Amino acid dipepetide frequency for Sphingomonas oleivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.802AlaAla: 20.802 ± 0.25	1.046AlaCys: 1.046 ± 0.035	7.773AlaAsp: 7.773 ± 0.099	8.28AlaGlu: 8.28 ± 0.124	4.348AlaPhe: 4.348 ± 0.067	12.044AlaGly: 12.044 ± 0.105	2.333AlaHis: 2.333 ± 0.039	7.21AlaIle: 7.21 ± 0.086	3.719AlaLys: 3.719 ± 0.07	14.899AlaLeu: 14.899 ± 0.153	3.779AlaMet: 3.779 ± 0.064	3.038AlaAsn: 3.038 ± 0.053	6.567AlaPro: 6.567 ± 0.095	4.11AlaGln: 4.11 ± 0.066	11.075AlaArg: 11.075 ± 0.111	6.626AlaSer: 6.626 ± 0.091	6.655AlaThr: 6.655 ± 0.082	8.322AlaVal: 8.322 ± 0.101	1.607AlaTrp: 1.607 ± 0.044	2.825AlaTyr: 2.825 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.033	0.091CysCys: 0.091 ± 0.01	0.452CysAsp: 0.452 ± 0.022	0.336CysGlu: 0.336 ± 0.017	0.27CysPhe: 0.27 ± 0.016	0.835CysGly: 0.835 ± 0.034	0.197CysHis: 0.197 ± 0.014	0.341CysIle: 0.341 ± 0.017	0.119CysLys: 0.119 ± 0.011	0.674CysLeu: 0.674 ± 0.027	0.138CysMet: 0.138 ± 0.013	0.165CysAsn: 0.165 ± 0.012	0.445CysPro: 0.445 ± 0.022	0.182CysGln: 0.182 ± 0.012	0.608CysArg: 0.608 ± 0.029	0.415CysSer: 0.415 ± 0.021	0.329CysThr: 0.329 ± 0.018	0.455CysVal: 0.455 ± 0.019	0.112CysTrp: 0.112 ± 0.011	0.157CysTyr: 0.157 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.614AspAla: 7.614 ± 0.098	0.412AspCys: 0.412 ± 0.02	2.966AspAsp: 2.966 ± 0.058	3.189AspGlu: 3.189 ± 0.061	2.121AspPhe: 2.121 ± 0.046	5.524AspGly: 5.524 ± 0.069	1.365AspHis: 1.365 ± 0.04	3.029AspIle: 3.029 ± 0.059	1.395AspLys: 1.395 ± 0.036	5.775AspLeu: 5.775 ± 0.072	1.415AspMet: 1.415 ± 0.036	1.21AspAsn: 1.21 ± 0.035	3.973AspPro: 3.973 ± 0.062	1.72AspGln: 1.72 ± 0.036	5.454AspArg: 5.454 ± 0.078	2.159AspSer: 2.159 ± 0.042	2.2AspThr: 2.2 ± 0.049	3.865AspVal: 3.865 ± 0.06	1.029AspTrp: 1.029 ± 0.032	1.679AspTyr: 1.679 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.234GluAla: 8.234 ± 0.121	0.286GluCys: 0.286 ± 0.017	2.633GluAsp: 2.633 ± 0.051	3.189GluGlu: 3.189 ± 0.073	1.442GluPhe: 1.442 ± 0.035	4.58GluGly: 4.58 ± 0.068	1.104GluHis: 1.104 ± 0.035	3.08GluIle: 3.08 ± 0.057	1.797GluLys: 1.797 ± 0.044	5.056GluLeu: 5.056 ± 0.088	1.37GluMet: 1.37 ± 0.035	1.279GluAsn: 1.279 ± 0.034	2.635GluPro: 2.635 ± 0.054	2.03GluGln: 2.03 ± 0.043	5.17GluArg: 5.17 ± 0.077	2.121GluSer: 2.121 ± 0.042	3.258GluThr: 3.258 ± 0.053	3.357GluVal: 3.357 ± 0.066	0.711GluTrp: 0.711 ± 0.03	0.94GluTyr: 0.94 