Amino acid dipepetide frequency for Burkholderiales bacterium LSUCC0115

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.898AlaAla: 13.898 ± 0.219	1.345AlaCys: 1.345 ± 0.051	6.365AlaAsp: 6.365 ± 0.091	5.729AlaGlu: 5.729 ± 0.108	3.992AlaPhe: 3.992 ± 0.082	9.494AlaGly: 9.494 ± 0.135	2.475AlaHis: 2.475 ± 0.072	5.635AlaIle: 5.635 ± 0.113	5.149AlaLys: 5.149 ± 0.135	12.447AlaLeu: 12.447 ± 0.176	3.452AlaMet: 3.452 ± 0.083	3.079AlaAsn: 3.079 ± 0.089	4.481AlaPro: 4.481 ± 0.103	6.22AlaGln: 6.22 ± 0.133	6.586AlaArg: 6.586 ± 0.123	7.029AlaSer: 7.029 ± 0.108	4.964AlaThr: 4.964 ± 0.107	8.225AlaVal: 8.225 ± 0.118	1.656AlaTrp: 1.656 ± 0.064	2.346AlaTyr: 2.346 ± 0.063	0.003AlaXaa: 0.003 ± 0.002
Cys	0.9CysAla: 0.9 ± 0.043	0.117CysCys: 0.117 ± 0.016	0.5CysAsp: 0.5 ± 0.029	0.552CysGlu: 0.552 ± 0.033	0.328CysPhe: 0.328 ± 0.022	0.981CysGly: 0.981 ± 0.045	0.304CysHis: 0.304 ± 0.026	0.423CysIle: 0.423 ± 0.028	0.248CysLys: 0.248 ± 0.021	1.078CysLeu: 1.078 ± 0.044	0.209CysMet: 0.209 ± 0.018	0.273CysAsn: 0.273 ± 0.022	0.585CysPro: 0.585 ± 0.037	0.457CysGln: 0.457 ± 0.033	0.581CysArg: 0.581 ± 0.036	0.576CysSer: 0.576 ± 0.034	0.461CysThr: 0.461 ± 0.033	0.628CysVal: 0.628 ± 0.037	0.129CysTrp: 0.129 ± 0.016	0.188CysTyr: 0.188 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.254AspAla: 5.254 ± 0.11	0.519AspCys: 0.519 ± 0.034	2.567AspAsp: 2.567 ± 0.075	3.027AspGlu: 3.027 ± 0.087	2.242AspPhe: 2.242 ± 0.076	4.061AspGly: 4.061 ± 0.087	1.351AspHis: 1.351 ± 0.054	2.503AspIle: 2.503 ± 0.074	1.88AspLys: 1.88 ± 0.055	6.496AspLeu: 6.496 ± 0.121	1.266AspMet: 1.266 ± 0.045	1.201AspAsn: 1.201 ± 0.05	3.112AspPro: 3.112 ± 0.072	3.188AspGln: 3.188 ± 0.073	3.778AspArg: 3.778 ± 0.079	2.387AspSer: 2.387 ± 0.069	2.17AspThr: 2.17 ± 0.061	3.495AspVal: 3.495 ± 0.073	1.137AspTrp: 1.137 ± 0.05	1.48AspTyr: 1.48 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.02GluAla: 6.02 ± 0.114	0.326GluCys: 0.326 ± 0.023	2.506GluAsp: 2.506 ± 0.067	2.493GluGlu: 2.493 ± 0.07	1.749GluPhe: 1.749 ± 0.057	3.498GluGly: 3.498 ± 0.074	1.118GluHis: 1.118 ± 0.053	2.875GluIle: 2.875 ± 0.077	2.258GluLys: 2.258 ± 0.073	5.29GluLeu: 5.29 ± 0.105	1.425GluMet: 1.425 ± 0.046	1.34GluAsn: 1.34 ± 0.044	2.434GluPro: 2.434 ± 0.06	3.169GluGln: 3.169 ± 0.083	3.762GluArg: 3.762 ± 0.079	3.036GluSer: 3.036 ± 0.083	2.689GluThr: 2.689 ± 0.065	3.886GluVal: 3.886 ± 0.093	0.595GluTrp: 0.595 ± 0.032	0.959GluTyr: 0.959 