Amino acid dipepetide frequency for Enterovibrio nigricans DSM 22720

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.118AlaAla: 8.118 ± 0.101	0.993AlaCys: 0.993 ± 0.03	4.796AlaAsp: 4.796 ± 0.067	5.608AlaGlu: 5.608 ± 0.077	3.847AlaPhe: 3.847 ± 0.054	6.11AlaGly: 6.11 ± 0.082	1.606AlaHis: 1.606 ± 0.033	6.043AlaIle: 6.043 ± 0.078	4.775AlaLys: 4.775 ± 0.065	10.233AlaLeu: 10.233 ± 0.098	3.042AlaMet: 3.042 ± 0.055	3.613AlaAsn: 3.613 ± 0.057	2.947AlaPro: 2.947 ± 0.054	3.441AlaGln: 3.441 ± 0.05	3.922AlaArg: 3.922 ± 0.053	5.679AlaSer: 5.679 ± 0.067	4.667AlaThr: 4.667 ± 0.057	6.222AlaVal: 6.222 ± 0.069	1.028AlaTrp: 1.028 ± 0.03	2.445AlaTyr: 2.445 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.803CysAla: 0.803 ± 0.025	0.187CysCys: 0.187 ± 0.012	0.642CysAsp: 0.642 ± 0.023	0.619CysGlu: 0.619 ± 0.024	0.481CysPhe: 0.481 ± 0.018	0.964CysGly: 0.964 ± 0.031	0.38CysHis: 0.38 ± 0.017	0.622CysIle: 0.622 ± 0.022	0.43CysLys: 0.43 ± 0.019	1.027CysLeu: 1.027 ± 0.029	0.245CysMet: 0.245 ± 0.017	0.355CysAsn: 0.355 ± 0.017	0.474CysPro: 0.474 ± 0.021	0.46CysGln: 0.46 ± 0.019	0.577CysArg: 0.577 ± 0.022	0.73CysSer: 0.73 ± 0.025	0.52CysThr: 0.52 ± 0.022	0.692CysVal: 0.692 ± 0.024	0.153CysTrp: 0.153 ± 0.01	0.339CysTyr: 0.339 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.302AspAla: 5.302 ± 0.074	0.569AspCys: 0.569 ± 0.023	3.461AspAsp: 3.461 ± 0.074	3.882AspGlu: 3.882 ± 0.063	2.455AspPhe: 2.455 ± 0.046	4.198AspGly: 4.198 ± 0.074	1.094AspHis: 1.094 ± 0.029	4.252AspIle: 4.252 ± 0.063	3.002AspLys: 3.002 ± 0.053	5.117AspLeu: 5.117 ± 0.07	1.581AspMet: 1.581 ± 0.038	2.48AspAsn: 2.48 ± 0.045	2.174AspPro: 2.174 ± 0.04	1.708AspGln: 1.708 ± 0.037	2.45AspArg: 2.45 ± 0.041	3.309AspSer: 3.309 ± 0.059	3.105AspThr: 3.105 ± 0.061	4.528AspVal: 4.528 ± 0.058	0.826AspTrp: 0.826 ± 0.026	1.863AspTyr: 1.863 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.488GluAla: 5.488 ± 0.066	0.55GluCys: 0.55 ± 0.021	3.064GluAsp: 3.064 ± 0.05	3.881GluGlu: 3.881 ± 0.061	2.274GluPhe: 2.274 ± 0.04	3.949GluGly: 3.949 ± 0.053	1.604GluHis: 1.604 ± 0.033	3.778GluIle: 3.778 ± 0.053	3.948GluLys: 3.948 ± 0.057	6.451GluLeu: 6.451 ± 0.074	1.844GluMet: 1.844 ± 0.036	2.892GluAsn: 2.892 ± 0.042	2.081GluPro: 2.081 ± 0.038	3.221GluGln: 3.221 ± 0.064	3.507GluArg: 3.507 ± 0.056	3.803GluSer: 3.803 ± 0.06	3.434GluThr: 3.434 ± 0.052	4.074GluVal: 4.074 ± 0.063	0.809GluTrp: 0.809 ± 