003 ± 0.0
Phe	1.743PheAla: 1.743 ± 0.01	0.86PheCys: 0.86 ± 0.006	1.685PheAsp: 1.685 ± 0.01	1.845PheGlu: 1.845 ± 0.01	1.353PhePhe: 1.353 ± 0.009	1.993PheGly: 1.993 ± 0.013	0.948PheHis: 0.948 ± 0.007	1.7PheIle: 1.7 ± 0.01	1.781PheLys: 1.781 ± 0.009	3.491PheLeu: 3.491 ± 0.013	0.767PheMet: 0.767 ± 0.006	1.428PheAsn: 1.428 ± 0.009	1.76PhePro: 1.76 ± 0.01	1.541PheGln: 1.541 ± 0.008	1.772PheArg: 1.772 ± 0.012	3.238PheSer: 3.238 ± 0.014	2.221PheThr: 2.221 ± 0.011	1.992PheVal: 1.992 ± 0.009	0.415PheTrp: 0.415 ± 0.004	1.053PheTyr: 1.053 ± 0.007	0.002PheXaa: 0.002 ± 0.0
Gly	4.116GlyAla: 4.116 ± 0.033	1.178GlyCys: 1.178 ± 0.009	3.268GlyAsp: 3.268 ± 0.017	4.253GlyGlu: 4.253 ± 0.019	2.297GlyPhe: 2.297 ± 0.011	5.557GlyGly: 5.557 ± 0.033	1.682GlyHis: 1.682 ± 0.01	2.376GlyIle: 2.376 ± 0.012	3.554GlyLys: 3.554 ± 0.015	5.335GlyLeu: 5.335 ± 0.022	1.507GlyMet: 1.507 ± 0.011	2.532GlyAsn: 2.532 ± 0.013	3.565GlyPro: 3.565 ± 0.033	2.804GlyGln: 2.804 ± 0.014	3.62GlyArg: 3.62 ± 0.016	6.004GlySer: 6.004 ± 0.021	3.296GlyThr: 3.296 ± 0.015	3.975GlyVal: 3.975 ± 0.018	0.722GlyTrp: 0.722 ± 0.006	1.87GlyTyr: 1.87 ± 0.019	0.005GlyXaa: 0.005 ± 0.0
His	1.297HisAla: 1.297 ± 0.008	0.737HisCys: 0.737 ± 0.006	0.987HisAsp: 0.987 ± 0.007	1.225HisGlu: 1.225 ± 0.008	0.971HisPhe: 0.971 ± 0.005	1.551HisGly: 1.551 ± 0.009	1.116HisHis: 1.116 ± 0.013	1.304HisIle: 1.304 ± 0.007	1.278HisLys: 1.278 ± 0.008	2.7HisLeu: 2.7 ± 0.012	0.701HisMet: 0.701 ± 0.006	1.031HisAsn: 1.031 ± 0.007	1.609HisPro: 1.609 ± 0.012	1.37HisGln: 1.37 ± 0.011	1.615HisArg: 1.615 ± 0.009	2.555HisSer: 2.555 ± 0.011	1.675HisThr: 1.675 ± 0.011	1.437HisVal: 1.437 ± 0.008	0.32HisTrp: 0.32 ± 0.004	0.799HisTyr: 0.799 ± 0.007	0.001HisXaa: 0.001 ± 0.0
Ile	2.379IleAla: 2.379 ± 0.011	0.984IleCys: 0.984 ± 0.007	2.049IleAsp: 2.049 ± 0.011	2.385IleGlu: 2.385 ± 0.011	1.614IlePhe: 1.614 ± 0.009	2.148IleGly: 2.148 ± 0.01	1.267IleHis: 1.267 ± 0.008	2.231IleIle: 2.231 ± 0.011	2.499IleLys: 2.499 ± 0.014	3.932IleLeu: 3.932 ± 0.016	1.022IleMet: 1.022 ± 0.006	1.926IleAsn: 1.926 ± 0.012	2.428IlePro: 2.428 ± 0.011	2.202IleGln: 2.202 ± 0.01	2.373IleArg: 2.373 ± 0.01	3.737IleSer: 3.737 ± 0.014	2.871IleThr: 2.871 ± 0.015	2.383IleVal: 2.383 ± 0.012	0.408IleTrp: 0.408 ± 0.004	1.204IleTyr: 1.204 ± 0.008	0.002IleXaa: 0.002 ± 0.0
