Amino acid dipepetide frequency for Chlorobium ferrooxidans DSM 13031

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.973AlaAla: 8.973 ± 0.129	0.911AlaCys: 0.911 ± 0.041	4.185AlaAsp: 4.185 ± 0.079	6.196AlaGlu: 6.196 ± 0.109	3.519AlaPhe: 3.519 ± 0.067	7.62AlaGly: 7.62 ± 0.16	1.57AlaHis: 1.57 ± 0.054	5.632AlaIle: 5.632 ± 0.093	3.991AlaLys: 3.991 ± 0.089	10.323AlaLeu: 10.323 ± 0.163	2.273AlaMet: 2.273 ± 0.073	2.655AlaAsn: 2.655 ± 0.107	3.012AlaPro: 3.012 ± 0.081	2.225AlaGln: 2.225 ± 0.062	4.589AlaArg: 4.589 ± 0.08	5.5AlaSer: 5.5 ± 0.12	4.194AlaThr: 4.194 ± 0.154	6.528AlaVal: 6.528 ± 0.116	0.939AlaTrp: 0.939 ± 0.038	2.318AlaTyr: 2.318 ± 0.064	0.001AlaXaa: 0.001 ± 0.001
Cys	0.786CysAla: 0.786 ± 0.033	0.192CysCys: 0.192 ± 0.018	0.578CysAsp: 0.578 ± 0.033	0.535CysGlu: 0.535 ± 0.029	0.51CysPhe: 0.51 ± 0.027	1.063CysGly: 1.063 ± 0.043	0.318CysHis: 0.318 ± 0.033	0.68CysIle: 0.68 ± 0.035	0.383CysLys: 0.383 ± 0.024	0.786CysLeu: 0.786 ± 0.039	0.261CysMet: 0.261 ± 0.019	0.43CysAsn: 0.43 ± 0.024	0.504CysPro: 0.504 ± 0.029	0.261CysGln: 0.261 ± 0.02	0.801CysArg: 0.801 ± 0.036	0.922CysSer: 0.922 ± 0.039	0.536CysThr: 0.536 ± 0.028	0.584CysVal: 0.584 ± 0.031	0.109CysTrp: 0.109 ± 0.013	0.336CysTyr: 0.336 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.513AspAla: 4.513 ± 0.109	0.488AspCys: 0.488 ± 0.033	2.537AspAsp: 2.537 ± 0.073	3.504AspGlu: 3.504 ± 0.094	2.377AspPhe: 2.377 ± 0.058	3.552AspGly: 3.552 ± 0.111	1.05AspHis: 1.05 ± 0.048	3.804AspIle: 3.804 ± 0.084	2.243AspLys: 2.243 ± 0.069	5.117AspLeu: 5.117 ± 0.094	1.177AspMet: 1.177 ± 0.04	1.708AspAsn: 1.708 ± 0.049	2.427AspPro: 2.427 ± 0.063	1.354AspGln: 1.354 ± 0.049	3.32AspArg: 3.32 ± 0.079	2.948AspSer: 2.948 ± 0.076	2.572AspThr: 2.572 ± 0.066	3.217AspVal: 3.217 ± 0.084	0.524AspTrp: 0.524 ± 0.026	1.842AspTyr: 1.842 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.663GluAla: 5.663 ± 0.116	0.639GluCys: 0.639 ± 0.03	2.481GluAsp: 2.481 ± 0.07	5.139GluGlu: 5.139 ± 0.124	2.546GluPhe: 2.546 ± 0.07	4.147GluGly: 4.147 ± 0.078	1.585GluHis: 1.585 ± 0.048	4.569GluIle: 4.569 ± 0.095	4.846GluLys: 4.846 ± 0.112	7.575GluLeu: 7.575 ± 0.133	1.612GluMet: 1.612 ± 0.05	2.501GluAsn: 2.501 ± 0.062	2.308GluPro: 2.308 ± 0.071	2.558GluGln: 2.558 ± 0.079	4.188GluArg: 4.188 ± 0.098	4.388GluSer: 4.388 ± 0.088	3.251GluThr: 3.251 ± 0.071	4.001GluVal: 4.001 ± 0.096	0.776GluTrp: 0.776 ± 0.039	1.886GluTyr: 1.886 ± 0.052	0.001GluXaa: 0.001 ± 0.001
