Amino acid dipepetide frequency for Cystoisospora suis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.18AlaAla: 8.18 ± 0.094	1.655AlaCys: 1.655 ± 0.019	3.214AlaAsp: 3.214 ± 0.028	4.651AlaGlu: 4.651 ± 0.039	2.489AlaPhe: 2.489 ± 0.023	5.837AlaGly: 5.837 ± 0.058	1.459AlaHis: 1.459 ± 0.018	2.111AlaIle: 2.111 ± 0.022	2.763AlaLys: 2.763 ± 0.026	6.333AlaLeu: 6.333 ± 0.049	1.111AlaMet: 1.111 ± 0.014	1.654AlaAsn: 1.654 ± 0.018	3.954AlaPro: 3.954 ± 0.036	2.322AlaGln: 2.322 ± 0.024	4.513AlaArg: 4.513 ± 0.038	8.721AlaSer: 8.721 ± 0.058	4.006AlaThr: 4.006 ± 0.035	4.836AlaVal: 4.836 ± 0.043	0.66AlaTrp: 0.66 ± 0.011	1.3AlaTyr: 1.3 ± 0.016	0.004AlaXaa: 0.004 ± 0.001
Cys	1.206CysAla: 1.206 ± 0.022	0.719CysCys: 0.719 ± 0.015	0.735CysAsp: 0.735 ± 0.011	0.951CysGlu: 0.951 ± 0.012	0.839CysPhe: 0.839 ± 0.013	1.33CysGly: 1.33 ± 0.02	0.49CysHis: 0.49 ± 0.008	0.724CysIle: 0.724 ± 0.01	0.654CysLys: 0.654 ± 0.012	2.072CysLeu: 2.072 ± 0.024	0.386CysMet: 0.386 ± 0.008	0.426CysAsn: 0.426 ± 0.009	1.276CysPro: 1.276 ± 0.021	0.641CysGln: 0.641 ± 0.013	1.525CysArg: 1.525 ± 0.016	2.369CysSer: 2.369 ± 0.026	1.098CysThr: 1.098 ± 0.014	1.226CysVal: 1.226 ± 0.016	0.218CysTrp: 0.218 ± 0.007	0.371CysTyr: 0.371 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.444AspAla: 3.444 ± 0.025	0.818AspCys: 0.818 ± 0.012	3.288AspAsp: 3.288 ± 0.032	4.93AspGlu: 4.93 ± 0.038	1.652AspPhe: 1.652 ± 0.018	3.946AspGly: 3.946 ± 0.031	1.131AspHis: 1.131 ± 0.013	1.655AspIle: 1.655 ± 0.018	2.22AspLys: 2.22 ± 0.026	4.095AspLeu: 4.095 ± 0.028	0.814AspMet: 0.814 ± 0.013	1.21AspAsn: 1.21 ± 0.014	2.229AspPro: 2.229 ± 0.018	1.668AspGln: 1.668 ± 0.018	3.585AspArg: 3.585 ± 0.025	4.416AspSer: 4.416 ± 0.027	2.517AspThr: 2.517 ± 0.02	2.973AspVal: 2.973 ± 0.021	0.438AspTrp: 0.438 ± 0.008	0.798AspTyr: 0.798 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	5.301GluAla: 5.301 ± 0.034	0.953GluCys: 0.953 ± 0.015	5.427GluAsp: 5.427 ± 0.047	15.689GluGlu: 15.689 ± 0.217	1.309GluPhe: 1.309 ± 0.018	7.111GluGly: 7.111 ± 0.055	1.2GluHis: 1.2 ± 0.013	2.301GluIle: 2.301 ± 0.02	7.046GluLys: 7.046 ± 0.083	4.133GluLeu: 4.133 ± 0.037	1.234GluMet: 1.234 ± 0.015	2.582GluAsn: 2.582 ± 0.025	2.111GluPro: 2.111 ± 0.022	2.853GluGln: 2.853 ± 0.024	7.397GluArg: 7.397 ± 0.072	4.857GluSer: 4.857 ± 0.029	3.913GluThr: 3.913 ± 0.029	3.669GluVal: 3.669 ± 0.024	0.538GluTrp: 0.538 ± 0.009	0.909GluTyr: 0.909 ± 0.013	0.004GluXaa: 0.004 ± 0.001