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.841PheAla: 3.841 ± 0.09	0.409PheCys: 0.409 ± 0.024	2.61PheAsp: 2.61 ± 0.082	2.403PheGlu: 2.403 ± 0.063	1.565PhePhe: 1.565 ± 0.07	3.469PheGly: 3.469 ± 0.082	0.711PheHis: 0.711 ± 0.032	1.523PheIle: 1.523 ± 0.047	1.333PheLys: 1.333 ± 0.053	3.222PheLeu: 3.222 ± 0.087	0.883PheMet: 0.883 ± 0.043	1.161PheAsn: 1.161 ± 0.053	1.408PhePro: 1.408 ± 0.051	1.351PheGln: 1.351 ± 0.047	1.685PheArg: 1.685 ± 0.054	2.372PheSer: 2.372 ± 0.064	1.727PheThr: 1.727 ± 0.056	2.882PheVal: 2.882 ± 0.074	0.543PheTrp: 0.543 ± 0.033	0.899PheTyr: 0.899 ± 0.04	0.005PheXaa: 0.005 ± 0.003
Gly	7.378GlyAla: 7.378 ± 0.123	1.047GlyCys: 1.047 ± 0.046	3.747GlyAsp: 3.747 ± 0.095	4.014GlyGlu: 4.014 ± 0.09	3.517GlyPhe: 3.517 ± 0.088	6.186GlyGly: 6.186 ± 0.114	2.091GlyHis: 2.091 ± 0.061	4.026GlyIle: 4.026 ± 0.09	3.133GlyLys: 3.133 ± 0.09	11.228GlyLeu: 11.228 ± 0.172	2.149GlyMet: 2.149 ± 0.065	1.787GlyAsn: 1.787 ± 0.065	3.283GlyPro: 3.283 ± 0.08	4.954GlyGln: 4.954 ± 0.113	5.215GlyArg: 5.215 ± 0.1	4.942GlySer: 4.942 ± 0.108	3.415GlyThr: 3.415 ± 0.101	6.149GlyVal: 6.149 ± 0.107	1.316GlyTrp: 1.316 ± 0.051	2.191GlyTyr: 2.191 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.277HisAla: 2.277 ± 0.066	0.283HisCys: 0.283 ± 0.022	1.044HisAsp: 1.044 ± 0.047	0.957HisGlu: 0.957 ± 0.044	0.809HisPhe: 0.809 ± 0.035	2.004HisGly: 2.004 ± 0.068	0.655HisHis: 0.655 ± 0.042	0.842HisIle: 0.842 ± 0.039	0.619HisLys: 0.619 ± 0.034	2.332HisLeu: 2.332 ± 0.067	0.495HisMet: 0.495 ± 0.032	0.535HisAsn: 0.535 ± 0.029	1.589HisPro: 1.589 ± 0.058	1.247HisGln: 1.247 ± 0.051	1.52HisArg: 1.52 ± 0.059	0.981HisSer: 0.981 ± 0.033	0.887HisThr: 0.887 ± 0.039	1.354HisVal: 1.354 ± 0.053	0.457HisTrp: 0.457 ± 0.031	0.59HisTyr: 0.59 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.528IleAla: 5.528 ± 0.098	0.505IleCys: 0.505 ± 0.026	3.455IleAsp: 3.455 ± 0.079	3.446IleGlu: 3.446 ± 0.092	1.533IlePhe: 1.533 ± 0.056	4.466IleGly: 4.466 ± 0.103	1.03IleHis: 1.03 ± 0.045	1.815IleIle: 1.815 ± 0.066	1.996IleLys: 1.996 ± 0.061	4.152IleLeu: 4.152 ± 0.089	0.975IleMet: 0.975 ± 0.043	1.585IleAsn: 1.585 ± 0.053	2.17IlePro: 2.17 ± 0.067	1.887IleGln: 1.887 ± 0.056	3.2IleArg: 3.2 ± 0.083	2.957IleSer: 2.957 ± 0.086	2.548IleThr: 2.548 ± 0.068	3.36IleVal: 3.36 ± 0.086	0.649IleTrp: 0.649 ± 0.032	1.085IleTyr: 1.085 ± 0.047	0.002IleXaa: 0.002 ± 0.002