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.892PheAla: 4.892 ± 0.08	0.286PheCys: 0.286 ± 0.015	2.624PheAsp: 2.624 ± 0.052	1.909PheGlu: 1.909 ± 0.038	1.323PhePhe: 1.323 ± 0.039	3.666PheGly: 3.666 ± 0.057	0.719PheHis: 0.719 ± 0.028	1.478PheIle: 1.478 ± 0.04	0.76PheLys: 0.76 ± 0.028	3.267PheLeu: 3.267 ± 0.068	0.688PheMet: 0.688 ± 0.026	0.988PheAsn: 0.988 ± 0.032	1.551PhePro: 1.551 ± 0.046	0.88PheGln: 0.88 ± 0.028	2.479PheArg: 2.479 ± 0.048	2.004PheSer: 2.004 ± 0.037	1.958PheThr: 1.958 ± 0.048	2.581PheVal: 2.581 ± 0.045	0.525PheTrp: 0.525 ± 0.02	0.942PheTyr: 0.942 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.362GlyAla: 10.362 ± 0.107	0.787GlyCys: 0.787 ± 0.027	4.759GlyAsp: 4.759 ± 0.077	4.82GlyGlu: 4.82 ± 0.071	3.643GlyPhe: 3.643 ± 0.055	8.107GlyGly: 8.107 ± 0.117	1.933GlyHis: 1.933 ± 0.04	4.661GlyIle: 4.661 ± 0.07	2.836GlyLys: 2.836 ± 0.063	9.265GlyLeu: 9.265 ± 0.101	2.307GlyMet: 2.307 ± 0.053	2.147GlyAsn: 2.147 ± 0.057	3.779GlyPro: 3.779 ± 0.053	2.939GlyGln: 2.939 ± 0.052	7.537GlyArg: 7.537 ± 0.092	4.838GlySer: 4.838 ± 0.077	4.727GlyThr: 4.727 ± 0.07	5.995GlyVal: 5.995 ± 0.079	1.69GlyTrp: 1.69 ± 0.038	2.364GlyTyr: 2.364 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.435HisAla: 2.435 ± 0.052	0.192HisCys: 0.192 ± 0.013	1.216HisAsp: 1.216 ± 0.035	0.97HisGlu: 0.97 ± 0.028	0.863HisPhe: 0.863 ± 0.029	2.071HisGly: 2.071 ± 0.046	0.586HisHis: 0.586 ± 0.025	1.012HisIle: 1.012 ± 0.031	0.398HisLys: 0.398 ± 0.018	1.965HisLeu: 1.965 ± 0.039	0.49HisMet: 0.49 ± 0.022	0.451HisAsn: 0.451 ± 0.022	1.274HisPro: 1.274 ± 0.039	0.533HisGln: 0.533 ± 0.022	1.58HisArg: 1.58 ± 0.043	0.93HisSer: 0.93 ± 0.034	0.534HisThr: 0.534 ± 0.021	1.599HisVal: 1.599 ± 0.034	0.335HisTrp: 0.335 ± 0.015	0.556HisTyr: 0.556 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	8.25IleAla: 8.25 ± 0.088	0.43IleCys: 0.43 ± 0.018	3.897IleAsp: 3.897 ± 0.055	3.754IleGlu: 3.754 ± 0.068	1.823IlePhe: 1.823 ± 0.04	5.6IleGly: 5.6 ± 0.077	0.951IleHis: 0.951 ± 0.027	2.081IleIle: 2.081 ± 0.045	1.004IleLys: 1.004 ± 0.033	4.54IleLeu: 4.54 ± 0.064	0.848IleMet: 0.848 ± 0.026	1.232IleAsn: 1.232 ± 0.038	2.154IlePro: 2.154 ± 0.042	1.124IleGln: 1.124 ± 0.033	3.514IleArg: 3.514 ± 0.055	2.759IleSer: 2.759 ± 0.056	2.28IleThr: 2.28 ± 0.051	4.391IleVal: 4.391 ± 0.071	0.67IleTrp: 0.67 ± 0.025	1.083IleTyr: 1.083 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.726LysAla: 