Lys	3.829LysAla: 3.829 ± 0.02	0.983LysCys: 0.983 ± 0.007	3.403LysAsp: 3.403 ± 0.018	4.952LysGlu: 4.952 ± 0.029	1.447LysPhe: 1.447 ± 0.009	3.394LysGly: 3.394 ± 0.02	1.404LysHis: 1.404 ± 0.008	2.308LysIle: 2.308 ± 0.011	4.669LysLys: 4.669 ± 0.03	4.88LysLeu: 4.88 ± 0.022	1.518LysMet: 1.518 ± 0.011	2.21LysAsn: 2.21 ± 0.012	3.152LysPro: 3.152 ± 0.021	2.624LysGln: 2.624 ± 0.014	3.544LysArg: 3.544 ± 0.014	4.121LysSer: 4.121 ± 0.018	3.34LysThr: 3.34 ± 0.016	3.483LysVal: 3.483 ± 0.016	0.559LysTrp: 0.559 ± 0.005	1.405LysTyr: 1.405 ± 0.011	0.005LysXaa: 0.005 ± 0.0
Leu	5.659LeuAla: 5.659 ± 0.02	2.028LeuCys: 2.028 ± 0.011	4.884LeuAsp: 4.884 ± 0.018	6.498LeuGlu: 6.498 ± 0.026	3.074LeuPhe: 3.074 ± 0.014	4.827LeuGly: 4.827 ± 0.018	2.737LeuHis: 2.737 ± 0.014	3.568LeuIle: 3.568 ± 0.015	5.725LeuLys: 5.725 ± 0.02	9.611LeuLeu: 9.611 ± 0.038	2.026LeuMet: 2.026 ± 0.009	3.506LeuAsn: 3.506 ± 0.013	5.299LeuPro: 5.299 ± 0.018	5.588LeuGln: 5.588 ± 0.025	5.587LeuArg: 5.587 ± 0.017	8.499LeuSer: 8.499 ± 0.022	5.154LeuThr: 5.154 ± 0.016	5.043LeuVal: 5.043 ± 0.02	0.963LeuTrp: 0.963 ± 0.007	2.324LeuTyr: 2.324 ± 0.011	0.004LeuXaa: 0.004 ± 0.0
Met	1.909MetAla: 1.909 ± 0.01	0.461MetCys: 0.461 ± 0.005	1.501MetAsp: 1.501 ± 0.008	2.125MetGlu: 2.125 ± 0.01	0.826MetPhe: 0.826 ± 0.006	1.483MetGly: 1.483 ± 0.01	0.512MetHis: 0.512 ± 0.005	0.833MetIle: 0.833 ± 0.006	1.523MetLys: 1.523 ± 0.008	2.088MetLeu: 2.088 ± 0.01	0.746MetMet: 0.746 ± 0.007	0.909MetAsn: 0.909 ± 0.007	1.178MetPro: 1.178 ± 0.014	1.057MetGln: 1.057 ± 0.006	1.239MetArg: 1.239 ± 0.008	2.04MetSer: 2.04 ± 0.009	1.291MetThr: 1.291 ± 0.01	1.508MetVal: 1.508 ± 0.007	0.257MetTrp: 0.257 ± 0.004	0.595MetTyr: 0.595 ± 0.005	0.001MetXaa: 0.001 ± 0.0
Asn	2.14AsnAla: 2.14 ± 0.01	0.795AsnCys: 0.795 ± 0.009	1.722AsnAsp: 1.722 ± 0.01	2.071AsnGlu: 2.071 ± 0.009	1.281AsnPhe: 1.281 ± 0.007	2.936AsnGly: 2.936 ± 0.025	1.019AsnHis: 1.019 ± 0.007	2.152AsnIle: 2.152 ± 0.014	2.3AsnLys: 2.3 ± 0.012	3.471AsnLeu: 3.471 ± 0.014	1.097AsnMet: 1.097 ± 0.009	1.868AsnAsn: 1.868 ± 0.012	2.261AsnPro: 2.261 ± 0.012	1.838AsnGln: 1.838 ± 0.01	2.035AsnArg: 2.035 ± 0.01	3.333AsnSer: 3.333 ± 0.015	2.371AsnThr: 2.371 ± 0.01	2.276AsnVal: 2.276 ± 0.012	0.387AsnTrp: 0.387 ± 0.004	1.078AsnTyr: 1.078 ± 0.009	0.002AsnXaa: 0.002 ± 0.0
Pro	4.485ProAla: 4.485 ± 0.026	1.019ProCys: 1.019 ± 0.009	2.921ProAsp: 2.921 ± 0.013	4.036ProGlu: 4.036 ± 0.019	1.71ProPhe: 1.71 ± 0.011	4.214ProGly: 4.214 ± 0.032	1.572ProHis: 1.572 ± 0.011	1.96ProIle: 1.96 ± 0.01	2.685ProLys: 2.685 ± 0.018	4.879ProLeu: 4.879 ± 0.019	1.109ProMet: 1.109 ± 0.007	2.046ProAsn: 2.046 ± 0.015	5.977ProPro: 5.977 ± 0.04	2.943ProGln: 2.943 ± 0.024	2.786ProArg: 2.786 ± 0.014	6.105ProSer: 6.105 ± 0.031	3.356ProThr: 3.356 ± 0.021	3.846ProVal: 3.846 ± 0.02	0.478ProTrp: 0.478 ± 0.005	1.42ProTyr: 1.42 ± 0.01	0.006ProXaa: 0.006 ± 0.0
