Amino acid dipepetide frequency for Mycobacteroides franklinii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.129AlaAla: 18.129 ± 0.171	0.924AlaCys: 0.924 ± 0.025	7.681AlaAsp: 7.681 ± 0.079	7.173AlaGlu: 7.173 ± 0.081	3.478AlaPhe: 3.478 ± 0.056	11.045AlaGly: 11.045 ± 0.092	2.532AlaHis: 2.532 ± 0.037	5.697AlaIle: 5.697 ± 0.064	3.181AlaLys: 3.181 ± 0.056	12.615AlaLeu: 12.615 ± 0.113	2.832AlaMet: 2.832 ± 0.04	2.68AlaAsn: 2.68 ± 0.045	6.272AlaPro: 6.272 ± 0.104	4.251AlaGln: 4.251 ± 0.056	7.846AlaArg: 7.846 ± 0.095	6.292AlaSer: 6.292 ± 0.06	6.918AlaThr: 6.918 ± 0.064	11.018AlaVal: 11.018 ± 0.081	1.518AlaTrp: 1.518 ± 0.032	2.376AlaTyr: 2.376 ± 0.036	0.001AlaXaa: 0.001 ± 0.001
Cys	1.055CysAla: 1.055 ± 0.03	0.087CysCys: 0.087 ± 0.008	0.454CysAsp: 0.454 ± 0.018	0.385CysGlu: 0.385 ± 0.017	0.231CysPhe: 0.231 ± 0.012	0.887CysGly: 0.887 ± 0.027	0.164CysHis: 0.164 ± 0.01	0.266CysIle: 0.266 ± 0.013	0.15CysLys: 0.15 ± 0.01	0.68CysLeu: 0.68 ± 0.02	0.149CysMet: 0.149 ± 0.009	0.172CysAsn: 0.172 ± 0.011	0.495CysPro: 0.495 ± 0.021	0.254CysGln: 0.254 ± 0.011	0.548CysArg: 0.548 ± 0.02	0.492CysSer: 0.492 ± 0.017	0.487CysThr: 0.487 ± 0.016	0.611CysVal: 0.611 ± 0.021	0.121CysTrp: 0.121 ± 0.008	0.185CysTyr: 0.185 ± 0.011	0.001CysXaa: 0.001 ± 0.001
Asp	7.101AspAla: 7.101 ± 0.076	0.422AspCys: 0.422 ± 0.017	3.674AspAsp: 3.674 ± 0.058	3.975AspGlu: 3.975 ± 0.057	1.764AspPhe: 1.764 ± 0.034	5.708AspGly: 5.708 ± 0.068	1.378AspHis: 1.378 ± 0.034	2.888AspIle: 2.888 ± 0.045	1.61AspLys: 1.61 ± 0.03	5.88AspLeu: 5.88 ± 0.056	1.083AspMet: 1.083 ± 0.029	1.315AspAsn: 1.315 ± 0.034	4.16AspPro: 4.16 ± 0.051	1.867AspGln: 1.867 ± 0.035	4.181AspArg: 4.181 ± 0.045	3.129AspSer: 3.129 ± 0.054	3.169AspThr: 3.169 ± 0.043	4.912AspVal: 4.912 ± 0.06	0.939AspTrp: 0.939 ± 0.025	1.39AspTyr: 1.39 ± 0.027	0.002AspXaa: 0.002 ± 0.001
Glu	5.785GluAla: 5.785 ± 0.066	0.351GluCys: 0.351 ± 0.016	2.543GluAsp: 2.543 ± 0.041	2.567GluGlu: 2.567 ± 0.052	1.823GluPhe: 1.823 ± 0.036	3.443GluGly: 3.443 ± 0.056	1.557GluHis: 1.557 ± 0.032	2.719GluIle: 2.719 ± 0.046	1.52GluLys: 1.52 ± 0.035	6.539GluLeu: 6.539 ± 0.07	1.005GluMet: 1.005 ± 0.027	1.298GluAsn: 1.298 ± 0.027	2.904GluPro: 2.904 ± 0.05	2.268GluGln: 2.268 ± 0.039	4.243GluArg: 4.243 ± 0.052	3.045GluSer: 3.045 ± 0.05	2.719GluThr: 2.719 ± 0.046	4.308GluVal: 4.308 ± 0.06	0.713GluTrp: 0.713 ± 0.021	1.219GluTyr: 1.219 ± 0.025	0.001GluXaa: 0.001 ± 0.001