3.726 ± 0.068	0.114LysCys: 0.114 ± 0.011	1.323LysAsp: 1.323 ± 0.039	1.161LysGlu: 1.161 ± 0.038	0.726LysPhe: 0.726 ± 0.027	2.379LysGly: 2.379 ± 0.044	0.466LysHis: 0.466 ± 0.022	1.359LysIle: 1.359 ± 0.036	0.867LysLys: 0.867 ± 0.033	2.967LysLeu: 2.967 ± 0.057	0.608LysMet: 0.608 ± 0.023	0.604LysAsn: 0.604 ± 0.024	1.794LysPro: 1.794 ± 0.046	0.769LysGln: 0.769 ± 0.031	2.057LysArg: 2.057 ± 0.043	1.498LysSer: 1.498 ± 0.045	1.417LysThr: 1.417 ± 0.036	1.947LysVal: 1.947 ± 0.05	0.321LysTrp: 0.321 ± 0.017	0.552LysTyr: 0.552 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.076LeuAla: 15.076 ± 0.161	0.751LeuCys: 0.751 ± 0.03	6.493LeuAsp: 6.493 ± 0.075	4.757LeuGlu: 4.757 ± 0.084	3.993LeuPhe: 3.993 ± 0.068	8.813LeuGly: 8.813 ± 0.096	1.914LeuHis: 1.914 ± 0.047	5.479LeuIle: 5.479 ± 0.08	2.886LeuLys: 2.886 ± 0.06	10.871LeuLeu: 10.871 ± 0.154	2.147LeuMet: 2.147 ± 0.048	2.392LeuAsn: 2.392 ± 0.049	5.862LeuPro: 5.862 ± 0.076	2.278LeuGln: 2.278 ± 0.043	7.435LeuArg: 7.435 ± 0.099	6.332LeuSer: 6.332 ± 0.078	5.168LeuThr: 5.168 ± 0.064	7.273LeuVal: 7.273 ± 0.085	1.246LeuTrp: 1.246 ± 0.04	2.047LeuTyr: 2.047 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.275MetAla: 3.275 ± 0.06	0.123MetCys: 0.123 ± 0.011	0.99MetAsp: 0.99 ± 0.027	0.996MetGlu: 0.996 ± 0.029	0.633MetPhe: 0.633 ± 0.028	1.723MetGly: 1.723 ± 0.041	0.372MetHis: 0.372 ± 0.017	1.395MetIle: 1.395 ± 0.038	0.808MetLys: 0.808 ± 0.025	2.705MetLeu: 2.705 ± 0.051	0.599MetMet: 0.599 ± 0.025	0.644MetAsn: 0.644 ± 0.026	1.509MetPro: 1.509 ± 0.037	0.645MetGln: 0.645 ± 0.022	1.819MetArg: 1.819 ± 0.041	1.364MetSer: 1.364 ± 0.032	1.58MetThr: 1.58 ± 0.037	1.526MetVal: 1.526 ± 0.036	0.198MetTrp: 0.198 ± 0.013	0.218MetTyr: 0.218 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.963AsnAla: 2.963 ± 0.058	0.212AsnCys: 0.212 ± 0.014	1.279AsnAsp: 1.279 ± 0.039	1.035AsnGlu: 1.035 ± 0.035	0.893AsnPhe: 0.893 ± 0.029	2.426AsnGly: 2.426 ± 0.058	0.477AsnHis: 0.477 ± 0.022	1.392AsnIle: 1.392 ± 0.038	0.566AsnLys: 0.566 ± 0.021	2.472AsnLeu: 2.472 ± 0.052	0.518AsnMet: 0.518 ± 0.019	0.672AsnAsn: 0.672 ± 0.03	1.635AsnPro: 1.635 ± 0.037	0.681AsnGln: 0.681 ± 0.025	1.8AsnArg: 1.8 ± 0.047	1.237AsnSer: 1.237 ± 0.042	0.861AsnThr: 0.861 ± 0.03	1.802AsnVal: 1.802 ± 0.045	0.403AsnTrp: 0.403 ± 0.02	0.671AsnTyr: 0.671 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.575ProAla: 7.575 ± 0.099	0.328ProCys: 0.328 ± 0.017	3.829ProAsp: 3.829 ± 0.061	3.56ProGlu: 3.56 ± 0.059	1.995ProPhe: 1.995 ± 0.045	5.009ProGly: 5.009 ± 0.071	1.068ProHis: 1.068 ± 0.035	2.575ProIle: 2.575 ± 0.055	1.423ProLys: 1.423 ± 0.035	5.344ProLeu: 5.344 ± 0.079	1.133ProMet: 1.133 ± 0.029	1.198ProAsn: 1.198 ± 0.038	2.948ProPro: 2.948 ± 0.066	1.556ProGln: 1.556 ± 0.046	3.322ProArg: 3.322 ± 0.062	2.933ProSer: 2.933 ± 0.054	2.443ProThr: 2.443 ± 0.049	4.22ProVal: 4.22 ± 0.056	0.758ProTrp: 0.758 ± 0.028	1.121ProTyr: 1.121 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.227GlnAla: 4.227 ± 0.067	0.198GlnCys: 0.198 ± 0.012	1.32GlnAsp: 1.32 ± 0.035	1.269GlnGlu: 1.269 ± 0.036	0.989GlnPhe: 0.989 ± 0.032	2.456GlnGly: 2.456 ± 0.048	0.558GlnHis: 0.558 ± 0.025	1.67GlnIle: 1.67 ± 0.044	0.771GlnLys: 0.771 ± 0.028	2.884GlnLeu: 2.884 ± 0.055	0.709GlnMet: 0.709 ± 0.027	0.703GlnAsn: 0.703 ± 0.023	1.827GlnPro: 1.827 ± 0.046	1.045GlnGln: 1.045 ± 0.039	2.347GlnArg: 2.347 ± 0.048	1.519GlnSer: 1.519 ± 0.036	1.466GlnThr: 1.466 ± 0.035	1.905GlnVal: 1.905 ± 0.04	0.382GlnTrp: 0.382 ± 0.019	0.603GlnTyr: 0.603 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.835ArgAla: 9.835 ± 0.111	0.51ArgCys: 0.51 ± 0.023	4.352ArgAsp: 4.352 ± 0.062	4.123ArgGlu: 4.123 ± 0.066	3.283ArgPhe: 3.283 ± 0.06	5.443ArgGly: 5.443 ± 0.064	1.865ArgHis: 1.865 ± 0.041	4.763ArgIle: 4.763 ± 0.065	1.991ArgLys: 1.991 ± 0.043	9.573ArgLeu: 9.573 ± 0.132	2.031ArgMet: 2.031 ± 0.038	1.884ArgAsn: 1.884 ± 0.041	4.342ArgPro: 4.342 ± 0.072	2.467ArgGln: 2.467 ± 0.048	6.785ArgArg: 6.785 ± 0.1	4.073ArgSer: 4.073 ± 0.068	3.807ArgThr: 3.807 ± 0.058	4.679ArgVal: 4.679 ± 0.07	1.238ArgTrp: 1.238 ± 0.034	2.02ArgTyr: 2.02 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.654SerAla: 6.654 ± 0.087	0.407SerCys: 0.407 ± 0.023	2.946SerAsp: 2.946 ± 0.056	2.534SerGlu: 2.534 ± 0.049	2.312SerPhe: 2.312 ± 0.045	5.424SerGly: 5.424 ± 0.094	0.994SerHis: 0.994 ± 0.031	2.777SerIle: 2.777 ± 0.055	1.246SerLys: 1.246 ± 0.035	5.322SerLeu: 5.322 ± 0.07	1.104SerMet: 1.104 ± 0.032	1.258SerAsn: 1.258 ± 0.039	2.971SerPro: 2.971 ± 0.055	1.38SerGln: 1.38 ± 0.042	3.822SerArg: 3.822 ± 0.067	2.802SerSer: 2.802 ± 0.059	2.483SerThr: 2.483 ± 0.047	3.499SerVal: 3.499 ± 0.056	0.785SerTrp: 0.785 ± 0.028	1.482SerTyr: 1.482 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.27ThrAla: 6.27 ± 0.078	0.307ThrCys: 0.307 ± 0.018	2.682ThrAsp: 2.682 ± 0.047	