Gln	3.196GlnAla: 3.196 ± 0.016	0.935GlnCys: 0.935 ± 0.008	2.409GlnAsp: 2.409 ± 0.01	3.726GlnGlu: 3.726 ± 0.018	1.346GlnPhe: 1.346 ± 0.007	2.871GlnGly: 2.871 ± 0.014	1.443GlnHis: 1.443 ± 0.009	1.914GlnIle: 1.914 ± 0.011	2.665GlnLys: 2.665 ± 0.015	4.515GlnLeu: 4.515 ± 0.022	1.215GlnMet: 1.215 ± 0.008	1.799GlnAsn: 1.799 ± 0.009	2.732GlnPro: 2.732 ± 0.021	3.923GlnGln: 3.923 ± 0.04	3.321GlnArg: 3.321 ± 0.015	3.814GlnSer: 3.814 ± 0.016	2.733GlnThr: 2.733 ± 0.012	2.671GlnVal: 2.671 ± 0.013	0.561GlnTrp: 0.561 ± 0.005	1.229GlnTyr: 1.229 ± 0.008	0.003GlnXaa: 0.003 ± 0.0
Arg	3.438ArgAla: 3.438 ± 0.015	1.155ArgCys: 1.155 ± 0.009	3.011ArgAsp: 3.011 ± 0.014	4.151ArgGlu: 4.151 ± 0.017	1.856ArgPhe: 1.856 ± 0.01	3.6ArgGly: 3.6 ± 0.02	1.56ArgHis: 1.56 ± 0.012	2.318ArgIle: 2.318 ± 0.011	3.536ArgLys: 3.536 ± 0.015	5.294ArgLeu: 5.294 ± 0.021	1.348ArgMet: 1.348 ± 0.008	2.115ArgAsn: 2.115 ± 0.009	3.017ArgPro: 3.017 ± 0.016	2.704ArgGln: 2.704 ± 0.013	4.415ArgArg: 4.415 ± 0.02	4.797ArgSer: 4.797 ± 0.02	2.914ArgThr: 2.914 ± 0.012	3.262ArgVal: 3.262 ± 0.014	0.636ArgTrp: 0.636 ± 0.006	1.442ArgTyr: 1.442 ± 0.008	0.003ArgXaa: 0.003 ± 0.0
Ser	5.825SerAla: 5.825 ± 0.017	2.027SerCys: 2.027 ± 0.013	4.727SerAsp: 4.727 ± 0.022	5.436SerGlu: 5.436 ± 0.019	2.992SerPhe: 2.992 ± 0.012	5.829SerGly: 5.829 ± 0.021	2.291SerHis: 2.291 ± 0.012	3.364SerIle: 3.364 ± 0.013	4.206SerLys: 4.206 ± 0.019	8.33SerLeu: 8.33 ± 0.025	1.992SerMet: 1.992 ± 0.009	3.193SerAsn: 3.193 ± 0.014	6.597SerPro: 6.597 ± 0.038	4.11SerGln: 4.11 ± 0.018	4.714SerArg: 4.714 ± 0.019	11.432SerSer: 11.432 ± 0.056	5.086SerThr: 5.086 ± 0.023	5.514SerVal: 5.514 ± 0.017	0.965SerTrp: 0.965 ± 0.006	2.147SerTyr: 2.147 ± 0.011	0.005SerXaa: 0.005 ± 0.0
Thr	4.078ThrAla: 4.078 ± 0.018	1.23ThrCys: 1.23 ± 0.01	2.983ThrAsp: 2.983 ± 0.012	4.114ThrGlu: 4.114 ± 0.02	2.066ThrPhe: 2.066 ± 0.01	3.657ThrGly: 3.657 ± 0.015	1.414ThrHis: 1.414 ± 0.009	2.389ThrIle: 2.389 ± 0.011	2.846ThrLys: 2.846 ± 0.015	5.394ThrLeu: 5.394 ± 0.014	1.284ThrMet: 1.284 ± 0.007	2.008ThrAsn: 2.008 ± 0.014	3.995ThrPro: 3.995 ± 0.023	2.469ThrGln: 2.469 ± 0.01	2.505ThrArg: 2.505 ± 0.012	5.193ThrSer: 5.193 ± 0.036	3.736ThrThr: 3.736 ± 0.036	4.005ThrVal: 4.005 ± 0.015	0.622ThrTrp: 0.622 ± 0.006	1.344ThrTyr: 1.344 ± 0.007	0.003ThrXaa: 0.003 ± 0.0
Val	3.909ValAla: 3.909 ± 0.014	1.59ValCys: 1.59 ± 0.01	3.177ValAsp: 3.177 ± 0.013	4.202ValGlu: 4.202 ± 0.017	2.428ValPhe: 2.428 ± 0.012	3.311ValGly: 3.311 ± 0.014	1.558ValHis: 1.558 ± 0.009	2.78ValIle: 2.78 ± 0.014	3.674ValLys: 3.674 ± 0.018	5.763ValLeu: 5.763 ± 0.019	1.502ValMet: 1.502 ± 0.008	2.486ValAsn: 2.486 ± 0.021	3.316ValPro: 3.316 ± 0.014	2.85ValGln: 2.85 ± 0.014	3.205ValArg: 3.205 ± 0.013	5.31ValSer: 5.31 ± 0.017	3.917ValThr: 3.917 ± 0.019	4.172ValVal: 4.172 ± 0.017	0.705ValTrp: 0.705 ± 0.006	1.639ValTyr: 1.639 ± 0.01	0.002ValXaa: 0.002 ± 0.0
Trp	0.625TrpAla: 0.625 ± 0.005	0.232TrpCys: 0.232 ± 0.003	0.588TrpAsp: 0.588 ± 0.006	0.728TrpGlu: 0.728 ± 0.006	0.416TrpPhe: 0.416 ± 0.005	0.563TrpGly: 0.563 ± 0.006	0.261TrpHis: 0.261 ± 0.003	0.524TrpIle: 0.524 ± 0.005	0.664TrpLys: 0.664 ± 0.006	1.047TrpLeu: 1.047 ± 0.008	0.336TrpMet: 0.336 ± 0.004	0.469TrpAsn: 0.469 ± 0.005	0.434TrpPro: 0.434 ± 0.004	0.457TrpGln: 0.457 ± 0.004	0.708TrpArg: 0.708 ± 0.006	0.907TrpSer: 0.907 ± 0.008	0.661TrpThr: 0.661 ± 0.006	0.604TrpVal: 0.604 ± 0.005	0.164TrpTrp: 0.164 ± 0.003	0.299TrpTyr: 0.299 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.331TyrAla: 1.331 ± 0.009	0.653TyrCys: 0.653 ± 0.006	1.279TyrAsp: 1.279 ± 0.008	1.515TyrGlu: 1.515 ± 0.009	1.046TyrPhe: 1.046 ± 0.007	1.675TyrGly: 1.675 ± 0.021	0.73TyrHis: 0.73 ± 0.006	1.351TyrIle: 1.351 ± 0.009	1.371TyrLys: 1.371 ± 0.01	2.35TyrLeu: 2.35 ± 0.01	0.648TyrMet: 0.648 ± 0.005	1.141TyrAsn: 1.141 ± 0.008	1.236TyrPro: 1.236 ± 0.01	1.236TyrGln: 1.236 ± 0.008	1.57TyrArg: 1.57 ± 0.01	2.323TyrSer: 2.323 ± 0.012	1.567TyrThr: 1.567 ± 0.011	1.415TyrVal: 1.415 ± 0.009	0.365TyrTrp: 0.365 ± 0.004	0.858TyrTyr: 0.858 ± 0.007	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.003XaaGlu: 0.003 ± 0.0	0.003XaaPhe: 0.003 ± 0.0	0.006XaaGly: 0.006 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.003XaaLys: 0.003 ± 0.0	0.004XaaLeu: 0.004 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.0	0.006XaaPro: 0.006 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.004XaaArg: 0.004 ± 0.0	0.005XaaSer: 0.005 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.003XaaVal: 0.003 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.001XaaXaa: 0.001 ± 0.0

Statistics based on 39919 proteins (28106559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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