Phe	3.75PheAla: 3.75 ± 0.052	0.333PheCys: 0.333 ± 0.016	2.442PheAsp: 2.442 ± 0.042	1.602PheGlu: 1.602 ± 0.033	1.07PhePhe: 1.07 ± 0.029	3.595PheGly: 3.595 ± 0.05	0.684PheHis: 0.684 ± 0.021	1.242PheIle: 1.242 ± 0.026	0.599PheLys: 0.599 ± 0.019	2.627PheLeu: 2.627 ± 0.043	0.554PheMet: 0.554 ± 0.019	0.809PheAsn: 0.809 ± 0.026	1.419PhePro: 1.419 ± 0.029	0.767PheGln: 0.767 ± 0.022	1.725PheArg: 1.725 ± 0.032	1.934PheSer: 1.934 ± 0.041	2.211PheThr: 2.211 ± 0.037	2.626PheVal: 2.626 ± 0.045	0.49PheTrp: 0.49 ± 0.02	0.727PheTyr: 0.727 ± 0.021	0.001PheXaa: 0.001 ± 0.001
Gly	9.86GlyAla: 9.86 ± 0.084	0.776GlyCys: 0.776 ± 0.025	4.836GlyAsp: 4.836 ± 0.06	4.367GlyGlu: 4.367 ± 0.059	3.127GlyPhe: 3.127 ± 0.046	7.425GlyGly: 7.425 ± 0.101	2.022GlyHis: 2.022 ± 0.039	4.416GlyIle: 4.416 ± 0.061	2.577GlyLys: 2.577 ± 0.047	8.481GlyLeu: 8.481 ± 0.093	2.081GlyMet: 2.081 ± 0.044	2.091GlyAsn: 2.091 ± 0.043	4.323GlyPro: 4.323 ± 0.057	2.98GlyGln: 2.98 ± 0.049	5.707GlyArg: 5.707 ± 0.058	5.432GlySer: 5.432 ± 0.071	5.403GlyThr: 5.403 ± 0.059	7.503GlyVal: 7.503 ± 0.081	1.667GlyTrp: 1.667 ± 0.039	2.47GlyTyr: 2.47 ± 0.046	0.001GlyXaa: 0.001 ± 0.001
His	2.406HisAla: 2.406 ± 0.039	0.224HisCys: 0.224 ± 0.013	1.376HisAsp: 1.376 ± 0.032	1.139HisGlu: 1.139 ± 0.029	0.71HisPhe: 0.71 ± 0.02	2.158HisGly: 2.158 ± 0.039	0.69HisHis: 0.69 ± 0.023	0.945HisIle: 0.945 ± 0.028	0.44HisLys: 0.44 ± 0.018	2.022HisLeu: 2.022 ± 0.038	0.41HisMet: 0.41 ± 0.019	0.514HisAsn: 0.514 ± 0.018	1.605HisPro: 1.605 ± 0.032	0.705HisGln: 0.705 ± 0.022	1.807HisArg: 1.807 ± 0.036	1.186HisSer: 1.186 ± 0.027	1.217HisThr: 1.217 ± 0.028	1.674HisVal: 1.674 ± 0.034	0.394HisTrp: 0.394 ± 0.015	0.544HisTyr: 0.544 ± 0.019	0.001HisXaa: 0.001 ± 0.001
Ile	6.803IleAla: 6.803 ± 0.069	0.419IleCys: 0.419 ± 0.017	3.459IleAsp: 3.459 ± 0.047	2.791IleGlu: 2.791 ± 0.045	1.259IlePhe: 1.259 ± 0.027	4.75IleGly: 4.75 ± 0.061	0.82IleHis: 0.82 ± 0.027	1.744IleIle: 1.744 ± 0.044	1.12IleLys: 1.12 ± 0.03	3.37IleLeu: 3.37 ± 0.046	0.663IleMet: 0.663 ± 0.022	1.279IleAsn: 1.279 ± 0.029	2.591IlePro: 2.591 ± 0.039	1.112IleGln: 1.112 ± 0.029	2.774IleArg: 2.774 ± 0.042	2.614IleSer: 2.614 ± 0.041	3.065IleThr: 3.065 ± 0.048	3.928IleVal: 3.928 ± 0.054	0.546IleTrp: 0.546 ± 0.019	0.896IleTyr: 0.896 ± 0.022	0.001IleXaa: 0.001 ± 0.001
