Amino acid dipepetide frequency for Alteribacillus persepolensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.326AlaAla: 8.326 ± 0.121	0.788AlaCys: 0.788 ± 0.029	4.316AlaAsp: 4.316 ± 0.069	5.693AlaGlu: 5.693 ± 0.092	3.535AlaPhe: 3.535 ± 0.065	6.424AlaGly: 6.424 ± 0.097	1.488AlaHis: 1.488 ± 0.045	4.817AlaIle: 4.817 ± 0.073	4.365AlaLys: 4.365 ± 0.064	7.713AlaLeu: 7.713 ± 0.098	2.214AlaMet: 2.214 ± 0.049	2.752AlaAsn: 2.752 ± 0.057	2.471AlaPro: 2.471 ± 0.055	2.494AlaGln: 2.494 ± 0.052	2.944AlaArg: 2.944 ± 0.056	4.735AlaSer: 4.735 ± 0.081	3.019AlaThr: 3.019 ± 0.054	7.0AlaVal: 7.0 ± 0.096	0.692AlaTrp: 0.692 ± 0.024	2.554AlaTyr: 2.554 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.557CysAla: 0.557 ± 0.024	0.114CysCys: 0.114 ± 0.013	0.422CysAsp: 0.422 ± 0.022	0.439CysGlu: 0.439 ± 0.021	0.315CysPhe: 0.315 ± 0.016	0.728CysGly: 0.728 ± 0.031	0.211CysHis: 0.211 ± 0.015	0.508CysIle: 0.508 ± 0.022	0.359CysLys: 0.359 ± 0.022	0.747CysLeu: 0.747 ± 0.03	0.207CysMet: 0.207 ± 0.014	0.238CysAsn: 0.238 ± 0.014	0.344CysPro: 0.344 ± 0.018	0.283CysGln: 0.283 ± 0.018	0.331CysArg: 0.331 ± 0.018	0.495CysSer: 0.495 ± 0.026	0.402CysThr: 0.402 ± 0.02	0.449CysVal: 0.449 ± 0.022	0.077CysTrp: 0.077 ± 0.009	0.246CysTyr: 0.246 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.794AspAla: 3.794 ± 0.072	0.386AspCys: 0.386 ± 0.02	2.985AspAsp: 2.985 ± 0.07	4.649AspGlu: 4.649 ± 0.089	2.126AspPhe: 2.126 ± 0.047	3.523AspGly: 3.523 ± 0.071	1.224AspHis: 1.224 ± 0.036	4.81AspIle: 4.81 ± 0.072	3.145AspLys: 3.145 ± 0.049	4.4AspLeu: 4.4 ± 0.07	1.695AspMet: 1.695 ± 0.041	2.07AspAsn: 2.07 ± 0.053	1.979AspPro: 1.979 ± 0.044	1.836AspGln: 1.836 ± 0.043	2.189AspArg: 2.189 ± 0.049	2.648AspSer: 2.648 ± 0.063	2.997AspThr: 2.997 ± 0.056	4.652AspVal: 4.652 ± 0.065	0.673AspTrp: 0.673 ± 0.026	2.187AspTyr: 2.187 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.372GluAla: 6.372 ± 0.1	0.41GluCys: 0.41 ± 0.02	4.411GluAsp: 4.411 ± 0.08	8.578GluGlu: 8.578 ± 0.157	2.171GluPhe: 2.171 ± 0.041	4.585GluGly: 4.585 ± 0.084	1.893GluHis: 1.893 ± 0.041	4.388GluIle: 4.388 ± 0.07	6.76GluLys: 6.76 ± 0.096	6.72GluLeu: 6.72 ± 0.095	2.432GluMet: 2.432 ± 0.05	3.981GluAsn: 3.981 ± 0.064	2.225GluPro: 2.225 ± 0.048	3.9GluGln: 3.9 ± 0.08	4.052GluArg: 4.052 ± 0.071	3.688GluSer: 3.688 ± 0.073	4.653GluThr: 4.653 ± 0.067	5.013GluVal: 5.013 ± 0.085	1.016GluTrp: 1.016 ± 0.036	2.201GluTyr: 