Amino acid dipepetide frequency for Rodent papillomavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.5AlaAla: 3.5 ± 1.805
1.75AlaCys: 1.75 ± 1.096
3.062AlaAsp: 3.062 ± 1.553
3.937AlaGlu: 3.937 ± 1.522
1.75AlaPhe: 1.75 ± 0.579
2.625AlaGly: 2.625 ± 0.961
0.437AlaHis: 0.437 ± 0.385
1.75AlaIle: 1.75 ± 0.892
3.937AlaLys: 3.937 ± 1.505
4.812AlaLeu: 4.812 ± 1.526
1.312AlaMet: 1.312 ± 0.627
1.312AlaAsn: 1.312 ± 0.331
3.937AlaPro: 3.937 ± 1.236
1.75AlaGln: 1.75 ± 0.815
3.5AlaArg: 3.5 ± 0.837
3.937AlaSer: 3.937 ± 1.75
4.374AlaThr: 4.374 ± 0.88
5.249AlaVal: 5.249 ± 1.255
0.437AlaTrp: 0.437 ± 0.332
1.312AlaTyr: 1.312 ± 0.592
0.0AlaXaa: 0.0 ± 0.0
Cys
1.312CysAla: 1.312 ± 0.652
1.312CysCys: 1.312 ± 0.997
1.312CysAsp: 1.312 ± 0.618
1.312CysGlu: 1.312 ± 0.858
0.437CysPhe: 0.437 ± 0.332
1.75CysGly: 1.75 ± 0.586
0.875CysHis: 0.875 ± 0.664
0.437CysIle: 0.437 ± 0.541
0.875CysLys: 0.875 ± 0.771
1.312CysLeu: 1.312 ± 0.849
0.437CysMet: 0.437 ± 0.473
0.875CysAsn: 0.875 ± 0.446
2.187CysPro: 2.187 ± 0.78
0.875CysGln: 0.875 ± 0.595
1.75CysArg: 1.75 ± 2.162
2.187CysSer: 2.187 ± 1.313
1.312CysThr: 1.312 ± 0.618
1.75CysVal: 1.75 ± 1.878
1.312CysTrp: 1.312 ± 0.412
0.437CysTyr: 0.437 ± 0.332
0.0CysXaa: 0.0 ± 0.0
Asp
3.937AspAla: 3.937 ± 1.407
2.625AspCys: 2.625 ± 1.142
3.5AspAsp: 3.5 ± 0.898
3.5AspGlu: 3.5 ± 1.292
3.5AspPhe: 3.5 ± 0.665
4.374AspGly: 4.374 ± 0.486
0.437AspHis: 0.437 ± 0.385
4.374AspIle: 4.374 ± 2.104
2.625AspLys: 2.625 ± 0.841
6.562AspLeu: 6.562 ± 1.826
0.437AspMet: 0.437 ± 0.385
3.062AspAsn: 3.062 ± 1.452
3.5AspPro: 3.5 ± 1.191
2.625AspGln: 2.625 ± 1.05
3.5AspArg: 3.5 ± 0.539
6.124AspSer: 6.124 ± 1.849
5.249AspThr: 5.249 ± 0.819
6.124AspVal: 6.124 ± 1.639
0.875AspTrp: 0.875 ± 0.42
1.75AspTyr: 1.75 ± 0.661
0.0AspXaa: 0.0 ± 0.0
Glu
6.124GluAla: 6.124 ± 1.496
0.0GluCys: 0.0 ± 0.0
4.812GluAsp: 4.812 ± 0.703
3.937GluGlu: 3.937 ± 1.407
1.75GluPhe: 1.75 ± 0.738
2.625GluGly: 2.625 ± 1.011
3.062GluHis: 3.062 ± 0.678
2.625GluIle: 2.625 ± 0.662
1.75GluLys: 1.75 ± 1.394
3.5GluLeu: 3.5 ± 1.149
1.312GluMet: 1.312 ± 0.686
3.062GluAsn: 3.062 ± 0.967
2.625GluPro: 2.625 ± 1.156
3.5GluGln: 3.5 ± 0.665
2.187GluArg: 2.187 ± 1.166
2.625GluSer: 2.625 ± 1.34
4.374GluThr: 4.374 ± 1.366
4.374GluVal: 4.374 ± 1.049
