Amino acid dipepetide frequency for Jejubacter calystegiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.704AlaAla: 10.704 ± 0.13	1.264AlaCys: 1.264 ± 0.031	5.125AlaAsp: 5.125 ± 0.081	5.329AlaGlu: 5.329 ± 0.065	3.509AlaPhe: 3.509 ± 0.059	8.169AlaGly: 8.169 ± 0.11	1.841AlaHis: 1.841 ± 0.04	5.909AlaIle: 5.909 ± 0.06	2.962AlaLys: 2.962 ± 0.054	12.724AlaLeu: 12.724 ± 0.122	3.047AlaMet: 3.047 ± 0.055	2.685AlaAsn: 2.685 ± 0.038	4.239AlaPro: 4.239 ± 0.06	4.458AlaGln: 4.458 ± 0.06	6.797AlaArg: 6.797 ± 0.094	5.933AlaSer: 5.933 ± 0.085	4.911AlaThr: 4.911 ± 0.09	6.73AlaVal: 6.73 ± 0.071	1.827AlaTrp: 1.827 ± 0.038	1.733AlaTyr: 1.733 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.048CysAla: 1.048 ± 0.03	0.195CysCys: 0.195 ± 0.012	0.64CysAsp: 0.64 ± 0.023	0.601CysGlu: 0.601 ± 0.021	0.443CysPhe: 0.443 ± 0.016	1.179CysGly: 1.179 ± 0.031	0.36CysHis: 0.36 ± 0.016	0.579CysIle: 0.579 ± 0.022	0.292CysLys: 0.292 ± 0.014	1.06CysLeu: 1.06 ± 0.03	0.244CysMet: 0.244 ± 0.013	0.328CysAsn: 0.328 ± 0.015	0.575CysPro: 0.575 ± 0.022	0.492CysGln: 0.492 ± 0.016	0.756CysArg: 0.756 ± 0.025	0.682CysSer: 0.682 ± 0.024	0.477CysThr: 0.477 ± 0.018	0.759CysVal: 0.759 ± 0.023	0.22CysTrp: 0.22 ± 0.012	0.348CysTyr: 0.348 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.268AspAla: 5.268 ± 0.097	0.555AspCys: 0.555 ± 0.021	3.099AspAsp: 3.099 ± 0.066	3.583AspGlu: 3.583 ± 0.052	2.067AspPhe: 2.067 ± 0.039	4.292AspGly: 4.292 ± 0.12	0.974AspHis: 0.974 ± 0.029	3.335AspIle: 3.335 ± 0.046	2.248AspLys: 2.248 ± 0.043	4.493AspLeu: 4.493 ± 0.055	1.322AspMet: 1.322 ± 0.033	2.18AspAsn: 2.18 ± 0.05	2.404AspPro: 2.404 ± 0.045	1.569AspGln: 1.569 ± 0.035	3.069AspArg: 3.069 ± 0.051	3.681AspSer: 3.681 ± 0.469	2.571AspThr: 2.571 ± 0.06	3.522AspVal: 3.522 ± 0.061	0.889AspTrp: 0.889 ± 0.028	1.896AspTyr: 1.896 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.582GluAla: 5.582 ± 0.072	0.504GluCys: 0.504 ± 0.02	2.165GluAsp: 2.165 ± 0.044	3.296GluGlu: 3.296 ± 0.064	1.719GluPhe: 1.719 ± 0.039	3.818GluGly: 3.818 ± 0.062	1.279GluHis: 1.279 ± 0.028	3.13GluIle: 3.13 ± 0.049	2.794GluLys: 2.794 ± 0.051	5.895GluLeu: 5.895 ± 0.07	1.753GluMet: 1.753 ± 0.033	2.106GluAsn: 2.106 ± 0.044	2.273GluPro: 2.273 ± 0.043	3.633GluGln: 3.633 ± 0.062	4.011GluArg: 4.011 ± 0.061	3.141GluSer: 3.141 ± 0.046	2.814GluThr: 2.814 ± 0.048	3.841GluVal: 3.841 ± 0.053	0.782GluTrp: 0.782 ± 0.025	