Amino acid dipepetide frequency for Vibrio genomosp. F6 str. FF-238

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.867AlaAla: 6.867 ± 0.09	0.901AlaCys: 0.901 ± 0.031	4.363AlaAsp: 4.363 ± 0.067	5.346AlaGlu: 5.346 ± 0.078	3.374AlaPhe: 3.374 ± 0.064	5.401AlaGly: 5.401 ± 0.084	1.604AlaHis: 1.604 ± 0.036	5.957AlaIle: 5.957 ± 0.073	4.915AlaLys: 4.915 ± 0.072	9.249AlaLeu: 9.249 ± 0.105	2.554AlaMet: 2.554 ± 0.059	3.385AlaAsn: 3.385 ± 0.052	2.682AlaPro: 2.682 ± 0.062	3.649AlaGln: 3.649 ± 0.054	3.333AlaArg: 3.333 ± 0.056	5.34AlaSer: 5.34 ± 0.076	4.342AlaThr: 4.342 ± 0.064	5.436AlaVal: 5.436 ± 0.077	0.89AlaTrp: 0.89 ± 0.03	2.202AlaTyr: 2.202 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.758CysAla: 0.758 ± 0.028	0.159CysCys: 0.159 ± 0.013	0.654CysAsp: 0.654 ± 0.025	0.668CysGlu: 0.668 ± 0.025	0.485CysPhe: 0.485 ± 0.02	0.922CysGly: 0.922 ± 0.027	0.364CysHis: 0.364 ± 0.018	0.624CysIle: 0.624 ± 0.025	0.476CysLys: 0.476 ± 0.02	0.971CysLeu: 0.971 ± 0.028	0.255CysMet: 0.255 ± 0.014	0.384CysAsn: 0.384 ± 0.019	0.43CysPro: 0.43 ± 0.02	0.468CysGln: 0.468 ± 0.017	0.447CysArg: 0.447 ± 0.02	0.758CysSer: 0.758 ± 0.03	0.515CysThr: 0.515 ± 0.022	0.652CysVal: 0.652 ± 0.023	0.144CysTrp: 0.144 ± 0.01	0.332CysTyr: 0.332 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.339AspAla: 4.339 ± 0.069	0.562AspCys: 0.562 ± 0.019	3.161AspAsp: 3.161 ± 0.066	3.988AspGlu: 3.988 ± 0.071	2.534AspPhe: 2.534 ± 0.053	3.796AspGly: 3.796 ± 0.077	1.163AspHis: 1.163 ± 0.036	4.119AspIle: 4.119 ± 0.062	3.324AspLys: 3.324 ± 0.05	5.391AspLeu: 5.391 ± 0.075	1.454AspMet: 1.454 ± 0.038	2.551AspAsn: 2.551 ± 0.058	2.022AspPro: 2.022 ± 0.042	2.101AspGln: 2.101 ± 0.046	2.245AspArg: 2.245 ± 0.048	3.655AspSer: 3.655 ± 0.069	2.702AspThr: 2.702 ± 0.053	4.003AspVal: 4.003 ± 0.067	0.826AspTrp: 0.826 ± 0.025	2.049AspTyr: 2.049 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.118GluAla: 5.118 ± 0.066	0.608GluCys: 0.608 ± 0.023	2.914GluAsp: 2.914 ± 0.056	4.004GluGlu: 4.004 ± 0.069	2.74GluPhe: 2.74 ± 0.045	3.584GluGly: 3.584 ± 0.063	1.628GluHis: 1.628 ± 0.039	4.003GluIle: 4.003 ± 0.073	4.048GluLys: 4.048 ± 0.054	7.412GluLeu: 7.412 ± 0.089	1.863GluMet: 1.863 ± 0.045	2.786GluAsn: 2.786 ± 0.051	1.973GluPro: 1.973 ± 0.048	3.844GluGln: 3.844 ± 0.068	3.294GluArg: 3.294 ± 0.058	4.165GluSer: 4.165 ± 0.059	3.282GluThr: 3.282 ± 0.055	4.391GluVal: 4.391 ± 0.066	0.836GluTrp: 0.836 ± 