0.437GluTrp: 0.437 ± 0.332
0.437GluTyr: 0.437 ± 0.385
0.0GluXaa: 0.0 ± 0.0
Phe
2.187PheAla: 2.187 ± 0.92
1.312PheCys: 1.312 ± 0.627
2.187PheAsp: 2.187 ± 0.863
4.374PheGlu: 4.374 ± 1.271
2.625PhePhe: 2.625 ± 1.259
2.625PheGly: 2.625 ± 0.472
0.0PheHis: 0.0 ± 0.0
1.312PheIle: 1.312 ± 0.596
3.062PheLys: 3.062 ± 1.028
5.249PheLeu: 5.249 ± 0.92
1.312PheMet: 1.312 ± 0.592
0.875PheAsn: 0.875 ± 0.771
3.062PhePro: 3.062 ± 0.509
0.437PheGln: 0.437 ± 0.385
1.75PheArg: 1.75 ± 0.616
3.937PheSer: 3.937 ± 1.051
3.062PheThr: 3.062 ± 1.053
3.062PheVal: 3.062 ± 1.048
1.312PheTrp: 1.312 ± 0.734
1.75PheTyr: 1.75 ± 0.495
0.0PheXaa: 0.0 ± 0.0
Gly
3.937GlyAla: 3.937 ± 1.654
2.625GlyCys: 2.625 ± 1.43
4.374GlyAsp: 4.374 ± 1.491
6.124GlyGlu: 6.124 ± 2.431
1.75GlyPhe: 1.75 ± 0.616
8.749GlyGly: 8.749 ± 3.292
1.75GlyHis: 1.75 ± 0.661
3.5GlyIle: 3.5 ± 0.649
1.75GlyLys: 1.75 ± 0.945
6.562GlyLeu: 6.562 ± 1.794
0.0GlyMet: 0.0 ± 0.0
5.249GlyAsn: 5.249 ± 1.37
6.999GlyPro: 6.999 ± 2.293
1.75GlyGln: 1.75 ± 0.49
7.437GlyArg: 7.437 ± 1.808
5.249GlySer: 5.249 ± 0.711
8.311GlyThr: 8.311 ± 2.247
3.937GlyVal: 3.937 ± 1.206
0.875GlyTrp: 0.875 ± 0.665
0.875GlyTyr: 0.875 ± 0.595
0.0GlyXaa: 0.0 ± 0.0
His
1.312HisAla: 1.312 ± 0.412
1.75HisCys: 1.75 ± 1.126
0.0HisAsp: 0.0 ± 0.0
1.75HisGlu: 1.75 ± 0.579
0.875HisPhe: 0.875 ± 0.664
2.625HisGly: 2.625 ± 1.225
0.0HisHis: 0.0 ± 0.0
1.75HisIle: 1.75 ± 0.527
0.437HisLys: 0.437 ± 0.385
1.312HisLeu: 1.312 ± 0.962
0.437HisMet: 0.437 ± 0.332
0.437HisAsn: 0.437 ± 0.379
1.75HisPro: 1.75 ± 0.894
0.875HisGln: 0.875 ± 0.446
0.875HisArg: 0.875 ± 0.665
0.875HisSer: 0.875 ± 0.446
1.312HisThr: 1.312 ± 1.154
0.875HisVal: 0.875 ± 0.42
0.875HisTrp: 0.875 ± 0.42
0.437HisTyr: 0.437 ± 0.379
0.0HisXaa: 0.0 ± 0.0
Ile
1.312IleAla: 1.312 ± 0.592
0.0IleCys: 0.0 ± 0.0
3.062IleAsp: 3.062 ± 1.37
3.5IleGlu: 3.5 ± 1.08
1.312IlePhe: 1.312 ± 1.136
4.812IleGly: 4.812 ± 2.245
0.875IleHis: 0.875 ± 0.369
3.062IleIle: 3.062 ± 1.684
1.75IleLys: 1.75 ± 0.815
3.5IleLeu: 3.5 ± 1.477
0.875IleMet: 0.875 ± 0.42
1.75IleAsn: 1.75 ± 0.894
2.187IlePro: 2.187 ± 0.917
1.75IleGln: 1.75 ± 0.87
1.312IleArg: 1.312 ± 0.67
2.625IleSer: 2.625 ± 0.434
2.187IleThr: 2.187 ± 0.915
2.625IleVal: 2.625 ± 1.148
0.0IleTrp: 0.0 ± 0.0
1.312IleTyr: 1.312 ± 0.457