0.022	1.728GluTyr: 1.728 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.556PheAla: 3.556 ± 0.048	0.496PheCys: 0.496 ± 0.02	2.903PheAsp: 2.903 ± 0.052	2.448PheGlu: 2.448 ± 0.045	1.759PhePhe: 1.759 ± 0.04	3.316PheGly: 3.316 ± 0.057	0.864PheHis: 0.864 ± 0.024	2.56PheIle: 2.56 ± 0.045	1.843PheLys: 1.843 ± 0.036	3.406PheLeu: 3.406 ± 0.055	0.998PheMet: 0.998 ± 0.031	2.037PheAsn: 2.037 ± 0.037	1.463PhePro: 1.463 ± 0.033	1.22PheGln: 1.22 ± 0.028	1.682PheArg: 1.682 ± 0.032	3.44PheSer: 3.44 ± 0.057	2.45PheThr: 2.45 ± 0.047	2.97PheVal: 2.97 ± 0.053	0.552PheTrp: 0.552 ± 0.021	1.308PheTyr: 1.308 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.603GlyAla: 5.603 ± 0.087	0.923GlyCys: 0.923 ± 0.026	4.031GlyAsp: 4.031 ± 0.069	4.674GlyGlu: 4.674 ± 0.056	3.316GlyPhe: 3.316 ± 0.052	5.08GlyGly: 5.08 ± 0.099	1.609GlyHis: 1.609 ± 0.034	4.693GlyIle: 4.693 ± 0.067	4.014GlyLys: 4.014 ± 0.054	6.884GlyLeu: 6.884 ± 0.082	2.132GlyMet: 2.132 ± 0.049	2.861GlyAsn: 2.861 ± 0.074	1.646GlyPro: 1.646 ± 0.036	2.696GlyGln: 2.696 ± 0.044	3.181GlyArg: 3.181 ± 0.053	4.313GlySer: 4.313 ± 0.062	3.634GlyThr: 3.634 ± 0.058	5.38GlyVal: 5.38 ± 0.068	1.017GlyTrp: 1.017 ± 0.03	2.446GlyTyr: 2.446 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.034	0.376HisCys: 0.376 ± 0.016	1.198HisAsp: 1.198 ± 0.031	1.167HisGlu: 1.167 ± 0.031	1.07HisPhe: 1.07 ± 0.026	1.569HisGly: 1.569 ± 0.033	0.715HisHis: 0.715 ± 0.026	1.406HisIle: 1.406 ± 0.03	0.967HisLys: 0.967 ± 0.029	2.163HisLeu: 2.163 ± 0.044	0.512HisMet: 0.512 ± 0.021	0.817HisAsn: 0.817 ± 0.024	1.197HisPro: 1.197 ± 0.035	1.061HisGln: 1.061 ± 0.027	1.126HisArg: 1.126 ± 0.029	1.351HisSer: 1.351 ± 0.032	1.121HisThr: 1.121 ± 0.029	1.419HisVal: 1.419 ± 0.036	0.359HisTrp: 0.359 ± 0.017	0.826HisTyr: 0.826 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.495IleAla: 6.495 ± 0.083	0.702IleCys: 0.702 ± 0.023	4.283IleAsp: 4.283 ± 0.058	4.459IleGlu: 4.459 ± 0.065	2.17IlePhe: 2.17 ± 0.042	4.565IleGly: 4.565 ± 0.069	1.244IleHis: 1.244 ± 0.033	3.326IleIle: 3.326 ± 0.056	2.967IleLys: 2.967 ± 0.047	5.027IleLeu: 5.027 ± 0.072	1.267IleMet: 1.267 ± 0.033	2.822IleAsn: 2.822 ± 0.045	2.66IlePro: 2.66 ± 0.045	2.14IleGln: 2.14 ± 0.036	2.86IleArg: 2.86 ± 0.041	4.534IleSer: 4.534 ± 0.057	3.637IleThr: 3.637 ± 0.067	4.232IleVal: 4.232 ± 0.07	0.637IleTrp: 0.637 ± 0.022	1.677IleTyr: 1.677 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.839LysAla: 