2.201 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.109PheAla: 3.109 ± 0.061	0.366PheCys: 0.366 ± 0.018	2.287PheAsp: 2.287 ± 0.045	2.593PheGlu: 2.593 ± 0.059	2.286PhePhe: 2.286 ± 0.055	3.143PheGly: 3.143 ± 0.07	1.168PheHis: 1.168 ± 0.031	3.418PheIle: 3.418 ± 0.077	1.627PheLys: 1.627 ± 0.045	4.305PheLeu: 4.305 ± 0.09	1.15PheMet: 1.15 ± 0.04	1.362PheAsn: 1.362 ± 0.037	1.703PhePro: 1.703 ± 0.039	1.766PheGln: 1.766 ± 0.044	1.582PheArg: 1.582 ± 0.04	2.925PheSer: 2.925 ± 0.056	2.512PheThr: 2.512 ± 0.049	3.073PheVal: 3.073 ± 0.062	0.461PheTrp: 0.461 ± 0.026	1.596PheTyr: 1.596 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.503GlyAla: 5.503 ± 0.097	0.639GlyCys: 0.639 ± 0.026	3.392GlyAsp: 3.392 ± 0.071	4.868GlyGlu: 4.868 ± 0.077	3.318GlyPhe: 3.318 ± 0.065	5.209GlyGly: 5.209 ± 0.084	1.484GlyHis: 1.484 ± 0.038	5.38GlyIle: 5.38 ± 0.087	4.488GlyLys: 4.488 ± 0.075	6.267GlyLeu: 6.267 ± 0.095	2.381GlyMet: 2.381 ± 0.048	2.469GlyAsn: 2.469 ± 0.052	1.958GlyPro: 1.958 ± 0.051	2.21GlyGln: 2.21 ± 0.051	2.992GlyArg: 2.992 ± 0.053	4.063GlySer: 4.063 ± 0.069	4.097GlyThr: 4.097 ± 0.071	5.289GlyVal: 5.289 ± 0.076	0.833GlyTrp: 0.833 ± 0.032	2.781GlyTyr: 2.781 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.793HisAla: 1.793 ± 0.047	0.253HisCys: 0.253 ± 0.018	1.268HisAsp: 1.268 ± 0.039	1.642HisGlu: 1.642 ± 0.041	1.087HisPhe: 1.087 ± 0.033	1.691HisGly: 1.691 ± 0.035	0.881HisHis: 0.881 ± 0.032	1.71HisIle: 1.71 ± 0.039	1.062HisLys: 1.062 ± 0.034	2.305HisLeu: 2.305 ± 0.054	0.695HisMet: 0.695 ± 0.025	0.852HisAsn: 0.852 ± 0.034	1.371HisPro: 1.371 ± 0.034	1.031HisGln: 1.031 ± 0.035	1.11HisArg: 1.11 ± 0.029	1.362HisSer: 1.362 ± 0.037	1.329HisThr: 1.329 ± 0.033	1.878HisVal: 1.878 ± 0.043	0.284HisTrp: 0.284 ± 0.018	1.037HisTyr: 1.037 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.644IleAla: 5.644 ± 0.081	0.577IleCys: 0.577 ± 0.023	4.009IleAsp: 4.009 ± 0.057	5.078IleGlu: 5.078 ± 0.083	2.661IlePhe: 2.661 ± 0.063	5.488IleGly: 5.488 ± 0.082	1.737IleHis: 1.737 ± 0.04	4.74IleIle: 4.74 ± 0.086	3.479IleLys: 3.479 ± 0.06	5.587IleLeu: 5.587 ± 0.093	1.629IleMet: 1.629 ± 0.041	2.659IleAsn: 2.659 ± 0.06	3.05IlePro: 3.05 ± 0.057	2.746IleGln: 2.746 ± 0.048	2.842IleArg: 2.842 ± 0.056	4.259IleSer: 4.259 ± 0.068	4.074IleThr: 4.074 ± 0.061	4.983IleVal: 4.983 ± 0.079	0.604IleTrp: 0.604 ± 0.029	2.065IleTyr: 2.065 