Phe	1.996PheAla: 1.996 ± 0.02	0.775PheCys: 0.775 ± 0.01	1.396PheAsp: 1.396 ± 0.017	1.436PheGlu: 1.436 ± 0.017	2.328PhePhe: 2.328 ± 0.029	1.665PheGly: 1.665 ± 0.022	0.947PheHis: 0.947 ± 0.013	1.104PheIle: 1.104 ± 0.013	0.988PheLys: 0.988 ± 0.014	4.428PheLeu: 4.428 ± 0.039	0.461PheMet: 0.461 ± 0.009	0.757PheAsn: 0.757 ± 0.011	2.369PhePro: 2.369 ± 0.02	1.092PheGln: 1.092 ± 0.013	1.84PheArg: 1.84 ± 0.02	5.591PheSer: 5.591 ± 0.051	1.502PheThr: 1.502 ± 0.016	1.844PheVal: 1.844 ± 0.02	0.327PheTrp: 0.327 ± 0.007	0.844PheTyr: 0.844 ± 0.011	0.002PheXaa: 0.002 ± 0.0
Gly	5.192GlyAla: 5.192 ± 0.053	1.321GlyCys: 1.321 ± 0.018	4.457GlyAsp: 4.457 ± 0.034	7.304GlyGlu: 7.304 ± 0.057	1.911GlyPhe: 1.911 ± 0.02	11.103GlyGly: 11.103 ± 0.177	1.564GlyHis: 1.564 ± 0.019	2.133GlyIle: 2.133 ± 0.024	3.56GlyLys: 3.56 ± 0.027	4.91GlyLeu: 4.91 ± 0.035	1.223GlyMet: 1.223 ± 0.014	2.044GlyAsn: 2.044 ± 0.02	2.868GlyPro: 2.868 ± 0.034	2.472GlyGln: 2.472 ± 0.024	6.207GlyArg: 6.207 ± 0.05	7.045GlySer: 7.045 ± 0.061	3.659GlyThr: 3.659 ± 0.038	4.736GlyVal: 4.736 ± 0.033	0.667GlyTrp: 0.667 ± 0.011	1.212GlyTyr: 1.212 ± 0.019	0.006GlyXaa: 0.006 ± 0.001
His	1.92HisAla: 1.92 ± 0.018	0.435HisCys: 0.435 ± 0.008	1.102HisAsp: 1.102 ± 0.012	1.602HisGlu: 1.602 ± 0.019	0.88HisPhe: 0.88 ± 0.011	1.651HisGly: 1.651 ± 0.017	1.33HisHis: 1.33 ± 0.029	0.786HisIle: 0.786 ± 0.01	0.816HisLys: 0.816 ± 0.013	2.699HisLeu: 2.699 ± 0.024	0.393HisMet: 0.393 ± 0.007	0.588HisAsn: 0.588 ± 0.011	2.067HisPro: 2.067 ± 0.024	1.226HisGln: 1.226 ± 0.017	2.102HisArg: 2.102 ± 0.019	2.861HisSer: 2.861 ± 0.027	1.49HisThr: 1.49 ± 0.018	1.391HisVal: 1.391 ± 0.013	0.196HisTrp: 0.196 ± 0.007	0.48HisTyr: 0.48 ± 0.01	0.002HisXaa: 0.002 ± 0.001
Ile	2.095IleAla: 2.095 ± 0.018	0.662IleCys: 0.662 ± 0.011	1.612IleAsp: 1.612 ± 0.017	2.082IleGlu: 2.082 ± 0.023	1.192IlePhe: 1.192 ± 0.017	1.773IleGly: 1.773 ± 0.02	0.896IleHis: 0.896 ± 0.012	0.912IleIle: 0.912 ± 0.015	1.195IleLys: 1.195 ± 0.017	2.949IleLeu: 2.949 ± 0.03	0.433IleMet: 0.433 ± 0.008	0.729IleAsn: 0.729 ± 0.011	1.981IlePro: 1.981 ± 0.019	1.27IleGln: 1.27 ± 0.016	2.033IleArg: 2.033 ± 0.02	3.323IleSer: 3.323 ± 0.028	1.322IleThr: 1.322 ± 0.016	1.703IleVal: 1.703 ± 0.019	0.285IleTrp: 0.285 ± 0.007	0.677IleTyr: 0.677 ± 0.012	0.001IleXaa: 0.001 ± 0.0
Lys	3.186LysAla: 3.186 ± 0.026	0.599LysCys: 0.599 ± 0.01	2.802LysAsp: 2.802 ± 0.028	6.365LysGlu: 6.365 ± 0.08	0.909LysPhe: 0.909 ± 0.014	3.4LysGly: 3.4 ± 0.028	0.999LysHis: 0.999 ± 0.012	1.583LysIle: 1.583 ± 0.02	6.334LysLys: 6.334 ± 0.088	2.906LysLeu: 2.906 ± 0.028	0.939LysMet: 0.939 ± 0.013	1.893LysAsn: 1.893 ± 0.023	1.789LysPro: 1.789 ± 0.019	2.074LysGln: 2.074 ± 0.022	4.418LysArg: 4.418 ± 0.039	3.403LysSer: 3.403 ± 0.028	2.913LysThr: 2.913 ± 0.027	2.076LysVal: 2.076 ± 0.022	0.346LysTrp: 0.346 ± 0.008	0.687LysTyr: 0.687 ± 0.012	0.004LysXaa: 0.004 ± 0.001
Leu	5.872LeuAla: 5.872 ± 0.046	1.734LeuCys: 1.734 ± 0.018	3.543LeuAsp: 3.543 ± 0.023	4.735LeuGlu: 4.735 ± 0.038	3.629LeuPhe: 3.629 ± 0.035	4.789LeuGly: 4.789 ± 0.037	3.013LeuHis: 3.013 ± 0.026	2.48LeuIle: 2.48 ± 0.027	3.523LeuLys: 3.523 ± 0.029	10.855LeuLeu: 10.855 ± 0.08	1.251LeuMet: 1.251 ± 0.014	2.042LeuAsn: 2.042 ± 0.023	6.699LeuPro: 6.699 ± 0.04	4.432LeuGln: 4.432 ± 0.035	6.448LeuArg: 6.448 ± 0.046	11.454LeuSer: 11.454 ± 0.078	3.953LeuThr: 3.953 ± 0.033	4.423LeuVal: 4.423 ± 0.036	0.863LeuTrp: 0.863 ± 0.012	1.857LeuTyr: 1.857 ± 0.019	0.004LeuXaa: 0.004 ± 0.001
Met	1.168MetAla: 1.168 ± 0.014	0.27MetCys: 0.27 ± 0.007	0.685MetAsp: 0.685 ± 0.01	1.042MetGlu: 1.042 ± 0.012	0.396MetPhe: 0.396 ± 0.008	0.817MetGly: 0.817 ± 0.013	0.375MetHis: 0.375 ± 0.007	0.589MetIle: 0.589 ± 0.01	1.317MetLys: 1.317 ± 0.017	1.265MetLeu: 1.265 ± 0.016	0.477MetMet: 0.477 ± 0.011	0.625MetAsn: 0.625 ± 0.011	0.817MetPro: 0.817 ± 0.013	0.67MetGln: 0.67 ± 0.011	1.224MetArg: 1.224 ± 0.013	1.354MetSer: 1.354 ± 0.015	0.965MetThr: 0.965 ± 0.011	0.747MetVal: 0.747 ± 0.011	0.155MetTrp: 0.155 ± 0.005	0.361MetTyr: 0.361 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	1.952AsnAla: 1.952 ± 0.017	0.454AsnCys: 0.454 ± 0.008	1.319AsnAsp: 1.319 ± 0.014	2.177AsnGlu: 2.177 ± 0.025	0.867AsnPhe: 0.867 ± 0.014	1.914AsnGly: 1.914 ± 0.02	0.644AsnHis: 0.644 ± 0.011	0.826AsnIle: 0.826 ± 0.012	1.317AsnLys: 1.317 ± 0.017	2.248AsnLeu: 2.248 ± 0.022	0.399AsnMet: 0.399 ± 0.008	0.842AsnAsn: 0.842 ± 0.014	1.536AsnPro: 1.536 ± 0.016	0.899AsnGln: 0.899 ± 0.013	1.992AsnArg: 1.992 ± 0.015	2.746AsnSer: 2.746 ± 0.025	1.55AsnThr: 1.55 ± 0.016	1.454AsnVal: 1.454 ± 0.015	0.214AsnTrp: 0.214 ± 0.005	0.468AsnTyr: 0.468 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.492ProAla: 4.492 ± 0.044	1.25ProCys: 1.25 ± 0.016	2.191ProAsp: 2.191 ± 0.021	2.903ProGlu: 2.903 ± 0.025	2.28ProPhe: 2.28 ± 0.02	4.095ProGly: 4.095 ± 0.042	1.766ProHis: 1.766 ± 0.021	1.308ProIle: 1.308 ± 0.015	1.63ProLys: 1.63 ± 0.019	5.682ProLeu: 5.682 ± 0.035	0.664ProMet: 0.664 ± 0.01	1.162ProAsn: 1.162 ± 0.013	6.634ProPro: 6.634 ± 0.076	2.172ProGln: 2.172 ± 0.019	3.918ProArg: 3.918 ± 0.031	10.277ProSer: 10.277 ± 0.079	3.095ProThr: 3.095 ± 0.026	3.428ProVal: 3.428 ± 0.029	0.52ProTrp: 0.52 ± 0.01	1.155ProTyr: 1.155 ± 0.014	0.005ProXaa: 0.005 ± 0.001
Gln	3.005GlnAla: 3.005 ± 0.027	0.523GlnCys: 0.523 ± 0.01	1.836GlnAsp: 1.836 ± 0.016	3.755GlnGlu: 3.755 ± 0.033	0.852GlnPhe: 0.852 ± 0.012	2.993GlnGly: 2.993 ± 0.026	1.26GlnHis: 1.26 ± 0.017	1.155GlnIle: 1.155 ± 0.015	2.223GlnLys: 2.223 ± 0.023	3.316GlnLeu: 3.316 ± 0.032	0.658GlnMet: 0.658 ± 0.01	1.144GlnAsn: 1.144 ± 0.012	2.023GlnPro: 2.023 ± 0.022	3.335GlnGln: 3.335 ± 0.052	3.429GlnArg: 3.429 ± 0.025	3.105GlnSer: 3.105 ± 0.025	2.029GlnThr: 2.029 ± 0.017	1.954GlnVal: 1.954 ± 0.021	0.352GlnTrp: 0.352 ± 0.008	0.605GlnTyr: 0.605 ± 0.01	0.001GlnXaa: 0.001 ± 0.0
Arg	4.479ArgAla: 4.479 ± 0.037	1.444ArgCys: 1.444 ± 0.018	3.915ArgAsp: 3.915 ± 0.028	7.196ArgGlu: 7.196 ± 0.063	2.024ArgPhe: 2.024 ± 0.018	6.519ArgGly: 6.519 ± 0.055	2.191ArgHis: 2.191 ± 0.02	2.178ArgIle: 2.178 ± 0.02	4.827ArgLys: 4.827 ± 0.044	6.243ArgLeu: 6.243 ± 0.04	1.264ArgMet: 1.264 ± 0.013	2.25ArgAsn: 2.25 ± 0.019	3.454ArgPro: 3.454 ± 0.028	3.597ArgGln: 3.597 ± 0.028	9.646ArgArg: 9.646 ± 0.088	7.191ArgSer: 7.191 ± 0.05	3.635ArgThr: 3.635 ± 0.026	3.606ArgVal: 3.606 ± 0.029	0.732ArgTrp: 0.732 ± 0.011	1.325ArgTyr: 1.325 ± 0.015	0.004ArgXaa: 0.004 ± 0.001
Ser	7.647SerAla: 7.647 ± 0.064	2.678SerCys: 2.678 ± 0.029	3.998SerAsp: 3.998 ± 0.028	5.162SerGlu: 5.162 ± 0.032	5.525SerPhe: 5.525 ± 0.049	7.043SerGly: 7.043 ± 0.059	3.302SerHis: 3.302 ± 0.035	3.081SerIle: 3.081 ± 0.03	3.455SerLys: 3.455 ± 0.029	11.852SerLeu: 11.852 ± 0.081	1.439SerMet: 1.439 ± 0.014	2.384SerAsn: 2.384 ± 0.02	10.052SerPro: 10.052 ± 0.084	3.949SerGln: 3.949 ± 0.029	7.963SerArg: 7.963 ± 0.051	32.438SerSer: 32.438 ± 0.383	6.409SerThr: 6.409 ± 0.041	5.601SerVal: 5.601 ± 0.038	0.87SerTrp: 0.87 ± 0.012	1.992SerTyr: 1.992 ± 0.022	0.008SerXaa: 0.008 ± 0.001
Thr	4.682ThrAla: 4.682 ± 0.035	1.05ThrCys: 1.05 ± 0.016	2.294ThrAsp: 2.294 ± 0.019	3.308ThrGlu: 3.308 ± 0.024	1.537ThrPhe: 1.537 ± 0.018	4.166ThrGly: 4.166 ± 0.037	1.245ThrHis: 1.245 ± 0.014	1.415ThrIle: 1.415 ± 0.016	2.166ThrLys: 2.166 ± 0.021	3.932ThrLeu: 3.932 ± 0.027	0.729ThrMet: 0.729 ± 0.01	1.289ThrAsn: 1.289 ± 0.015	3.981ThrPro: 3.981 ± 0.03	1.774ThrGln: 1.774 ± 0.019	3.684ThrArg: 3.684 ± 0.028	6.991ThrSer: 6.991 ± 0.043	3.854ThrThr: 3.854 ± 0.042	2.851ThrVal: 2.851 ± 0.025	0.462ThrTrp: 0.462 ± 0.01	0.88ThrTyr: 0.88 ± 0.011	0.002ThrXaa: 0.002 ± 0.001