Lys	2.956LysAla: 2.956 ± 0.049	0.124LysCys: 0.124 ± 0.01	1.397LysAsp: 1.397 ± 0.03	1.167LysGlu: 1.167 ± 0.027	0.723LysPhe: 0.723 ± 0.023	1.778LysGly: 1.778 ± 0.032	0.58LysHis: 0.58 ± 0.02	1.234LysIle: 1.234 ± 0.028	0.824LysLys: 0.824 ± 0.033	2.402LysLeu: 2.402 ± 0.046	0.525LysMet: 0.525 ± 0.018	0.683LysAsn: 0.683 ± 0.022	1.613LysPro: 1.613 ± 0.036	0.854LysGln: 0.854 ± 0.025	1.689LysArg: 1.689 ± 0.033	1.49LysSer: 1.49 ± 0.035	1.559LysThr: 1.559 ± 0.035	2.119LysVal: 2.119 ± 0.044	0.342LysTrp: 0.342 ± 0.015	0.63LysTyr: 0.63 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.401LeuAla: 13.401 ± 0.107	0.786LeuCys: 0.786 ± 0.023	6.288LeuAsp: 6.288 ± 0.059	4.323LeuGlu: 4.323 ± 0.061	2.758LeuPhe: 2.758 ± 0.048	8.722LeuGly: 8.722 ± 0.074	2.041LeuHis: 2.041 ± 0.038	4.357LeuIle: 4.357 ± 0.06	2.106LeuLys: 2.106 ± 0.035	9.56LeuLeu: 9.56 ± 0.101	1.834LeuMet: 1.834 ± 0.035	2.296LeuAsn: 2.296 ± 0.044	5.702LeuPro: 5.702 ± 0.062	2.68LeuGln: 2.68 ± 0.044	7.217LeuArg: 7.217 ± 0.078	6.063LeuSer: 6.063 ± 0.068	6.471LeuThr: 6.471 ± 0.074	8.485LeuVal: 8.485 ± 0.083	1.246LeuTrp: 1.246 ± 0.029	1.723LeuTyr: 1.723 ± 0.032	0.001LeuXaa: 0.001 ± 0.001
Met	2.513MetAla: 2.513 ± 0.038	0.199MetCys: 0.199 ± 0.011	0.906MetAsp: 0.906 ± 0.026	0.718MetGlu: 0.718 ± 0.024	0.657MetPhe: 0.657 ± 0.022	1.573MetGly: 1.573 ± 0.033	0.441MetHis: 0.441 ± 0.017	0.992MetIle: 0.992 ± 0.025	0.522MetLys: 0.522 ± 0.021	2.05MetLeu: 2.05 ± 0.04	0.462MetMet: 0.462 ± 0.02	0.581MetAsn: 0.581 ± 0.019	1.227MetPro: 1.227 ± 0.029	0.549MetGln: 0.549 ± 0.019	1.565MetArg: 1.565 ± 0.034	1.692MetSer: 1.692 ± 0.036	1.87MetThr: 1.87 ± 0.038	1.641MetVal: 1.641 ± 0.031	0.273MetTrp: 0.273 ± 0.013	0.366MetTyr: 0.366 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.741AsnAla: 2.741 ± 0.041	0.205AsnCys: 0.205 ± 0.012	1.35AsnAsp: 1.35 ± 0.029	1.139AsnGlu: 1.139 ± 0.026	0.745AsnPhe: 0.745 ± 0.021	2.247AsnGly: 2.247 ± 0.038	0.487AsnHis: 0.487 ± 0.018	1.132AsnIle: 1.132 ± 0.031	0.577AsnLys: 0.577 ± 0.019	2.233AsnLeu: 2.233 ± 0.038	0.468AsnMet: 0.468 ± 0.017	0.672AsnAsn: 0.672 ± 0.025	1.935AsnPro: 1.935 ± 0.041	0.777AsnGln: 0.777 ± 0.024	1.569AsnArg: 1.569 ± 0.032	1.326AsnSer: 1.326 ± 0.03	1.472AsnThr: 1.472 ± 0.03	1.918AsnVal: 1.918 ± 0.034	0.413AsnTrp: 0.413 ± 0.016	0.63AsnTyr: 0.63 ± 0.022	0.001AsnXaa: 0.001 ± 0.001