0.024	1.831GluTyr: 1.831 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.424PheAla: 3.424 ± 0.052	0.534PheCys: 0.534 ± 0.02	2.836PheAsp: 2.836 ± 0.057	2.692PheGlu: 2.692 ± 0.049	1.735PhePhe: 1.735 ± 0.045	3.166PheGly: 3.166 ± 0.064	0.828PheHis: 0.828 ± 0.03	2.923PheIle: 2.923 ± 0.059	2.101PheLys: 2.101 ± 0.047	3.427PheLeu: 3.427 ± 0.066	1.059PheMet: 1.059 ± 0.032	2.143PheAsn: 2.143 ± 0.048	1.47PhePro: 1.47 ± 0.037	1.361PheGln: 1.361 ± 0.038	1.461PheArg: 1.461 ± 0.032	3.611PheSer: 3.611 ± 0.065	2.387PheThr: 2.387 ± 0.041	2.821PheVal: 2.821 ± 0.054	0.545PheTrp: 0.545 ± 0.024	1.285PheTyr: 1.285 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	4.95GlyAla: 4.95 ± 0.077	0.883GlyCys: 0.883 ± 0.026	3.665GlyAsp: 3.665 ± 0.067	4.311GlyGlu: 4.311 ± 0.067	3.266GlyPhe: 3.266 ± 0.05	4.621GlyGly: 4.621 ± 0.087	1.529GlyHis: 1.529 ± 0.033	4.721GlyIle: 4.721 ± 0.067	4.044GlyLys: 4.044 ± 0.068	6.916GlyLeu: 6.916 ± 0.09	2.03GlyMet: 2.03 ± 0.043	2.582GlyAsn: 2.582 ± 0.05	1.549GlyPro: 1.549 ± 0.038	2.67GlyGln: 2.67 ± 0.043	2.9GlyArg: 2.9 ± 0.053	4.221GlySer: 4.221 ± 0.058	3.317GlyThr: 3.317 ± 0.062	5.118GlyVal: 5.118 ± 0.066	0.911GlyTrp: 0.911 ± 0.028	2.46GlyTyr: 2.46 ± 0.049	0.001GlyXaa: 0.001 ± 0.001
His	1.583HisAla: 1.583 ± 0.041	0.324HisCys: 0.324 ± 0.017	1.158HisAsp: 1.158 ± 0.033	1.181HisGlu: 1.181 ± 0.032	1.097HisPhe: 1.097 ± 0.037	1.458HisGly: 1.458 ± 0.036	0.744HisHis: 0.744 ± 0.026	1.484HisIle: 1.484 ± 0.037	1.087HisLys: 1.087 ± 0.031	2.227HisLeu: 2.227 ± 0.051	0.511HisMet: 0.511 ± 0.019	0.925HisAsn: 0.925 ± 0.028	1.116HisPro: 1.116 ± 0.034	1.252HisGln: 1.252 ± 0.036	0.993HisArg: 0.993 ± 0.029	1.571HisSer: 1.571 ± 0.039	1.117HisThr: 1.117 ± 0.035	1.257HisVal: 1.257 ± 0.037	0.377HisTrp: 0.377 ± 0.019	0.879HisTyr: 0.879 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.275IleAla: 6.275 ± 0.084	0.711IleCys: 0.711 ± 0.023	4.458IleAsp: 4.458 ± 0.062	5.056IleGlu: 5.056 ± 0.067	2.39IlePhe: 2.39 ± 0.057	4.833IleGly: 4.833 ± 0.068	1.28IleHis: 1.28 ± 0.034	3.88IleIle: 3.88 ± 0.076	3.557IleLys: 3.557 ± 0.053	5.563IleLeu: 5.563 ± 0.077	1.366IleMet: 1.366 ± 0.034	3.227IleAsn: 3.227 ± 0.047	2.673IlePro: 2.673 ± 0.042	2.652IleGln: 2.652 ± 0.051	2.816IleArg: 2.816 ± 0.049	4.965IleSer: 4.965 ± 0.065	3.806IleThr: 3.806 ± 0.066	4.338IleVal: 4.338 ± 0.075	0.66IleTrp: 0.66 ± 0.023	1.799IleTyr: 1.799 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.842LysAla: 