0.0IleXaa: 0.0 ± 0.0
Lys
0.875LysAla: 0.875 ± 0.769
1.312LysCys: 1.312 ± 0.664
2.187LysAsp: 2.187 ± 0.737
2.625LysGlu: 2.625 ± 0.823
2.187LysPhe: 2.187 ± 1.13
5.249LysGly: 5.249 ± 2.108
1.75LysHis: 1.75 ± 0.982
0.875LysIle: 0.875 ± 0.757
2.187LysLys: 2.187 ± 0.767
3.5LysLeu: 3.5 ± 1.216
0.437LysMet: 0.437 ± 0.694
0.437LysAsn: 0.437 ± 0.385
1.312LysPro: 1.312 ± 0.652
3.5LysGln: 3.5 ± 1.197
3.062LysArg: 3.062 ± 0.435
2.625LysSer: 2.625 ± 1.183
3.062LysThr: 3.062 ± 1.02
2.625LysVal: 2.625 ± 0.801
0.437LysTrp: 0.437 ± 0.385
2.187LysTyr: 2.187 ± 0.799
0.0LysXaa: 0.0 ± 0.0
Leu
4.374LeuAla: 4.374 ± 0.85
1.75LeuCys: 1.75 ± 1.419
8.749LeuAsp: 8.749 ± 1.79
3.937LeuGlu: 3.937 ± 1.053
6.562LeuPhe: 6.562 ± 2.662
8.311LeuGly: 8.311 ± 1.513
2.625LeuHis: 2.625 ± 0.9
3.5LeuIle: 3.5 ± 1.186
5.249LeuLys: 5.249 ± 1.233
6.124LeuLeu: 6.124 ± 1.711
0.875LeuMet: 0.875 ± 0.748
0.437LeuAsn: 0.437 ± 0.385
3.062LeuPro: 3.062 ± 1.329
4.812LeuGln: 4.812 ± 1.009
3.5LeuArg: 3.5 ± 0.708
6.124LeuSer: 6.124 ± 0.656
4.812LeuThr: 4.812 ± 1.563
6.562LeuVal: 6.562 ± 2.096
0.437LeuTrp: 0.437 ± 0.541
3.062LeuTyr: 3.062 ± 1.346
0.0LeuXaa: 0.0 ± 0.0
Met
0.875MetAla: 0.875 ± 0.42
1.312MetCys: 1.312 ± 0.865
1.312MetAsp: 1.312 ± 0.592
0.0MetGlu: 0.0 ± 0.0
0.875MetPhe: 0.875 ± 0.42
0.437MetGly: 0.437 ± 0.385
0.437MetHis: 0.437 ± 0.385
0.0MetIle: 0.0 ± 0.0
0.437MetLys: 0.437 ± 0.332
0.875MetLeu: 0.875 ± 0.622
0.0MetMet: 0.0 ± 0.0
1.75MetAsn: 1.75 ± 0.661
0.875MetPro: 0.875 ± 0.446
0.437MetGln: 0.437 ± 0.385
0.875MetArg: 0.875 ± 0.369
0.875MetSer: 0.875 ± 0.665
0.875MetThr: 0.875 ± 0.63
1.75MetVal: 1.75 ± 0.243
0.437MetTrp: 0.437 ± 0.385
0.875MetTyr: 0.875 ± 0.446
0.0MetXaa: 0.0 ± 0.0
Asn
1.312AsnAla: 1.312 ± 0.412
0.437AsnCys: 0.437 ± 0.379
2.625AsnAsp: 2.625 ± 1.259
1.75AsnGlu: 1.75 ± 0.599
3.5AsnPhe: 3.5 ± 1.317
2.625AsnGly: 2.625 ± 1.007
0.437AsnHis: 0.437 ± 0.332
0.875AsnIle: 0.875 ± 0.757
1.75AsnLys: 1.75 ± 0.616
2.625AsnLeu: 2.625 ± 0.507
0.437AsnMet: 0.437 ± 0.385
1.312AsnAsn: 1.312 ± 0.331
3.5AsnPro: 3.5 ± 1.903
0.875AsnGln: 0.875 ± 0.42
3.5AsnArg: 3.5 ± 0.974
4.374AsnSer: 4.374 ± 1.368
3.062AsnThr: 3.062 ± 1.325
1.75AsnVal: 1.75 ± 0.574
0.437AsnTrp: 0.437 ± 0.332
0.875AsnTyr: 0.875 ± 0.665
0.0AsnXaa: 0.0 ± 0.0