Phe	3.63PheAla: 3.63 ± 0.083	0.518PheCys: 0.518 ± 0.03	2.68PheAsp: 2.68 ± 0.066	2.439PheGlu: 2.439 ± 0.06	2.244PhePhe: 2.244 ± 0.066	3.251PheGly: 3.251 ± 0.07	0.864PheHis: 0.864 ± 0.039	2.825PheIle: 2.825 ± 0.075	1.602PheLys: 1.602 ± 0.044	4.116PheLeu: 4.116 ± 0.114	1.032PheMet: 1.032 ± 0.042	1.674PheAsn: 1.674 ± 0.048	1.718PhePro: 1.718 ± 0.056	1.234PheGln: 1.234 ± 0.043	2.576PheArg: 2.576 ± 0.068	3.828PheSer: 3.828 ± 0.076	2.643PheThr: 2.643 ± 0.063	2.598PheVal: 2.598 ± 0.065	0.496PheTrp: 0.496 ± 0.027	1.365PheTyr: 1.365 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.923GlyAla: 5.923 ± 0.2	0.897GlyCys: 0.897 ± 0.036	3.407GlyAsp: 3.407 ± 0.09	4.54GlyGlu: 4.54 ± 0.095	3.563GlyPhe: 3.563 ± 0.069	5.622GlyGly: 5.622 ± 0.235	1.479GlyHis: 1.479 ± 0.056	5.599GlyIle: 5.599 ± 0.107	4.441GlyLys: 4.441 ± 0.071	6.642GlyLeu: 6.642 ± 0.145	2.051GlyMet: 2.051 ± 0.053	2.665GlyAsn: 2.665 ± 0.076	1.768GlyPro: 1.768 ± 0.049	1.961GlyGln: 1.961 ± 0.058	4.146GlyArg: 4.146 ± 0.091	5.803GlySer: 5.803 ± 0.178	4.823GlyThr: 4.823 ± 0.406	5.519GlyVal: 5.519 ± 0.11	0.833GlyTrp: 0.833 ± 0.039	2.772GlyTyr: 2.772 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	1.803HisAla: 1.803 ± 0.052	0.29HisCys: 0.29 ± 0.021	1.155HisAsp: 1.155 ± 0.052	1.453HisGlu: 1.453 ± 0.048	0.989HisPhe: 0.989 ± 0.041	1.498HisGly: 1.498 ± 0.056	0.695HisHis: 0.695 ± 0.036	1.309HisIle: 1.309 ± 0.043	0.836HisLys: 0.836 ± 0.036	2.253HisLeu: 2.253 ± 0.074	0.394HisMet: 0.394 ± 0.024	0.866HisAsn: 0.866 ± 0.039	1.27HisPro: 1.27 ± 0.051	0.646HisGln: 0.646 ± 0.034	1.27HisArg: 1.27 ± 0.046	1.374HisSer: 1.374 ± 0.049	1.078HisThr: 1.078 ± 0.039	1.089HisVal: 1.089 ± 0.045	0.231HisTrp: 0.231 ± 0.019	0.808HisTyr: 0.808 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.664IleAla: 6.664 ± 0.113	0.73IleCys: 0.73 ± 0.029	4.029IleAsp: 4.029 ± 0.084	4.819IleGlu: 4.819 ± 0.101	2.558IlePhe: 2.558 ± 0.066	5.234IleGly: 5.234 ± 0.096	1.259IleHis: 1.259 ± 0.043	4.381IleIle: 4.381 ± 0.094	3.037IleLys: 3.037 ± 0.078	5.608IleLeu: 5.608 ± 0.1	1.436IleMet: 1.436 ± 0.047	2.654IleAsn: 2.654 ± 0.065	3.013IlePro: 3.013 ± 0.068	1.686IleGln: 1.686 ± 0.054	3.902IleArg: 3.902 ± 0.1	4.852IleSer: 4.852 ± 0.094	4.239IleThr: 4.239 ± 0.121	4.377IleVal: 4.377 ± 0.086	0.515IleTrp: 0.515 ± 0.027	1.888IleTyr: 1.888 ± 0.057	0.001IleXaa: 0.001 ± 0.001