4.842 ± 0.066	0.378LysCys: 0.378 ± 0.018	2.831LysAsp: 2.831 ± 0.06	3.737LysGlu: 3.737 ± 0.058	1.715LysPhe: 1.715 ± 0.042	3.482LysGly: 3.482 ± 0.064	1.295LysHis: 1.295 ± 0.029	3.247LysIle: 3.247 ± 0.057	3.287LysLys: 3.287 ± 0.065	5.603LysLeu: 5.603 ± 0.079	1.585LysMet: 1.585 ± 0.035	2.392LysAsn: 2.392 ± 0.043	2.486LysPro: 2.486 ± 0.051	3.072LysGln: 3.072 ± 0.056	2.806LysArg: 2.806 ± 0.05	3.503LysSer: 3.503 ± 0.058	3.017LysThr: 3.017 ± 0.051	3.871LysVal: 3.871 ± 0.059	0.639LysTrp: 0.639 ± 0.025	1.511LysTyr: 1.511 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	9.273LeuAla: 9.273 ± 0.11	1.064LeuCys: 1.064 ± 0.032	5.949LeuAsp: 5.949 ± 0.076	6.41LeuGlu: 6.41 ± 0.09	4.345LeuPhe: 4.345 ± 0.077	6.802LeuGly: 6.802 ± 0.089	2.049LeuHis: 2.049 ± 0.049	6.523LeuIle: 6.523 ± 0.082	5.494LeuLys: 5.494 ± 0.065	10.23LeuLeu: 10.23 ± 0.138	2.794LeuMet: 2.794 ± 0.05	4.859LeuAsn: 4.859 ± 0.062	4.594LeuPro: 4.594 ± 0.068	3.519LeuGln: 3.519 ± 0.063	4.203LeuArg: 4.203 ± 0.071	8.152LeuSer: 8.152 ± 0.092	6.026LeuThr: 6.026 ± 0.076	6.924LeuVal: 6.924 ± 0.094	0.978LeuTrp: 0.978 ± 0.029	2.597LeuTyr: 2.597 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.445MetAla: 2.445 ± 0.053	0.224MetCys: 0.224 ± 0.015	1.378MetAsp: 1.378 ± 0.034	1.325MetGlu: 1.325 ± 0.034	1.008MetPhe: 1.008 ± 0.029	1.812MetGly: 1.812 ± 0.039	0.514MetHis: 0.514 ± 0.018	1.678MetIle: 1.678 ± 0.041	1.676MetLys: 1.676 ± 0.037	2.832MetLeu: 2.832 ± 0.057	0.872MetMet: 0.872 ± 0.032	1.264MetAsn: 1.264 ± 0.027	1.2MetPro: 1.2 ± 0.034	1.084MetGln: 1.084 ± 0.033	1.153MetArg: 1.153 ± 0.036	2.112MetSer: 2.112 ± 0.041	1.68MetThr: 1.68 ± 0.038	1.855MetVal: 1.855 ± 0.042	0.241MetTrp: 0.241 ± 0.015	0.617MetTyr: 0.617 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.366AsnAla: 3.366 ± 0.062	0.424AsnCys: 0.424 ± 0.018	2.506AsnAsp: 2.506 ± 0.061	2.645AsnGlu: 2.645 ± 0.043	1.66AsnPhe: 1.66 ± 0.037	3.012AsnGly: 3.012 ± 0.051	1.074AsnHis: 1.074 ± 0.029	3.036AsnIle: 3.036 ± 0.051	2.425AsnLys: 2.425 ± 0.052	4.219AsnLeu: 4.219 ± 0.059	1.029AsnMet: 1.029 ± 0.032	2.0AsnAsn: 2.0 ± 0.051	2.044AsnPro: 2.044 ± 0.051	2.258AsnGln: 2.258 ± 0.044	2.095AsnArg: 2.095 ± 0.038	2.877AsnSer: 2.877 ± 0.053	2.355AsnThr: 2.355 ± 0.049	2.9AsnVal: 2.9 ± 0.047	0.567AsnTrp: 0.567 ± 0.021	1.372AsnTyr: 1.372 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.777ProAla: 2.777 ± 0.053	0.335ProCys: 0.335 ± 0.017	2.196ProAsp: 2.196 ± 0.042	3.101ProGlu: 3.101 ± 0.054	1.679ProPhe: 1.679 ± 0.039	1.973ProGly: 1.973 ± 0.048	0.839ProHis: 0.839 ± 0.026	2.653ProIle: 2.653 ± 0.048	2.101ProLys: 2.101 ± 0.042	3.935ProLeu: 3.935 ± 0.065	1.041ProMet: 1.041 ± 0.026	1.787ProAsn: 1.787 ± 0.041	1.019ProPro: 1.019 ± 0.027	1.693ProGln: 1.693 ± 0.038	1.271ProArg: 1.271 ± 0.033	2.601ProSer: 2.601 ± 0.05	2.21ProThr: 2.21 ± 0.043	2.855ProVal: 2.855 ± 0.046	0.484ProTrp: 0.484 ± 0.023	1.255ProTyr: 1.255 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	4.102GlnAla: 4.102 ± 0.057	0.438GlnCys: 0.438 ± 0.022	2.139GlnAsp: 2.139 ± 0.048	2.616GlnGlu: 2.616 ± 0.051	1.78GlnPhe: 1.78 ± 0.038	2.864GlnGly: 2.864 ± 0.057	1.168GlnHis: 1.168 ± 0.032	2.713GlnIle: 2.713 ± 0.049	2.201GlnLys: 2.201 ± 0.046	5.12GlnLeu: 5.12 ± 0.086	1.117GlnMet: 1.117 ± 0.032	1.719GlnAsn: 1.719 ± 0.04	1.736GlnPro: 1.736 ± 0.041	2.835GlnGln: 2.835 ± 0.072	2.125GlnArg: 2.125 ± 0.043	3.085GlnSer: 3.085 ± 0.06	2.22GlnThr: 2.22 ± 0.043	3.203GlnVal: 3.203 ± 0.061	0.583GlnTrp: 0.583 ± 0.022	1.472GlnTyr: 1.472 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.099ArgAla: 3.099 ± 0.052	0.444ArgCys: 0.444 ± 0.019	2.442ArgAsp: 2.442 ± 0.047	2.916ArgGlu: 2.916 ± 0.059	2.126ArgPhe: 2.126 ± 0.044	2.447ArgGly: 2.447 ± 0.049	1.039ArgHis: 1.039 ± 0.031	3.034ArgIle: 3.034 ± 0.053	2.493ArgLys: 2.493 ± 0.046	4.643ArgLeu: 4.643 ± 0.073	1.199ArgMet: 1.199 ± 0.027	1.925ArgAsn: 1.925 ± 0.044	1.461ArgPro: 1.461 ± 0.034	1.979ArgGln: 1.979 ± 0.043	2.214ArgArg: 2.214 ± 0.048	2.76ArgSer: 2.76 ± 0.05	2.099ArgThr: 2.099 ± 0.047	3.052ArgVal: 3.052 ± 0.055	0.575ArgTrp: 0.575 ± 0.022	1.65ArgTyr: 1.65 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	5.368SerAla: 5.368 ± 0.081	0.644SerCys: 0.644 ± 0.026	3.987SerAsp: 3.987 ± 0.071	4.437SerGlu: 4.437 ± 0.064	2.981SerPhe: 2.981 ± 0.056	5.135SerGly: 5.135 ± 0.079	1.62SerHis: 1.62 ± 0.039	4.855SerIle: 4.855 ± 0.071	3.567SerLys: 3.567 ± 0.059	7.335SerLeu: 7.335 ± 0.08	1.908SerMet: 1.908 ± 0.041	3.122SerAsn: 3.122 ± 0.058	2.492SerPro: 2.492 ± 0.051	3.269SerGln: 3.269 ± 0.062	2.982SerArg: 2.982 ± 0.058	5.032SerSer: 5.032 ± 0.086	3.507SerThr: 3.507 ± 0.065	4.788SerVal: 4.788 ± 0.074	0.816SerTrp: 0.816 ± 0.032	2.113SerTyr: 2.113 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.248ThrAla: 4.248 ± 0.07	0.499ThrCys: 0.499 ± 0.02	2.927ThrAsp: 2.927 ± 0.055	