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.853LysAla: 4.853 ± 0.087	0.249LysCys: 0.249 ± 0.019	3.42LysAsp: 3.42 ± 0.061	6.736LysGlu: 6.736 ± 0.083	1.319LysPhe: 1.319 ± 0.035	4.038LysGly: 4.038 ± 0.061	1.668LysHis: 1.668 ± 0.04	3.185LysIle: 3.185 ± 0.06	5.39LysLys: 5.39 ± 0.094	4.393LysLeu: 4.393 ± 0.057	1.898LysMet: 1.898 ± 0.047	2.783LysAsn: 2.783 ± 0.047	2.131LysPro: 2.131 ± 0.055	3.647LysGln: 3.647 ± 0.063	3.519LysArg: 3.519 ± 0.065	2.821LysSer: 2.821 ± 0.054	3.608LysThr: 3.608 ± 0.066	3.813LysVal: 3.813 ± 0.063	0.718LysTrp: 0.718 ± 0.026	1.719LysTyr: 1.719 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.163LeuAla: 7.163 ± 0.103	0.675LeuCys: 0.675 ± 0.027	4.682LeuAsp: 4.682 ± 0.074	6.857LeuGlu: 6.857 ± 0.081	4.522LeuPhe: 4.522 ± 0.094	6.1LeuGly: 6.1 ± 0.097	2.499LeuHis: 2.499 ± 0.054	5.81LeuIle: 5.81 ± 0.093	5.375LeuLys: 5.375 ± 0.075	9.561LeuLeu: 9.561 ± 0.141	2.489LeuMet: 2.489 ± 0.046	3.34LeuAsn: 3.34 ± 0.063	4.089LeuPro: 4.089 ± 0.07	4.073LeuGln: 4.073 ± 0.075	3.703LeuArg: 3.703 ± 0.059	6.277LeuSer: 6.277 ± 0.084	5.317LeuThr: 5.317 ± 0.081	5.628LeuVal: 5.628 ± 0.083	0.789LeuTrp: 0.789 ± 0.031	3.089LeuTyr: 3.089 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.049	0.164MetCys: 0.164 ± 0.013	1.634MetAsp: 1.634 ± 0.041	2.311MetGlu: 2.311 ± 0.048	1.168MetPhe: 1.168 ± 0.037	1.866MetGly: 1.866 ± 0.046	0.533MetHis: 0.533 ± 0.022	1.906MetIle: 1.906 ± 0.046	2.373MetLys: 2.373 ± 0.048	2.632MetLeu: 2.632 ± 0.058	0.933MetMet: 0.933 ± 0.034	1.606MetAsn: 1.606 ± 0.039	1.124MetPro: 1.124 ± 0.032	1.107MetGln: 1.107 ± 0.035	1.143MetArg: 1.143 ± 0.038	1.681MetSer: 1.681 ± 0.037	1.846MetThr: 1.846 ± 0.039	1.942MetVal: 1.942 ± 0.052	0.232MetTrp: 0.232 ± 0.014	0.794MetTyr: 0.794 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.694AsnAla: 2.694 ± 0.053	0.25AsnCys: 0.25 ± 0.018	2.3AsnAsp: 2.3 ± 0.044	3.26AsnGlu: 3.26 ± 0.066	1.234AsnPhe: 1.234 ± 0.03	3.084AsnGly: 3.084 ± 0.06	1.095AsnHis: 1.095 ± 0.035	3.063AsnIle: 3.063 ± 0.049	2.57AsnLys: 2.57 ± 0.058	2.85AsnLeu: 2.85 ± 0.057	1.215AsnMet: 1.215 ± 0.033	1.884AsnAsn: 1.884 ± 0.047	1.866AsnPro: 1.866 ± 0.044	1.797AsnGln: 1.797 ± 0.046	1.936AsnArg: 1.936 ± 0.046	1.772AsnSer: 1.772 ± 0.046	2.214AsnThr: 2.214 ± 0.049	3.133AsnVal: 3.133 ± 0.054	0.462AsnTrp: 0.462 ± 0.021	1.218AsnTyr: 1.218 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.939ProAla: 2.939 ± 0.057	0.232ProCys: 