Pro	6.962ProAla: 6.962 ± 0.093	0.29ProCys: 0.29 ± 0.016	4.077ProAsp: 4.077 ± 0.051	3.801ProGlu: 3.801 ± 0.052	1.644ProPhe: 1.644 ± 0.033	5.479ProGly: 5.479 ± 0.058	1.254ProHis: 1.254 ± 0.028	2.329ProIle: 2.329 ± 0.04	1.475ProLys: 1.475 ± 0.035	4.851ProLeu: 4.851 ± 0.053	1.184ProMet: 1.184 ± 0.029	1.47ProAsn: 1.47 ± 0.03	3.324ProPro: 3.324 ± 0.079	1.895ProGln: 1.895 ± 0.046	3.222ProArg: 3.222 ± 0.048	3.222ProSer: 3.222 ± 0.048	3.386ProThr: 3.386 ± 0.049	5.01ProVal: 5.01 ± 0.063	0.889ProTrp: 0.889 ± 0.025	1.176ProTyr: 1.176 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	3.685GlnAla: 3.685 ± 0.046	0.223GlnCys: 0.223 ± 0.011	1.391GlnAsp: 1.391 ± 0.032	1.315GlnGlu: 1.315 ± 0.028	1.07GlnPhe: 1.07 ± 0.028	2.265GlnGly: 2.265 ± 0.044	0.785GlnHis: 0.785 ± 0.024	1.68GlnIle: 1.68 ± 0.034	0.739GlnLys: 0.739 ± 0.021	3.763GlnLeu: 3.763 ± 0.055	0.736GlnMet: 0.736 ± 0.024	0.75GlnAsn: 0.75 ± 0.024	1.873GlnPro: 1.873 ± 0.035	1.52GlnGln: 1.52 ± 0.048	2.741GlnArg: 2.741 ± 0.048	1.737GlnSer: 1.737 ± 0.034	1.658GlnThr: 1.658 ± 0.034	2.741GlnVal: 2.741 ± 0.046	0.634GlnTrp: 0.634 ± 0.02	0.775GlnTyr: 0.775 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.735ArgAla: 7.735 ± 0.076	0.512ArgCys: 0.512 ± 0.019	4.107ArgAsp: 4.107 ± 0.061	3.893ArgGlu: 3.893 ± 0.048	2.361ArgPhe: 2.361 ± 0.041	4.866ArgGly: 4.866 ± 0.052	1.676ArgHis: 1.676 ± 0.034	3.491ArgIle: 3.491 ± 0.044	1.734ArgLys: 1.734 ± 0.038	6.897ArgLeu: 6.897 ± 0.079	1.791ArgMet: 1.791 ± 0.035	1.64ArgAsn: 1.64 ± 0.031	3.658ArgPro: 3.658 ± 0.051	2.382ArgGln: 2.382 ± 0.039	5.842ArgArg: 5.842 ± 0.079	3.942ArgSer: 3.942 ± 0.05	4.053ArgThr: 4.053 ± 0.051	5.347ArgVal: 5.347 ± 0.057	1.329ArgTrp: 1.329 ± 0.031	1.877ArgTyr: 1.877 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.277SerAla: 7.277 ± 0.074	0.478SerCys: 0.478 ± 0.017	3.392SerAsp: 3.392 ± 0.055	2.888SerGlu: 2.888 ± 0.044	1.809SerPhe: 1.809 ± 0.034	5.886SerGly: 5.886 ± 0.078	1.13SerHis: 1.13 ± 0.027	2.533SerIle: 2.533 ± 0.041	1.355SerLys: 1.355 ± 0.031	5.184SerLeu: 5.184 ± 0.058	1.496SerMet: 1.496 ± 0.035	1.283SerAsn: 1.283 ± 0.031	3.209SerPro: 3.209 ± 0.05	1.673SerGln: 1.673 ± 0.038	3.777SerArg: 3.777 ± 0.049	3.528SerSer: 3.528 ± 0.057	3.635SerThr: 3.635 ± 0.055	4.983SerVal: 4.983 ± 0.06	0.99SerTrp: 0.99 ± 0.026	1.281SerTyr: 1.281 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.649ThrAla: 7.649 ± 0.069	0.423ThrCys: 0.423 ± 0.016	3.649ThrAsp: 3.649 ± 0.049	3.311ThrGlu: 