2.188ThrGlu: 2.188 ± 0.047	1.621ThrPhe: 1.621 ± 0.048	5.022ThrGly: 5.022 ± 0.069	0.901ThrHis: 0.901 ± 0.025	3.094ThrIle: 3.094 ± 0.053	1.184ThrLys: 1.184 ± 0.034	5.688ThrLeu: 5.688 ± 0.08	1.07ThrMet: 1.07 ± 0.031	1.253ThrAsn: 1.253 ± 0.04	3.243ThrPro: 3.243 ± 0.053	1.273ThrGln: 1.273 ± 0.035	3.414ThrArg: 3.414 ± 0.058	2.62ThrSer: 2.62 ± 0.042	2.448ThrThr: 2.448 ± 0.05	3.825ThrVal: 3.825 ± 0.054	0.473ThrTrp: 0.473 ± 0.02	1.052ThrTyr: 1.052 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.831ValAla: 9.831 ± 0.109	0.458ValCys: 0.458 ± 0.022	4.304ValAsp: 4.304 ± 0.063	4.496ValGlu: 4.496 ± 0.079	1.806ValPhe: 1.806 ± 0.044	5.283ValGly: 5.283 ± 0.074	1.347ValHis: 1.347 ± 0.037	3.396ValIle: 3.396 ± 0.056	1.913ValLys: 1.913 ± 0.044	5.959ValLeu: 5.959 ± 0.069	1.457ValMet: 1.457 ± 0.036	1.877ValAsn: 1.877 ± 0.047	3.919ValPro: 3.919 ± 0.064	1.924ValGln: 1.924 ± 0.042	5.398ValArg: 5.398 ± 0.064	3.818ValSer: 3.818 ± 0.061	4.341ValThr: 4.341 ± 0.069	4.87ValVal: 4.87 ± 0.065	0.704ValTrp: 0.704 ± 0.024	1.358ValTyr: 1.358 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.405TrpAla: 1.405 ± 0.037	0.121TrpCys: 0.121 ± 0.011	0.687TrpAsp: 0.687 ± 0.028	0.579TrpGlu: 0.579 ± 0.022	0.521TrpPhe: 0.521 ± 0.021	0.871TrpGly: 0.871 ± 0.031	0.342TrpHis: 0.342 ± 0.02	0.734TrpIle: 0.734 ± 0.028	0.441TrpLys: 0.441 ± 0.02	1.799TrpLeu: 1.799 ± 0.05	0.312TrpMet: 0.312 ± 0.016	0.433TrpAsn: 0.433 ± 0.02	0.742TrpPro: 0.742 ± 0.031	0.577TrpGln: 0.577 ± 0.023	1.345TrpArg: 1.345 ± 0.035	0.857TrpSer: 0.857 ± 0.027	0.762TrpThr: 0.762 ± 0.025	0.704TrpVal: 0.704 ± 0.027	0.226TrpTrp: 0.226 ± 0.014	0.295TrpTyr: 0.295 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.68TyrAla: 2.68 ± 0.053	0.217TyrCys: 0.217 ± 0.014	1.568TyrAsp: 1.568 ± 0.037	1.128TyrGlu: 1.128 ± 0.037	0.916TyrPhe: 0.916 ± 0.029	2.223TyrGly: 2.223 ± 0.049	0.497TyrHis: 0.497 ± 0.021	0.858TyrIle: 0.858 ± 0.024	0.53TyrLys: 0.53 ± 0.022	2.189TyrLeu: 2.189 ± 0.044	0.398TyrMet: 0.398 ± 0.018	0.568TyrAsn: 0.568 ± 0.027	1.169TyrPro: 1.169 ± 0.041	0.733TyrGln: 0.733 ± 0.033	2.103TyrArg: 2.103 ± 0.046	1.294TyrSer: 1.294 ± 0.038	0.91TyrThr: 0.91 ± 0.031	1.646TyrVal: 1.646 ± 0.042	0.34TyrTrp: 0.34 ± 0.018	0.67TyrTyr: 0.67 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3532 proteins (1144095 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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