4.839 ± 0.071	0.37LysCys: 0.37 ± 0.017	2.735LysAsp: 2.735 ± 0.047	3.284LysGlu: 3.284 ± 0.051	1.48LysPhe: 1.48 ± 0.034	3.5LysGly: 3.5 ± 0.055	1.261LysHis: 1.261 ± 0.033	2.642LysIle: 2.642 ± 0.051	2.872LysLys: 2.872 ± 0.053	4.87LysLeu: 4.87 ± 0.063	1.341LysMet: 1.341 ± 0.028	2.137LysAsn: 2.137 ± 0.04	2.354LysPro: 2.354 ± 0.042	2.441LysGln: 2.441 ± 0.049	2.905LysArg: 2.905 ± 0.056	3.045LysSer: 3.045 ± 0.051	2.935LysThr: 2.935 ± 0.048	3.572LysVal: 3.572 ± 0.052	0.571LysTrp: 0.571 ± 0.02	1.372LysTyr: 1.372 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.619LeuAla: 9.619 ± 0.102	1.153LeuCys: 1.153 ± 0.032	5.83LeuAsp: 5.83 ± 0.069	5.91LeuGlu: 5.91 ± 0.068	4.164LeuPhe: 4.164 ± 0.068	6.855LeuGly: 6.855 ± 0.075	2.025LeuHis: 2.025 ± 0.041	5.917LeuIle: 5.917 ± 0.085	5.011LeuLys: 5.011 ± 0.065	10.051LeuLeu: 10.051 ± 0.123	2.743LeuMet: 2.743 ± 0.049	4.544LeuAsn: 4.544 ± 0.061	4.853LeuPro: 4.853 ± 0.074	3.265LeuGln: 3.265 ± 0.058	4.65LeuArg: 4.65 ± 0.065	8.309LeuSer: 8.309 ± 0.093	5.995LeuThr: 5.995 ± 0.074	7.028LeuVal: 7.028 ± 0.084	1.022LeuTrp: 1.022 ± 0.028	2.513LeuTyr: 2.513 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.712MetAla: 2.712 ± 0.048	0.217MetCys: 0.217 ± 0.014	1.341MetAsp: 1.341 ± 0.032	1.422MetGlu: 1.422 ± 0.032	0.996MetPhe: 0.996 ± 0.029	1.852MetGly: 1.852 ± 0.043	0.5MetHis: 0.5 ± 0.018	1.496MetIle: 1.496 ± 0.035	1.549MetLys: 1.549 ± 0.034	2.917MetLeu: 2.917 ± 0.05	0.851MetMet: 0.851 ± 0.027	1.089MetAsn: 1.089 ± 0.028	1.317MetPro: 1.317 ± 0.029	1.032MetGln: 1.032 ± 0.027	1.284MetArg: 1.284 ± 0.034	2.035MetSer: 2.035 ± 0.038	1.794MetThr: 1.794 ± 0.036	1.92MetVal: 1.92 ± 0.034	0.224MetTrp: 0.224 ± 0.012	0.544MetTyr: 0.544 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.965AsnAla: 3.965 ± 0.058	0.404AsnCys: 0.404 ± 0.015	2.392AsnAsp: 2.392 ± 0.065	2.409AsnGlu: 2.409 ± 0.043	1.52AsnPhe: 1.52 ± 0.034	3.212AsnGly: 3.212 ± 0.052	0.928AsnHis: 0.928 ± 0.027	2.735AsnIle: 2.735 ± 0.053	2.145AsnLys: 2.145 ± 0.045	3.788AsnLeu: 3.788 ± 0.05	0.99AsnMet: 0.99 ± 0.027	1.912AsnAsn: 1.912 ± 0.043	2.156AsnPro: 2.156 ± 0.043	1.768AsnGln: 1.768 ± 0.039	2.097AsnArg: 2.097 ± 0.044	2.384AsnSer: 2.384 ± 0.048	2.356AsnThr: 2.356 ± 0.043	3.075AsnVal: 3.075 ± 0.05	0.589AsnTrp: 0.589 ± 0.022	1.247AsnTyr: 1.247 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.192ProAla: 3.192 ± 0.049	0.37ProCys: 0.37 ± 0.017	2.606ProAsp: 2.606 ± 0.049	3.238ProGlu: 3.238 ± 0.048	1.803ProPhe: 1.803 ± 0.035	2.287ProGly: 2.287 ± 0.042	0.915ProHis: 0.915 ± 0.026	2.451ProIle: 2.451 ± 0.039	1.844ProLys: 1.844 ± 0.041	4.201ProLeu: 4.201 ± 0.066	1.099ProMet: 1.099 ± 0.029	1.657ProAsn: 1.657 ± 0.035	1.336ProPro: 1.336 ± 0.036	1.485ProGln: 1.485 ± 0.035	1.458ProArg: 1.458 ± 0.033	2.841ProSer: 2.841 ± 0.049	2.282ProThr: 2.282 ± 0.039	3.185ProVal: 3.185 ± 0.047	0.529ProTrp: 0.529 ± 0.018	1.286ProTyr: 1.286 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.627GlnAla: 3.627 ± 0.057	0.394GlnCys: 0.394 ± 0.019	1.837GlnAsp: 1.837 ± 0.033	2.129GlnGlu: 2.129 ± 0.041	1.675GlnPhe: 1.675 ± 0.035	2.737GlnGly: 2.737 ± 0.05	1.051GlnHis: 1.051 ± 0.026	2.279GlnIle: 2.279 ± 0.043	1.875GlnLys: 1.875 ± 0.038	4.295GlnLeu: 4.295 ± 0.063	1.085GlnMet: 1.085 ± 0.024	1.494GlnAsn: 1.494 ± 0.035	1.589GlnPro: 1.589 ± 0.034	2.227GlnGln: 2.227 ± 0.051	2.326GlnArg: 2.326 ± 0.043	2.578GlnSer: 2.578 ± 0.051	2.17GlnThr: 2.17 ± 0.043	2.642GlnVal: 2.642 ± 0.042	0.58GlnTrp: 0.58 ± 0.021	1.228GlnTyr: 1.228 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.745ArgAla: 3.745 ± 0.055	0.558ArgCys: 0.558 ± 0.018	2.671ArgAsp: 2.671 ± 0.047	3.223ArgGlu: 3.223 ± 0.047	2.305ArgPhe: 2.305 ± 0.042	2.733ArgGly: 2.733 ± 0.047	1.229ArgHis: 1.229 ± 0.029	3.09ArgIle: 3.09 ± 0.052	2.442ArgLys: 2.442 ± 0.051	5.097ArgLeu: 5.097 ± 0.067	1.255ArgMet: 1.255 ± 0.031	1.947ArgAsn: 1.947 ± 0.033	1.726ArgPro: 1.726 ± 0.031	2.199ArgGln: 2.199 ± 0.048	2.595ArgArg: 2.595 ± 0.051	2.673ArgSer: 2.673 ± 0.049	2.267ArgThr: 2.267 ± 0.043	3.415ArgVal: 3.415 ± 0.054	0.712ArgTrp: 0.712 ± 0.026	1.825ArgTyr: 1.825 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.603SerAla: 5.603 ± 0.067	0.599SerCys: 0.599 ± 0.025	3.952SerAsp: 3.952 ± 0.052	4.08SerGlu: 4.08 ± 0.059	2.783SerPhe: 2.783 ± 0.046	5.248SerGly: 5.248 ± 0.075	1.562SerHis: 1.562 ± 0.034	4.008SerIle: 4.008 ± 0.059	3.075SerLys: 3.075 ± 0.052	7.304SerLeu: 7.304 ± 0.083	1.776SerMet: 1.776 ± 0.04	2.702SerAsn: 2.702 ± 0.049	2.717SerPro: 2.717 ± 0.041	2.709SerGln: 2.709 ± 0.042	3.087SerArg: 3.087 ± 0.055	4.483SerSer: 4.483 ± 0.072	3.485SerThr: 3.485 ± 0.055	5.075SerVal: 5.075 ± 0.066	0.806SerTrp: 0.806 ± 0.026	1.902SerTyr: 1.902 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.823ThrAla: 4.823 ± 0.061	0.49ThrCys: 0.49 ± 0.02	3.02ThrAsp: 3.02 ± 0.051	