0.232 ± 0.016	2.368ProAsp: 2.368 ± 0.053	3.226ProGlu: 3.226 ± 0.067	1.983ProPhe: 1.983 ± 0.049	2.68ProGly: 2.68 ± 0.053	0.953ProHis: 0.953 ± 0.032	2.346ProIle: 2.346 ± 0.055	1.973ProLys: 1.973 ± 0.052	3.717ProLeu: 3.717 ± 0.064	0.955ProMet: 0.955 ± 0.032	1.475ProAsn: 1.475 ± 0.039	1.342ProPro: 1.342 ± 0.038	1.212ProGln: 1.212 ± 0.035	1.267ProArg: 1.267 ± 0.036	2.481ProSer: 2.481 ± 0.05	1.673ProThr: 1.673 ± 0.039	3.296ProVal: 3.296 ± 0.051	0.439ProTrp: 0.439 ± 0.021	1.481ProTyr: 1.481 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.611GlnAla: 3.611 ± 0.059	0.232GlnCys: 0.232 ± 0.016	1.87GlnAsp: 1.87 ± 0.037	3.705GlnGlu: 3.705 ± 0.079	1.437GlnPhe: 1.437 ± 0.042	2.356GlnGly: 2.356 ± 0.047	1.149GlnHis: 1.149 ± 0.037	2.21GlnIle: 2.21 ± 0.043	2.744GlnLys: 2.744 ± 0.057	3.906GlnLeu: 3.906 ± 0.07	1.211GlnMet: 1.211 ± 0.036	1.476GlnAsn: 1.476 ± 0.04	1.498GlnPro: 1.498 ± 0.044	2.481GlnGln: 2.481 ± 0.061	1.879GlnArg: 1.879 ± 0.05	2.29GlnSer: 2.29 ± 0.047	2.533GlnThr: 2.533 ± 0.054	2.507GlnVal: 2.507 ± 0.055	0.519GlnTrp: 0.519 ± 0.022	1.304GlnTyr: 1.304 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.784ArgAla: 2.784 ± 0.059	0.302ArgCys: 0.302 ± 0.017	2.303ArgAsp: 2.303 ± 0.045	3.418ArgGlu: 3.418 ± 0.057	2.047ArgPhe: 2.047 ± 0.042	2.549ArgGly: 2.549 ± 0.048	1.031ArgHis: 1.031 ± 0.032	2.861ArgIle: 2.861 ± 0.05	3.105ArgLys: 3.105 ± 0.057	4.232ArgLeu: 4.232 ± 0.075	1.416ArgMet: 1.416 ± 0.03	1.704ArgAsn: 1.704 ± 0.043	1.481ArgPro: 1.481 ± 0.042	1.857ArgGln: 1.857 ± 0.042	2.088ArgArg: 2.088 ± 0.047	2.38ArgSer: 2.38 ± 0.047	2.233ArgThr: 2.233 ± 0.048	2.834ArgVal: 2.834 ± 0.055	0.468ArgTrp: 0.468 ± 0.023	1.729ArgTyr: 1.729 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.23SerAla: 4.23 ± 0.068	0.414SerCys: 0.414 ± 0.019	2.947SerAsp: 2.947 ± 0.063	3.946SerGlu: 3.946 ± 0.069	3.156SerPhe: 3.156 ± 0.067	4.261SerGly: 4.261 ± 0.068	1.376SerHis: 1.376 ± 0.036	4.37SerIle: 4.37 ± 0.076	3.077SerLys: 3.077 ± 0.059	5.84SerLeu: 5.84 ± 0.091	1.919SerMet: 1.919 ± 0.041	2.089SerAsn: 2.089 ± 0.046	2.218SerPro: 2.218 ± 0.045	2.098SerGln: 2.098 ± 0.052	2.381SerArg: 2.381 ± 0.053	3.92SerSer: 3.92 ± 0.076	2.979SerThr: 2.979 ± 0.052	4.321SerVal: 4.321 ± 0.061	0.652SerTrp: 0.652 ± 0.027	2.168SerTyr: 2.168 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.874ThrAla: 4.874 ± 0.071	0.393ThrCys: 0.393 ± 0.019	2.95ThrAsp: 2.95 ± 0.061	3.855ThrGlu: 3.855 ± 0.057	2.619ThrPhe: 2.619 ± 0.056	4.473ThrGly: 4.473 ± 0.064	1.138ThrHis: 1.138 ± 0.034	3.918ThrIle: 3.918 ± 0.073	3.015ThrLys: 3.015 ± 0.054	5.229ThrLeu: 5.229 ± 0.072	1.527ThrMet: 1.527 ± 0.038	2.25ThrAsn: 2.25 ± 0.058	2.45ThrPro: 2.45 ± 0.057	1.495ThrGln: 1.495 ± 0.035	1.877ThrArg: 1.877 ± 0.045	3.348ThrSer: 3.348 ± 0.054	2.965ThrThr: 2.965 ± 0.062	4.322ThrVal: 4.322 ± 0.068	0.582ThrTrp: 0.582 ± 0.026	1.986ThrTyr: 1.986 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.849ValAla: 4.849 ± 0.076	0.652ValCys: 0.652 ± 0.026	3.833ValAsp: 3.833 ± 0.061	5.212ValGlu: 5.212 ± 0.088	3.315ValPhe: 3.315 ± 0.06	4.288ValGly: 4.288 ± 0.065	1.876ValHis: 1.876 ± 0.039	5.537ValIle: 5.537 ± 0.078	4.343ValLys: 4.343 ± 0.077	7.314ValLeu: 7.314 ± 0.098	2.105ValMet: 2.105 ± 0.047	2.984ValAsn: 2.984 ± 0.057	2.938ValPro: 2.938 ± 0.063	2.819ValGln: 2.819 ± 0.056	2.877ValArg: 2.877 ± 0.056	4.771ValSer: 4.771 ± 0.073	4.37ValThr: 4.37 ± 0.065	5.27ValVal: 5.27 ± 0.083	0.714ValTrp: 0.714 ± 0.028	2.412ValTyr: 2.412 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.623TrpAla: 0.623 ± 0.027	0.08TrpCys: 0.08 ± 0.008	0.533TrpAsp: 0.533 ± 0.023	0.784TrpGlu: 0.784 ± 0.03	0.486TrpPhe: 0.486 ± 0.023	0.661TrpGly: 0.661 ± 0.026	0.259TrpHis: 0.259 ± 0.016	0.762TrpIle: 0.762 ± 0.029	0.872TrpLys: 0.872 ± 0.032	1.22TrpLeu: 1.22 ± 0.037	0.421TrpMet: 0.421 ± 0.023	0.546TrpAsn: 0.546 ± 0.025	0.324TrpPro: 0.324 ± 0.017	0.464TrpGln: 0.464 ± 0.021	0.409TrpArg: 0.409 ± 0.023	0.624TrpSer: 0.624 ± 0.027	0.57TrpThr: 0.57 ± 0.023	0.659TrpVal: 0.659 ± 0.024	0.141TrpTrp: 0.141 ± 0.012	0.333TrpTyr: 0.333 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.26TyrAla: 2.26 ± 0.047	0.297TyrCys: 0.297 ± 0.018	2.038TyrAsp: 2.038 ± 0.047	2.598TyrGlu: 2.598 ± 0.048	1.643TyrPhe: 1.643 ± 0.042	2.477TyrGly: 2.477 ± 0.046	0.978TyrHis: 0.978 ± 0.036	2.172TyrIle: 2.172 ± 0.044	1.786TyrLys: 1.786 ± 0.041	3.1TyrLeu: 3.1 ± 0.06	0.869TyrMet: 0.869 ± 0.029	1.376TyrAsn: 1.376 ± 0.032	1.476TyrPro: 1.476 ± 0.043	1.602TyrGln: 1.602 ± 0.043	1.701TyrArg: 1.701 ± 0.041	1.82TyrSer: 1.82 ± 0.044	1.874TyrThr: 1.874 ± 0.045	2.417TyrVal: 2.417 ± 0.05	0.415TyrTrp: 0.415 ± 0.02	1.408TyrTyr: 1.408 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3572 proteins (1005916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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