1.363GluTyr: 1.363 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.51PheAla: 3.51 ± 0.052	0.541PheCys: 0.541 ± 0.017	2.245PheAsp: 2.245 ± 0.044	1.683PheGlu: 1.683 ± 0.036	1.6PhePhe: 1.6 ± 0.036	3.165PheGly: 3.165 ± 0.056	0.82PheHis: 0.82 ± 0.022	2.372PheIle: 2.372 ± 0.047	1.005PheLys: 1.005 ± 0.029	3.213PheLeu: 3.213 ± 0.06	0.963PheMet: 0.963 ± 0.027	1.597PheAsn: 1.597 ± 0.032	1.526PhePro: 1.526 ± 0.028	1.097PheGln: 1.097 ± 0.024	1.954PheArg: 1.954 ± 0.042	3.081PheSer: 3.081 ± 0.048	2.242PheThr: 2.242 ± 0.066	2.404PheVal: 2.404 ± 0.038	0.659PheTrp: 0.659 ± 0.022	1.15PheTyr: 1.15 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.059GlyAla: 7.059 ± 0.089	1.074GlyCys: 1.074 ± 0.028	4.155GlyAsp: 4.155 ± 0.094	4.919GlyGlu: 4.919 ± 0.062	3.299GlyPhe: 3.299 ± 0.049	6.069GlyGly: 6.069 ± 0.087	1.792GlyHis: 1.792 ± 0.039	4.976GlyIle: 4.976 ± 0.069	3.561GlyLys: 3.561 ± 0.048	8.037GlyLeu: 8.037 ± 0.092	2.55GlyMet: 2.55 ± 0.042	2.905GlyAsn: 2.905 ± 0.09	2.306GlyPro: 2.306 ± 0.047	3.264GlyGln: 3.264 ± 0.047	4.444GlyArg: 4.444 ± 0.065	4.722GlySer: 4.722 ± 0.103	3.794GlyThr: 3.794 ± 0.082	5.937GlyVal: 5.937 ± 0.068	1.47GlyTrp: 1.47 ± 0.036	2.69GlyTyr: 2.69 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.884HisAla: 1.884 ± 0.039	0.322HisCys: 0.322 ± 0.015	1.175HisAsp: 1.175 ± 0.028	1.075HisGlu: 1.075 ± 0.028	1.005HisPhe: 1.005 ± 0.027	1.846HisGly: 1.846 ± 0.038	0.813HisHis: 0.813 ± 0.025	1.234HisIle: 1.234 ± 0.031	0.68HisLys: 0.68 ± 0.021	2.151HisLeu: 2.151 ± 0.039	0.534HisMet: 0.534 ± 0.019	0.796HisAsn: 0.796 ± 0.024	1.4HisPro: 1.4 ± 0.03	1.283HisGln: 1.283 ± 0.031	1.354HisArg: 1.354 ± 0.032	1.343HisSer: 1.343 ± 0.031	1.055HisThr: 1.055 ± 0.023	1.153HisVal: 1.153 ± 0.032	0.448HisTrp: 0.448 ± 0.021	0.883HisTyr: 0.883 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.239IleAla: 6.239 ± 0.078	0.68IleCys: 0.68 ± 0.023	3.449IleAsp: 3.449 ± 0.054	3.063IleGlu: 3.063 ± 0.047	1.926IlePhe: 1.926 ± 0.041	4.551IleGly: 4.551 ± 0.075	1.185IleHis: 1.185 ± 0.029	3.147IleIle: 3.147 ± 0.061	1.964IleLys: 1.964 ± 0.044	4.769IleLeu: 4.769 ± 0.062	1.224IleMet: 1.224 ± 0.031	2.434IleAsn: 2.434 ± 0.051	2.676IlePro: 2.676 ± 0.041	1.835IleGln: 1.835 ± 0.034	3.114IleArg: 3.114 ± 0.052	3.676IleSer: 3.676 ± 0.055	3.347IleThr: 3.347 ± 0.072	3.749IleVal: 3.749 ± 0.053	0.711IleTrp: 0.711 ± 0.023	1.445IleTyr: 1.445 