3.153ThrGlu: 3.153 ± 0.046	2.352ThrPhe: 2.352 ± 0.044	4.18ThrGly: 4.18 ± 0.059	1.242ThrHis: 1.242 ± 0.029	3.394ThrIle: 3.394 ± 0.06	2.317ThrLys: 2.317 ± 0.042	6.755ThrLeu: 6.755 ± 0.077	1.239ThrMet: 1.239 ± 0.027	2.072ThrAsn: 2.072 ± 0.039	2.753ThrPro: 2.753 ± 0.044	2.26ThrGln: 2.26 ± 0.044	2.398ThrArg: 2.398 ± 0.04	3.448ThrSer: 3.448 ± 0.055	3.026ThrThr: 3.026 ± 0.057	4.3ThrVal: 4.3 ± 0.066	0.588ThrTrp: 0.588 ± 0.023	1.542ThrTyr: 1.542 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.619ValAla: 6.619 ± 0.082	0.825ValCys: 0.825 ± 0.026	4.258ValAsp: 4.258 ± 0.06	4.623ValGlu: 4.623 ± 0.06	2.909ValPhe: 2.909 ± 0.051	4.87ValGly: 4.87 ± 0.064	1.295ValHis: 1.295 ± 0.033	4.707ValIle: 4.707 ± 0.071	3.608ValLys: 3.608 ± 0.05	7.067ValLeu: 7.067 ± 0.084	2.086ValMet: 2.086 ± 0.039	3.04ValAsn: 3.04 ± 0.045	2.852ValPro: 2.852 ± 0.044	2.163ValGln: 2.163 ± 0.046	3.153ValArg: 3.153 ± 0.048	5.393ValSer: 5.393 ± 0.074	4.373ValThr: 4.373 ± 0.079	5.69ValVal: 5.69 ± 0.074	0.805ValTrp: 0.805 ± 0.028	1.918ValTyr: 1.918 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.882TrpAla: 0.882 ± 0.024	0.16TrpCys: 0.16 ± 0.01	0.612TrpAsp: 0.612 ± 0.019	0.649TrpGlu: 0.649 ± 0.023	0.567TrpPhe: 0.567 ± 0.022	0.815TrpGly: 0.815 ± 0.029	0.357TrpHis: 0.357 ± 0.017	0.683TrpIle: 0.683 ± 0.021	0.569TrpLys: 0.569 ± 0.02	1.653TrpLeu: 1.653 ± 0.042	0.378TrpMet: 0.378 ± 0.017	0.454TrpAsn: 0.454 ± 0.018	0.471TrpPro: 0.471 ± 0.018	0.783TrpGln: 0.783 ± 0.022	0.685TrpArg: 0.685 ± 0.022	0.703TrpSer: 0.703 ± 0.022	0.56TrpThr: 0.56 ± 0.021	0.937TrpVal: 0.937 ± 0.029	0.209TrpTrp: 0.209 ± 0.012	0.355TrpTyr: 0.355 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.322TyrAla: 2.322 ± 0.043	0.363TyrCys: 0.363 ± 0.017	1.722TyrAsp: 1.722 ± 0.04	1.523TyrGlu: 1.523 ± 0.031	1.344TyrPhe: 1.344 ± 0.034	2.095TyrGly: 2.095 ± 0.038	0.764TyrHis: 0.764 ± 0.024	1.624TyrIle: 1.624 ± 0.035	1.273TyrLys: 1.273 ± 0.034	3.151TyrLeu: 3.151 ± 0.047	0.626TyrMet: 0.626 ± 0.02	1.147TyrAsn: 1.147 ± 0.028	1.297TyrPro: 1.297 ± 0.034	1.538TyrGln: 1.538 ± 0.037	1.765TyrArg: 1.765 ± 0.035	1.906TyrSer: 1.906 ± 0.035	1.541TyrThr: 1.541 ± 0.041	1.895TyrVal: 1.895 ± 0.037	0.466TyrTrp: 0.466 ± 0.018	0.941TyrTyr: 0.941 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4788 proteins (1452864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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