Val	4.261ValAla: 4.261 ± 0.04	1.344ValCys: 1.344 ± 0.015	2.788ValAsp: 2.788 ± 0.02	3.619ValGlu: 3.619 ± 0.025	2.086ValPhe: 2.086 ± 0.023	3.598ValGly: 3.598 ± 0.035	1.408ValHis: 1.408 ± 0.015	1.654ValIle: 1.654 ± 0.017	2.401ValLys: 2.401 ± 0.02	4.942ValLeu: 4.942 ± 0.038	0.865ValMet: 0.865 ± 0.012	1.395ValAsn: 1.395 ± 0.016	3.268ValPro: 3.268 ± 0.029	2.017ValGln: 2.017 ± 0.022	3.421ValArg: 3.421 ± 0.027	6.199ValSer: 6.199 ± 0.037	2.806ValThr: 2.806 ± 0.024	3.465ValVal: 3.465 ± 0.035	0.579ValTrp: 0.579 ± 0.009	1.392ValTyr: 1.392 ± 0.017	0.002ValXaa: 0.002 ± 0.001
Trp	0.498TrpAla: 0.498 ± 0.009	0.198TrpCys: 0.198 ± 0.006	0.359TrpAsp: 0.359 ± 0.009	0.502TrpGlu: 0.502 ± 0.009	0.258TrpPhe: 0.258 ± 0.007	0.628TrpGly: 0.628 ± 0.011	0.191TrpHis: 0.191 ± 0.005	0.399TrpIle: 0.399 ± 0.008	0.532TrpLys: 0.532 ± 0.01	0.872TrpLeu: 0.872 ± 0.013	0.241TrpMet: 0.241 ± 0.007	0.329TrpAsn: 0.329 ± 0.008	0.386TrpPro: 0.386 ± 0.008	0.347TrpGln: 0.347 ± 0.008	0.977TrpArg: 0.977 ± 0.012	0.783TrpSer: 0.783 ± 0.011	0.478TrpThr: 0.478 ± 0.008	0.451TrpVal: 0.451 ± 0.008	0.168TrpTrp: 0.168 ± 0.005	0.181TrpTyr: 0.181 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.195TyrAla: 1.195 ± 0.016	0.373TyrCys: 0.373 ± 0.009	0.867TyrAsp: 0.867 ± 0.014	1.125TyrGlu: 1.125 ± 0.015	0.725TyrPhe: 0.725 ± 0.011	1.208TyrGly: 1.208 ± 0.016	0.603TyrHis: 0.603 ± 0.011	0.73TyrIle: 0.73 ± 0.013	0.653TyrLys: 0.653 ± 0.013	1.861TyrLeu: 1.861 ± 0.019	0.34TyrMet: 0.34 ± 0.007	0.469TyrAsn: 0.469 ± 0.01	1.131TyrPro: 1.131 ± 0.016	0.738TyrGln: 0.738 ± 0.011	1.391TyrArg: 1.391 ± 0.018	1.721TyrSer: 1.721 ± 0.019	1.1TyrThr: 1.1 ± 0.015	1.076TyrVal: 1.076 ± 0.014	0.189TyrTrp: 0.189 ± 0.005	0.525TyrTyr: 0.525 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.004XaaGlu: 0.004 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.006XaaGly: 0.006 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.004XaaLys: 0.004 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.005XaaArg: 0.005 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.424XaaXaa: 0.424 ± 0.04

Statistics based on 11541 proteins (6987384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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