Lys	4.409LysAla: 4.409 ± 0.088	0.336LysCys: 0.336 ± 0.026	1.992LysAsp: 1.992 ± 0.061	3.856LysGlu: 3.856 ± 0.107	1.484LysPhe: 1.484 ± 0.051	3.796LysGly: 3.796 ± 0.081	1.013LysHis: 1.013 ± 0.04	3.682LysIle: 3.682 ± 0.098	3.848LysLys: 3.848 ± 0.101	4.795LysLeu: 4.795 ± 0.11	1.231LysMet: 1.231 ± 0.048	2.358LysAsn: 2.358 ± 0.074	2.403LysPro: 2.403 ± 0.067	1.878LysGln: 1.878 ± 0.057	2.867LysArg: 2.867 ± 0.069	3.502LysSer: 3.502 ± 0.071	3.134LysThr: 3.134 ± 0.077	3.286LysVal: 3.286 ± 0.076	0.426LysTrp: 0.426 ± 0.026	1.4LysTyr: 1.4 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	8.711LeuAla: 8.711 ± 0.132	1.205LeuCys: 1.205 ± 0.049	5.572LeuAsp: 5.572 ± 0.098	6.345LeuGlu: 6.345 ± 0.127	5.185LeuPhe: 5.185 ± 0.117	6.68LeuGly: 6.68 ± 0.129	2.473LeuHis: 2.473 ± 0.066	5.848LeuIle: 5.848 ± 0.118	5.817LeuLys: 5.817 ± 0.117	11.813LeuLeu: 11.813 ± 0.235	2.397LeuMet: 2.397 ± 0.068	3.816LeuAsn: 3.816 ± 0.082	4.884LeuPro: 4.884 ± 0.098	3.916LeuGln: 3.916 ± 0.086	5.532LeuArg: 5.532 ± 0.108	8.106LeuSer: 8.106 ± 0.154	5.245LeuThr: 5.245 ± 0.194	6.387LeuVal: 6.387 ± 0.097	0.947LeuTrp: 0.947 ± 0.04	2.984LeuTyr: 2.984 ± 0.079	0.0LeuXaa: 0.0 ± 0.0
Met	2.173MetAla: 2.173 ± 0.066	0.146MetCys: 0.146 ± 0.014	0.997MetAsp: 0.997 ± 0.039	1.425MetGlu: 1.425 ± 0.041	0.783MetPhe: 0.783 ± 0.039	1.431MetGly: 1.431 ± 0.048	0.612MetHis: 0.612 ± 0.029	1.595MetIle: 1.595 ± 0.056	1.697MetLys: 1.697 ± 0.046	2.657MetLeu: 2.657 ± 0.072	0.687MetMet: 0.687 ± 0.034	1.163MetAsn: 1.163 ± 0.042	1.218MetPro: 1.218 ± 0.048	1.206MetGln: 1.206 ± 0.041	1.276MetArg: 1.276 ± 0.05	1.511MetSer: 1.511 ± 0.043	1.407MetThr: 1.407 ± 0.045	1.766MetVal: 1.766 ± 0.047	0.167MetTrp: 0.167 ± 0.015	0.372MetTyr: 0.372 ± 0.027	0.001MetXaa: 0.001 ± 0.001
Asn	3.178AsnAla: 3.178 ± 0.088	0.432AsnCys: 0.432 ± 0.024	1.751AsnAsp: 1.751 ± 0.06	1.939AsnGlu: 1.939 ± 0.053	1.394AsnPhe: 1.394 ± 0.042	2.733AsnGly: 2.733 ± 0.107	0.8AsnHis: 0.8 ± 0.036	2.803AsnIle: 2.803 ± 0.069	1.606AsnLys: 1.606 ± 0.061	3.654AsnLeu: 3.654 ± 0.087	0.786AsnMet: 0.786 ± 0.033	1.496AsnAsn: 1.496 ± 0.048	2.322AsnPro: 2.322 ± 0.052	0.974AsnGln: 0.974 ± 0.037	2.662AsnArg: 2.662 ± 0.064	2.7AsnSer: 2.7 ± 0.117	1.995AsnThr: 1.995 ± 0.073	2.232AsnVal: 2.232 ± 0.061	0.423AsnTrp: 0.423 ± 0.028	1.286AsnTyr: 1.286 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.778ProAla: 3.778 ± 0.113	0.403ProCys: 0.403 ± 