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.68LysAla: 3.68 ± 0.063	0.22LysCys: 0.22 ± 0.012	1.65LysAsp: 1.65 ± 0.035	2.084LysGlu: 2.084 ± 0.045	0.926LysPhe: 0.926 ± 0.027	2.706LysGly: 2.706 ± 0.051	0.696LysHis: 0.696 ± 0.021	1.962LysIle: 1.962 ± 0.041	1.774LysLys: 1.774 ± 0.04	3.6LysLeu: 3.6 ± 0.059	1.044LysMet: 1.044 ± 0.026	1.339LysAsn: 1.339 ± 0.035	1.853LysPro: 1.853 ± 0.04	1.676LysGln: 1.676 ± 0.04	2.383LysArg: 2.383 ± 0.046	2.07LysSer: 2.07 ± 0.042	2.128LysThr: 2.128 ± 0.042	2.67LysVal: 2.67 ± 0.05	0.403LysTrp: 0.403 ± 0.018	0.986LysTyr: 0.986 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.953LeuAla: 11.953 ± 0.116	1.392LeuCys: 1.392 ± 0.032	5.373LeuAsp: 5.373 ± 0.069	5.669LeuGlu: 5.669 ± 0.067	4.299LeuPhe: 4.299 ± 0.073	7.701LeuGly: 7.701 ± 0.091	2.25LeuHis: 2.25 ± 0.042	5.603LeuIle: 5.603 ± 0.08	4.047LeuLys: 4.047 ± 0.062	12.143LeuLeu: 12.143 ± 0.151	3.054LeuMet: 3.054 ± 0.051	4.079LeuAsn: 4.079 ± 0.057	5.663LeuPro: 5.663 ± 0.078	3.785LeuGln: 3.785 ± 0.06	6.61LeuArg: 6.61 ± 0.085	7.491LeuSer: 7.491 ± 0.077	6.293LeuThr: 6.293 ± 0.077	7.209LeuVal: 7.209 ± 0.08	1.646LeuTrp: 1.646 ± 0.034	2.571LeuTyr: 2.571 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.101MetAla: 3.101 ± 0.049	0.209MetCys: 0.209 ± 0.012	1.214MetAsp: 1.214 ± 0.03	1.336MetGlu: 1.336 ± 0.032	0.829MetPhe: 0.829 ± 0.025	1.951MetGly: 1.951 ± 0.041	0.472MetHis: 0.472 ± 0.018	1.384MetIle: 1.384 ± 0.029	1.337MetLys: 1.337 ± 0.036	3.098MetLeu: 3.098 ± 0.049	0.899MetMet: 0.899 ± 0.027	1.092MetAsn: 1.092 ± 0.025	1.402MetPro: 1.402 ± 0.033	1.097MetGln: 1.097 ± 0.029	1.528MetArg: 1.528 ± 0.033	1.807MetSer: 1.807 ± 0.039	1.819MetThr: 1.819 ± 0.036	2.021MetVal: 2.021 ± 0.035	0.261MetTrp: 0.261 ± 0.015	0.463MetTyr: 0.463 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.412AsnAla: 3.412 ± 0.061	0.346AsnCys: 0.346 ± 0.015	1.91AsnAsp: 1.91 ± 0.043	1.683AsnGlu: 1.683 ± 0.033	1.21AsnPhe: 1.21 ± 0.029	3.11AsnGly: 3.11 ± 0.061	0.837AsnHis: 0.837 ± 0.025	2.13AsnIle: 2.13 ± 0.044	1.299AsnLys: 1.299 ± 0.034	3.383AsnLeu: 3.383 ± 0.054	0.828AsnMet: 0.828 ± 0.025	1.413AsnAsn: 1.413 ± 0.036	1.995AsnPro: 1.995 ± 0.039	1.591AsnGln: 1.591 ± 0.039	2.076AsnArg: 2.076 ± 0.044	1.993AsnSer: 1.993 ± 0.046	1.784AsnThr: 1.784 ± 0.044	2.226AsnVal: 2.226 ± 0.04	0.547AsnTrp: 0.547 ± 0.02	1.068AsnTyr: 1.068 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.519ProAla: 4.519 ± 0.065	0.417ProCys: 0.417 ± 0.016	3.105ProAsp: 3.105 ± 0.058	3.82ProGlu: 3.82 ± 0.059	1.826ProPhe: 1.826 ± 0.039	4.108ProGly: 4.108 ± 0.053	1.056ProHis: 1.056 ± 0.026	1.704ProIle: 1.704 ± 0.036	1.288ProLys: 1.288 ± 0.031	5.293ProLeu: 5.293 ± 0.076	1.117ProMet: 1.117 ± 0.032	1.21ProAsn: 1.21 ± 0.026	1.811ProPro: 1.811 ± 0.041	2.506ProGln: 2.506 ± 0.051	2.248ProArg: 2.248 ± 0.046	2.136ProSer: 2.136 ± 0.041	2.163ProThr: 2.163 ± 0.043	4.058ProVal: 4.058 ± 0.057	0.93ProTrp: 0.93 ± 0.026	1.085ProTyr: 1.085 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.913GlnAla: 4.913 ± 0.071	0.384GlnCys: 0.384 ± 0.016	1.816GlnAsp: 1.816 ± 0.038	2.306GlnGlu: 2.306 ± 0.052	1.319GlnPhe: 1.319 ± 0.028	3.376GlnGly: 3.376 ± 0.044	1.141GlnHis: 1.141 ± 0.031	2.268GlnIle: 2.268 ± 0.043	1.533GlnLys: 1.533 ± 0.033	4.917GlnLeu: 4.917 ± 0.062	1.25GlnMet: 1.25 ± 0.03	1.328GlnAsn: 1.328 ± 0.028	2.301GlnPro: 2.301 ± 0.05	3.268GlnGln: 3.268 ± 0.061	3.443GlnArg: 3.443 ± 0.067	2.335GlnSer: 2.335 ± 0.039	2.074GlnThr: 2.074 ± 0.039	3.082GlnVal: 3.082 ± 0.047	0.628GlnTrp: 0.628 ± 0.022	1.106GlnTyr: 1.106 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.313ArgAla: 5.313 ± 0.077	0.683ArgCys: 0.683 ± 0.022	3.437ArgAsp: 3.437 ± 0.059	4.128ArgGlu: 4.128 ± 0.055	2.633ArgPhe: 2.633 ± 0.041	3.898ArgGly: 3.898 ± 0.053	1.864ArgHis: 1.864 ± 0.04	3.521ArgIle: 3.521 ± 0.058	2.179ArgLys: 2.179 ± 0.046	7.368ArgLeu: 7.368 ± 0.095	1.71ArgMet: 1.71 ± 0.034	2.069ArgAsn: 2.069 ± 0.043	2.634ArgPro: 2.634 ± 0.045	3.609ArgGln: 3.609 ± 0.066	4.41ArgArg: 4.41 ± 0.074	3.096ArgSer: 3.096 ± 0.055	2.622ArgThr: 2.622 ± 0.035	4.048ArgVal: 4.048 ± 0.057	1.178ArgTrp: 1.178 ± 0.03	2.412ArgTyr: 2.412 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.014SerAla: 6.014 ± 0.103	0.601SerCys: 0.601 ± 0.02	3.966SerAsp: 3.966 ± 0.463	3.228SerGlu: 3.228 ± 0.055	2.26SerPhe: 2.26 ± 0.048	5.994SerGly: 5.994 ± 0.115	1.533SerHis: 1.533 ± 0.032	2.809SerIle: 2.809 ± 0.05	1.722SerLys: 1.722 ± 0.041	6.766SerLeu: 6.766 ± 0.068	1.458SerMet: 1.458 ± 0.03	1.741SerAsn: 1.741 ± 0.035	2.79SerPro: 2.79 ± 0.055	2.621SerGln: 2.621 ± 0.04	3.854SerArg: 3.854 ± 0.057	3.55SerSer: 3.55 ± 0.061	2.852SerThr: 2.852 ± 0.046	4.411SerVal: 4.411 ± 0.074	1.086SerTrp: 1.086 ± 0.028	1.6SerTyr: 1.6 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.92ThrAla: 4.92 ± 0.073	0.487ThrCys: 0.487 ± 0.019	2.568ThrAsp: 2.568 ± 0.078	2.386ThrGlu: 2.386 ± 0.043	1.88ThrPhe: 1.88 ± 0.04	4.7ThrGly: 4.7 ± 0.071	1.153ThrHis: 1.153 ± 0.028	2.786ThrIle: 2.786 ± 0.066	1.191ThrLys: 1.191 ± 0.028	7.375ThrLeu: 7.375 ± 0.088	1.119ThrMet: 1.119 ± 0.028	1.439ThrAsn: 1.439 ± 0.045	3.407ThrPro: 3.407 ± 0.055	1.947ThrGln: 1.947 ± 0.034	3.433ThrArg: 3.433 ± 0.046	2.792ThrSer: 2.792 ± 0.057	2.743ThrThr: 2.743 ± 0.057	3.731ThrVal: 3.731 ± 0.124	0.924ThrTrp: 0.924 ± 0.028	1.022ThrTyr: 1.022 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.403ValAla: 7.403 ± 0.066	0.823ValCys: 0.823 ± 0.022	3.721ValAsp: 3.721 ± 0.063	3.96ValGlu: 3.96 ± 0.063	2.305ValPhe: 2.305 ± 0.038	5.065ValGly: 5.065 ± 0.063	1.169ValHis: 1.169 ± 0.03	4.189ValIle: 4.189 ± 0.063	2.695ValLys: 2.695 ± 0.049	7.073ValLeu: 7.073 ± 0.08	2.175ValMet: 2.175 ± 0.037	2.682ValAsn: 2.682 ± 0.054	3.069ValPro: 3.069 ± 0.048	2.217ValGln: 2.217 ± 0.048	3.923ValArg: 3.923 ± 0.057	4.611ValSer: 4.611 ± 0.066	4.408ValThr: 4.408 ± 0.106	5.613ValVal: 5.613 ± 0.067	1.054ValTrp: 1.054 ± 0.03	1.54ValTyr: 1.54 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.06TrpAla: 1.06 ± 0.031	0.212TrpCys: 0.212 ± 0.013	0.637TrpAsp: 0.637 ± 0.02	0.618TrpGlu: 0.618 ± 0.022	0.711TrpPhe: 0.711 ± 0.023	1.055TrpGly: 1.055 ± 0.029	0.49TrpHis: 0.49 ± 0.018	0.797TrpIle: 0.797 ± 0.024	0.497TrpLys: 0.497 ± 0.018	2.625TrpLeu: 2.625 ± 0.047	0.453TrpMet: 0.453 ± 0.016	0.502TrpAsn: 0.502 ± 0.017	0.727TrpPro: 0.727 ± 0.024	1.262TrpGln: 1.262 ± 0.035	1.442TrpArg: 1.442 ± 0.039	0.982TrpSer: 0.982 ± 0.037	0.555TrpThr: 0.555 ± 0.022	0.983TrpVal: 0.983 ± 0.029	0.254TrpTrp: 0.254 ± 0.011	0.465TrpTyr: 0.465 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.04	0.372TyrCys: 0.372 ± 0.017	1.567TyrAsp: 1.567 ± 0.044	1.133TyrGlu: 1.133 ± 0.03	1.062TyrPhe: 1.062 ± 0.028	2.271TyrGly: 2.271 ± 0.038	0.709TyrHis: 0.709 ± 0.021	1.35TyrIle: 1.35 ± 0.031	0.781TyrLys: 0.781 ± 0.024	2.846TyrLeu: 2.846 ± 0.056	0.577TyrMet: 0.577 ± 0.018	0.915TyrAsn: 0.915 ± 0.026	1.35TyrPro: 1.35 ± 0.03	1.577TyrGln: 1.577 ± 0.033	1.96TyrArg: 1.96 ± 0.037	1.733TyrSer: 1.733 ± 0.038	1.35TyrThr: 1.35 ± 0.038	1.547TyrVal: 1.547 ± 0.032	0.413TyrTrp: 0.413 ± 0.018	0.89TyrTyr: 0.89 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4678 proteins (1506925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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