Pro
3.062ProAla: 3.062 ± 2.214
0.875ProCys: 0.875 ± 0.771
7.437ProAsp: 7.437 ± 2.377
3.937ProGlu: 3.937 ± 1.662
1.312ProPhe: 1.312 ± 0.618
3.937ProGly: 3.937 ± 1.572
0.0ProHis: 0.0 ± 0.0
3.5ProIle: 3.5 ± 1.418
2.625ProLys: 2.625 ± 1.012
6.562ProLeu: 6.562 ± 1.757
0.437ProMet: 0.437 ± 0.332
2.625ProAsn: 2.625 ± 1.012
6.999ProPro: 6.999 ± 1.299
3.062ProGln: 3.062 ± 0.974
4.812ProArg: 4.812 ± 1.717
3.937ProSer: 3.937 ± 1.463
3.937ProThr: 3.937 ± 1.855
1.75ProVal: 1.75 ± 0.574
0.437ProTrp: 0.437 ± 0.385
1.75ProTyr: 1.75 ± 0.833
0.0ProXaa: 0.0 ± 0.0
Gln
2.187GlnAla: 2.187 ± 0.631
1.75GlnCys: 1.75 ± 0.74
2.625GlnAsp: 2.625 ± 1.369
1.75GlnGlu: 1.75 ± 0.982
1.75GlnPhe: 1.75 ± 0.49
3.062GlnGly: 3.062 ± 0.893
0.875GlnHis: 0.875 ± 0.665
1.75GlnIle: 1.75 ± 1.159
1.75GlnLys: 1.75 ± 0.661
3.937GlnLeu: 3.937 ± 1.286
0.437GlnMet: 0.437 ± 0.385
2.625GlnAsn: 2.625 ± 1.84
2.187GlnPro: 2.187 ± 0.608
1.312GlnGln: 1.312 ± 0.331
2.187GlnArg: 2.187 ± 0.552
1.75GlnSer: 1.75 ± 0.945
1.75GlnThr: 1.75 ± 0.839
4.374GlnVal: 4.374 ± 1.031
0.875GlnTrp: 0.875 ± 0.446
1.75GlnTyr: 1.75 ± 1.193
0.0GlnXaa: 0.0 ± 0.0
Arg
3.937ArgAla: 3.937 ± 1.458
1.75ArgCys: 1.75 ± 0.797
3.5ArgAsp: 3.5 ± 1.599
2.187ArgGlu: 2.187 ± 1.044
3.062ArgPhe: 3.062 ± 1.007
3.062ArgGly: 3.062 ± 1.131
3.062ArgHis: 3.062 ± 1.157
0.437ArgIle: 0.437 ± 0.379
3.5ArgLys: 3.5 ± 0.53
6.999ArgLeu: 6.999 ± 0.845
1.312ArgMet: 1.312 ± 0.554
2.625ArgAsn: 2.625 ± 0.972
3.5ArgPro: 3.5 ± 0.665
2.625ArgGln: 2.625 ± 0.92
10.061ArgArg: 10.061 ± 2.872
3.5ArgSer: 3.5 ± 1.16
3.5ArgThr: 3.5 ± 1.097
6.562ArgVal: 6.562 ± 1.475
0.0ArgTrp: 0.0 ± 0.0
2.625ArgTyr: 2.625 ± 1.107
0.0ArgXaa: 0.0 ± 0.0
Ser
4.812SerAla: 4.812 ± 1.928
0.875SerCys: 0.875 ± 0.63
3.5SerAsp: 3.5 ± 0.867
2.187SerGlu: 2.187 ± 1.503
4.374SerPhe: 4.374 ± 1.533
6.999SerGly: 6.999 ± 1.329
0.437SerHis: 0.437 ± 0.332
2.187SerIle: 2.187 ± 1.002
2.187SerLys: 2.187 ± 0.994
7.874SerLeu: 7.874 ± 1.782
0.875SerMet: 0.875 ± 0.369
3.062SerAsn: 3.062 ± 1.283
3.937SerPro: 3.937 ± 0.752
3.5SerGln: 3.5 ± 1.118
2.625SerArg: 2.625 ± 1.079
6.124SerSer: 6.124 ± 2.621
7.874SerThr: 7.874 ± 1.237
6.124SerVal: 6.124 ± 1.963
0.437SerTrp: 0.437 ± 0.332
1.312SerTyr: 1.312 ± 0.686
0.0SerXaa: 0.0 ± 0.0
Thr
2.625ThrAla: 2.625 ± 0.835