3.311 ± 0.049	1.907ThrPhe: 1.907 ± 0.036	5.671ThrGly: 5.671 ± 0.059	1.249ThrHis: 1.249 ± 0.034	2.612ThrIle: 2.612 ± 0.047	1.518ThrLys: 1.518 ± 0.039	5.691ThrLeu: 5.691 ± 0.059	1.214ThrMet: 1.214 ± 0.03	1.39ThrAsn: 1.39 ± 0.033	3.816ThrPro: 3.816 ± 0.057	1.681ThrGln: 1.681 ± 0.03	3.64ThrArg: 3.64 ± 0.051	3.37ThrSer: 3.37 ± 0.055	3.915ThrThr: 3.915 ± 0.06	5.955ThrVal: 5.955 ± 0.065	0.86ThrTrp: 0.86 ± 0.023	1.403ThrTyr: 1.403 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.759ValAla: 10.759 ± 0.097	0.725ValCys: 0.725 ± 0.018	5.423ValAsp: 5.423 ± 0.061	4.258ValGlu: 4.258 ± 0.053	2.645ValPhe: 2.645 ± 0.044	6.823ValGly: 6.823 ± 0.072	1.8ValHis: 1.8 ± 0.036	4.264ValIle: 4.264 ± 0.063	1.857ValLys: 1.857 ± 0.036	9.03ValLeu: 9.03 ± 0.09	1.633ValMet: 1.633 ± 0.032	2.168ValAsn: 2.168 ± 0.039	4.73ValPro: 4.73 ± 0.052	2.392ValGln: 2.392 ± 0.038	5.8ValArg: 5.8 ± 0.068	5.09ValSer: 5.09 ± 0.056	5.592ValThr: 5.592 ± 0.06	8.173ValVal: 8.173 ± 0.09	1.052ValTrp: 1.052 ± 0.026	1.617ValTyr: 1.617 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.54TrpAla: 1.54 ± 0.032	0.139TrpCys: 0.139 ± 0.01	0.776TrpAsp: 0.776 ± 0.023	0.658TrpGlu: 0.658 ± 0.02	0.559TrpPhe: 0.559 ± 0.02	1.054TrpGly: 1.054 ± 0.029	0.415TrpHis: 0.415 ± 0.016	0.71TrpIle: 0.71 ± 0.022	0.369TrpLys: 0.369 ± 0.016	1.703TrpLeu: 1.703 ± 0.041	0.356TrpMet: 0.356 ± 0.016	0.411TrpAsn: 0.411 ± 0.016	0.803TrpPro: 0.803 ± 0.025	0.663TrpGln: 0.663 ± 0.022	1.236TrpArg: 1.236 ± 0.027	0.944TrpSer: 0.944 ± 0.027	0.923TrpThr: 0.923 ± 0.025	1.188TrpVal: 1.188 ± 0.027	0.372TrpTrp: 0.372 ± 0.017	0.365TrpTyr: 0.365 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.352TyrAla: 2.352 ± 0.04	0.234TyrCys: 0.234 ± 0.013	1.328TyrAsp: 1.328 ± 0.028	1.099TyrGlu: 1.099 ± 0.026	0.865TyrPhe: 0.865 ± 0.023	2.17TyrGly: 2.17 ± 0.041	0.464TyrHis: 0.464 ± 0.017	0.755TyrIle: 0.755 ± 0.022	0.416TyrLys: 0.416 ± 0.017	2.479TyrLeu: 2.479 ± 0.045	0.32TyrMet: 0.32 ± 0.016	0.532TyrAsn: 0.532 ± 0.019	1.282TyrPro: 1.282 ± 0.028	0.811TyrGln: 0.811 ± 0.024	2.003TyrArg: 2.003 ± 0.039	1.257TyrSer: 1.257 ± 0.031	1.204TyrThr: 1.204 ± 0.03	1.688TyrVal: 1.688 ± 0.034	0.393TyrTrp: 0.393 ± 0.018	0.501TyrTyr: 0.501 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4855 proteins (1535828 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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