Lys	5.064LysAla: 5.064 ± 0.112	0.207LysCys: 0.207 ± 0.022	2.139LysAsp: 2.139 ± 0.069	1.899LysGlu: 1.899 ± 0.061	1.066LysPhe: 1.066 ± 0.05	3.186LysGly: 3.186 ± 0.089	0.662LysHis: 0.662 ± 0.033	1.768LysIle: 1.768 ± 0.063	1.954LysLys: 1.954 ± 0.107	3.455LysLeu: 3.455 ± 0.085	0.994LysMet: 0.994 ± 0.049	1.121LysAsn: 1.121 ± 0.054	2.463LysPro: 2.463 ± 0.088	1.439LysGln: 1.439 ± 0.054	2.468LysArg: 2.468 ± 0.073	2.443LysSer: 2.443 ± 0.07	2.536LysThr: 2.536 ± 0.077	2.71LysVal: 2.71 ± 0.08	0.419LysTrp: 0.419 ± 0.028	0.697LysTyr: 0.697 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	14.205LeuAla: 14.205 ± 0.185	0.883LeuCys: 0.883 ± 0.037	5.547LeuAsp: 5.547 ± 0.11	5.39LeuGlu: 5.39 ± 0.106	3.496LeuPhe: 3.496 ± 0.102	8.884LeuGly: 8.884 ± 0.153	2.053LeuHis: 2.053 ± 0.062	5.187LeuIle: 5.187 ± 0.114	4.2LeuLys: 4.2 ± 0.098	10.683LeuLeu: 10.683 ± 0.184	2.913LeuMet: 2.913 ± 0.072	2.862LeuAsn: 2.862 ± 0.065	5.623LeuPro: 5.623 ± 0.096	4.495LeuGln: 4.495 ± 0.104	6.52LeuArg: 6.52 ± 0.112	7.786LeuSer: 7.786 ± 0.142	5.906LeuThr: 5.906 ± 0.116	8.656LeuVal: 8.656 ± 0.143	1.295LeuTrp: 1.295 ± 0.059	1.991LeuTyr: 1.991 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	3.672MetAla: 3.672 ± 0.094	0.117MetCys: 0.117 ± 0.013	1.133MetAsp: 1.133 ± 0.042	0.944MetGlu: 0.944 ± 0.043	0.63MetPhe: 0.63 ± 0.034	2.322MetGly: 2.322 ± 0.063	0.459MetHis: 0.459 ± 0.03	1.201MetIle: 1.201 ± 0.038	1.157MetLys: 1.157 ± 0.045	2.553MetLeu: 2.553 ± 0.074	0.662MetMet: 0.662 ± 0.037	0.844MetAsn: 0.844 ± 0.037	1.625MetPro: 1.625 ± 0.053	1.154MetGln: 1.154 ± 0.049	1.69MetArg: 1.69 ± 0.053	1.818MetSer: 1.818 ± 0.063	1.835MetThr: 1.835 ± 0.053	2.206MetVal: 2.206 ± 0.068	0.176MetTrp: 0.176 ± 0.019	0.279MetTyr: 0.279 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.793AsnAla: 2.793 ± 0.078	0.281AsnCys: 0.281 ± 0.025	1.34AsnAsp: 1.34 ± 0.054	1.214AsnGlu: 1.214 ± 0.049	0.916AsnPhe: 0.916 ± 0.048	2.277AsnGly: 2.277 ± 0.078	0.55AsnHis: 0.55 ± 0.035	1.316AsnIle: 1.316 ± 0.054	1.0AsnLys: 1.0 ± 0.042	2.976AsnLeu: 2.976 ± 0.077	0.619AsnMet: 0.619 ± 0.034	0.761AsnAsn: 0.761 ± 0.038	2.015AsnPro: 2.015 ± 0.066	1.273AsnGln: 1.273 ± 0.045	1.675AsnArg: 1.675 ± 0.051	1.278AsnSer: 1.278 ± 0.057	1.468AsnThr: 1.468 ± 0.054	1.804AsnVal: 1.804 ± 0.054	0.448AsnTrp: 0.448 ± 0.028	0.607AsnTyr: 0.607 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.558ProAla: 5.558 ± 0.122	0.383ProCys: 0.383 ± 0.026	2.953ProAsp: 2.953 ± 0.083	3.181ProGlu: 3.181 ± 0.088	1.675ProPhe: 1.675 ± 0.054	4.092ProGly: 4.092 ± 0.086	1.032ProHis: 1.032 ± 0.042	2.553ProIle: 2.553 ± 0.061	2.191ProLys: 2.191 ± 0.068	4.523ProLeu: 4.523 ± 0.089	1.451ProMet: 1.451 ± 0.048	1.601ProAsn: 1.601 ± 0.051	1.946ProPro: 1.946 ± 0.068	2.004ProGln: 2.004 ± 0.065	2.265ProArg: 2.265 ± 0.065	3.46ProSer: 3.46 ± 0.08	2.796ProThr: 2.796 ± 0.068	4.057ProVal: 4.057 ± 0.092	0.742ProTrp: 0.742 ± 0.037	1.063ProTyr: 1.063 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	7.717GlnAla: 7.717 ± 0.165	0.279GlnCys: 0.279 ± 0.02	2.199GlnAsp: 2.199 ± 0.064	1.901GlnGlu: 1.901 ± 0.06	1.447GlnPhe: 1.447 ± 0.054	3.419GlnGly: 3.419 ± 0.078	0.864GlnHis: 0.864 ± 0.043	2.453GlnIle: 2.453 ± 0.065	1.651GlnLys: 1.651 ± 0.052	4.657GlnLeu: 4.657 ± 0.1	1.233GlnMet: 1.233 ± 0.045	0.971GlnAsn: 0.971 ± 0.039	2.534GlnPro: 2.534 ± 0.072	2.458GlnGln: 2.458 ± 0.083	3.005GlnArg: 3.005 ± 0.078	2.898GlnSer: 2.898 ± 0.077	3.279GlnThr: 3.279 ± 0.07	3.769GlnVal: 3.769 ± 0.079	0.712GlnTrp: 0.712 ± 0.037	0.826GlnTyr: 0.826 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	6.213ArgAla: 6.213 ± 0.107	0.569ArgCys: 0.569 ± 0.033	3.072ArgAsp: 3.072 ± 0.067	3.291ArgGlu: 3.291 ± 0.076	2.465ArgPhe: 2.465 ± 0.067	4.061ArgGly: 4.061 ± 0.094	1.451ArgHis: 1.451 ± 0.053	3.1ArgIle: 3.1 ± 0.073	1.954ArgLys: 1.954 ± 0.063	8.156ArgLeu: 8.156 ± 0.157	1.739ArgMet: 1.739 ± 0.056	1.444ArgAsn: 1.444 ± 0.047	2.96ArgPro: 2.96 ± 0.083	3.393ArgGln: 3.393 ± 0.075	4.195ArgArg: 4.195 ± 0.103	3.472ArgSer: 3.472 ± 0.09	2.448ArgThr: 2.448 ± 0.077	4.695ArgVal: 4.695 ± 0.092	0.954ArgTrp: 0.954 ± 0.045	1.685ArgTyr: 1.685 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.638SerAla: 6.638 ± 0.131	0.555SerCys: 0.555 ± 0.031	3.131SerAsp: 3.131 ± 0.072	2.913SerGlu: 2.913 ± 0.082	2.287SerPhe: 2.287 ± 0.062	5.639SerGly: 5.639 ± 0.115	1.323SerHis: 1.323 ± 0.052	3.015SerIle: 3.015 ± 0.087	2.191SerLys: 2.191 ± 0.072	7.274SerLeu: 7.274 ± 0.142	1.625SerMet: 1.625 ± 0.055	1.58SerAsn: 1.58 ± 0.057	3.16SerPro: 3.16 ± 0.066	2.888SerGln: 2.888 ± 0.072	3.797SerArg: 3.797 ± 0.086	3.783SerSer: 3.783 ± 0.099	3.048SerThr: 3.048 ± 0.086	4.633SerVal: 4.633 ± 0.097	0.79SerTrp: 0.79 ± 0.043	1.29SerTyr: 1.29 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.404ThrAla: 5.404 ± 0.107	0.421ThrCys: 0.421 ± 0.029	2.867ThrAsp: 2.867 ± 0.074	2.453ThrGlu: 2.453 ± 0.063	1.623ThrPhe: 1.623 ± 0.063	4.82ThrGly: 4.82 ± 0.103	1.152ThrHis: 1.152 ± 0.041	2.67ThrIle: 2.67 ± 0.069	1.825ThrLys: 1.825 ± 0.064	5.408ThrLeu: 5.408 ± 0.123	1.197ThrMet: 1.197 ± 0.048	1.439ThrAsn: 1.439 ± 0.057	3.127ThrPro: 3.127 ± 0.079	2.049ThrGln: 2.049 ± 0.065	2.625ThrArg: 2.625 ± 0.07	2.996ThrSer: 2.996 ± 0.073	2.738ThrThr: 2.738 ± 0.089	4.116ThrVal: 4.116 ± 0.1	0.619ThrTrp: 0.619 ± 0.031	1.063ThrTyr: 1.063 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	8.275ValAla: 8.275 ± 0.148	0.845ValCys: 0.845 ± 0.042	4.288ValAsp: 4.288 ± 0.092	3.971ValGlu: 3.971 ± 0.094	3.074ValPhe: 3.074 ± 0.083	6.006ValGly: 6.006 ± 0.115	1.499ValHis: 1.499 ± 0.056	3.959ValIle: 3.959 ± 0.082	2.77ValLys: 2.77 ± 0.086	8.043ValLeu: 8.043 ± 0.123	2.313ValMet: 2.313 ± 0.074	2.142ValAsn: 2.142 ± 0.065	3.246ValPro: 3.246 ± 0.073	2.791ValGln: 2.791 ± 0.068	4.249ValArg: 4.249 ± 0.087	5.159ValSer: 5.159 ± 0.09	4.061ValThr: 4.061 ± 0.096	6.903ValVal: 6.903 ± 0.132	1.009ValTrp: 1.009 ± 0.041	1.623ValTyr: 1.623 ± 0.051	0.002ValXaa: 0.002 ± 0.002
Trp	1.508TrpAla: 1.508 ± 0.058	0.171TrpCys: 0.171 ± 0.017	0.5TrpAsp: 0.5 ± 0.026	0.486TrpGlu: 0.486 ± 0.03	0.626TrpPhe: 0.626 ± 0.035	0.887TrpGly: 0.887 ± 0.039	0.316TrpHis: 0.316 ± 0.027	0.64TrpIle: 0.64 ± 0.03	0.348TrpLys: 0.348 ± 0.023	2.272TrpLeu: 2.272 ± 0.078	0.405TrpMet: 0.405 ± 0.029	0.304TrpAsn: 0.304 ± 0.022	0.73TrpPro: 0.73 ± 0.043	0.876TrpGln: 0.876 ± 0.043	1.045TrpArg: 1.045 ± 0.047	0.89TrpSer: 0.89 ± 0.041	0.604TrpThr: 0.604 ± 0.029	1.168TrpVal: 1.168 ± 0.048	0.257TrpTrp: 0.257 ± 0.021	0.231TrpTyr: 0.231 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.425TyrAla: 2.425 ± 0.064	0.254TyrCys: 0.254 ± 0.021	1.149TyrAsp: 1.149 ± 0.041	1.161TyrGlu: 1.161 ± 0.046	0.961TyrPhe: 0.961 ± 0.041	2.016TyrGly: 2.016 ± 0.069	0.383TyrHis: 0.383 ± 0.027	0.84TyrIle: 0.84 ± 0.039	0.831TyrLys: 0.831 ± 0.037	2.33TyrLeu: 2.33 ± 0.06	0.471TyrMet: 0.471 ± 0.029	0.583TyrAsn: 0.583 ± 0.03	1.032TyrPro: 1.032 ± 0.04	0.98TyrGln: 0.98 ± 0.046	1.456TyrArg: 1.456 ± 0.045	1.297TyrSer: 1.297 ± 0.055	1.033TyrThr: 1.033 ± 0.045	1.532TyrVal: 1.532 ± 0.054	0.359TyrTrp: 0.359 ± 0.026	0.536TyrTyr: 0.536 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.002	0.002XaaPro: 0.002 ± 0.002	0.002XaaGln: 0.002 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1762 proteins (579727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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