0.023	2.932ProAsp: 2.932 ± 0.077	4.151ProGlu: 4.151 ± 0.099	1.971ProPhe: 1.971 ± 0.068	3.332ProGly: 3.332 ± 0.074	0.832ProHis: 0.832 ± 0.035	1.942ProIle: 1.942 ± 0.057	1.818ProLys: 1.818 ± 0.054	4.515ProLeu: 4.515 ± 0.103	0.931ProMet: 0.931 ± 0.035	1.149ProAsn: 1.149 ± 0.045	1.537ProPro: 1.537 ± 0.058	1.284ProGln: 1.284 ± 0.041	1.509ProArg: 1.509 ± 0.05	2.718ProSer: 2.718 ± 0.064	1.564ProThr: 1.564 ± 0.046	3.894ProVal: 3.894 ± 0.085	0.454ProTrp: 0.454 ± 0.026	1.222ProTyr: 1.222 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.703GlnAla: 2.703 ± 0.071	0.29GlnCys: 0.29 ± 0.023	1.289GlnAsp: 1.289 ± 0.044	2.091GlnGlu: 2.091 ± 0.064	1.23GlnPhe: 1.23 ± 0.044	1.941GlnGly: 1.941 ± 0.05	0.798GlnHis: 0.798 ± 0.032	2.071GlnIle: 2.071 ± 0.062	2.152GlnLys: 2.152 ± 0.076	3.451GlnLeu: 3.451 ± 0.077	0.79GlnMet: 0.79 ± 0.031	1.337GlnAsn: 1.337 ± 0.046	1.269GlnPro: 1.269 ± 0.045	1.52GlnGln: 1.52 ± 0.053	1.822GlnArg: 1.822 ± 0.061	2.138GlnSer: 2.138 ± 0.06	1.481GlnThr: 1.481 ± 0.057	1.893GlnVal: 1.893 ± 0.046	0.371GlnTrp: 0.371 ± 0.026	0.812GlnTyr: 0.812 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.182ArgAla: 4.182 ± 0.081	0.532ArgCys: 0.532 ± 0.031	2.815ArgAsp: 2.815 ± 0.073	4.624ArgGlu: 4.624 ± 0.093	2.796ArgPhe: 2.796 ± 0.071	2.923ArgGly: 2.923 ± 0.07	1.365ArgHis: 1.365 ± 0.05	4.13ArgIle: 4.13 ± 0.077	3.52ArgLys: 3.52 ± 0.082	5.794ArgLeu: 5.794 ± 0.112	1.531ArgMet: 1.531 ± 0.055	2.364ArgAsn: 2.364 ± 0.055	2.019ArgPro: 2.019 ± 0.067	2.253ArgGln: 2.253 ± 0.055	3.098ArgArg: 3.098 ± 0.085	3.749ArgSer: 3.749 ± 0.088	2.618ArgThr: 2.618 ± 0.072	3.696ArgVal: 3.696 ± 0.083	0.575ArgTrp: 0.575 ± 0.029	2.06ArgTyr: 2.06 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	6.422SerAla: 6.422 ± 0.198	0.869SerCys: 0.869 ± 0.041	3.593SerAsp: 3.593 ± 0.085	4.211SerGlu: 4.211 ± 0.088	3.207SerPhe: 3.207 ± 0.073	7.3SerGly: 7.3 ± 0.317	1.308SerHis: 1.308 ± 0.043	4.507SerIle: 4.507 ± 0.075	2.829SerLys: 2.829 ± 0.076	7.018SerLeu: 7.018 ± 0.122	1.812SerMet: 1.812 ± 0.051	2.345SerAsn: 2.345 ± 0.083	2.914SerPro: 2.914 ± 0.066	1.797SerGln: 1.797 ± 0.055	4.168SerArg: 4.168 ± 0.082	5.131SerSer: 5.131 ± 0.143	3.432SerThr: 3.432 ± 0.092	4.739SerVal: 4.739 ± 0.117	0.815SerTrp: 0.815 ± 0.034	2.045SerTyr: 2.045 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.101ThrAla: 5.101 ± 0.161	0.453ThrCys: 0.453 ± 0.03	2.613ThrAsp: 2.613 ± 0.107	3.038ThrGlu: 3.038 ± 0.079	2.104ThrPhe: 2.104 ± 0.073	5.487ThrGly: 5.487 ± 0.262	0.953ThrHis: 0.953 ± 0.038	4.055ThrIle: 4.055 ± 0.128	1.984ThrLys: 1.984 ± 0.068	6.499ThrLeu: 6.499 ± 0.267	1.149ThrMet: 1.149 ± 0.044	1.772ThrAsn: 1.772 ± 0.132	2.815ThrPro: 2.815 ± 0.063	1.128ThrGln: 1.128 ± 0.044	2.409ThrArg: 2.409 ± 0.055	3.226ThrSer: 3.226 ± 0.101	3.178ThrThr: 3.178 ± 0.173	4.266ThrVal: 4.266 ± 0.142	0.469ThrTrp: 0.469 ± 0.027	1.539ThrTyr: 1.539 ± 0.104	0.0ThrXaa: 0.0 ± 0.0
Val	5.607ValAla: 5.607 ± 0.11	0.748ValCys: 0.748 ± 0.038	3.538ValAsp: 3.538 ± 0.076	4.175ValGlu: 4.175 ± 0.103	2.971ValPhe: 2.971 ± 0.073	3.901ValGly: 3.901 ± 0.087	1.353ValHis: 1.353 ± 0.044	5.009ValIle: 5.009 ± 0.097	3.226ValLys: 3.226 ± 0.077	6.826ValLeu: 6.826 ± 0.1	1.844ValMet: 1.844 ± 0.058	2.467ValAsn: 2.467 ± 0.063	2.757ValPro: 2.757 ± 0.071	1.988ValGln: 1.988 ± 0.052	3.668ValArg: 3.668 ± 0.068	4.984ValSer: 4.984 ± 0.117	4.66ValThr: 4.66 ± 0.214	5.041ValVal: 5.041 ± 0.094	0.645ValTrp: 0.645 ± 0.035	1.825ValTyr: 1.825 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.701TrpAla: 0.701 ± 0.032	0.096TrpCys: 0.096 ± 0.011	0.469TrpAsp: 0.469 ± 0.027	0.521TrpGlu: 0.521 ± 0.029	0.545TrpPhe: 0.545 ± 0.028	0.578TrpGly: 0.578 ± 0.029	0.244TrpHis: 0.244 ± 0.019	0.705TrpIle: 0.705 ± 0.035	0.596TrpLys: 0.596 ± 0.028	1.149TrpLeu: 1.149 ± 0.047	0.309TrpMet: 0.309 ± 0.02	0.458TrpAsn: 0.458 ± 0.025	0.397TrpPro: 0.397 ± 0.022	0.574TrpGln: 0.574 ± 0.033	0.584TrpArg: 0.584 ± 0.029	0.737TrpSer: 0.737 ± 0.035	0.472TrpThr: 0.472 ± 0.031	0.567TrpVal: 0.567 ± 0.027	0.164TrpTrp: 0.164 ± 0.016	0.369TrpTyr: 0.369 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.233TyrAla: 2.233 ± 0.054	0.398TyrCys: 0.398 ± 0.023	1.656TyrAsp: 1.656 ± 0.056	1.661TyrGlu: 1.661 ± 0.057	1.36TyrPhe: 1.36 ± 0.047	2.365TyrGly: 2.365 ± 0.067	0.737TyrHis: 0.737 ± 0.034	1.734TyrIle: 1.734 ± 0.046	1.223TyrLys: 1.223 ± 0.047	3.274TyrLeu: 3.274 ± 0.084	0.585TyrMet: 0.585 ± 0.03	1.286TyrAsn: 1.286 ± 0.048	1.382TyrPro: 1.382 ± 0.042	1.006TyrGln: 1.006 ± 0.038	2.258TyrArg: 2.258 ± 0.053	2.345TyrSer: 2.345 ± 0.12	1.716TyrThr: 1.716 ± 0.089	1.555TyrVal: 1.555 ± 0.049	0.355TyrTrp: 0.355 ± 0.021	1.014TyrTyr: 1.014 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2158 proteins (717850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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