3.144ThrGlu: 3.144 ± 0.049	2.139ThrPhe: 2.139 ± 0.048	3.837ThrGly: 3.837 ± 0.059	1.268ThrHis: 1.268 ± 0.034	3.571ThrIle: 3.571 ± 0.061	2.636ThrLys: 2.636 ± 0.049	6.163ThrLeu: 6.163 ± 0.081	1.245ThrMet: 1.245 ± 0.037	2.212ThrAsn: 2.212 ± 0.043	2.593ThrPro: 2.593 ± 0.043	2.567ThrGln: 2.567 ± 0.053	2.13ThrArg: 2.13 ± 0.041	3.638ThrSer: 3.638 ± 0.063	2.926ThrThr: 2.926 ± 0.059	3.682ThrVal: 3.682 ± 0.053	0.613ThrTrp: 0.613 ± 0.023	1.474ThrTyr: 1.474 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	5.977ValAla: 5.977 ± 0.094	0.792ValCys: 0.792 ± 0.024	4.129ValAsp: 4.129 ± 0.062	4.678ValGlu: 4.678 ± 0.066	2.758ValPhe: 2.758 ± 0.051	4.672ValGly: 4.672 ± 0.073	1.246ValHis: 1.246 ± 0.029	4.817ValIle: 4.817 ± 0.071	3.837ValLys: 3.837 ± 0.071	6.589ValLeu: 6.589 ± 0.082	2.084ValMet: 2.084 ± 0.045	2.955ValAsn: 2.955 ± 0.047	2.529ValPro: 2.529 ± 0.047	2.29ValGln: 2.29 ± 0.045	2.888ValArg: 2.888 ± 0.052	5.013ValSer: 5.013 ± 0.067	4.007ValThr: 4.007 ± 0.056	5.278ValVal: 5.278 ± 0.081	0.738ValTrp: 0.738 ± 0.027	1.8ValTyr: 1.8 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.823TrpAla: 0.823 ± 0.032	0.148TrpCys: 0.148 ± 0.01	0.625TrpAsp: 0.625 ± 0.023	0.592TrpGlu: 0.592 ± 0.025	0.605TrpPhe: 0.605 ± 0.025	0.8TrpGly: 0.8 ± 0.031	0.309TrpHis: 0.309 ± 0.016	0.737TrpIle: 0.737 ± 0.026	0.603TrpLys: 0.603 ± 0.023	1.657TrpLeu: 1.657 ± 0.042	0.346TrpMet: 0.346 ± 0.017	0.488TrpAsn: 0.488 ± 0.023	0.416TrpPro: 0.416 ± 0.018	0.757TrpGln: 0.757 ± 0.027	0.603TrpArg: 0.603 ± 0.024	0.713TrpSer: 0.713 ± 0.025	0.477TrpThr: 0.477 ± 0.02	0.819TrpVal: 0.819 ± 0.029	0.19TrpTrp: 0.19 ± 0.012	0.375TrpTyr: 0.375 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.156TyrAla: 2.156 ± 0.039	0.395TyrCys: 0.395 ± 0.02	1.668TyrAsp: 1.668 ± 0.041	1.479TyrGlu: 1.479 ± 0.039	1.395TyrPhe: 1.395 ± 0.037	2.047TyrGly: 2.047 ± 0.043	0.781TyrHis: 0.781 ± 0.028	1.731TyrIle: 1.731 ± 0.037	1.427TyrLys: 1.427 ± 0.036	3.3TyrLeu: 3.3 ± 0.061	0.654TyrMet: 0.654 ± 0.023	1.158TyrAsn: 1.158 ± 0.032	1.321TyrPro: 1.321 ± 0.037	1.917TyrGln: 1.917 ± 0.044	1.636TyrArg: 1.636 ± 0.036	2.187TyrSer: 2.187 ± 0.051	1.522TyrThr: 1.522 ± 0.041	1.831TyrVal: 1.831 ± 0.04	0.468TyrTrp: 0.468 ± 0.022	1.043TyrTyr: 1.043 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 3650 proteins (1184933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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