1.312ThrCys: 1.312 ± 0.72
5.687ThrAsp: 5.687 ± 1.196
3.5ThrGlu: 3.5 ± 0.974
3.062ThrPhe: 3.062 ± 0.867
8.311ThrGly: 8.311 ± 1.845
2.187ThrHis: 2.187 ± 0.863
3.5ThrIle: 3.5 ± 1.409
0.875ThrLys: 0.875 ± 0.769
5.687ThrLeu: 5.687 ± 1.578
1.312ThrMet: 1.312 ± 0.742
2.187ThrAsn: 2.187 ± 0.713
6.124ThrPro: 6.124 ± 0.618
1.75ThrGln: 1.75 ± 0.945
6.124ThrArg: 6.124 ± 1.981
5.687ThrSer: 5.687 ± 1.875
5.249ThrThr: 5.249 ± 1.779
6.124ThrVal: 6.124 ± 1.773
0.437ThrTrp: 0.437 ± 0.385
0.875ThrTyr: 0.875 ± 0.369
0.0ThrXaa: 0.0 ± 0.0
Val
4.812ValAla: 4.812 ± 0.554
1.312ValCys: 1.312 ± 0.627
6.124ValAsp: 6.124 ± 0.838
2.625ValGlu: 2.625 ± 0.625
3.062ValPhe: 3.062 ± 0.71
6.124ValGly: 6.124 ± 1.792
1.312ValHis: 1.312 ± 0.884
3.5ValIle: 3.5 ± 0.877
2.625ValLys: 2.625 ± 0.65
2.625ValLeu: 2.625 ± 0.964
1.75ValMet: 1.75 ± 0.637
2.625ValAsn: 2.625 ± 0.593
4.812ValPro: 4.812 ± 1.873
3.937ValGln: 3.937 ± 1.051
4.812ValArg: 4.812 ± 1.806
7.437ValSer: 7.437 ± 1.848
5.249ValThr: 5.249 ± 2.227
3.5ValVal: 3.5 ± 1.068
1.312ValTrp: 1.312 ± 0.742
2.625ValTyr: 2.625 ± 1.347
0.0ValXaa: 0.0 ± 0.0
Trp
0.875TrpAla: 0.875 ± 0.665
0.0TrpCys: 0.0 ± 0.0
0.875TrpAsp: 0.875 ± 0.42
0.437TrpGlu: 0.437 ± 0.385
0.0TrpPhe: 0.0 ± 0.0
0.875TrpGly: 0.875 ± 0.449
0.0TrpHis: 0.0 ± 0.0
0.437TrpIle: 0.437 ± 0.332
0.437TrpLys: 0.437 ± 0.332
1.75TrpLeu: 1.75 ± 0.839
0.0TrpMet: 0.0 ± 0.0
0.875TrpAsn: 0.875 ± 0.42
0.437TrpPro: 0.437 ± 0.385
0.437TrpGln: 0.437 ± 0.385
1.312TrpArg: 1.312 ± 0.618
0.437TrpSer: 0.437 ± 0.385
1.312TrpThr: 1.312 ± 0.764
1.312TrpVal: 1.312 ± 0.686
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.312TyrAla: 1.312 ± 0.734
0.0TyrCys: 0.0 ± 0.0
1.75TyrAsp: 1.75 ± 0.586
1.75TyrGlu: 1.75 ± 1.094
1.75TyrPhe: 1.75 ± 0.616
2.625TyrGly: 2.625 ± 0.66
0.0TyrHis: 0.0 ± 0.0
0.437TyrIle: 0.437 ± 0.385
3.062TyrLys: 3.062 ± 1.028
3.5TyrLeu: 3.5 ± 0.99
0.875TyrMet: 0.875 ± 0.446
0.875TyrAsn: 0.875 ± 0.447
0.0TyrPro: 0.0 ± 0.0
0.875TyrGln: 0.875 ± 0.42
2.625TyrArg: 2.625 ± 0.722
0.875TyrSer: 0.875 ± 0.497
1.75TyrThr: 1.75 ± 0.584
1.75TyrVal: 1.75 ± 0.574
0.437TyrTrp: 0.437 ± 0.385
3.5TyrTyr: 3.5 ± 0.876
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2287 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski