Amino acid dipepetide frequency for Maribacter sp. T28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.277AlaAla: 4.277 ± 0.087	0.536AlaCys: 0.536 ± 0.019	3.482AlaAsp: 3.482 ± 0.054	3.951AlaGlu: 3.951 ± 0.064	3.182AlaPhe: 3.182 ± 0.053	4.079AlaGly: 4.079 ± 0.07	1.111AlaHis: 1.111 ± 0.03	5.605AlaIle: 5.605 ± 0.079	4.61AlaLys: 4.61 ± 0.069	6.226AlaLeu: 6.226 ± 0.084	1.656AlaMet: 1.656 ± 0.04	3.656AlaAsn: 3.656 ± 0.06	1.904AlaPro: 1.904 ± 0.039	2.3AlaGln: 2.3 ± 0.045	1.891AlaArg: 1.891 ± 0.041	4.058AlaSer: 4.058 ± 0.061	3.709AlaThr: 3.709 ± 0.057	4.059AlaVal: 4.059 ± 0.052	0.616AlaTrp: 0.616 ± 0.024	2.449AlaTyr: 2.449 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.428CysAla: 0.428 ± 0.019	0.091CysCys: 0.091 ± 0.009	0.384CysAsp: 0.384 ± 0.019	0.421CysGlu: 0.421 ± 0.022	0.391CysPhe: 0.391 ± 0.017	0.547CysGly: 0.547 ± 0.027	0.186CysHis: 0.186 ± 0.014	0.604CysIle: 0.604 ± 0.027	0.446CysLys: 0.446 ± 0.019	0.575CysLeu: 0.575 ± 0.025	0.142CysMet: 0.142 ± 0.011	0.416CysAsn: 0.416 ± 0.019	0.322CysPro: 0.322 ± 0.017	0.213CysGln: 0.213 ± 0.013	0.198CysArg: 0.198 ± 0.013	0.529CysSer: 0.529 ± 0.025	0.457CysThr: 0.457 ± 0.027	0.395CysVal: 0.395 ± 0.018	0.068CysTrp: 0.068 ± 0.008	0.281CysTyr: 0.281 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.741AspAla: 3.741 ± 0.054	0.384AspCys: 0.384 ± 0.02	3.085AspAsp: 3.085 ± 0.056	3.784AspGlu: 3.784 ± 0.047	3.606AspPhe: 3.606 ± 0.06	4.135AspGly: 4.135 ± 0.079	0.928AspHis: 0.928 ± 0.03	4.647AspIle: 4.647 ± 0.067	4.081AspLys: 4.081 ± 0.068	5.092AspLeu: 5.092 ± 0.066	1.225AspMet: 1.225 ± 0.035	3.381AspAsn: 3.381 ± 0.061	1.673AspPro: 1.673 ± 0.046	1.461AspGln: 1.461 ± 0.036	1.833AspArg: 1.833 ± 0.041	3.488AspSer: 3.488 ± 0.063	2.951AspThr: 2.951 ± 0.05	3.578AspVal: 3.578 ± 0.056	0.778AspTrp: 0.778 ± 0.025	2.763AspTyr: 2.763 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.012GluAla: 4.012 ± 0.065	0.346GluCys: 0.346 ± 0.017	3.584GluAsp: 3.584 ± 0.054	4.845GluGlu: 4.845 ± 0.075	3.061GluPhe: 3.061 ± 0.052	3.876GluGly: 3.876 ± 0.056	1.23GluHis: 1.23 ± 0.034	5.722GluIle: 5.722 ± 0.066	5.797GluLys: 5.797 ± 0.082	6.51GluLeu: 6.51 ± 0.09	1.644GluMet: 1.644 ± 0.035	4.848GluAsn: 4.848 ± 0.063	1.706GluPro: 1.706 ± 0.036	2.331GluGln: 2.331 ± 0.047	2.529GluArg: 2.529 ± 0.047	3.553GluSer: 3.553 ± 0.054	3.639GluThr: 3.639 ± 0.054	4.34GluVal: 4.34 ± 0.061	0.701GluTrp: 0.701 ± 0.022	2.484GluTyr: 2.484 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.808PheAla: 2.808 ± 0.05	0.375PheCys: 0.375 ± 0.016	3.133PheAsp: 3.133 ± 0.053	3.351PheGlu: 3.351 ± 0.053	2.67PhePhe: 2.67 ± 0.055	3.652PheGly: 3.652 ± 0.067	0.811PheHis: 0.811 ± 0.027	3.987PheIle: 3.987 ± 0.071	3.852PheLys: 3.852 ± 0.058	4.838PheLeu: 4.838 ± 0.068	1.179PheMet: 1.179 ± 0.03	3.429PheAsn: 3.429 ± 0.059	1.73PhePro: 1.73 ± 0.037	1.541PheGln: 1.541 ± 0.037	1.538PheArg: 1.538 ± 0.037	3.828PheSer: 3.828 ± 0.052	3.138PheThr: 3.138 ± 0.053	2.965PheVal: 2.965 ± 0.049	0.57PheTrp: 0.57 ± 0.02	2.175PheTyr: 2.175 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.168GlyAla: 4.168 ± 0.071	0.579GlyCys: 0.579 ± 0.03	3.561GlyAsp: 3.561 ± 0.07	3.877GlyGlu: 3.877 ± 0.062	3.693GlyPhe: 3.693 ± 0.062	4.687GlyGly: 4.687 ± 0.099	1.121GlyHis: 1.121 ± 0.028	5.75GlyIle: 5.75 ± 0.076	4.934GlyLys: 4.934 ± 0.074	6.059GlyLeu: 6.059 ± 0.08	1.66GlyMet: 1.66 ± 0.039	3.802GlyAsn: 3.802 ± 0.07	1.468GlyPro: 1.468 ± 0.038	1.952GlyGln: 1.952 ± 0.056	2.086GlyArg: 2.086 ± 0.047	4.186GlySer: 4.186 ± 0.068	4.057GlyThr: 4.057 ± 0.076	4.409GlyVal: 4.409 ± 0.057	0.794GlyTrp: 0.794 ± 0.023	2.878GlyTyr: 2.878 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	0.981HisAla: 0.981 ± 0.029	0.186HisCys: 0.186 ± 0.013	0.794HisAsp: 0.794 ± 0.026	0.948HisGlu: 0.948 ± 0.027	1.04HisPhe: 1.04 ± 0.03	1.056HisGly: 1.056 ± 0.03	0.44HisHis: 0.44 ± 0.021	1.424HisIle: 1.424 ± 0.038	1.218HisLys: 1.218 ± 0.033	1.712HisLeu: 1.712 ± 0.039	0.348HisMet: 0.348 ± 0.018	0.905HisAsn: 0.905 ± 0.03	0.907HisPro: 0.907 ± 0.025	0.639HisGln: 0.639 ± 0.028	0.646HisArg: 0.646 ± 0.021	1.022HisSer: 1.022 ± 0.028	0.986HisThr: 0.986 ± 0.026	1.005HisVal: 1.005 ± 0.031	0.223HisTrp: 0.223 ± 0.013	0.746HisTyr: 0.746 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.765IleAla: 5.765 ± 0.075	0.625IleCys: 0.625 ± 0.024	4.946IleAsp: 4.946 ± 0.062	5.376IleGlu: 5.376 ± 0.075	3.677IlePhe: 3.677 ± 0.06	5.353IleGly: 5.353 ± 0.073	1.293IleHis: 1.293 ± 0.033	6.079IleIle: 6.079 ± 0.085	5.777IleLys: 5.777 ± 0.073	7.381IleLeu: 7.381 ± 0.09	1.462IleMet: 1.462 ± 0.039	4.68IleAsn: 4.68 ± 0.061	3.271IlePro: 3.271 ± 0.053	2.342IleGln: 2.342 ± 0.044	2.511IleArg: 2.511 ± 0.043	5.867IleSer: 5.867 ± 0.072	4.966IleThr: 4.966 ± 0.084	4.788IleVal: 4.788 ± 0.064	0.751IleTrp: 0.751 ± 0.026	2.869IleTyr: 2.869 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.766LysAla: 4.766 ± 0.071	0.313LysCys: 0.313 ± 0.017	4.433LysAsp: 4.433 ± 0.069	6.391LysGlu: 6.391 ± 0.08	2.927LysPhe: 2.927 ± 0.05	4.608LysGly: 4.608 ± 0.069	1.276LysHis: 1.276 ± 0.037	6.074LysIle: 6.074 ± 0.083	6.748LysLys: 6.748 ± 0.078	6.624LysLeu: 6.624 ± 0.086	2.005LysMet: 2.005 ± 0.044	5.207LysAsn: 5.207 ± 0.075	2.363LysPro: 2.363 ± 0.048	2.528LysGln: 2.528 ± 0.052	2.746LysArg: 2.746 ± 0.062	4.727LysSer: 4.727 ± 0.078	4.441LysThr: 4.441 ± 0.06	4.665LysVal: 4.665 ± 0.074	0.829LysTrp: 0.829 ± 0.025	2.867LysTyr: 2.867 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	6.011LeuAla: 6.011 ± 0.091	0.664LeuCys: 0.664 ± 0.026	5.369LeuAsp: 5.369 ± 0.076	6.238LeuGlu: 6.238 ± 0.079	4.918LeuPhe: 4.918 ± 0.087	6.128LeuGly: 6.128 ± 0.081	1.534LeuHis: 1.534 ± 0.042	6.878LeuIle: 6.878 ± 0.088	7.849LeuLys: 7.849 ± 0.096	9.099LeuLeu: 9.099 ± 0.122	2.116LeuMet: 2.116 ± 0.047	5.976LeuAsn: 5.976 ± 0.066	3.615LeuPro: 3.615 ± 0.05	3.15LeuGln: 3.15 ± 0.055	3.196LeuArg: 3.196 ± 0.056	6.601LeuSer: 6.601 ± 0.08	5.187LeuThr: 5.187 ± 0.063	5.659LeuVal: 5.659 ± 0.077	0.875LeuTrp: 0.875 ± 0.031	3.115LeuTyr: 3.115 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.771MetAla: 1.771 ± 0.034	0.135MetCys: 0.135 ± 0.01	1.288MetAsp: 1.288 ± 0.031	1.516MetGlu: 1.516 ± 0.037	0.925MetPhe: 0.925 ± 0.037	1.619MetGly: 1.619 ± 0.037	0.416MetHis: 0.416 ± 0.02	1.483MetIle: 1.483 ± 0.032	2.061MetLys: 2.061 ± 0.045	2.025MetLeu: 2.025 ± 0.048	0.563MetMet: 0.563 ± 0.026	1.395MetAsn: 1.395 ± 0.035	0.917MetPro: 0.917 ± 0.032	0.846MetGln: 0.846 ± 0.026	0.876MetArg: 0.876 ± 0.025	1.408MetSer: 1.408 ± 0.035	1.164MetThr: 1.164 ± 0.029	1.532MetVal: 1.532 ± 0.036	0.172MetTrp: 0.172 ± 0.013	0.743MetTyr: 0.743 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.899AsnAla: 3.899 ± 0.056	0.44AsnCys: 0.44 ± 0.022	3.411AsnAsp: 3.411 ± 0.065	4.141AsnGlu: 4.141 ± 0.06	3.143AsnPhe: 3.143 ± 0.049	4.369AsnGly: 4.369 ± 0.1	1.04AsnHis: 1.04 ± 0.028	4.57AsnIle: 4.57 ± 0.07	4.309AsnLys: 4.309 ± 0.066	5.634AsnLeu: 5.634 ± 0.072	1.361AsnMet: 1.361 ± 0.035	3.969AsnAsn: 3.969 ± 0.08	2.664AsnPro: 2.664 ± 0.05	2.099AsnGln: 2.099 ± 0.044	2.192AsnArg: 2.192 ± 0.043	4.204AsnSer: 4.204 ± 0.061	3.74AsnThr: 3.74 ± 0.068	3.526AsnVal: 3.526 ± 0.068	0.811AsnTrp: 0.811 ± 0.031	2.737AsnTyr: 2.737 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.903ProAla: 1.903 ± 0.042	0.195ProCys: 0.195 ± 0.012	2.023ProAsp: 2.023 ± 0.044	2.786ProGlu: 2.786 ± 0.045	1.862ProPhe: 1.862 ± 0.037	2.005ProGly: 2.005 ± 0.045	0.582ProHis: 0.582 ± 0.022	2.835ProIle: 2.835 ± 0.048	2.664ProLys: 2.664 ± 0.054	3.071ProLeu: 3.071 ± 0.057	0.77ProMet: 0.77 ± 0.025	2.39ProAsn: 2.39 ± 0.047	0.866ProPro: 0.866 ± 0.029	1.03ProGln: 1.03 ± 0.026	0.883ProArg: 0.883 ± 0.028	2.17ProSer: 2.17 ± 0.046	2.141ProThr: 2.141 ± 0.047	2.267ProVal: 2.267 ± 0.044	0.374ProTrp: 0.374 ± 0.018	1.361ProTyr: 1.361 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.787GlnAla: 1.787 ± 0.039	0.167GlnCys: 0.167 ± 0.014	1.664GlnAsp: 1.664 ± 0.035	2.344GlnGlu: 2.344 ± 0.047	1.613GlnPhe: 1.613 ± 0.038	1.82GlnGly: 1.82 ± 0.042	0.601GlnHis: 0.601 ± 0.022	2.523GlnIle: 2.523 ± 0.049	2.646GlnLys: 2.646 ± 0.049	3.508GlnLeu: 3.508 ± 0.056	0.795GlnMet: 0.795 ± 0.023	2.018GlnAsn: 2.018 ± 0.046	1.074GlnPro: 1.074 ± 0.025	1.29GlnGln: 1.29 ± 0.039	1.29GlnArg: 1.29 ± 0.048	1.808GlnSer: 1.808 ± 0.046	1.685GlnThr: 1.685 ± 0.036	1.916GlnVal: 1.916 ± 0.038	0.39GlnTrp: 0.39 ± 0.018	1.209GlnTyr: 1.209 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.999ArgAla: 1.999 ± 0.046	0.18ArgCys: 0.18 ± 0.012	1.76ArgAsp: 1.76 ± 0.039	2.058ArgGlu: 2.058 ± 0.041	1.78ArgPhe: 1.78 ± 0.04	1.884ArgGly: 1.884 ± 0.041	0.564ArgHis: 0.564 ± 0.023	2.893ArgIle: 2.893 ± 0.053	2.653ArgLys: 2.653 ± 0.052	3.19ArgLeu: 3.19 ± 0.058	0.932ArgMet: 0.932 ± 0.026	2.15ArgAsn: 2.15 ± 0.045	1.166ArgPro: 1.166 ± 0.036	1.027ArgGln: 1.027 ± 0.03	1.23ArgArg: 1.23 ± 0.035	1.912ArgSer: 1.912 ± 0.038	1.983ArgThr: 1.983 ± 0.052	1.96ArgVal: 1.96 ± 0.041	0.402ArgTrp: 0.402 ± 0.017	1.464ArgTyr: 1.464 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.829SerAla: 3.829 ± 0.07	0.625SerCys: 0.625 ± 0.023	3.445SerAsp: 3.445 ± 0.056	4.097SerGlu: 4.097 ± 0.062	3.799SerPhe: 3.799 ± 0.063	4.512SerGly: 4.512 ± 0.082	1.038SerHis: 1.038 ± 0.033	5.55SerIle: 5.55 ± 0.071	5.061SerLys: 5.061 ± 0.069	6.284SerLeu: 6.284 ± 0.079	1.38SerMet: 1.38 ± 0.033	3.873SerAsn: 3.873 ± 0.068	2.148SerPro: 2.148 ± 0.042	2.021SerGln: 2.021 ± 0.041	2.056SerArg: 2.056 ± 0.036	4.36SerSer: 4.36 ± 0.067	3.839SerThr: 3.839 ± 0.056	4.002SerVal: 4.002 ± 0.055	0.725SerTrp: 0.725 ± 0.029	2.718SerTyr: 2.718 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.859ThrAla: 3.859 ± 0.062	0.364ThrCys: 0.364 ± 0.022	3.562ThrAsp: 3.562 ± 0.079	3.619ThrGlu: 3.619 ± 0.06	3.031ThrPhe: 3.031 ± 0.05	4.09ThrGly: 4.09 ± 0.063	0.99ThrHis: 0.99 ± 0.03	5.09ThrIle: 5.09 ± 0.073	3.901ThrLys: 3.901 ± 0.061	5.346ThrLeu: 5.346 ± 0.064	1.106ThrMet: 1.106 ± 0.025	3.374ThrAsn: 3.374 ± 0.061	2.401ThrPro: 2.401 ± 0.052	1.674ThrGln: 1.674 ± 0.038	1.577ThrArg: 1.577 ± 0.034	3.869ThrSer: 3.869 ± 0.064	3.611ThrThr: 3.611 ± 0.077	3.797ThrVal: 3.797 ± 0.063	0.641ThrTrp: 0.641 ± 0.031	2.471ThrTyr: 2.471 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.245ValAla: 4.245 ± 0.064	0.479ValCys: 0.479 ± 0.019	3.664ValAsp: 3.664 ± 0.06	3.869ValGlu: 3.869 ± 0.053	3.295ValPhe: 3.295 ± 0.049	3.893ValGly: 3.893 ± 0.069	1.063ValHis: 1.063 ± 0.032	4.705ValIle: 4.705 ± 0.069	4.253ValLys: 4.253 ± 0.062	6.21ValLeu: 6.21 ± 0.088	1.395ValMet: 1.395 ± 0.034	3.532ValAsn: 3.532 ± 0.065	2.232ValPro: 2.232 ± 0.045	1.845ValGln: 1.845 ± 0.037	1.966ValArg: 1.966 ± 0.045	4.484ValSer: 4.484 ± 0.061	3.66ValThr: 3.66 ± 0.071	4.243ValVal: 4.243 ± 0.064	0.629ValTrp: 0.629 ± 0.023	2.303ValTyr: 2.303 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.621TrpAla: 0.621 ± 0.023	0.087TrpCys: 0.087 ± 0.008	0.685TrpAsp: 0.685 ± 0.028	0.727TrpGlu: 0.727 ± 0.025	0.578TrpPhe: 0.578 ± 0.023	0.698TrpGly: 0.698 ± 0.026	0.231TrpHis: 0.231 ± 0.013	0.756TrpIle: 0.756 ± 0.025	0.856TrpLys: 0.856 ± 0.03	0.997TrpLeu: 0.997 ± 0.029	0.324TrpMet: 0.324 ± 0.017	0.756TrpAsn: 0.756 ± 0.029	0.268TrpPro: 0.268 ± 0.017	0.425TrpGln: 0.425 ± 0.02	0.408TrpArg: 0.408 ± 0.017	0.714TrpSer: 0.714 ± 0.028	0.567TrpThr: 0.567 ± 0.023	0.674TrpVal: 0.674 ± 0.024	0.166TrpTrp: 0.166 ± 0.01	0.44TrpTyr: 0.44 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.488TyrAla: 2.488 ± 0.05	0.326TyrCys: 0.326 ± 0.016	2.34TyrAsp: 2.34 ± 0.048	2.416TyrGlu: 2.416 ± 0.045	2.378TyrPhe: 2.378 ± 0.045	2.709TyrGly: 2.709 ± 0.049	0.772TyrHis: 0.772 ± 0.022	2.602TyrIle: 2.602 ± 0.045	2.823TyrLys: 2.823 ± 0.05	3.797TyrLeu: 3.797 ± 0.065	0.792TyrMet: 0.792 ± 0.025	2.502TyrAsn: 2.502 ± 0.048	1.484TyrPro: 1.484 ± 0.035	1.432TyrGln: 1.432 ± 0.039	1.536TyrArg: 1.536 ± 0.035	2.574TyrSer: 2.574 ± 0.053	2.454TyrThr: 2.454 ± 0.051	2.186TyrVal: 2.186 ± 0.048	0.461TyrTrp: 0.461 ± 0.02	1.774TyrTyr: 1.774 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3578 proteins (1244144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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